Ceramide formation as a target in beta-cell survival and function

Insulin resistance and Alzheimer's disease

(2011) Suzanne M. De La Monte   BMB Reports

Brain pathology in Niemann Pick disease type A: insights from the acid sphingomyelinase knockout mice

(2011) Maria Dolores Ledesma et al.   JOURNAL OF NEUROCHEMISTRY

Tiam1/Rac1 signaling pathway mediates palmitate-induced, ceramide-sensitive generation of superoxides and lipid peroxides and the loss of mitochondrial membrane potential in pancreatic β-cells

(2010) Ismail Syed et al.   BIOCHEMICAL PHARMACOLOGY

Group VIA Ca2+-independent phospholipase A2 (iPLA2β) and its role in β-cell programmed cell death

(2010) Xiaoyong Lei et al.   BIOCHIMIE

Ceramide in Pseudomonas aeruginosa Infections and Cystic Fibrosis

(2010) Katrin Anne Becker et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Spingolipids in Multiple Sclerosis

(2010) Silke Walter et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

FTY720-Induced Suicidal Erythrocyte Death

(2010) Matthias Eberhard et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Palmitate-Induced Inhibition of Insulin Gene Expression in Rat Islet β-Cells Involves the Ceramide Transport Protein

(2010) Jun Guo et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Small Molecule Inhibitors of Acid Sphingomyelinase

(2010) Christoph Arenz   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Functional Inhibitors of Acid Sphingomyelinase (FIASMAs): A Novel Pharmacological Group of Drugs with Broad Clinical Applications

(2010) Johannes Kornhuber et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Vascular Barrier Regulation by PAF, Ceramide, Caveolae, and NO - an Intricate Signaling Network with Discrepant Effects in the Pulmonary and Systemic Vasculature

(2010) Wolfgang M. Kuebler et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Acid Sphingomyelinase Deficiency Attenuates Bleomycin-Induced Lung Inflammation and Fibrosis in Mice

(2010) Rajwinder Dhami et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Ceramide in Redox Signaling and Cardiovascular Diseases

(2010) Xiang Li et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Ceramide in Suicidal Death of Erythrocytes

(2010) Florian Lang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Peroxisome-Generated Hydrogen Peroxide as Important Mediator of Lipotoxicity in Insulin-Producing Cells

(2010) M. Elsner et al.   DIABETES

Causes and cures for endoplasmic reticulum stress in lipotoxic β-cell dysfunction

(2010) M. Cnop et al.   DIABETES OBESITY & METABOLISM

Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: the missing links. The Claude Bernard Lecture 2009

(2010) R. A. DeFronzo   DIABETOLOGIA

Glucolipotoxicity Alters Lipid Partitioning and Causes Mitochondrial Dysfunction, Cholesterol, and Ceramide Deposition and Reactive Oxygen Species Production in INS832/13 ß-Cells

(2010) Wissal El-Assaad et al.   ENDOCRINOLOGY

Novel Proapoptotic Effect of Hepatocyte Growth Factor: Synergy with Palmitate to Cause Pancreatic β-Cell Apoptosis

(2010) José A. González-Pertusa et al.   ENDOCRINOLOGY

Ceramide-rich platforms in transmembrane signaling

(2010) Branka Stancevic et al.   FEBS LETTERS

Mitochondrial Dysfunction and Increased Reactive Oxygen Species Impair Insulin Secretion in Sphingomyelin Synthase 1-null Mice

(2010) Masato Yano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fatty acid-induced oxidation and triglyceride formation is higher in insulin-producing MIN6 cells exposed to oleate compared to palmitate

(2010) Kristofer Thörn et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Blockage of ceramide metabolism exacerbates palmitate inhibition of pro-insulin gene expression in pancreatic β-cells

(2010) Jun Guo et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin

(2010) William L Holland et al.   NATURE MEDICINE

Differential regulation of AKT, MAPK and GSK3β during C2-ceramide-induced neuronal death

(2010) Gonzalo Arboleda et al.   NEUROTOXICOLOGY

Oxidative stress and beta-cell dysfunction

(2010) Gisela Drews et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Sphingomyelinase dependent apoptosis following treatment of pancreatic beta-cells with amyloid peptides Aß1-42 or IAPP

(2009) Ying Zhang et al.   APOPTOSIS

High extracellular glucose inhibits exocytosis through disruption of syntaxin 1A-containing lipid rafts

(2009) Sangeeta Somanath et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Therapeutic Efficacy and Safety of Amitriptyline in Patients with Cystic Fibrosis

(2009) Joachim Riethmüller et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Triggering of Suicidal Erythrocyte Death by Amphotericin B

(2009) Hasan Mahmud et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

A Ceramide-binding C1 Domain Mediates Kinase Suppressor of Ras Membrane Translocation

(2009) Xianglei Yin et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Involvement of Per-Arnt-Sim Kinase and Extracellular-Regulated Kinases-1/2 in Palmitate Inhibition of Insulin Gene Expression in Pancreatic  -Cells

(2009) G. Fontes et al.   DIABETES

Overexpression of Kinase-Negative Protein Kinase C  in Pancreatic  -Cells Protects Mice From Diet-Induced Glucose Intolerance and  -Cell Dysfunction

(2009) A. M. Hennige et al.   DIABETES

Acute activation of acid ceramidase affects cytokine-induced cytotoxicity in rat islet β-cells

(2009) Qun Zhu et al.   FEBS LETTERS

Spontaneous Development of Endoplasmic Reticulum Stress That Can Lead to Diabetes Mellitus Is Associated with Higher Calcium-independent Phospholipase A2Expression

(2009) Xiaoyong Lei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Down-regulation of expression and function of nucleoside diphosphate kinase in insulin-secreting β-cells under in vitro conditions of glucolipotoxicity

(2009) Rajakrishnan Veluthakal et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Islet Inflammation Impairs the Pancreatic β-Cell in Type 2 Diabetes

(2009) Marc Y. Donath et al.   PHYSIOLOGY

Genetic Determinants of Circulating Sphingolipid Concentrations in European Populations

(2009) Andrew A. Hicks et al.   PLoS Genetics

β-Glycosphingolipids improve glucose intolerance and hepatic steatosis of the Cohen diabetic rat

(2008) Ehud Zigmond et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Small Interfering RNA-Mediated Suppression of Proislet Amyloid Polypeptide Expression Inhibits Islet Amyloid Formation and Enhances Survival of Human Islets in Culture

(2008) L. Marzban et al.   DIABETES

β-cell apoptosis in type 2 diabetes: quantitative and functional consequences

(2008) R. Lupi et al.   DIABETES & METABOLISM

Calcium elevation in mouse pancreatic beta cells evoked by extracellular human islet amyloid polypeptide involves activation of the mechanosensitive ion channel TRPV4

(2008) S. Casas et al.   DIABETOLOGIA

Sphingolipids, Insulin Resistance, and Metabolic Disease: New Insights fromin VivoManipulation of Sphingolipid Metabolism

(2008) William L. Holland et al.   ENDOCRINE REVIEWS

Islet Amyloid in Type 2 Diabetes, and the Toxic Oligomer Hypothesis

(2008) Leena Haataja et al.   ENDOCRINE REVIEWS

Real-Time Monitoring of Apoptosis by Caspase-3-Like Protease Induced FRET Reduction Triggered by Amyloid Aggregation

(2008) Johan F. Paulsson et al.   Experimental Diabetes Research

Calcium-independent Phospholipase A2(iPLA2β)-mediated Ceramide Generation Plays a Key Role in the Cross-talk between the Endoplasmic Reticulum (ER) and Mitochondria during ER Stress-induced Insulin-secreting Cell Apoptosis

(2008) Xiaoyong Lei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis

(2008) Volker Teichgräber et al.   NATURE MEDICINE

Egr-1 and Hipk2 are required for the TrkA to p75NTR switch that occurs downstream of IGF1-R

(2008) Hui Li et al.   NEUROBIOLOGY OF AGING

Amyloid oligomers in diabetic and nondiabetic human pancreas

(2008) Hai-Lu Zhao et al.   Translational Research