Interleukin-6 (IL-6) Trans Signaling Drives a STAT3-dependent Pathway That Leads to Hyperactive Transforming Growth Factor-β (TGF-β) Signaling Promoting SMAD3 Activation and Fibrosis via Gremlin Protein

Gremlin-1 Identifies Fibrosis and Predicts Adverse Outcome in Patients With Heart Failure Undergoing Endomyocardial Biopsy

(2013) Karin A.L. Mueller et al.   JOURNAL OF CARDIAC FAILURE

The IL-6 Trans-Signaling-STAT3 Pathway Mediates ECM and Cellular Proliferation in Fibroblasts from Hypertrophic Scar

(2013) Sutapa Ray et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Clinical and pathological significance of interleukin 6 overexpression in systemic sclerosis

(2012) Korsa Khan et al.   ANNALS OF THE RHEUMATIC DISEASES

JAK-2 as a novel mediator of the profibrotic effects of transforming growth factor β in systemic sclerosis

(2012) Clara Dees et al.   ARTHRITIS AND RHEUMATISM

Tumor necrosis factor-costimulated T lymphocytes from patients with systemic sclerosis trigger collagen production in fibroblasts

(2012) Thomas Hügle et al.   ARTHRITIS AND RHEUMATISM

Gremlin Plays a Key Role in the Pathogenesis of Pulmonary Hypertension

(2012) Edwina Cahill et al.   CIRCULATION

Interleukin-6, its role in fibrosing conditions

(2012) Steven O’Reilly et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis

(2012) Robert J. J. O'Donoghue et al.   EMBO Molecular Medicine

IL-6 Blockade Attenuates the Development of Murine Sclerodermatous Chronic Graft-Versus-Host Disease

(2012) Doanh Le Huu et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

T cells in systemic sclerosis: a reappraisal

(2012) S. O'Reilly et al.   RHEUMATOLOGY

Understanding fibrosis in systemic sclerosis: shifting paradigms, emerging opportunities

(2011) Swati Bhattacharyya et al.   Nature Reviews Rheumatology

SOCS3 regulates graft-versus-host disease

(2010) G. R. Hill et al.   BLOOD

Gremlin is a novel agonist of the major proangiogenic receptor VEGFR2

(2010) S. Mitola et al.   BLOOD

Allelic Depletion of grem1 Attenuates Diabetic Kidney Disease

(2009) S. A. Roxburgh et al.   DIABETES

Role of Interleukin-6 in Bleomycin-Induced Lung Inflammatory Changes in Mice

(2007) Fumitake Saito et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY