Dickkopf1 destabilizes atherosclerotic plaques and promotes plaque formation by inducing apoptosis of endothelial cells through activation of ER stress

Beta Blockers Suppress Dextrose-Induced Endoplasmic Reticulum Stress, Oxidative Stress, and Apoptosis in Human Coronary Artery Endothelial Cells

(2016) Michael J. Haas et al.   AMERICAN JOURNAL OF THERAPEUTICS

Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis

(2016) Michael A. Gimbrone et al.   CIRCULATION RESEARCH

WNT/β-catenin signaling promotes VSMCs to osteogenic transdifferentiation and calcification through directly modulating Runx2 gene expression

(2016) Ting Cai et al.   EXPERIMENTAL CELL RESEARCH

Physiology and pathophysiology of oxLDL uptake by vascular wall cells in atherosclerosis

(2016) Natalia Di Pietro et al.   VASCULAR PHARMACOLOGY

Dysfunction of Wntless triggers the retrograde Golgi-to-ER transport of Wingless and induces ER stress

(2016) Peng Zhang et al.   Scientific Reports

Angiopoietin-2 attenuates angiotensin II-induced aortic aneurysm and atherosclerosis in apolipoprotein E-deficient mice

(2016) Hongyou Yu et al.   Scientific Reports

The Role of Endoplasmic Reticulum Stress in Human Pathology

(2015) Scott A. Oakes et al.   Annual Review of Pathology-Mechanisms of Disease

Hyperlipidemia induces vascular smooth muscle cell proliferation involving Wnt/β-catenin signaling

(2015) Yu Zhuang et al.   CELL BIOLOGY INTERNATIONAL

The Atherosclerotic Plaque Vulnerability: Focus on the Oxidative and Endoplasmic Reticulum Stress in Orchestrating the Macrophage Apoptosis in the Formation of the Necrotic Core

(2015) Luciano Cominacini et al.   CURRENT MEDICINAL CHEMISTRY

Experimental Evidence Shows Salubrinal, an eIF2α Dephosphorylation Inhibitor, Reduces Xenotoxicant-Induced Cellular Damage

(2015) Masato Matsuoka et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Upregulation of Dickkopf1 by oscillatory shear stress accelerates atherogenesis

(2015) Mengmeng Li et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

TRAIL protects against endothelium injury in diabetes via Akt-eNOS signaling

(2014) Min Liu et al.   ATHEROSCLEROSIS

Induction of DKK1 by ox-LDL negatively regulates intracellular lipid accumulation in macrophages

(2014) Yu Zhang et al.   FEBS LETTERS

A novel therapeutic approach with Caviunin-based isoflavonoid that en routes bone marrow cells to bone formation via BMP2/Wnt-β-catenin signaling

(2014) P Kushwaha et al.   Cell Death & Disease

Endoplasmic Reticulum Stress and Nox-Mediated Reactive Oxygen Species Signaling in the Peripheral Vasculature: Potential Role in Hypertension

(2013) Celio X.C. Santos et al.   ANTIOXIDANTS & REDOX SIGNALING

Dickkopf-1 as a Novel Predictor Is Associated with Risk Stratification by GRACE Risk Scores for Predictive Value in Patients with Acute Coronary Syndrome: A Retrospective Research

(2013) Lin Wang et al.   PLoS One

The UPR in atherosclerosis

(2013) Alex X. Zhou et al.   Seminars in Immunopathology

The WNT Inhibitor Dickkopf 1 and Bone Morphogenetic Protein 4 Rescue Adipogenesis in Hypertrophic Obesity in Humans

(2012) Birgit Gustafson et al.   DIABETES

c-Jun NH2-Terminal Kinase 1/2 and Endoplasmic Reticulum Stress as Interdependent and Reciprocal Causation in Diabetic Embryopathy

(2012) X. Li et al.   DIABETES

Update on acute coronary syndromes: the pathologists' view

(2012) Erling Falk et al.   EUROPEAN HEART JOURNAL

Asymmetric Dimethyarginine as Marker and Mediator in Ischemic Stroke

(2012) Shufen Chen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dickkopf-1 inhibits thyroid cancer cell survival and migration through regulation of β-catenin/E-cadherin signaling

(2012) Sun Wook Cho et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The importance of the endothelium in atherothrombosis and coronary stenting

(2012) Fumiyuki Otsuka et al.   Nature Reviews Cardiology

Stress management at the ER: Regulators of ER stress-induced apoptosis

(2012) Adrienne M. Gorman et al.   PHARMACOLOGY & THERAPEUTICS

Mechanisms of ER Stress-Induced Apoptosis in Atherosclerosis

(2011) Christopher M. Scull et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Salermide up-regulates death receptor 5 expression through the ATF4-ATF3-CHOP axis and leads to apoptosis in human cancer cells

(2011) Guangbo Liu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Cellular prion protein is implicated in the regulation of local Ca2+ movements in cerebellar granule neurons

(2011) Cristian Lazzari et al.   JOURNAL OF NEUROCHEMISTRY

Progress and challenges in translating the biology of atherosclerosis

(2011) Peter Libby et al.   NATURE

The Wnt Antagonist Dickkopf-1 Increases Endothelial Progenitor Cell Angiogenic Potential

(2010) David M. Smadja et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Control of Dkk-1 ameliorates chondrocyte apoptosis, cartilage destruction, and subchondral bone deterioration in osteoarthritic knees

(2010) Lin-Hsiu Weng et al.   ARTHRITIS AND RHEUMATISM

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

Endoplasmic Reticulum Stress As a Therapeutic Target in Cardiovascular Disease

(2010) Tetsuo Minamino et al.   CIRCULATION RESEARCH

Wnt antagonist DKK1 acts as a tumor suppressor gene that induces apoptosis and inhibits proliferation in human renal cell carcinoma

(2010) Hiroshi Hirata et al.   INTERNATIONAL JOURNAL OF CANCER

Partial carotid ligation is a model of acutely induced disturbed flow, leading to rapid endothelial dysfunction and atherosclerosis

(2009) Douglas Nam et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Dickkopf-1 Enhances Inflammatory Interaction Between Platelets and Endothelial Cells and Shows Increased Expression in Atherosclerosis

(2009) Thor Ueland et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The role of Dickkopf-1 in bone development, homeostasis, and disease

(2008) J. J. Pinzone et al.   BLOOD

The Wnt Antagonist Dickkopf-1 Mobilizes Vasculogenic Progenitor Cells via Activation of the Bone Marrow Endosteal Stem Cell Niche

(2008) Alexandra Aicher et al.   CIRCULATION RESEARCH

Hypoglycemic pharmacological treatment of type 2 diabetes: Targeting the endothelium

(2008) David Nathanson et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability

(2008) Christopher A Jones et al.   NATURE MEDICINE

The Wnt Antagonist, Dickkopf-1, as a Target for the Treatment of Neurodegenerative Disorders

(2008) Filippo Caraci et al.   NEUROCHEMICAL RESEARCH

Inflammation induction of Dickkopf-1 mediates chondrocyte apoptosis in osteoarthritic joint

(2008) L.-H. Weng et al.   OSTEOARTHRITIS AND CARTILAGE