Maladaptive Modulations of NLRP3 Inflammasome and Cardioprotective Pathways Are Involved in Diet-Induced Exacerbation of Myocardial Ischemia/Reperfusion Injury in Mice

The Inflammasome in Myocardial Injury and Cardiac Remodeling

(2015) Stefano Toldo et al.   ANTIOXIDANTS & REDOX SIGNALING

NLRP3 inflammasome activation by mitochondrial reactive oxygen species plays a key role in long-term cognitive impairment induced by paraquat exposure

(2015) Liuji Chen et al.   NEUROBIOLOGY OF AGING

Overexpression of the muscle-specific protein, melusin, protects from cardiac ischemia/reperfusion injury

(2014) Claudia Penna et al.   BASIC RESEARCH IN CARDIOLOGY

TXNIP mediates NLRP3 inflammasome activation in cardiac microvascular endothelial cells as a novel mechanism in myocardial ischemia/reperfusion injury

(2014) Yi Liu et al.   BASIC RESEARCH IN CARDIOLOGY

A non-erythropoietic peptide derivative of erythropoietin decreases susceptibility to diet-induced insulin resistance in mice

(2014) M Collino et al.   BRITISH JOURNAL OF PHARMACOLOGY

High carbohydrate and high fat diets protect the heart against ischaemia/reperfusion injury

(2014) Ruduwaan Salie et al.   Cardiovascular Diabetology

Activation of Toll-Like Receptors and Inflammasome Complexes in the Diabetic Cardiomyopathy-Associated Inflammation

(2014) J. Fuentes-Antrás et al.   International Journal of Endocrinology

HIF-1α in heart: Protective mechanisms

(2013) Joe Wu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Myocardial structure, function and ischaemic tolerance in a rodent model of obesity with insulin resistance

(2013) I. Wensley et al.   EXPERIMENTAL PHYSIOLOGY

Hypercholesterolemia blocked sevoflurane-induced cardioprotection against ischemia–reperfusion injury by alteration of the MG53/RISK/GSK3β signaling

(2013) Lei-Lei Ma et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

A Novel Pharmacologic Inhibitor of the NLRP3 Inflammasome Limits Myocardial Injury After Ischemia–Reperfusion in the Mouse

(2013) Carlo Marchetti et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

The NLRP3 Inflammasome as a Novel Player of the Intercellular Crosstalk in Metabolic Disorders

(2013) Elisa Benetti et al.   MEDIATORS OF INFLAMMATION

A liver Hif-2α–Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition

(2013) Kevin Wei et al.   NATURE MEDICINE

Cross-talk between hypoxia and insulin signaling through Phd3 regulates hepatic glucose and lipid metabolism and ameliorates diabetes

(2013) Cullen M Taniguchi et al.   NATURE MEDICINE

Hypercholesterolemic Myocardium Is Vulnerable to Ischemia-Reperfusion Injury and Refractory to Sevoflurane-Induced Protection

(2013) Yong Xu et al.   PLoS One

Reversal of the deleterious effects of chronic dietary HFCS-55 intake by PPAR-δ agonism correlates with impaired NLRP3 inflammasome activation

(2012) Massimo Collino et al.   BIOCHEMICAL PHARMACOLOGY

Obestatin induced recovery of myocardial dysfunction in type 1 diabetic rats: underlying mechanisms

(2012) Manuela Aragno et al.   Cardiovascular Diabetology

Cannabinoid 1 Receptor Promotes Cardiac Dysfunction, Oxidative Stress, Inflammation, and Fibrosis in Diabetic Cardiomyopathy

(2012) M. Rajesh et al.   DIABETES

Upregulated NLRP3 Inflammasome Activation in Patients With Type 2 Diabetes

(2012) Hye-Mi Lee et al.   DIABETES

Inflammation links excess fat to insulin resistance: the role of the interleukin-1 family

(2012) Cees J. Tack et al.   IMMUNOLOGICAL REVIEWS

Oxidative stress activates NLRP3 inflammasomes in ARPE-19 cells—Implications for age-related macular degeneration (AMD)

(2012) Anu Kauppinen et al.   IMMUNOLOGY LETTERS

Expression of NLRP3 inflammasome and T cell population markers in adipose tissue are associated with insulin resistance and impaired glucose metabolism in humans

(2012) Gijs H. Goossens et al.   MOLECULAR IMMUNOLOGY

Hypoxia-inducible factor as a therapeutic target for cardioprotection

(2012) Sang-Ging Ong et al.   PHARMACOLOGY & THERAPEUTICS

Adaptive mechanisms to compensate for overnutrition-induced cardiovascular abnormalities

(2011) Lakshmi Pulakat et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Inflammasome Activation of Cardiac Fibroblasts Is Essential for Myocardial Ischemia/Reperfusion Injury

(2011) Masanori Kawaguchi et al.   CIRCULATION

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

The inflammasome promotes adverse cardiac remodeling following acute myocardial infarction in the mouse

(2011) E. Mezzaroma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cardioprotective Pathways During Reperfusion: Focus on Redox Signaling and Other Modalities of Cell Signaling

(2010) Pasquale Pagliaro et al.   ANTIOXIDANTS & REDOX SIGNALING

Diabetes mellitus abrogates erythropoietin-induced cardioprotection against ischemic-reperfusion injury by alteration of the RISK/GSK-3β signaling

(2010) Nehmat Ghaboura et al.   BASIC RESEARCH IN CARDIOLOGY

Hearts of Hypoxia-inducible Factor Prolyl 4-Hydroxylase-2 Hypomorphic Mice Show Protection against Acute Ischemia-Reperfusion Injury

(2010) Jaana Hyvärinen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myocardial Fatty Acid Metabolism in Health and Disease

(2010) Gary D. Lopaschuk et al.   PHYSIOLOGICAL REVIEWS

Hypoxia-Inducible Factor 2 Regulates Hepatic Lipid Metabolism

(2009) E. B. Rankin et al.   MOLECULAR AND CELLULAR BIOLOGY

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Ischemic-reperfusion syndromes: Biochemical and immunologic rationale for IL-1 targeted therapy

(2008) Alan A. Wanderer   CLINICAL IMMUNOLOGY

Increased Myocardial Susceptibility to Repetitive Ischemia With High-fat diet-induced Obesit

(2008) Geeta D. Thakker et al.   Obesity