Dietary Sugars and Endogenous Formation of Advanced Glycation Endproducts: Emerging Mechanisms of Disease

Acute metabolic and endocrine responses induced by glucose and fructose in healthy young subjects: A double-blinded, randomized, crossover trial

(2018) Wenwen Cai et al.   CLINICAL NUTRITION

Ilex paraguariensis and its main component chlorogenic acid inhibit fructose formation of advanced glycation endproducts with amino acids at conditions compatible with those in the digestive system

(2017) Yasmin Bains et al.   FITOTERAPIA

Long-term administration of advanced glycation end-product stimulates the activation of NLRP3 inflammasome and sparking the development of renal injury

(2017) Wan-Ju Yeh et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

High-fructose corn syrup-55 consumption alters hepatic lipid metabolism and promotes triglyceride accumulation

(2017) Kaitlin Mock et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Chronic administration of saturated fats and fructose differently affect SREBP activity resulting in different modulation of Nrf2 and Nlrp3 inflammasome pathways in mice liver

(2017) Debora Nigro et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Regulatory landscape of AGE-RAGE-oxidative stress axis and its modulation by PPARγ activation in high fructose diet-induced metabolic syndrome

(2017) Luca Cannizzaro et al.   Nutrition & Metabolism

The Scientific Basis of Guideline Recommendations on Sugar Intake

(2016) Jennifer Erickson et al.   ANNALS OF INTERNAL MEDICINE

Guidelines to Limit Added Sugar Intake: Junk Science or Junk Food?

(2016) Dean Schillinger et al.   ANNALS OF INTERNAL MEDICINE

Dietary fructose as a risk factor for non-alcoholic fatty liver disease (NAFLD)

(2016) Salamah Mohammad Alwahsh et al.   ARCHIVES OF TOXICOLOGY

Short-term isocaloric fructose restriction lowers apoC-III levels and yields less atherogenic lipoprotein profiles in children with obesity and metabolic syndrome

(2016) Alejandro Gugliucci et al.   ATHEROSCLEROSIS

Toll-like receptor-6 (TLR6) deficient mice are protected from myocardial fibrosis induced by high fructose feeding through anti-oxidant and inflammatory signaling pathway

(2016) Yuan Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Association between carbohydrate nutrition and prevalence of depressive symptoms in older adults

(2016) Bamini Gopinath et al.   BRITISH JOURNAL OF NUTRITION

Improved Glycemic Control and Vascular Function in Overweight and Obese Subjects by Glyoxalase 1 Inducer Formulation

(2016) Mingzhan Xue et al.   DIABETES

Oral AGE restriction ameliorates insulin resistance in obese individuals with the metabolic syndrome: a randomised controlled trial

(2016) Helen Vlassara et al.   DIABETOLOGIA

Energy and Nutrient Timing for Weight Control

(2016) Megan A. McCrory et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Sugars, obesity, and cardiovascular disease: results from recent randomized control trials

(2016) James M. Rippe et al.   EUROPEAN JOURNAL OF NUTRITION

Galectin-3 regulates inflammasome activation in cholestatic liver injury

(2016) Jijing Tian et al.   FASEB JOURNAL

Fructose-derived advanced glycation end-products drive lipogenesis and skeletal muscle reprogramming via SREBP-1c dysregulation in mice

(2016) R. Mastrocola et al.   FREE RADICAL BIOLOGY AND MEDICINE

ChREBP regulates fructose-induced glucose production independently of insulin signaling

(2016) Mi-Sung Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Nonalcoholic fatty liver disease is associated with excessive calorie intake rather than a distinctive dietary pattern

(2016) Malte H. Wehmeyer et al.   MEDICINE

Polydatin attenuates AGEs-induced upregulation of fibronectin and ICAM-1 in rat glomerular mesangial cells and db/db diabetic mice kidneys by inhibiting the activation of the SphK1-S1P signaling pathway

(2016) Cheng Chen et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

High-fructose intake as risk factor for neurodegeneration: Key role for carboxy methyllysine accumulation in mice hippocampal neurons

(2016) Raffaella Mastrocola et al.   NEUROBIOLOGY OF DISEASE

Pathologic role of dietary advanced glycation end products in cardiometabolic disorders, and therapeutic intervention

(2016) Sho-ichi Yamagishi et al.   NUTRITION

Maladaptive Modulations of NLRP3 Inflammasome and Cardioprotective Pathways Are Involved in Diet-Induced Exacerbation of Myocardial Ischemia/Reperfusion Injury in Mice

(2016) Raffaella Mastrocola et al.   Oxidative Medicine and Cellular Longevity

Intake of high-fructose corn syrup sweetened soft drinks, fruit drinks and apple juice is associated with prevalent arthritis in US adults, aged 20–30 years

(2016) L R DeChristopher et al.   Nutrition & Diabetes

Sugar Industry and Coronary Heart Disease Research

(2016) Cristin E. Kearns et al.   JAMA Internal Medicine

Cinnamaldehyde and allopurinol reduce fructose-induced cardiac inflammation and fibrosis by attenuating CD36-mediated TLR4/6-IRAK4/1 signaling to suppress NLRP3 inflammasome activation

(2016) Lin-Lin Kang et al.   Scientific Reports

Betanin reduces the accumulation and cross-links of collagen in high-fructose-fed rat heart through inhibiting non-enzymatic glycation

(2015) Junyan Han et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Delayed Intervention With Pyridoxamine Improves Metabolic Function and Prevents Adipose Tissue Inflammation and Insulin Resistance in High-Fat Diet–Induced Obese Mice

(2015) Dionne E. Maessen et al.   DIABETES

Effects of chronic sugar consumption on lipid accumulation and autophagy in the skeletal muscle

(2015) Daniela De Stefanis et al.   EUROPEAN JOURNAL OF NUTRITION

Pterostilbene and allopurinol reduce fructose-induced podocyte oxidative stress and inflammation via microRNA-377

(2015) Wei Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

A review of sugar consumption from nationally representative dietary surveys across the world

(2015) K. J. Newens et al.   JOURNAL OF HUMAN NUTRITION AND DIETETICS

Unknown

(2015) Ilija Jeftic et al.   MOLECULAR MEDICINE

Targeting the NLRP3 Inflammasome to Reduce Diet-Induced Metabolic Abnormalities in Mice

(2015) Fausto Chiazza et al.   MOLECULAR MEDICINE

Intake of high fructose corn syrup sweetened soft drinks is associated with prevalent chronic bronchitis in U.S. Adults, ages 20–55 y

(2015) Luanne Robalo DeChristopher et al.   Nutrition Journal

Isocaloric fructose restriction and metabolic improvement in children with obesity and metabolic syndrome

(2015) Robert H. Lustig et al.   Obesity

Intakes of apple juice, fruit drinks and soda are associated with prevalent asthma in US children aged 2–9 years

(2015) Luanne Robalo DeChristopher et al.   PUBLIC HEALTH NUTRITION

Cognitive and behavioural effects of sugar consumption in rodents. A review

(2014) Michael D. Kendig   APPETITE

N ε -(Carboxymethyl)lysine-Receptor for Advanced Glycation End Product Axis Is a Key Modulator of Obesity-Induced Dysregulation of Adipokine Expression and Insulin Resistance

(2014) Katrien H.J. Gaens et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The effect of high-fat–high-fructose diet on skeletal muscle mitochondrial energetics in adult rats

(2014) Raffaella Crescenzo et al.   EUROPEAN JOURNAL OF NUTRITION

Quercetin inhibits AMPK/TXNIP activation and reduces inflammatory lesions to improve insulin signaling defect in the hypothalamus of high fructose-fed rats

(2014) Qing-Yu Zhang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Kinetics of Glycoxidation of Bovine Serum Albumin by Methylglyoxal and Glyoxal and its Prevention by Various Compounds

(2014) Izabela Sadowska-Bartosz et al.   MOLECULES

Oral glycotoxins are a modifiable cause of dementia and the metabolic syndrome in mice and humans

(2014) Weijing Cai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Variability in Myosteatosis and Insulin Resistance Induced by High-Fat Diet in Mouse Skeletal Muscles

(2014) Massimo Collino et al.   Biomed Research International

New Unsweetened Truths About Sugar

(2014) Laura A. Schmidt   JAMA Internal Medicine

Added Sugar Intake and Cardiovascular Diseases Mortality Among US Adults

(2014) Quanhe Yang et al.   JAMA Internal Medicine

Advanced glycation end products promote hepatosteatosis by interfering with SCAP-SREBP pathway in fructose-drinking mice

(2013) Raffaella Mastrocola et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Morin reduces hepatic inflammation-associated lipid accumulation in high fructose-fed rats via inhibiting sphingosine kinase 1/sphingosine 1-phosphate signaling pathway

(2013) Xing Wang et al.   BIOCHEMICAL PHARMACOLOGY

Post-translational modification derived products (PTMDPs): toxins in chronic diseases?

(2013) Philippe Gillery et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Increased plasma sphingosine-1-phosphate in obese individuals and its capacity to increase the expression of plasminogen activator inhibitor-1 in adipocytes

(2013) Shiori Ito et al.   CORONARY ARTERY DISEASE

Galectin-3 Deficiency Accelerates High-Fat Diet-Induced Obesity and Amplifies Inflammation in Adipose Tissue and Pancreatic Islets

(2013) N. N. Pejnovic et al.   DIABETES

Dietary advanced glycation end-product restriction for the attenuation of insulin resistance, oxidative stress and endothelial dysfunction: a systematic review

(2013) N J Kellow et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Advanced glycoxidation and lipoxidation end products (AGEs and ALEs): an overview of their mechanisms of formation

(2013) G. Vistoli et al.   FREE RADICAL RESEARCH

High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase

(2013) Takuji Ishimoto et al.   HEPATOLOGY

Development of Nonalcoholic Hepatopathy: Contributions of Oxidative Stress and Advanced Glycation End Products

(2013) Juliana Santos et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nlrp3 is a key modulator of diet-induced nephropathy and renal cholesterol accumulation

(2013) Pieter J. Bakker et al.   KIDNEY INTERNATIONAL

High Sugar Intake and Development of Skeletal Muscle Insulin Resistance and Inflammation in Mice: A Protective Role for PPAR-δAgonism

(2013) Elisa Benetti et al.   MEDIATORS OF INFLAMMATION

Aging risk factors and Parkinson's disease: contrasting roles of common dietary constituents

(2013) Alan R. Hipkiss   NEUROBIOLOGY OF AGING

Spatial memory impairments in a prediabetic rat model

(2013) E. Soares et al.   NEUROSCIENCE

Galectin-3 is a regulator of metaflammation in adipose tissue and pancreatic islets

(2013) Nada N Pejnovic et al.   Adipocyte

HMGB1 Promotes the Synthesis of Pro-IL-1β and Pro-IL-18 by Activation of p38 MAPK and NF-κB Through Receptors for Advanced Glycation End-products in Macrophages

(2012) Qiang He et al.   Asian Pacific Journal of Cancer Prevention

Allopurinol, quercetin and rutin ameliorate renal NLRP3 inflammasome activation and lipid accumulation in fructose-fed rats

(2012) Qing-Hua Hu et al.   BIOCHEMICAL PHARMACOLOGY

Reversal of the deleterious effects of chronic dietary HFCS-55 intake by PPAR-δ agonism correlates with impaired NLRP3 inflammasome activation

(2012) Massimo Collino et al.   BIOCHEMICAL PHARMACOLOGY

"Toxic" effects of sugar: should we be afraid of fructose?

(2012) Luc Tappy   BMC BIOLOGY

Increased hepatic de novo lipogenesis and mitochondrial efficiency in a model of obesity induced by diets rich in fructose

(2012) Raffaella Crescenzo et al.   EUROPEAN JOURNAL OF NUTRITION

Plasma sphingolipids are biomarkers of metabolic syndrome in non-human primates maintained on a Western-style diet

(2012) J T Brozinick et al.   INTERNATIONAL JOURNAL OF OBESITY

Consumption of fructose- but not glucose-sweetened beverages for 10 weeks increases circulating concentrations of uric acid, retinol binding protein-4, and gamma-glutamyl transferase activity in overweight/obese humans

(2012) Chad L Cox et al.   Nutrition & Metabolism

Kinetics of Advanced Glycation End Products Formation on Bovine Serum Albumin with Various Reducing Sugars and Dicarbonyl Compounds in Equimolar Ratios

(2012) Lars Luers et al.   REJUVENATION RESEARCH

Restriction of Advanced Glycation End Products Improves Insulin Resistance in Human Type 2 Diabetes: Potential role of AGER1 and SIRT1

(2011) J. Uribarri et al.   DIABETES CARE

Nutrition and Alzheimer's disease: The detrimental role of a high carbohydrate diet

(2011) Stephanie Seneff et al.   European Journal of Internal Medicine

Serum concentration of an inflammatory glycotoxin, methylglyoxal, is associated with increased cognitive decline in elderly individuals

(2011) Michal Schnaider Beeri et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Changes in Diet and Lifestyle and Long-Term Weight Gain in Women and Men

(2011) Dariush Mozaffarian et al.   NEW ENGLAND JOURNAL OF MEDICINE

Fructose containing sugars modulate mRNA of lipogenic genes ACC and FAS and protein levels of transcription factors ChREBP and SREBP1c with no effect on body weight or liver fat

(2011) Mile Janevski et al.   Food & Function

Fructose: a highly lipogenic nutrient implicated in insulin resistance, hepatic steatosis, and the metabolic syndrome

(2010) Mark J. Dekker et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Sugar-Sweetened Beverages, Obesity, Type 2 Diabetes Mellitus, and Cardiovascular Disease Risk

(2010) Vasanti S. Malik et al.   CIRCULATION

Intake of Added Sugars and Selected Nutrients in the United States, National Health and Nutrition Examination Survey (NHANES) 2003—2006

(2010) Bernadette P. Marriott et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Inhibition of De Novo Ceramide Synthesis Reverses Diet-Induced Insulin Resistance and Enhances Whole-Body Oxygen Consumption

(2010) J. R. Ussher et al.   DIABETES

Soft drinks consumption and nonalcoholic fatty liver disease

(2010) William Nseir   WORLD JOURNAL OF GASTROENTEROLOGY

Fructose overconsumption causes dyslipidemia and ectopic lipid deposition in healthy subjects with and without a family history of type 2 diabetes

(2009) Kim-Anne Lê et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans

(2009) Kimber L. Stanhope et al.   JOURNAL OF CLINICAL INVESTIGATION

Soft drink consumption is associated with fatty liver disease independent of metabolic syndrome

(2009) Ali Abid et al.   JOURNAL OF HEPATOLOGY

Oral Glycotoxins Determine the Effects of Calorie Restriction on Oxidant Stress, Age-Related Diseases, and Lifespan

(2008) Weijing Cai et al.   AMERICAN JOURNAL OF PATHOLOGY

Dietary fructose induces a wide range of genes with distinct shift in carbohydrate and lipid metabolism in fed and fasted rat liver

(2008) Hyun-Young Koo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Role of diet and fuel overabundance in the development and progression of heart failure

(2008) D. J. Chess et al.   CARDIOVASCULAR RESEARCH

Fructose and carbonyl metabolites as endogenous toxins

(2008) O. Lee et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Dietary fructose and the metabolic syndrome

(2008) Abigale Miller et al.   CURRENT OPINION IN GASTROENTEROLOGY

Plasma Ceramides Are Elevated in Obese Subjects With Type 2 Diabetes and Correlate With the Severity of Insulin Resistance

(2008) J. M. Haus et al.   DIABETES

Evidence for sugar addiction: Behavioral and neurochemical effects of intermittent, excessive sugar intake

(2007) Nicole M. Avena et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS