Article
Biochemistry & Molecular Biology
Ana Andres-Hernando, David J. Orlicky, Christina Cicerchi, Masanari Kuwabara, Gabriela E. Garcia, Takahiko Nakagawa, Laura Gabriela Sanchez-Lozada, Richard J. Johnson, Miguel A. Lanaspa
Summary: Obesity and metabolic syndrome increase the susceptibility to chronic kidney disease (CKD), potentially due to enhanced absorption and utilization of fructose. Pound mice with metabolic syndrome showed increased expression of fructose transporter and fructokinase, leading to enhanced fructose absorption. Administration of high fructose corn syrup (HFCS) rapidly induced CKD in pound mice, whereas pound mice lacking fructokinase were protected from CKD. Lowering added sugar intake may reduce the risk for CKD in subjects with metabolic syndrome.
Review
Nutrition & Dietetics
Xiang Li, Yunqi Luan, Yuejin Li, Shili Ye, Guihui Wang, Xinlun Cai, Yucai Liang, Hamed Kord Varkaneh, Yunpeng Luan
Summary: The meta-analysis suggests that HFCS intake is associated with an increase in CRP levels compared to sucrose, while no significant differences were observed in other anthropometric and metabolic parameters between the two sweeteners.
FRONTIERS IN NUTRITION
(2022)
Article
Food Science & Technology
Ta-Kang Huang, Min-Chieh Chuang, Yi Kung, Bo-Chuan Hsieh
Summary: The study developed a sensing approach using charge transfer resistance (RCT) and logarithmic impedance (Log Z) to differentiate pure honey, blended honey, and HFCS, with good resolution and reproducibility. The data acquisition time for obtaining RCT and Log Z were only 3 min and 4 s, suitable for routine rapid screening purpose.
Article
Biochemistry & Molecular Biology
Hidemi Hattori, Yuma Hanai, Yuto Oshima, Hiroaki Kataoka, Nozomu Eto
Summary: Excessive consumption of HFCS drinks, such as soft drinks, without a proper diet, induces nonobese IGT due to insulin-secretion defect. This study found that excess HFCS-water intake did not lead to obesity, but impaired glucose tolerance (IGT) due to insulin-secretion defect. The intake of HFCS-water affected glucose and fructose metabolism by decreasing the expression of certain enzymes in the pancreas.
Article
Endocrinology & Metabolism
Grigorios Papadopoulos, Aigli-Ioanna Legaki, Konstantina Georgila, Panagiotis Vorkas, Eirini Giannousi, George Stamatakis, Ioannis I. Moustakas, Maria Petrocheilou, Iryna Pyrina, Bettina Gercken, Eva Kassi, Triantafyllos Chavakis, Ioannis S. Pateras, George Panayotou, Helen Gika, Martina Samiotaki, Aristides G. Eliopoulos, Antonios Chatzigeorgiou
Summary: The consumption of High-Fructose Corn Syrup (HFCS) is associated with the emergence and progression of Non-Alcoholic Fatty Liver Disease (NAFLD). In this study, the role of HFCS in obesity-associated NAFLD was characterized using omics approaches. The results revealed that HFCS aggravates steatosis, increases hepatic insulin resistance, and activates the de novo lipogenesis (DNL) pathway and the Tricarboxylic Acid (TCA) cycle.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2023)
Article
Biochemistry & Molecular Biology
Yoshitaka Ando, Hiroya Yamada, Eiji Munetsuna, Mirai Yamazaki, Itsuki Kageyama, Atsushi Teshigawara, Yuki Nouchi, Ryosuke Fujii, Genki Mizuno, Nao Sadamoto, Hiroaki Ishikawa, Koji Suzuki, Shuji Hashimoto, Koji Ohashi
Summary: There are concerns about the negative effects of fructose intake during pregnancy on the next generation. This study found that maternal high-fructose corn syrup (HFCS) consumption led to insulin resistance and hyperlipidemia in offspring. The downregulation of peroxisome proliferator-activated receptor alpha (PPAR alpha) expression and enhanced DNA methylation of its promoter region were identified as potential molecular mechanisms underlying these effects.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Chemistry, Applied
M. Soyseven, B. Sezgin, G. Arli
Summary: A novel and robust HPLC-ELSD method was developed and validated for simultaneous determination of fructose, glucose, and sucrose in food products. The method showed good linear relationship and low LOD and LOQ values. It was successfully applied to various types of food samples.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2022)
Article
Food Science & Technology
Nasim Khorshidian, Mahdi Shadnoush, Maryam Zabihzadeh Khajavi, Sara Sohrabvandi, Mojtaba Yousefi, Amir M. Mortazavian
Summary: High-fructose syrups are commonly used in the food industry, but their intake may have direct relationships with adverse health effects such as obesity and the metabolic syndrome, attracting negative attention recently. Studies have suggested potential correlations between high fructose-rich diet and negative effects, but generalizing these findings to high fructose corn syrup (HFCS) is not certain due to using high concentrations of pure fructose in prior research. The advantages and possible disadvantages of HFCS application and consumption are currently challenging issues between nutritionists and food technologists.
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
(2021)
Article
Behavioral Sciences
Meenu Minhas, Cheryl L. Limebeer, Evan Strom, Linda A. Parker, Francesco Leri
Summary: The study suggests that dietary sugars may affect vulnerability to opioid abuse. The findings indicate that high fructose corn syrup may increase place preference induced by oxycodone, enhance its suppressant effect on locomotion, and attenuate its elevation in dopamine overflow in the NAc.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2021)
Article
Food Science & Technology
Rinee Najwa Mohamat, Nur Rabiatul Adawiah Mohammad Noor, Yus Aniza Yusof, Suriana Sabri, Norhasnida Zawawi
Summary: This study examines the physicochemical, rheological, and antibacterial properties of sugar-based adulterated stingless bee honey. The results demonstrate that the addition of high fructose corn syrup (HFCS) significantly alters the properties and antimicrobial activity of the honey. These findings are crucial for regulatory bodies to ensure the authenticity and quality of honey sold in the market.
Article
Chemistry, Physical
Yuxi Jiang, Xilei Lyu, Hao Chen, Xiwen Wei, Zihao Zhang, Xiuyang Lu
Summary: This study reports the catalytic conversion of high fructose corn syrup (HFCS) to methyl lactate (MLA) using a CoO@silicalite-1 catalyst synthesized via citric acid treatment. The maximum yield of MLA was achieved after optimizing reaction conditions and Co loading, and the catalyst showed capability for upgrading wet HFCS. Additionally, the activity of the catalyst could be regenerated through simple calcination.
Article
Food Science & Technology
Jaza Alshammari, Nitin Dhowlaghar, Yucen Xie, Jie Xu, Juming Tang, Shyam Sablani, Mei-Jun Zhu
Summary: The study showed that Salmonella and its surrogate cannot survive in honey and high fructose corn syrup at room temperature for more than a month. The high osmotic pressure of these liquid sugars is likely the main reason for bacterial death. This provides important information for developing microbial-safe strategies in the preparation or storage of low-moisture foods.
Article
Nutrition & Dietetics
Yu Shen, Yangying Sun, Xiaoli Wang, Yingping Xiao, Lingyan Ma, Wentao Lyu, Zibin Zheng, Wen Wang, Jinjun Li
Summary: This study found that HFCS can affect lipid metabolism by affecting the expression of lipid metabolism-related genes through the gut microbiome.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Xiaoqiang Han, Zhiguo Feng, Yizhang Chen, Liying Zhu, Xiaoqiong Li, Xin Wang, Haibiao Sun, Jinjun Li
Summary: This study investigated the correlation between gut microbiota and bone health, and found that high-fructose corn syrup had negative effects on both. It was also observed that HFCS altered the abundance and composition of gut microbiota.
FRONTIERS IN NUTRITION
(2022)
Review
Nutrition & Dietetics
Cuihong Huang, Zhiya Liang, Jianping Ma, Dongsheng Hu, Feifei Yao, Pei Qin
Summary: This study conducted a systematic review and dose-response meta-analysis to examine the association between total sugars, added sugars, fructose, and sucrose with all-cause, cardiovascular disease (CVD), and cancer mortality. The findings showed that increased intake of total sugars and fructose was associated with higher rates of all-cause and CVD mortality, but not with cancer mortality.