Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: A novel mouse model for scleroderma?

Narrative Review: Fibrotic Diseases: Cellular and Molecular Mechanisms and Novel Therapies

(2013) Joel Rosenbloom   ANNALS OF INTERNAL MEDICINE

Nuclear β-Catenin Is Increased in Systemic Sclerosis Pulmonary Fibrosis and Promotes Lung Fibroblast Migration and Proliferation

(2011) Anna P. Lam et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis

(2010) Sonali Sonnylal et al.   ARTHRITIS AND RHEUMATISM

Peroxisome proliferator-activated receptor γ: innate protection from excessive fibrogenesis and potential therapeutic target in systemic sclerosis

(2010) Jun Wei et al.   CURRENT OPINION IN RHEUMATOLOGY

Activation of Canonical Wingless-type MMTV Integration Site Family (Wnt) Signaling in Mature Adipocytes Increases β-Catenin Levels and Leads to Cell Dedifferentiation and Insulin Resistance

(2010) Birgit Gustafson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SPARC Suppresses Apoptosis of Idiopathic Pulmonary Fibrosis Fibroblasts through Constitutive Activation of β-Catenin

(2010) Wenteh Chang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plasminogen Activator Inhibitor-1 Is a Transcriptional Target of the Canonical Pathway of Wnt/β-Catenin Signaling

(2010) Weichun He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CTGF directs fibroblast differentiation from human mesenchymal stem/stromal cells and defines connective tissue healing in a rodent injury model

(2010) Chang H. Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

Antagonistic Effect of the Matricellular Signaling Protein CCN3 on TGF-β- and Wnt-Mediated Fibrillinogenesis in Systemic Sclerosis and Marfan Syndrome

(2010) Raphael Lemaire et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

PPARγ Downregulation by TGFß in Fibroblast and Impaired Expression and Function in Systemic Sclerosis: A Novel Mechanism for Progressive Fibrogenesis

(2010) Jun Wei et al.   PLoS One

Inhibition of Wnt/ -catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis

(2010) W. R. Henderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rosiglitazone Abrogates Bleomycin-Induced Scleroderma and Blocks Profibrotic Responses Through Peroxisome Proliferator-Activated Receptor-γ

(2009) Minghua Wu et al.   AMERICAN JOURNAL OF PATHOLOGY

Dermal Transforming Growth Factor-β Responsiveness Mediates Wound Contraction and Epithelial Closure

(2009) Magaly Martinez-Ferrer et al.   AMERICAN JOURNAL OF PATHOLOGY

Towards an integrated view of Wnt signaling in development

(2009) R. van Amerongen et al.   DEVELOPMENT

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

A Wnt Survival Guide: From Flies to Human Disease

(2009) Andy J. Chien et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Transforming growth factor β as a therapeutic target in systemic sclerosis

(2009) John Varga et al.   Nature Reviews Rheumatology

The Transcriptional Cofactor Nab2 Is Induced by TGF-β and Suppresses Fibroblast Activation: Physiological Roles and Impaired Expression in Scleroderma

(2009) Swati Bhattacharyya et al.   PLoS One

 -Catenin has sequential roles in the survival and specification of ventral dermis

(2008) J. Ohtola et al.   DEVELOPMENT

Functional Wnt Signaling Is Increased in Idiopathic Pulmonary Fibrosis

(2008) Melanie Königshoff et al.   PLoS One

Idiopathic Pulmonary Fibrosis: Aberrant Recapitulation of Developmental Programs?

(2008) Moisés Selman et al.   PLOS MEDICINE

In perspective: Murine models of scleroderma

(2008) Minghua Wu et al.   Current Rheumatology Reports

Increased Expression of Wnt2 and SFRP4 in Tsk Mouse Skin: Role of Wnt Signaling in Altered Dermal Fibrillin Deposition and Systemic Sclerosis

(2007) Julie Bayle et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY