A thiocyanopalladation/carbocyclization transformation identified through enzymatic screening: stereocontrolled tandem C–SCN and C–C bond formation

Synthesis and Deployment of an Elusive Fluorovinyl Cation Equivalent: Access to Quaternary α-(1′-Fluoro)vinyl Amino Acids as Potential PLP Enzyme Inactivators

(2017) Christopher D. McCune et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Discovery of Multicomponent Heterogeneous Catalysts via Admixture Screening: PdBiTe Catalysts for Aerobic Oxidative Esterification of Primary Alcohols

(2017) David S. Mannel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Practical High-Throughput Experimentation for Chemists

(2017) Michael Shevlin   ACS Medicinal Chemistry Letters

Regioselective Synthesis of 2-Substituted Indoles from Benzotriazoles and Alkynes by Photoinitiated Denitrogenation

(2017) Michael Teders et al.   ACS Catalysis

An NAD(P)H-Dependent Artificial Transfer Hydrogenase for Multienzymatic Cascades

(2016) Yasunori Okamoto et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nitrile Probes of Electric Field Agree with Independently Measured Fields in Green Fluorescent Protein Even in the Presence of Hydrogen Bonding

(2016) Joshua D. Slocum et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Non-covalent S⋯O interactions control conformation in a scaffold that disrupts islet amyloid polypeptide fibrillation

(2016) Hayden Peacock et al.   Chemical Science

One-Pot Cascade Synthesis of Mono- and Disubstituted Piperidines and Pyrrolidines using Carboxylic Acid Reductase (CAR), ω-Transaminase (ω-TA), and Imine Reductase (IRED) Biocatalysts

(2016) Scott P. France et al.   ACS Catalysis

Miniature high-throughput chemosensing of yield, ee, and absolute configuration from crude reaction mixtures

(2016) K. W. Bentley et al.   Science Advances

Ruthenium(0)-Catalyzed [4+2] Cycloaddition of Acetylenic Aldehydes with α-Ketols: Convergent Construction of Angucycline Ring Systems

(2015) Aakarsh Saxena et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Decarboxylative Cross-Coupling of Aryl Chlorides and Benzoates without ActivatingorthoSubstituents

(2015) Jie Tang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes

(2015) Stuart L. Schreiber et al.   CELL

Recent advances in C–S bond formation via C–H bond functionalization and decarboxylation

(2015) Chao Shen et al.   CHEMICAL SOCIETY REVIEWS

Rhodium-Catalyzed CS and CN Functionalization of Arenes: Combination of CH Activation and Hypervalent Iodine Chemistry

(2015) Fen Wang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Diastereoselective Synthesis of Fluorine-Containing Pyrrolizidines via Triphenylcarbenium Tetrafluoroborate-Promoted Carbofluorination of N-3-Arylpropargylpyrrolidine-Tethered Tertiary Allylic Alcohols

(2015) Ming-Chang P. Yeh et al.   JOURNAL OF ORGANIC CHEMISTRY

Combining a Clostridial Enzyme Exhibiting Unusual Active Site Plasticity with a Remarkably Facile Sigmatropic Rearrangement: Rapid, Stereocontrolled Entry into Densely Functionalized Fluorinated Phosphonates for Chemical Biology

(2015) Kaushik Panigrahi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Copper-Catalyzed Intermolecular Trifluoromethylazidation and Trifluoromethylthiocyanation of Allenes: Efficient Access to CF3-Containing Allyl Azides and Thiocyanates

(2015) Na Zhu et al.   ORGANIC LETTERS

Activation of Aryl Thiocyanates Followed by Aryne Insertion: Access to 1,2-Thiobenzonitriles

(2015) Martin Pawliczek et al.   ORGANIC LETTERS

Copper-Catalyzed Intermolecular Trifluoromethylthiocyanation of Alkenes: Convenient Access to CF3-Containing Alkyl Thiocyanates

(2015) Zhaoli Liang et al.   ORGANIC LETTERS

Identifying lead hits in catalyst discovery by screening and deconvoluting complex mixtures of catalyst components

(2015) Eléna Wolf et al.   Chemical Science

Mini-ISES identifies promising carbafructopyranose-based salens for asymmetric catalysis: Tuning ligand shape via the anomeric effect

(2015) K. R. Karukurichi et al.   Science Advances

Catalytic Enantioselective 1,3-Dipolar Cycloadditions of Azomethine Ylides for Biology-Oriented Synthesis

(2014) Rishikesh Narayan et al.   ACCOUNTS OF CHEMICAL RESEARCH

General Platform for Systematic Quantitative Evaluation of Small-Molecule Permeability in Bacteria

(2014) Tony D. Davis et al.   ACS Chemical Biology

[4+2+2] Cycloaddition catalyzed by a new cationic rhodium–bisphosphine monooxide complex

(2014) Gino Martin R. Canlas et al.   CHEMICAL COMMUNICATIONS

Combining the ‘two worlds’ of chemocatalysis and biocatalysis towards multi-step one-pot processes in aqueous media

(2014) Harald Gröger et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Construction of Enantioenriched [3.1.0] Bicycles via a Ruthenium-Catalyzed Asymmetric Redox Bicycloisomerization Reaction

(2014) Barry M. Trost et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Contemporary screening approaches to reaction discovery and development

(2014) Karl D. Collins et al.   Nature Chemistry

Nanomole-scale high-throughput chemistry for the synthesis of complex molecules

(2014) A. Buitrago Santanilla et al.   SCIENCE

Threefold Cross-Linked Polystyrene-Triphenylphosphane Hybrids: Mono-P-Ligating Behavior and Catalytic Applications for Aryl Chloride Cross-Coupling and C(sp3)H Borylation

(2013) Tomohiro Iwai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Two Steps in One Pot: Enzyme Cascade for the Synthesis of Nor(pseudo)ephedrine from Inexpensive Starting Materials

(2013) Torsten Sehl et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chemical tagging of a drug target using 5-sulfonyl tetrazole

(2013) Satsuki Otsuki et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Infrared Probes for Studying the Structure and Dynamics of Biomolecules

(2013) Heejae Kim et al.   CHEMICAL REVIEWS

Stereocontrolled Synthesis of a Cn-Cn+7Building Block (“Eastern Moiety”) for the Unnatural Enantiomers of Important Polyol,Polyene Antibiotics Based on a Ring-Closing Metathesis and an Aldol Addition of a Lactone Enolate

(2013) Sonja B. Kamptmann et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Dioxatricyclic and Oxabicyclic Polyketides from Trichocladium opacum

(2013) Shenxi Chen et al.   JOURNAL OF NATURAL PRODUCTS

Enantioselective Synthesis of 5,7-Bicyclic Ring Systems from Axially Chiral Allenes Using a Rh(I)-Catalyzed Cyclocarbonylation Reaction

(2013) Francois Grillet et al.   JOURNAL OF ORGANIC CHEMISTRY

Biocatalytic retrosynthesis

(2013) Nicholas J Turner et al.   Nature Chemical Biology

Label-assisted mass spectrometry for the acceleration of reaction discovery and optimization

(2013) Jaime R. Cabrera-Pardo et al.   Nature Chemistry

A new and more powerfully activating diamine for practical and scalable enantioselective aldehyde crotylsilylation reactions

(2013) Linda M. Suen et al.   Chemical Science

Electrostatic Effects of Mutations of Ras Glutamine 61 Measured Using Vibrational Spectroscopy of a Thiocyanate Probe

(2012) Amy J. Stafford et al.   BIOCHEMISTRY

Charting, Navigating, and Populating Natural Product Chemical Space for Drug Discovery

(2012) Hugo Lachance et al.   JOURNAL OF MEDICINAL CHEMISTRY

Calculation of Vibrational Shifts of Nitrile Probes in the Active Site of Ketosteroid Isomerase upon Ligand Binding

(2012) Joshua P. Layfield et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stereoselective Rhodium-Catalyzed [3 + 2 + 1] Carbocyclization of Alkenylidenecyclopropanes with Carbon Monoxide: Theoretical Evidence for a Trimethylenemethane Metallacycle Intermediate

(2012) Shivnath Mazumder et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Halocarbocyclization Entry into the Oxabicyclo[4.3.1]decyl Exomethylene-δ-Lactone Cores of Linearifolin and Zaluzanin A: Exploiting Combinatorial Catalysis

(2012) Sandeep K. Ginotra et al.   ORGANIC LETTERS

Enantioselective Rhodium-Catalyzed Synthesis of α-Chloromethylene-γ-Butyrolactams from N-Allylic Alkynamides

(2012) Olivier Jackowski et al.   ORGANIC LETTERS

Biotinylated Rh(III) Complexes in Engineered Streptavidin for Accelerated Asymmetric C-H Activation

(2012) T. K. Hyster et al.   SCIENCE

Combinatorial Catalysis Employing a Visible Enzymatic Beacon in Real Time: Synthetically Versatile (Pseudo)Halometalation/Carbocyclizations

(2011) Jacob A. Friest et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Electrostatic Fields near the Active Site of Human Aldose Reductase: 2. New Inhibitors and Complications Caused by Hydrogen Bonds

(2011) Lin Xu et al.   BIOCHEMISTRY

Transition-Metal-Catalyzed C−S, C−Se, and C−Te Bond Formation via Cross-Coupling and Atom-Economic Addition Reactions

(2011) Irina P. Beletskaya et al.   CHEMICAL REVIEWS

Synthesis of Cyclopentenols and Cyclopentenones via Nickel-Catalyzed Reductive Cycloaddition

(2011) Aireal D. Jenkins et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Carbon−Sulfur Bond Formation via Iridium-Catalyzed Asymmetric Allylation of Aliphatic Thiols

(2011) Ning Gao et al.   ORGANIC LETTERS

Neuraminidase Inhibitory Polyketides from the Marine-derived FungusPhoma herbarum

(2011) Gao Zhang et al.   PLANTA MEDICA

A P,N-Ligand for Palladium-Catalyzed Ammonia Arylation: Coupling of Deactivated Aryl Chlorides, Chemoselective Arylations, and Room Temperature Reactions

(2010) Rylan J. Lundgren et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

One-Pot Synthesis of Unsymmetrical Diaryl Thioethers by Palladium-Catalyzed Coupling of Two Aryl Bromides and a Thiol Surrogate

(2010) Manuel A. Fernández-Rodríguez et al.   CHEMISTRY-A EUROPEAN JOURNAL

Recent advances in multicomponent reactions for diversity-oriented synthesis

(2010) James E. Biggs-Houck et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Privileged scaffolds for library design and drug discovery

(2010) Matthew E Welsch et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Reaction Discovery Using Microfluidic-Based Multidimensional Screening of Polycyclic Iminium Ethers

(2010) Jennifer L. Treece et al.   JOURNAL OF ORGANIC CHEMISTRY

The Effects of α-Helical Structure and Cyanylated Cysteine on Each Other

(2010) Lena Edelstein et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Cyanylated Cysteine: A Covalently Attached Vibrational Probe of Protein−Lipid Contacts

(2010) Heather A. McMahon et al.   Journal of Physical Chemistry Letters

An Efficient Copper-Catalyzed Carbon−Sulfur Bond Formation Protocol in Water

(2010) Fang Ke et al.   ORGANIC LETTERS

Reengineering Enzymes

(2010) S. Lutz   SCIENCE

Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture

(2010) C. K. Savile et al.   SCIENCE

Computational Design of an Enzyme Catalyst for a Stereoselective Bimolecular Diels-Alder Reaction

(2010) J. B. Siegel et al.   SCIENCE

Identification ofN-(5-tert-Butyl-isoxazol-3-yl)-N′-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea Dihydrochloride (AC220), a Uniquely Potent, Selective, and Efficacious FMS-Like Tyrosine Kinase-3 (FLT3) Inhibitor

(2009) Qi Chao et al.   JOURNAL OF MEDICINAL CHEMISTRY

4-Pyridylanilinothiazoles That Selectively Target von Hippel−Lindau Deficient Renal Cell Carcinoma Cells by Inducing Autophagic Cell Death

(2009) Michael P. Hay et al.   JOURNAL OF MEDICINAL CHEMISTRY

A General, Efficient, and Functional-Group-Tolerant Catalyst System for the Palladium-Catalyzed Thioetherification of Aryl Bromides and Iodides

(2009) Manuel A. Fernández-Rodríguez et al.   JOURNAL OF ORGANIC CHEMISTRY

Evolution of a Fourth Generation Catalyst for the Amination and Thioetherification of Aryl Halides

(2008) John F. Hartwig   ACCOUNTS OF CHEMICAL RESEARCH

A Rationally Designed Aldolase Foldamer

(2008) Manuel M. Müller et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Electrostatic Fields Near the Active Site of Human Aldose Reductase: 1. New Inhibitors and Vibrational Stark Effect Measurements†

(2008) Lauren J. Webb et al.   BIOCHEMISTRY

A Cheap Metal for a “Noble” Task:  Preparative and Mechanistic Aspects of Cycloisomerization and Cycloaddition Reactions Catalyzed by Low-Valent Iron Complexes

(2008) Alois Fürstner et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

De Novo Computational Design of Retro-Aldol Enzymes

(2008) L. Jiang et al.   SCIENCE