Letter
Medicine, General & Internal
Juan P. Frias, Laura Fernandez Lando, Katelyn Brown
Summary: In the SURPASS-2 trial, treatment with Tirzepatide showed better glycemic control and greater weight loss compared to Semaglutide in patients with type 2 diabetes. Additionally, there were no significant differences in mean systolic blood pressure among the enrolled patients in different treatment groups.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Medicine, Research & Experimental
Mandy Otto, Laura Brabenec, Melanie Mueller, Sebastian Kintrup, Katharina E. M. Hellenthal, Richard Holtmeier, Sophie Charlotte Steinbuch, Ole Sonken Karsten, Heorhii Pryvalov, Jan Rossaint, Eric R. Gross, Nana-Maria Wagner
Summary: The study suggests that 12-HETE may serve as a biomarker for endothelial dysfunction and HFpEF in patients with type 2 diabetes. Antagonizing 12-HETE is a potent way to control the development and progression of HFpEF in type 2 diabetes by preserving vascular function.
Article
Cardiac & Cardiovascular Systems
C. H. Lee, M. Z. Wu, D. T. W. Lui, C. H. Y. Fong, Q. W. Ren, S. Y. Yu, M. M. A. Yuen, W. S. Chow, J. Y. Huang, A. Xu, K. H. Yiu, K. S. L. Lam
Summary: This study found that serum TSP2 levels were independently associated with incident heart failure and deterioration in diastolic function in patients with type 2 diabetes.
CARDIOVASCULAR DIABETOLOGY
(2022)
Review
Medicine, Research & Experimental
Simeon I. Taylor, Zhinous Shahidzadeh Yazdi, Amber L. Beitelshees
Summary: Diabetes mellitus is a significant public health issue, with pharmacotherapy aiming to prevent complications. Clinical trials have shown that intensive glycemic control can slow the progression of complications, with some drugs also demonstrating cardiovascular benefits and slowed progression of diabetic kidney disease.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Clinical Neurology
Xinming Xu, Chengwu Feng, Han Han, Tongtong Li, Nan Wang, Qishan Yang, Yi Guo, Xinyi Gan, Xiaohua Liu, Liang Sun, Alexandru Dregan, Geng Zong, Xiang Gao
Summary: Depressive symptoms in individuals with type 2 diabetes were found to be associated with a higher risk of cardiovascular diseases, with dose-response relationships observed between depressive symptoms and various cardiovascular outcomes. This suggests that screening for depressive symptoms could help predict cardiovascular disease outcomes in individuals with type 2 diabetes.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Medicine, General & Internal
Min Zhuo, Elvira D'Andrea, Julie M. Paik, Deborah J. Wexler, Brendan M. Everett, Robert J. Glynn, Seoyoung C. Kim, Elisabetta Patorno
Summary: The use of SGLT-2 inhibitors is associated with a reduced risk of incident atrial fibrillation in older adults with type 2 diabetes.
Article
Multidisciplinary Sciences
Eiichiro Kanda, Atsushi Suzuki, Masaki Makino, Hiroo Tsubota, Satomi Kanemata, Koichi Shirakawa, Toshitaka Yajima
Summary: A novel machine learning model was developed to predict the risk of developing CKD/HF in early-stage T2DM patients, showing good predictive performance in external validation. Early diagnosis and intervention based on ML models may improve the prognosis of high-risk patients.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Fu-Shun Yen, James Cheng-Chung Wei, Lu-Ting Chiu, Chih-Cheng Hsu, Chii-Min Hwu
Summary: In patients with both type 2 diabetes mellitus and chronic obstructive pulmonary disease, the use of metformin is associated with a lower risk of cardiovascular disease, and the longer the duration of metformin use, the lower the risk. Further prospective studies are needed to verify these findings.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Arnaud D. Kaze, Sebhat Erqou, Prasanna Santhanam, Alain G. Bertoni, Rexford S. Ahima, Gregg C. Fonarow, Justin B. Echouffo-Tcheugui
Summary: This study found that greater variability in adiposity indices in individuals with type 2 diabetes was associated with a higher risk of incident heart failure, independently of traditional risk factors and baseline adiposity levels.
CARDIOVASCULAR DIABETOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Rachel L. Washburn, Karl Mueller, Gurvinder Kaur, Tanir Moreno, Naima Moustaid-Moussa, Latha Ramalingam, Jannette M. Dufour
Summary: Diabetes mellitus is a complex metabolic disease affecting one-third of the United States population, characterized by hyperglycemia. For patients with Type 1 diabetes, C-peptide may have potential therapeutic effects on various complications.
Article
Biochemistry & Molecular Biology
Noura N. Ballasy, Anshul S. Jadli, Pariya Edalat, Sean Kang, Ali Fatehi Hassanabad, Karina P. Gomes, Paul W. M. Fedak, Vaibhav B. Patel
Summary: The study found that epicardial adipose tissue (EAT) treated with high glucose, high palmitate, and lipopolysaccharide released a large amount of proinflammatory cytokines, which may lead to EAT inflammation in patients with type 2 diabetes, causing coronary artery endothelial cell dysfunction.
Article
Cardiac & Cardiovascular Systems
Amera Halabi, Elizabeth Potter, Hilda Yang, Leah Wright, Julian W. Sacre, Jonathan E. Shaw, Thomas H. Marwick
Summary: This study investigated the association between clinical scores and biomarkers with subclinical LV dysfunction and evaluated their ability to identify patients who require echocardiography. The results showed a weak relationship between these assessment tools and subclinical LV dysfunction. They had limited ability to discriminate abnormal global longitudinal strain, diastolic function, and left ventricular mass.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Angelo Avogaro, Francesco Barilla, Franco Cavalot, Agostino Consoli, Massimo Federici, Massimo Mancone, Stefania Paolillo, Roberto Pedrinelli, Gianluca Perseghin, Pasquale Perrone Filardi, Roberto Scicali, Gianfranco Sinagra, Carmen Spaccarotella, Ciro Indolfi, Francesco Purrello
Summary: This review, a joint effort of the Italian Societies of Cardiology (SIC) and Diabetes (SID), aims to define the state of the art in cardiovascular risk management for type 2 diabetes mellitus. The synthesis consists of six chapters that examine various aspects of pathophysiology, diagnosis, and therapy, reflecting recent scientific innovations and clinical studies. Collaboration and sharing of knowledge amongst scientific societies are emphasized for the continuous evolution in this field.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Cell Biology
Shuai Huang, Gen Chen, Jia Sun, Yunjie Chen, Nan Wang, Yetong Dong, Enzhao Shen, Zhicheng Hu, Wenjie Gong, Litai Jin, Weitao Cong
Summary: The study reveals that inhibiting histone deacetylase 3 (HDAC3) can reduce vascular endothelial inflammation and oxidative stress by regulating nuclear factor-E2-related factor 2 (Nrf2), thus improving endothelial function. Silencing HDAC3 decreases ROS production and inflammation in HUVECs treated under high glucose-palmitic acid conditions through the Keap1-Nrf2-Nox4 signaling pathway.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Endocrinology & Metabolism
Yilu Lin, Hui Shao, Lizheng Shi, Amanda H. Anderson, Vivian Fonseca
Summary: This study aimed to predict the risk of heart failure among patients with diabetes using a scoring algorithm. The model showed good discrimination and calibration in predicting the risk of heart failure, and age, healthcare utilization, and cardiovascular disease-related variables were found to be the strongest predictors. The model can be easily applied in clinical practice for risk stratification.
DIABETES OBESITY & METABOLISM
(2022)
Article
Cell Biology
Karina A. Pena, Sofya Savransky, Breanna Lewis
Summary: Compartmentalization of GPCR signaling is an emerging topic that emphasizes the importance of spatial bias in signaling for physiological relevance. PTH1R was the first GPCR discovered to signal via cAMP from endosomes, challenging the conventional model of GPCR signaling. The location of cAMP generation determines the physiological outcomes of GPCR signaling.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Cheng-Xu Ma, Xiao-Ni Ma, Jin-Jin Liu, Cong-Hui Guan, Ying-Dong Li, Nan Zhao, Didac Mauricio, Song-Bo Fu
Summary: The downregulation of primary cilia (PCs) due to BRAFV600E mutation contributes to the aggressiveness and lymph node metastasis of Papillary Thyroid Cancer (PTC).
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Kejun Wu, Cuihua Huang, Wenrong Zheng, Yubin Wu, Qintao Huang, Menghua Lin, Ruonan Gao, Liqin Qi, Guanlian He, Xiaoying Liu, Xiaohong Liu, Linxi Wang, Zhou Chen, Libin Liu
Summary: Recurrent non-severe hypoglycemia in patients with diabetes is associated with cognitive impairment. This study found that this condition is associated with reduced mitophagy in the hippocampus, leading to mitochondrial dysfunction and neurological impairment.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Yifei Lv, Yizhou Huang, Huiyu Fan, Yunxiu Zhao, Linjuan Ma, Yibing Lan, Chunming Li, Peiqiong Chen, Zheng Lou, Jianhong Zhou
Summary: Before menopause, females have a lower incidence of cardiovascular disease than age-matched males, possibly due to the protective effects of sex hormones. 17 beta-E2 inhibits THBS1 expression, preventing cell senescence and apoptosis, and counteracts oxidative stress by suppressing the TGF-beta/Smad signaling pathway.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Ana C. L. Camargo, Flavia B. Constantino, Sergio A. A. Santos, Ketlin T. Colombelli, Luiz M. F. Portela, Matheus N. Fioretto, Luisa A. Barata, Guilherme T. Valente, Carlos S. Moreno, Luis A. Justulin
Summary: This study examined the effects of maternal malnutrition on the transcriptomic landscape of the ventral prostate in rats. It found that changes in molecular pathways related to cellular development and tissue morphogenesis were associated with maternal malnutrition. The Abcg1 gene was found to be deregulated in both malnourished rats and prostate cancer models and patients.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Sandra Romero-Cordoba, Mayel Chirinos, Nancy Noyola-Martinez, Nayeli Torres-Ramirez, Mitzi Garcia-Olivares, Juan Pablo Aragon-Hernandez, Ixchel Ramirez-Camacho, Rosa Zuniga, Fernando Larrea, Ali Halhali, David Barrera
Summary: This study analyzed the effects of calcitriol, TGF-131, and their combination on human trophoblast cells. The results showed that the combination treatment modified the transcriptional landscape and mainly affected the storage, activity, and metabolism of lipids, which may have an impact on placental development.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Traver J. Wright, Richard B. Pyles, Melinda Sheffield-Moore, Rachel R. Deer, Kathleen M. Randolph, Kristen A. Mcgovern, Christopher P. Danesi, Charles R. Gilkison, Weston W. Ward, Jayson A. Vargas, Peyton A. Armstrong, Sarah E. Lindsay, Mohammed F. Zaidan, Justin Seashore, Tamara L. Wexler, Brent E. Masel, Randall J. Urban
Summary: This study investigates the persistent neurologic symptoms in COVID-19 patients after recovery and explores the association between these symptoms and disrupted growth hormone secretion and gastrointestinal discomfort.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Li-Li Chen, Ya-Qin Li, Zhi-Hui Kang, Xuan Zhang, Su-Yan Gu, Na Wang, Xue-Yan Shen
Summary: Defects in trophoblastic EMT caused by dysregulation of circTNRC18's interaction with LIN28A play a vital role in the development of preeclampsia. LIN28A overexpression suppresses circTNRC18-mediated inhibition of trophoblast migration, invasion, and EMT, while LIN28A knockdown promotes them. Furthermore, circTNRC18 regulates the intracellular distribution of LIN28A and the expression of insulin-like growth factor II, affecting cell migration and invasion. Targeting the circTNRC18-LIN28A regulatory axis may provide a novel treatment approach for preeclampsia.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)