Epigenetic factors as drivers of fibrosis in systemic sclerosis

Treatment of cardiovascular pathology with epigenetically active agents: Focus on natural and synthetic inhibitors of DNA methylation and histone deacetylation

(2017) Dimitry A. Chistiakov et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Modulation of chromatin function through linker histone H1 variants

(2016) Andrzej Kowalski et al.   BIOLOGY OF THE CELL

New Xist -Interacting Proteins in X-Chromosome Inactivation

(2016) Hegias Mira-Bontenbal et al.   CURRENT BIOLOGY

Azacitidine: A Review in Myelodysplastic Syndromes and Acute Myeloid Leukaemia

(2016) Lesley J. Scott   DRUGS

Long non-coding RNA TSIX is upregulated in scleroderma dermal fibroblasts and controls collagen mRNA stabilization

(2016) Zhongzhi Wang et al.   EXPERIMENTAL DERMATOLOGY

Plasma DNA methylation: a potential biomarker for stratification of liver fibrosis in non-alcoholic fatty liver disease

(2016) Timothy Hardy et al.   GUT

Evolution of Cytokine Receptor Signaling

(2016) Clifford Liongue et al.   JOURNAL OF IMMUNOLOGY

Canonical Wnt signaling in systemic sclerosis

(2016) Christina Bergmann et al.   LABORATORY INVESTIGATION

Maintenance therapy with decitabine in younger adults with acute myeloid leukemia in first remission: a phase 2 Cancer and Leukemia Group B Study (CALGB 10503)

(2016) W Blum et al.   LEUKEMIA

The European Medicines Agency Review of Decitabine (Dacogen) for the Treatment of Adult Patients With Acute Myeloid Leukemia: Summary of the Scientific Assessment of the Committee for Medicinal Products for Human Use

(2016) Maria Nieto et al.   ONCOLOGIST

Non-coding RNAs in Development and Disease: Background, Mechanisms, and Therapeutic Approaches

(2016) Julia Beermann et al.   PHYSIOLOGICAL REVIEWS

The emerging role of long non-coding RNAs in endometrial cancer

(2016) Konii Takenaka et al.   Cancer Genetics

A phase I trial of azacitidine and nanoparticle albumin bound paclitaxel in patients with advanced or metastatic solid tumors

(2016) Adam L. Cohen et al.   Oncotarget

SIRT3 is attenuated in systemic sclerosis skin and lungs, and its pharmacologic activation mitigates organ fibrosis

(2016) Kaname Akamata et al.   Oncotarget

IL-13 mediates collagen deposition via STAT6 and microRNA-135b: a role for epigenetics

(2016) Steven O’Reilly et al.   Scientific Reports

Histone Deacetylase 5 Is Overexpressed in Scleroderma Endothelial Cells and Impairs Angiogenesis via Repression of Proangiogenic Factors

(2016) Pei-Suen Tsou et al.   Arthritis & Rheumatology

Editorial: Epigenetics in Systemic Sclerosis

(2016) Robert Lafyatis   Arthritis & Rheumatology

Histone Demethylation and Toll-like Receptor 8-Dependent Cross-Talk in Monocytes Promotes Transdifferentiation of Fibroblasts in Systemic Sclerosis Via Fra-2

(2016) Marzena Ciechomska et al.   Arthritis & Rheumatology

Targeting miR-155 to Treat Experimental Scleroderma

(2016) Qingran Yan et al.   Scientific Reports

Design and synthesis of new non nucleoside inhibitors of DNMT3A

(2015) Alexandre Erdmann et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Epigenetics in rheumatoid arthritis

(2015) Kerstin Klein et al.   CURRENT OPINION IN RHEUMATOLOGY

A brief review of nucleosome structure

(2015) Amber R. Cutter et al.   FEBS LETTERS

SOCS3 and its role in associated diseases

(2015) Yanlin Yin et al.   HUMAN IMMUNOLOGY

Epigenetic suppression of Fli1, a potential predisposing factor in the pathogenesis of systemic sclerosis

(2015) Yoshihide Asano   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

MECP2 disorders: from the clinic to mice and back

(2015) Laura Marie Lombardi et al.   JOURNAL OF CLINICAL INVESTIGATION

Sustained β-catenin activity in dermal fibroblasts promotes fibrosis by up-regulating expression of extracellular matrix protein-coding genes

(2015) Emily Hamburg-Shields et al.   JOURNAL OF PATHOLOGY

Safety and tolerability of guadecitabine (SGI-110) in patients with myelodysplastic syndrome and acute myeloid leukaemia: a multicentre, randomised, dose-escalation phase 1 study

(2015) Jean-Pierre J Issa et al.   LANCET ONCOLOGY

DNA methylation pathways and their crosstalk with histone methylation

(2015) Jiamu Du et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Specific autoantibody profiles and disease subgroups correlate with circulating micro-RNA in systemic sclerosis

(2015) Dirk M. Wuttge et al.   RHEUMATOLOGY

The Histone Deacetylase Sirtuin 1 Is Reduced in Systemic Sclerosis and Abrogates Fibrotic Responses by Targeting Transforming Growth Factor β Signaling

(2015) Jun Wei et al.   Arthritis & Rheumatology

Fibrosis, Vascular Activation, and Immune Abnormalities Resembling Systemic Sclerosis in Bleomycin-Treated Fli-1-Haploinsufficient Mice

(2015) Takashi Taniguchi et al.   Arthritis & Rheumatology

Genome-wide DNA methylation analysis in dermal fibroblasts from patients with diffuse and limited systemic sclerosis reveals common and subset-specific DNA methylation aberrancies

(2014) Nezam Altorok et al.   ANNALS OF THE RHEUMATIC DISEASES

Sirt1 regulates canonical TGF-β signalling to control fibroblast activation and tissue fibrosis

(2014) Pawel Zerr et al.   ANNALS OF THE RHEUMATIC DISEASES

Mortality in systemic sclerosis

(2014) Mandana Nikpour et al.   CURRENT OPINION IN RHEUMATOLOGY

Histone deacetylase inhibition promotes fibroblast apoptosis and ameliorates pulmonary fibrosis in mice

(2014) Y. Y. Sanders et al.   EUROPEAN RESPIRATORY JOURNAL

Interleukin-6 (IL-6) Trans Signaling Drives a STAT3-dependent Pathway That Leads to Hyperactive Transforming Growth Factor-β (TGF-β) Signaling Promoting SMAD3 Activation and Fibrosis via Gremlin Protein

(2014) Steven O'Reilly et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New Insights on the Mechanism of Quinoline-based DNA Methyltransferase Inhibitors

(2014) Christina Gros et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identifying Novel Selective Non-Nucleoside DNA Methyltransferase 1 Inhibitors through Docking-Based Virtual Screening

(2014) Shijie Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Class I HDACs regulate angiotensin II-dependent cardiac fibrosis via fibroblasts and circulating fibrocytes

(2014) Sarah M. Williams et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The role of genetics and epigenetics in the pathogenesis of systemic sclerosis

(2014) Jasper C. A. Broen et al.   Nature Reviews Rheumatology

MiR-29a Reduces TIMP-1 Production by Dermal Fibroblasts via Targeting TGF-β Activated Kinase 1 Binding Protein 1, Implications for Systemic Sclerosis

(2014) Marzena Ciechomska et al.   PLoS One

Oxidative DNA damage induces the ATM-mediated transcriptional suppression of the Wnt inhibitor WIF-1 in systemic sclerosis and fibrosis

(2014) S. Svegliati et al.   Science Signaling

Epigenetische Modifikationen bei Autoimmunerkrankungen

(2014) A. Ramming et al.   ZEITSCHRIFT FUR RHEUMATOLOGIE

Simultaneous downregulation of KLF5 and Fli1 is a key feature underlying systemic sclerosis

(2014) Shinji Noda et al.   Nature Communications

Identification of Novel Inhibitors of DNA Methylation by Screening of a Chemical Library

(2013) Alexandre Ceccaldi et al.   ACS Chemical Biology

The Wnt antagonists DKK1 and SFRP1 are downregulated by promoter hypermethylation in systemic sclerosis

(2013) Clara Dees et al.   ANNALS OF THE RHEUMATIC DISEASES

Hypoxia-induced epigenetic modifications are associated with cardiac tissue fibrosis and the development of a myofibroblast-like phenotype

(2013) Chris J. Watson et al.   HUMAN MOLECULAR GENETICS

Detection of hair-microRNAs as the novel potent biomarker: Evaluation of the usefulness for the diagnosis of scleroderma

(2013) Zhongzhi Wang et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

The Downregulation of microRNA let-7a Contributes to the Excessive Expression of Type I Collagen in Systemic and Localized Scleroderma

(2013) K. Makino et al.   JOURNAL OF IMMUNOLOGY

Synthesis and Evaluation of Analogues of N-Phthaloyl-l-tryptophan (RG108) as Inhibitors of DNA Methyltransferase 1

(2013) Saâdia Asgatay et al.   JOURNAL OF MEDICINAL CHEMISTRY

MicroRNA-29b Inhibits Diabetic Nephropathy in db/db Mice

(2013) Hai-Yong Chen et al.   MOLECULAR THERAPY

Identification of Kazinol Q, a Natural Product from Formosan Plants, as an Inhibitor of DNA Methyltransferase

(2013) Jing-Ru Weng et al.   PHYTOTHERAPY RESEARCH

miR-150 Down-Regulation Contributes to the Constitutive Type I Collagen Overexpression in Scleroderma Dermal Fibroblasts via the Induction of Integrin β3

(2012) Noritoshi Honda et al.   AMERICAN JOURNAL OF PATHOLOGY

β-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis

(2012) Christian Beyer et al.   ANNALS OF THE RHEUMATIC DISEASES

Inhibition of H3K27 histone trimethylation activates fibroblasts and induces fibrosis

(2012) Marlene Krämer et al.   ANNALS OF THE RHEUMATIC DISEASES

JAK-2 as a novel mediator of the profibrotic effects of transforming growth factor β in systemic sclerosis

(2012) Clara Dees et al.   ARTHRITIS AND RHEUMATISM

Tumor necrosis factor-costimulated T lymphocytes from patients with systemic sclerosis trigger collagen production in fibroblasts

(2012) Thomas Hügle et al.   ARTHRITIS AND RHEUMATISM

Epigenetic regulation of wound healing and fibrosis

(2012) Jelena Mann et al.   CURRENT OPINION IN RHEUMATOLOGY

Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis

(2012) Robert J. J. O'Donoghue et al.   EMBO Molecular Medicine

Histone methyltransferase ASH1 orchestrates fibrogenic gene transcription during myofibroblast transdifferentiation

(2012) Maria Jesus Perugorria et al.   HEPATOLOGY

MicroRNA Expression Abnormalities in Limited Cutaneous Scleroderma and Diffuse Cutaneous Scleroderma

(2012) Honglin Zhu et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Impaired IL-17 Signaling Pathway Contributes to the Increased Collagen Expression in Scleroderma Fibroblasts

(2012) T. Nakashima et al.   JOURNAL OF IMMUNOLOGY

TGF- -Mediated Downregulation of MicroRNA-196a Contributes to the Constitutive Upregulated Type I Collagen Expression in Scleroderma Dermal Fibroblasts

(2012) N. Honda et al.   JOURNAL OF IMMUNOLOGY

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

(2012) Thomas A Wynn et al.   NATURE MEDICINE

Functions of DNA methylation: islands, start sites, gene bodies and beyond

(2012) Peter A. Jones   NATURE REVIEWS GENETICS

The Fra-2 transgenic mouse model of systemic sclerosis

(2012) Britta Maurer et al.   VASCULAR PHARMACOLOGY

Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis

(2012) Alfiya Akhmetshina et al.   Nature Communications

Increased Accumulation of Extracellular Thrombospondin-2 Due to Low Degradation Activity Stimulates Type I Collagen Expression in Scleroderma Fibroblasts

(2011) Ikko Kajihara et al.   AMERICAN JOURNAL OF PATHOLOGY

Inhibition of glycogen synthase kinase 3  induces dermal fibrosis by activation of the canonical Wnt pathway

(2011) C. Bergmann et al.   ANNALS OF THE RHEUMATIC DISEASES

Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: A novel mouse model for scleroderma?

(2011) Jun Wei et al.   ARTHRITIS AND RHEUMATISM

Circulating miR-142-3p levels in patients with systemic sclerosis

(2011) K. Makino et al.   CLINICAL AND EXPERIMENTAL DERMATOLOGY

Synthesis and Biochemical Evaluation of Δ2-Isoxazoline Derivatives as DNA Methyltransferase 1 Inhibitors

(2011) Sabrina Castellano et al.   JOURNAL OF MEDICINAL CHEMISTRY

TGF- /Smad3 Signaling Promotes Renal Fibrosis by Inhibiting miR-29

(2011) W. Qin et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Hypermethylation of PTGER2 Confers Prostaglandin E2 Resistance in Fibrotic Fibroblasts from Humans and Mice

(2010) Steven K. Huang et al.   AMERICAN JOURNAL OF PATHOLOGY

miR-29 Is a Major Regulator of Genes Associated with Pulmonary Fibrosis

(2010) Leah Cushing et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

MicroRNA-29, a key regulator of collagen expression in systemic sclerosis

(2010) Britta Maurer et al.   ARTHRITIS AND RHEUMATISM

SOCS3 regulates graft-versus-host disease

(2010) G. R. Hill et al.   BLOOD

Renal Medullary MicroRNAs in Dahl Salt-Sensitive Rats

(2010) Yong Liu et al.   HYPERTENSION

The impact of Fli1 deficiency on the pathogenesis of systemic sclerosis

(2010) Yoshihide Asano et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Nanaomycin A Selectively Inhibits DNMT3B and Reactivates Silenced Tumor Suppressor Genes in Human Cancer Cells

(2010) D. Kuck et al.   MOLECULAR CANCER THERAPEUTICS

Methylation determines fibroblast activation and fibrogenesis in the kidney

(2010) Wibke Bechtel et al.   NATURE MEDICINE

Inhibition of Wnt/ -catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis

(2010) W. R. Henderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA array analysis of microRNAs related to systemic scleroderma

(2010) Haitao Li et al.   RHEUMATOLOGY INTERNATIONAL

The Biology of Chromatin Remodeling Complexes

(2009) Cedric R. Clapier et al.   Annual Review of Biochemistry

Phase I Study of MG98, an Oligonucleotide Antisense Inhibitor of Human DNA Methyltransferase 1, Given as a 7-Day Infusion in Patients with Advanced Solid Tumors

(2009) R. Plummer et al.   CLINICAL CANCER RESEARCH

Histone H3 lysine 4 (H3K4) methylation in development and differentiation

(2009) Joel C. Eissenberg et al.   DEVELOPMENTAL BIOLOGY

Peroxisome proliferator-activated receptor-γ abrogates Smad-dependent collagen stimulation by targeting the p300 transcriptional coactivator

(2009) Asish K. Ghosh et al.   FASEB JOURNAL

MeCP2 Controls an Epigenetic Pathway That Promotes Myofibroblast Transdifferentiation and Fibrosis

(2009) Jelena Mann et al.   GASTROENTEROLOGY

Wnt/ -Catenin Signaling Promotes Renal Interstitial Fibrosis

(2009) W. He et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Scleroderma

(2009) Armando Gabrielli et al.   NEW ENGLAND JOURNAL OF MEDICINE

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

(2009) M. Tahiliani et al.   SCIENCE

Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?

(2008) Witold Filipowicz et al.   NATURE REVIEWS GENETICS

Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis

(2008) E. van Rooij et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA