Food-Derived Antioxidant Polysaccharides and Their Pharmacological Potential in Neurodegenerative Diseases

Lycium barbarum polysaccharide protects human keratinocytes against UVB-induced photo-damage

(2017) Huaping Li et al.   FREE RADICAL RESEARCH

Inhibitory effect of Sophora subprosrate polysaccharide on mitochondria oxidative stress induced by PCV-2 infection in RAW264.7 cells

(2017) Zi-Jie Su et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Characterization, antioxidant activity and immunomodulatory activity of polysaccharides from the swollen culms of Zizania latifolia

(2017) Mingchun Wang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Exopolysaccharides Isolated from Milk Fermented with Lactic Acid Bacteria Prevent Ultraviolet-Induced Skin Damage in Hairless Mice

(2017) Masashi Morifuji et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Protective effect of a polysaccharide from Anoectochilus roxburghii against carbon tetrachloride-induced acute liver injury in mice

(2017) Biyu Zeng et al.   JOURNAL OF ETHNOPHARMACOLOGY

Sulfated Hetero-Polysaccharides Protect SH-SY5Y Cells from H2O2-Induced Apoptosis by Affecting the PI3K/Akt Signaling Pathway

(2017) Jing Wang et al.   Marine Drugs

Protective Effects of Fucoidan on Aβ25–35 and d-Gal-Induced Neurotoxicity in PC12 Cells and d-Gal-Induced Cognitive Dysfunction in Mice

(2017) Hengyun Wei et al.   Marine Drugs

EpimediumPolysaccharide Alleviates Polyglutamine-Induced Neurotoxicity inCaenorhabditis elegansby Reducing Oxidative Stress

(2017) Yanxia Xiang et al.   REJUVENATION RESEARCH

Review on cell models to evaluate the potential antioxidant activity of polysaccharides

(2017) Zhi-Jun Wang et al.   Food & Function

Angelica Sinensis Polysaccharide Prevents Hematopoietic Stem Cells Senescence in D-Galactose-Induced Aging Mouse Model

(2017) Xinyi Mu et al.   Stem Cells International

Polysaccharides from Ganoderma lucidum Promote Cognitive Function and Neural Progenitor Proliferation in Mouse Model of Alzheimer's Disease

(2017) Shichao Huang et al.   Stem Cell Reports

High Plasma Levels of Vitamin E Forms and Reduced Alzheimer's Disease Risk in Advanced Age

(2017) Francesca Mangialasche et al.   JOURNAL OF ALZHEIMERS DISEASE

Neuroprotective Effects of Polysaccharides from Wolfberry, the Fruits of Lycium barbarum, Against Homocysteine-induced Toxicity in Rat Cortical Neurons

(2017) Yuen-Shan Ho et al.   JOURNAL OF ALZHEIMERS DISEASE

Neuroprotective Effects of Sulphated Agaran from Marine AlgaGracilaria corneain Rat 6-Hydroxydopamine Parkinson's Disease Model: Behavioural, Neurochemical and Transcriptional Alterations

(2016) Ricardo Basto Souza et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Neuroprotective effect of sulfated polysaccharide isolated from sea cucumber Stichopus japonicus on 6-OHDA-induced death in SH-SY5Y through inhibition of MAPK and NF-κB and activation of PI3K/Akt signaling pathways

(2016) Chao Cui et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Molecular mechanisms of ROS production and oxidative stress in diabetes

(2016) P. Newsholme et al.   BIOCHEMICAL JOURNAL

Neuroprotective effect of crude polysaccharide isolated from the fruiting bodies of Morchella importuna against H 2 O 2 -induced PC12 cell cytotoxicity by reducing oxidative stress

(2016) Chuan Xiong et al.   BIOMEDICINE & PHARMACOTHERAPY

β-glucan attenuated scopolamine induced cognitive impairment via hippocampal acetylcholinesterase inhibition in rats

(2016) Ali Haider et al.   BRAIN RESEARCH

Box–Behnken design for extraction optimization, characterization and in vitro antioxidant activity of Cicer arietinum L. hull polysaccharides

(2016) Zipeng Ye et al.   CARBOHYDRATE POLYMERS

Structural elucidation and protective role of a polysaccharide from Sargassum fusiforme on ameliorating learning and memory deficiencies in mice

(2016) Pei Hu et al.   CARBOHYDRATE POLYMERS

Protein aggregation and neurodegenerative diseases: From theory to therapy

(2016) Vijay Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structural, functional, and antioxidant properties of water-soluble polysaccharides from potatoes peels

(2016) Khawla Ben Jeddou et al.   FOOD CHEMISTRY

A polysaccharide isolated from Cynomorium songaricum Rupr. protects PC12 cells against H2O2-induced injury

(2016) Fengxia Wang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Neuroprotective effect of fucoidan from Turbinaria decurrens in MPTP intoxicated Parkinsonic mice

(2016) Selvaraju Meenakshi et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Structure–activity relationship of sulfated hetero/galactofucan polysaccharides on dopaminergic neuron

(2016) Jing Wang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Antioxidant and anti-aging activities of the polysaccharide TLH-3 from Tricholoma lobayense

(2016) Qiuying Ding et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Protective effects of polysaccharides from Psidium guajava leaves against oxidative stresses

(2016) Seo-Young Kim et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Polysaccharides from Pleurotus ostreatus alleviate cognitive impairment in a rat model of Alzheimer’s disease

(2016) Yan Zhang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Lycium barbarum polysaccharide attenuates the cytotoxicity of mutant huntingtin and increases the activity of AKT

(2016) Fang Fang et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Antioxidant and neuroprotective effects of Dictyophora indusiata polysaccharide in Caenorhabditis elegans

(2016) Ju Zhang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Hericium erinaceus mycelium and its isolated erinacine A protection from MPTP-induced neurotoxicity through the ER stress, triggering an apoptosis cascade

(2016) Hsing-Chun Kuo et al.   Journal of Translational Medicine

Polysaccharides from Laminaria japonica : Structural characteristics and antioxidant activity

(2016) Chun Cui et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

κ-carrageenan-derived pentasaccharide attenuates Aβ25–35-induced apoptosis in SH-SY5Y cells via suppression of the JNK signaling pathway

(2016) Yang Liu et al.   Molecular Medicine Reports

Optimization Extraction, Preliminary Characterization and Antioxidant Activities of Polysaccharides from Semen Juglandis

(2016) Xueyong Ren et al.   MOLECULES

Immunomodulatory and Antioxidant Effects of Polysaccharides from Gynostemma pentaphyllum Makino in Immunosuppressed Mice

(2016) Xiaoya Shang et al.   MOLECULES

Defects in trafficking bridge Parkinson's disease pathology and genetics

(2016) Asa Abeliovich et al.   NATURE

Reviews on Mechanisms ofIn VitroAntioxidant Activity of Polysaccharides

(2016) Junqiao Wang et al.   Oxidative Medicine and Cellular Longevity

The Structure-Activity Relationship of Glycosaminoglycans and Their Analogues with β-Amyloid Peptide

(2016) Xiang Zhou et al.   PROTEIN AND PEPTIDE LETTERS

Effect of polysaccharides from Tremella fuciformis on UV-induced photoaging

(2016) Lingrong Wen et al.   Journal of Functional Foods

Water-soluble ginseng oligosaccharides protect against scopolamine-induced cognitive impairment by functioning as an antineuroinflammatory agent

(2016) Ting Xu et al.   Journal of Ginseng Research

Compromised MAPK signaling in human diseases: an update

(2015) Eun Kyung Kim et al.   ARCHIVES OF TOXICOLOGY

Oxidative stress, mitochondrial dysfunction and neurodegenerative diseases; a mechanistic insight

(2015) Aashiq Hussain Bhat et al.   BIOMEDICINE & PHARMACOTHERAPY

Purification, characterization and neuroprotective effects of a polysaccharide from Gynostemma pentaphyllum

(2015) Dong Jia et al.   CARBOHYDRATE POLYMERS

A polysaccharide from Polygonatum sibiricum attenuates amyloid-β-induced neurotoxicity in PC12 cells

(2015) Huixue Zhang et al.   CARBOHYDRATE POLYMERS

Purification and structural characterization of Chinese yam polysaccharide and its activities

(2015) Weifang Yang et al.   CARBOHYDRATE POLYMERS

2015 Update on Parkinson disease

(2015) H. H. FERNANDEZ   CLEVELAND CLINIC JOURNAL OF MEDICINE

ROS-dependent signal transduction

(2015) Colleen R Reczek et al.   CURRENT OPINION IN CELL BIOLOGY

Antioxidant and antimicrobial properties of water soluble polysaccharide extracted from carrot peels by-products

(2015) Imen Ghazala et al.   JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE

Oxidative Stress in Neurodegenerative Diseases

(2015) Ewa Niedzielska et al.   MOLECULAR NEUROBIOLOGY

Protective effects of a polysaccharide from Spirulina platensis on dopaminergic neurons in an MPTP-induced Parkinson′s disease model in C57BL/6J mice

(2015) Fang Zhang et al.   Neural Regeneration Research

Huntington Disease

(2015) Praveen Dayalu et al.   NEUROLOGIC CLINICS

Interrelation of Oxidative Stress and Inflammation in Neurodegenerative Disease: Role of TNF

(2015) Roman Fischer et al.   Oxidative Medicine and Cellular Longevity

Investigation into anti-epileptic effect and mechanisms of Ganoderma lucidum polysaccharides in in vivo and in vitro models

(2015) S. Zhou et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Polysaccharides from Flammulina velutipes improve scopolamine-induced impairment of learning and memory of rats

(2015) Wenjian Yang et al.   Journal of Functional Foods

Oxidative Stress and Antioxidants in Disease and Cancer: A Review

(2014) Rakesh Kumar Gupta et al.   Asian Pacific Journal of Cancer Prevention

A glucan isolated from flowers of Lonicera japonica Thunb. inhibits aggregation and neurotoxicity of Aβ42

(2014) Peipei Wang et al.   CARBOHYDRATE POLYMERS

TOP 1 and 2, polysaccharides from Taraxacum officinale, inhibit NFκB-mediated inflammation and accelerate Nrf2-induced antioxidative potential through the modulation of PI3K-Akt signaling pathway in RAW 264.7 cells

(2014) Chung Mu Park et al.   FOOD AND CHEMICAL TOXICOLOGY

Nox family NADPH oxidases: Molecular mechanisms of activation

(2014) Ralf P. Brandes et al.   FREE RADICAL BIOLOGY AND MEDICINE

Isolation, identification, and antioxidant activity of polysaccharides from the shell of abalone (Haliotis discus hannai Ino)

(2014) Z.L. Wang et al.   GENETICS AND MOLECULAR RESEARCH

Protective effects of Gynostemma pentaphyllum polysaccharides on PC12 cells impaired by MPP+

(2014) Qi Deng et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Antioxidant and antibacterial activities of exopolysaccharides from Bifidobacterium bifidum WBIN03 and Lactobacillus plantarum R315

(2014) Shengjie Li et al.   JOURNAL OF DAIRY SCIENCE

Anti-apoptosis effect of polysaccharide isolated from the seeds of Cuscuta chinensis Lam on cardiomyocytes in aging rats

(2014) Shou-Li Sun et al.   MOLECULAR BIOLOGY REPORTS

Salidroside Protects Caenorhabditis elegans Neurons from Polyglutamine-Mediated Toxicity by Reducing Oxidative Stress

(2014) Lingyun Xiao et al.   MOLECULES

Protective Effects of Lycium barbarum Polysaccharide on 6-OHDA-Induced Apoptosis in PC12 Cells through the ROS-NO Pathway

(2014) Kai Gao et al.   MOLECULES

A protective factor for the ageing brain

(2014) Li-Huei Tsai et al.   NATURE

Neurodegenerative disease: Brain windfall

(2014) Katharine Gammon   NATURE

Polysaccharides from Angelica sinensis alleviate neuronal cell injury caused by oxidative stress

(2014) Weijing Liao et al.   Neural Regeneration Research

Association between Paraoxonases Gene Expression and Oxidative Stress in Hepatotoxicity Induced by CCl4

(2014) Mohamed M. Hafez et al.   Oxidative Medicine and Cellular Longevity

Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal

(2014) Antonio Ayala et al.   Oxidative Medicine and Cellular Longevity

Lycium barbarum Polysaccharides Prevent Memory and Neurogenesis Impairments in Scopolamine-Treated Rats

(2014) Weiwei Chen et al.   PLoS One

Lycium barbarum Polysaccharides Protect Human Lens Epithelial Cells against Oxidative Stress–Induced Apoptosis and Senescence

(2014) Bing Qi et al.   PLoS One

Immunomodulatory activities of polysaccharides from Chlorella pyrenoidosa in a mouse model of Parkinson's disease

(2014) Phoebe B. Chen et al.   Journal of Functional Foods

Oxidative stress in Alzheimer’s disease

(2014) Zhichun Chen et al.   Neuroscience Bulletin

Oxidative Stress, Prooxidants, and Antioxidants: The Interplay

(2014) Anu Rahal et al.   Biomed Research International

Treatment of D-galactose induced mouse aging with Lycium barbarum polysaccharides and its mechanism study

(2013) T Tang et al.   African Journal of Traditional Complementary and Alternative Medicines

The neuroprotective activities of heteropolysaccharides extracted from Saccharina japonica

(2013) Weihua Jin et al.   CARBOHYDRATE POLYMERS

An Overview on Natural Polysaccharides with Antioxidant Properties

(2013) H. Wang et al.   CURRENT MEDICINAL CHEMISTRY

Food, Nutrigenomics, and Neurodegeneration—Neuroprotection by What You Eat!

(2013) Ashraf Virmani et al.   MOLECULAR NEUROBIOLOGY

ULTRASONIC-ASSISTED PRODUCTION OF ANTIOXIDATIVE POLYSACCHARIDES FROMCrassostrea hongkongensis

(2013) Bingna Cai et al.   PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY

The effects of Gouqi extracts on Morris maze learning in the APP/PS1 double transgenic mouse model of Alzheimer’s disease

(2013) QIANLIN ZHANG et al.   Experimental and Therapeutic Medicine

Role of Redox Signaling in Neuroinflammation and Neurodegenerative Diseases

(2013) Hsi-Lung Hsieh et al.   Biomed Research International

Optimum conditions for Radix Rehmanniae polysaccharides by RSM and its antioxidant and immunity activity in UVB mice

(2012) Zhifu Sui et al.   CARBOHYDRATE POLYMERS

Current Opinions and Perspectives on the Role of Immune System in the Pathogenesis of Parkinson's Disease

(2012) Maria Antonietta Panaro et al.   CURRENT PHARMACEUTICAL DESIGN

Excitotoxicity: Bridge to various triggers in neurodegenerative disorders

(2012) Ankita Mehta et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Lipid peroxidation triggers neurodegeneration: A redox proteomics view into the Alzheimer disease brain

(2012) Rukhsana Sultana et al.   FREE RADICAL BIOLOGY AND MEDICINE

Antioxidant and antitumor activities of the polysaccharide from seed cake of Camellia oleifera Abel

(2012) Xianchun Jin et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Antioxidant activities potential of tea polysaccharide fractions obtained by ultra filtration

(2012) Yuanfeng Wang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Ganoderma atrum Polysaccharide Improves Age-Related Oxidative Stress and Immune Impairment in Mice

(2012) Wen-Juan Li et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Antioxidative activities and chemical characterization of polysaccharide extracts from the widely used mushrooms Ganoderma applanatum, Ganoderma lucidum, Lentinus edodes and Trametes versicolor

(2012) Maja Kozarski et al.   JOURNAL OF FOOD COMPOSITION AND ANALYSIS

Mitochondria, oxidative stress and neurodegeneration

(2012) Antonio Federico et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Antioxidant Therapies for Alzheimer's Disease

(2012) Ye Feng et al.   Oxidative Medicine and Cellular Longevity

Oxidative Stress and Antioxidant Defense

(2012) Esra Birben et al.   World Allergy Organization Journal

In vitro and in vivo antioxidant activity of exopolysaccharide fractions from Bifidobacterium animalis RH

(2011) Rihua Xu et al.   ANAEROBE

Macromolecular and small-molecule modulation of intracellular Aβ42aggregation and associated toxicity

(2011) Sohini Chakrabortee et al.   BIOCHEMICAL JOURNAL

Fucoidan, a sulfated polysaccharide from brown algae, improves cognitive impairment induced by infusion of Aβ peptide in rats

(2011) Yonglin Gao et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Sulphated modification of a polysaccharide obtained from fresh persimmon (Diospyros kaki L.) fruit and antioxidant activities of the sulphated derivatives

(2011) Yali Zhang et al.   FOOD CHEMISTRY

Ganoderma lucidum ameliorate mitochondrial damage in isoproterenol-induced myocardial infarction in rats by enhancing the activities of TCA cycle enzymes and respiratory chain complexes

(2011) N.P. Sudheesh et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Cysteine Oxidation within N-terminal Mutant Huntingtin Promotes Oligomerization and Delays Clearance of Soluble Protein

(2011) Jonathan H. Fox et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein aggregation and neurodegeneration

(2011) Katie J. Mayo et al.   METHODS

Neurotoxin-based models of Parkinson's disease

(2011) J. Bové et al.   NEUROSCIENCE

Oxidative Stress in Neurodegenerative Diseases: Mechanisms and Therapeutic Perspectives

(2011) Ailton Melo et al.   Oxidative Medicine and Cellular Longevity

A comparison study between different molecular weight polysaccharides derived fromLentinus edodesand their antioxidant activitiesin vivo

(2011) Ruxu You et al.   PHARMACEUTICAL BIOLOGY

Multifunctional antioxidant activity of polysaccharide fractions from the soybean byproduct okara

(2010) I. Mateos-Aparicio et al.   CARBOHYDRATE POLYMERS

Antioxidant and moisture-retention activities of the polysaccharide from Nostoc commune

(2010) Haifeng Li et al.   CARBOHYDRATE POLYMERS

Antioxidant activities of polysaccharides from the fruiting bodies of Zizyphus Jujuba cv. Jinsixiaozao

(2010) Jinwei Li et al.   CARBOHYDRATE POLYMERS

Purified Auricularia auricular-judae polysaccharide (AAP I-a) prevents oxidative stress in an ageing mouse model

(2010) Hua Zhang et al.   CARBOHYDRATE POLYMERS

Clinical Review and Treatment of Select Adverse Effects of Dopamine Receptor Agonists in Parkinsonʼs Disease

(2010) Lindy D. Wood   DRUGS & AGING

Structural characterization of polysaccharides from Zizyphus jujuba and evaluation of antioxidant activity

(2010) S.C. Chang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Role of proteoglycans and glycosaminoglycans in the pathogenesis of Alzheimer's disease and related disorders: Amyloidogenesis and therapeutic strategies-A review

(2010) Toshio Ariga et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Antioxidative Activity of Water Soluble Polysaccharide in Pumpkin Fruits (Cucurbita maximaDuchesne)

(2009) Kazuhiro NARA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Protective effect of Potentilla anserine polysaccharide (PAP) on hydrogen peroxide induced apoptosis in murine splenic lymphocytes

(2009) TingJun Hu et al.   CARBOHYDRATE POLYMERS

Characterization of a neutral polysaccharide with antioxidant capacity from red wine

(2009) M.J. Aguirre et al.   CARBOHYDRATE RESEARCH

Upstream reactive oxidative species (ROS) signals in exogenous oxidative stress-induced mitochondrial dysfunction

(2009) Min Lu et al.   CELL BIOLOGY INTERNATIONAL

Neuroprotective and Antioxidative Effect of Cactus Polysaccharides In Vivo and In Vitro

(2009) Xianju Huang et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Polysaccharides from Wolfberry Antagonizes Glutamate Excitotoxicity in Rat Cortical Neurons

(2009) Yuen-Shan Ho et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Protection of wheat bran feruloyl oligosaccharides against free radical-induced oxidative damage in normal human erythrocytes

(2009) Jing Wang et al.   FOOD AND CHEMICAL TOXICOLOGY

Naringin alleviates cognitive impairment, mitochondrial dysfunction and oxidative stress induced by d-galactose in mice

(2009) Anil Kumar et al.   FOOD AND CHEMICAL TOXICOLOGY

Nrf2:INrf2 (Keap1) signaling in oxidative stress

(2009) James W. Kaspar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Physicochemical Properties and Antioxidant Capacity of 3 Polysaccharides from Green Tea, Oolong Tea, and Black Tea

(2009) Haixia Chen et al.   JOURNAL OF FOOD SCIENCE

Aspects of antioxidant foods and supplements in health and disease

(2009) Emilio Herrera et al.   NUTRITION REVIEWS

The insulin paradox: aging, proteotoxicity and neurodegeneration

(2008) Ehud Cohen et al.   NATURE REVIEWS NEUROSCIENCE

Protective effects of Angelica sinensis extract on amyloid β-peptide-induced neurotoxicity

(2008) Shih-Hao Huang et al.   PHYTOMEDICINE

Antagonizing β-amyloid peptide neurotoxicity of the anti-aging fungus Ganoderma lucidum

(2007) Cora Sau-Wan Lai et al.   BRAIN RESEARCH