Ascorbate as a Co-Factor for Fe- and 2-Oxoglutarate Dependent Dioxygenases: Physiological Activity in Tumor Growth and Progression

FTO and Obesity: Mechanisms of Association

(2014) Xu Zhao et al.   Current Diabetes Reports

Intracellular ascorbate enhances hypoxia-inducible factor (HIF)-hydroxylase activity and preferentially suppresses the HIF-1 transcriptional response

(2014) Caroline Kuiper et al.   FREE RADICAL BIOLOGY AND MEDICINE

OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation

(2014) R. S. Singleton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TET1-Mediated Hydroxymethylation Facilitates Hypoxic Gene Induction in Neuroblastoma

(2014) Christopher J. Mariani et al.   Cell Reports

Increased Tumor Ascorbate is Associated with Extended Disease-Free Survival and Decreased Hypoxia-Inducible Factor-1 Activation in Human Colorectal Cancer

(2014) Caroline Kuiper et al.   Frontiers in Oncology

Breathing-in epigenetic change with vitamin C

(2013) Asun Monfort et al.   EMBO REPORTS

What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer

(2013) J.-A. Losman et al.   GENES & DEVELOPMENT

Ascorbate Induces Ten-Eleven Translocation (Tet) Methylcytosine Dioxygenase-mediated Generation of 5-Hydroxymethylcytosine

(2013) Emily A. Minor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ascorbic Acid Enhances Tet-Mediated 5-Methylcytosine Oxidation and Promotes DNA Demethylation in Mammals

(2013) Ruichuan Yin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells

(2013) Kathryn Blaschke et al.   NATURE

Vitamin C modulates TET1 function during somatic cell reprogramming

(2013) Jiekai Chen et al.   NATURE GENETICS

Sprouts of RNA epigenetics

(2013) Guanqun Zheng et al.   RNA Biology

Kinetic analysis of FTO (fat mass and obesity-associated) reveals that it is unlikely to function as a sensor for 2-oxoglutarate

(2012) Marcella Ma et al.   BIOCHEMICAL JOURNAL

Changes in Protein Dynamics of the DNA Repair Dioxygenase AlkB upon Binding of Fe2+ and 2-Oxoglutarate

(2012) Boris Bleijlevens et al.   BIOCHEMISTRY

Ascorbic acid: Chemistry, biology and the treatment of cancer

(2012) Juan Du et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity

(2012) Norma Masson et al.   EMBO REPORTS

Autocatalysed oxidative modifications to 2-oxoglutarate dependent oxygenases

(2012) Monica Mantri et al.   FEBS Journal

Enhanced antitumor activity of vitamin C via p53 in Cancer cells

(2012) Jinsun Kim et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ascorbate supplementation inhibits growth and metastasis of B16FO melanoma and 4T1 breast cancer cells in vitamin C-deficient mice

(2012) JOHN CHA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans

(2012) Wei Ge et al.   Nature Chemical Biology

SVCT-2 in breast cancer acts as an indicator for L-ascorbate treatment

(2012) S-W Hong et al.   ONCOGENE

Phase I Evaluation of Intravenous Ascorbic Acid in Combination with Gemcitabine and Erlotinib in Patients with Metastatic Pancreatic Cancer

(2012) Daniel A. Monti et al.   PLoS One

High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq

(2011) J. Schodel et al.   BLOOD

Vitamin C is dispensable for oxygen sensing in vivo

(2011) K. J. Nytko et al.   BLOOD

The SLC23 family of ascorbate transporters: ensuring that you get and keep your daily dose of vitamin C

(2011) James M May   BRITISH JOURNAL OF PHARMACOLOGY

The Histone Demethylases Jhdm1a/1b Enhance Somatic Cell Reprogramming in a Vitamin-C-Dependent Manner

(2011) Tao Wang et al.   Cell Stem Cell

Hypoxia-mediated drug resistance: Novel insights on the functional interaction of HIFs and cell death pathways

(2011) Nadine Rohwer et al.   DRUG RESISTANCE UPDATES

Pharmacologic ascorbate synergizes with gemcitabine in preclinical models of pancreatic cancer

(2011) Michael Graham Espey et al.   FREE RADICAL BIOLOGY AND MEDICINE

Effects of ascorbic acid on carcinogenicity and acute toxicity of nickel subsulfide, and on tumor transplants growth in gulonolactone oxidase knock-out mice and wild-type C57BL mice

(2011) Kazimierz S. Kasprzak et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Prostate Imaging Modalities that Can Be Used for Complementary and Alternative Medicine Clinical Studies

(2011) Reginald W. Dusing et al.   UROLOGIC CLINICS OF NORTH AMERICA

Chelation of intracellular iron enhances endothelial barrier function: A role for vitamin C?

(2010) James M. May et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Cellular pathways for transport and efflux of ascorbate and dehydroascorbate

(2010) Alessandro Corti et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents

(2010) Emily Flashman et al.   BIOCHEMICAL JOURNAL

Ascorbate exerts anti-proliferative effects through cell cycle inhibition and sensitizes tumor cells towards cytostatic drugs

(2010) Anja Frömberg et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Low Ascorbate Levels Are Associated with Increased Hypoxia-Inducible Factor-1 Activity and an Aggressive Tumor Phenotype in Endometrial Cancer

(2010) C. Kuiper et al.   CANCER RESEARCH

Vitamin C Enhances the Generation of Mouse and Human Induced Pluripotent Stem Cells

(2010) Miguel Angel Esteban et al.   Cell Stem Cell

Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

(2010) Shinsuke Ito et al.   NATURE

Vitamin C: Intravenous Use by Complementary and Alternative Medicine Practitioners and Adverse Effects

(2010) Sebastian J. Padayatty et al.   PLoS One

Physiological and biochemical aspects of hydroxylations and demethylations catalyzed by human 2-oxoglutarate oxygenases

(2010) Christoph Loenarz et al.   TRENDS IN BIOCHEMICAL SCIENCES

Cobalt-induced oxidant stress in cultured endothelial cells: Prevention by ascorbate in relation to HIF-1α

(2009) Huan Qiao et al.   BIOFACTORS

HIF-1: upstream and downstream of cancer metabolism

(2009) Gregg L Semenza   CURRENT OPINION IN GENETICS & DEVELOPMENT

Pharmacologic concentrations of ascorbate are achieved by parenteral administration and exhibit antitumoral effects

(2009) Julien Verrax et al.   FREE RADICAL BIOLOGY AND MEDICINE

Antiproliferative Effect of Ascorbic Acid Is Associated with the Inhibition of Genes Necessary to Cell Cycle Progression

(2009) Sophie Belin et al.   PLoS One

CANCER: Puzzling Patterns of Predisposition

(2009) P. J. Pollard et al.   SCIENCE

Jmjd6 Catalyses Lysyl-Hydroxylation of U2AF65, a Protein Associated with RNA Splicing

(2009) Celia J. Webby et al.   SCIENCE

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

(2009) M. Tahiliani et al.   SCIENCE

Kinetic characterization and identification of a novel inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 using a time-resolved fluorescence resonance energy transfer-based assay technology

(2008) Jennifer H. Dao et al.   ANALYTICAL BIOCHEMISTRY

Phase I clinical trial of i.v. ascorbic acid in advanced malignancy

(2008) L. J. Hoffer et al.   ANNALS OF ONCOLOGY

Increased levels of 8-hydroxydeoxyguanosine and its relationship with lipid peroxidation and antioxidant vitamins in lung cancer

(2008) Emel Çalışkan-Can et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Reactive Oxygen Species Regulate Hypoxia-Inducible Factor 1  Differentially in Cancer and Ischemia

(2008) A. A. Qutub et al.   MOLECULAR AND CELLULAR BIOLOGY

Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice

(2008) Q. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metal Ions-Stimulated Iron Oxidation in Hydroxylases Facilitates Stabilization of HIF-1α Protein

(2008) Monika Kaczmarek et al.   TOXICOLOGICAL SCIENCES