Sirt1 regulates canonical TGF-β signalling to control fibroblast activation and tissue fibrosis

SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism

(2014) Hongwei Yao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Stimulation of the soluble guanylate cyclase (sGC) inhibits fibrosis by blocking non-canonical TGFβ signalling

(2014) Christian Beyer et al.   ANNALS OF THE RHEUMATIC DISEASES

Combined inhibition of morphogen pathways demonstrates additive antifibrotic effects and improved tolerability

(2014) Alfiya Distler et al.   ANNALS OF THE RHEUMATIC DISEASES

Inhibition of casein kinase II reduces TGFβ induced fibroblast activation and ameliorates experimental fibrosis

(2014) Yun Zhang et al.   ANNALS OF THE RHEUMATIC DISEASES

Activation of liver X receptors inhibits experimental fibrosis by interfering with interleukin-6 release from macrophages

(2014) Christian Beyer et al.   ANNALS OF THE RHEUMATIC DISEASES

Heat shock protein 90 (Hsp90) inhibition targets canonical TGF-β signalling to prevent fibrosis

(2013) Michal Tomcik et al.   ANNALS OF THE RHEUMATIC DISEASES

Inactivation of evenness interrupted (EVI) reduces experimental fibrosis by combined inhibition of canonical and non-canonical Wnt signalling

(2013) Alfiya Distler et al.   ANNALS OF THE RHEUMATIC DISEASES

The Wnt antagonists DKK1 and SFRP1 are downregulated by promoter hypermethylation in systemic sclerosis

(2013) Clara Dees et al.   ANNALS OF THE RHEUMATIC DISEASES

Blockade of canonical Wnt signalling ameliorates experimental dermal fibrosis

(2013) Christian Beyer et al.   ANNALS OF THE RHEUMATIC DISEASES

2013 classification criteria for systemic sclerosis: an American college of rheumatology/European league against rheumatism collaborative initiative

(2013) Frank van den Hoogen et al.   ANNALS OF THE RHEUMATIC DISEASES

SIRT1 inhibits TNF-α-induced apoptosis of vascular adventitial fibroblasts partly through the deacetylation of FoxO1

(2013) Weirong Wang et al.   APOPTOSIS

Sirt1 resists advanced glycation end products-induced expressions of fibronectin and TGF-β1 by activating the Nrf2/ARE pathway in glomerular mesangial cells

(2013) Kaipeng Huang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Crosstalk between Oxidative Stress and SIRT1: Impact on the Aging Process

(2013) Antero Salminen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sirt1 Activation Ameliorates Renal Fibrosis by Inhibiting the TGF-β/Smad3 Pathway

(2013) Xin-Zhong Huang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

SIRT1 Suppresses the Epithelial-to-Mesenchymal Transition in Cancer Metastasis and Organ Fibrosis

(2013) Petra Simic et al.   Cell Reports

Inhibition of hedgehog signalling prevents experimental fibrosis and induces regression of established fibrosis

(2012) Angelika Horn et al.   ANNALS OF THE RHEUMATIC DISEASES

Stimulation of soluble guanylate cyclase reduces experimental dermal fibrosis

(2012) Christian Beyer et al.   ANNALS OF THE RHEUMATIC DISEASES

Jun N-terminal kinase as a potential molecular target for prevention and treatment of dermal fibrosis

(2012) Nicole Reich et al.   ANNALS OF THE RHEUMATIC DISEASES

Inactivation of fatty acid amide hydrolase exacerbates experimental fibrosis by enhanced endocannabinoid-mediated activation of CB1

(2012) Katrin Palumbo-Zerr et al.   ANNALS OF THE RHEUMATIC DISEASES

Pomalidomide is effective for prevention and treatment of experimental skin fibrosis

(2012) Simon Weingärtner et al.   ANNALS OF THE RHEUMATIC DISEASES

Hedgehog signaling controls fibroblast activation and tissue fibrosis in systemic sclerosis

(2012) Angelika Horn et al.   ARTHRITIS AND RHEUMATISM

JAK-2 as a novel mediator of the profibrotic effects of transforming growth factor β in systemic sclerosis

(2012) Clara Dees et al.   ARTHRITIS AND RHEUMATISM

TGF-β signaling in tissue fibrosis: Redox controls, target genes and therapeutic opportunities

(2012) Rohan Samarakoon et al.   CELLULAR SIGNALLING

Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis

(2012) Alfiya Akhmetshina et al.   Nature Communications

The transcription factor JunD mediates transforming growth factor  -induced fibroblast activation and fibrosis in systemic sclerosis

(2011) K. Palumbo et al.   ANNALS OF THE RHEUMATIC DISEASES

SIRT1 overexpression in the rheumatoid arthritis synovium contributes to proinflammatory cytokine production and apoptosis resistance

(2011) F. Niederer et al.   ANNALS OF THE RHEUMATIC DISEASES

Notch signalling regulates fibroblast activation and collagen release in systemic sclerosis

(2011) C. Dees et al.   ANNALS OF THE RHEUMATIC DISEASES

Inhibition of Notch signaling prevents experimental fibrosis and induces regression of established fibrosis

(2011) Clara Dees et al.   ARTHRITIS AND RHEUMATISM

Inhibition of activator protein 1 signaling abrogates transforming growth factor β-mediated activation of fibroblasts and prevents experimental fibrosis

(2011) Jérôme Avouac et al.   ARTHRITIS AND RHEUMATISM

Platelet-derived serotonin links vascular disease and tissue fibrosis

(2011) Clara Dees et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Resveratrol Inhibits Renal Fibrosis in the Obstructed Kidney

(2010) Jinhua Li et al.   AMERICAN JOURNAL OF PATHOLOGY

Causes and risk factors for death in systemic sclerosis: a study from the EULAR Scleroderma Trials and Research (EUSTAR) database

(2010) A. J. Tyndall et al.   ANNALS OF THE RHEUMATIC DISEASES

Animal models of systemic sclerosis: Prospects and limitations

(2010) Christian Beyer et al.   ARTHRITIS AND RHEUMATISM

SIRT1 modulates expression of matrix metalloproteinases in human dermal fibroblasts

(2010) K. Ohguchi et al.   BRITISH JOURNAL OF DERMATOLOGY

Peroxisome proliferator-activated receptor γ: innate protection from excessive fibrogenesis and potential therapeutic target in systemic sclerosis

(2010) Jun Wei et al.   CURRENT OPINION IN RHEUMATOLOGY

SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1

(2010) Michelle Pacholec et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The cannabinoid receptor CB2 exerts antifibrotic effects in experimental dermal fibrosis

(2009) Alfiya Akhmetshina et al.   ARTHRITIS AND RHEUMATISM

The transcription factor Fra-2 regulates the production of extracellular matrix in systemic sclerosis

(2009) Nicole Reich et al.   ARTHRITIS AND RHEUMATISM

Resveratrol is Not a Direct Activator of SIRT1 Enzyme Activity

(2009) Dirk Beher et al.   Chemical Biology & Drug Design

Resveratrol augments the canonical Wnt signaling pathway in promoting osteoblastic differentiation of multipotent mesenchymal cells

(2009) Haibin Zhou et al.   EXPERIMENTAL CELL RESEARCH

Scleroderma

(2009) Armando Gabrielli et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sirt1 protects against oxidative stress-induced renal tubular cell apoptosis by the bidirectional regulation of catalase expression

(2008) Kazuhiro Hasegawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sirtuins — novel therapeutic targets to treat age-associated diseases

(2008) Siva Lavu et al.   NATURE REVIEWS DRUG DISCOVERY