Non-covalent S⋯O interactions control conformation in a scaffold that disrupts islet amyloid polypeptide fibrillation

Delineating the Role of Helical Intermediates in Natively Unfolded Polypeptide Amyloid Assembly and Cytotoxicity

(2015) Carole Anne De Carufel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

β-Strand Mimetic Foldamers Rigidified through Dipolar Repulsion

(2015) Elizabeth A. German et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Islet Amyloid-Induced Cell Death and Bilayer Integrity Loss Share a Molecular Origin Targetable with Oligopyridylamide-Based α-Helical Mimetics

(2015) Sunil Kumar et al.   CHEMISTRY & BIOLOGY

A Modular Synthesis of Conformationally Preorganised Extended β-Strand Peptidomimetics

(2015) Tohru Yamashita et al.   CHEMISTRY-A EUROPEAN JOURNAL

Structure-based inhibition of protein–protein interactions

(2015) Andrew M. Watkins et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A Survey of the Role of Noncovalent Sulfur Interactions in Drug Design

(2015) Brett R. Beno et al.   JOURNAL OF MEDICINAL CHEMISTRY

Extended Piperidine–Piperidinone Protein Interface Mimics

(2015) Dongyue Xin et al.   JOURNAL OF ORGANIC CHEMISTRY

Amphiphilic oligoamide α-helix peptidomimetics inhibit islet amyloid polypeptide aggregation

(2015) Oleg V. Kulikov et al.   TETRAHEDRON LETTERS

A Multifaceted Secondary Structure Mimic Based On Piperidine-piperidinones

(2014) Dongyue Xin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Screening and classifying small-molecule inhibitors of amyloid formation using ion mobility spectrometry–mass spectrometry

(2014) Lydia M. Young et al.   Nature Chemistry

The amyloid state and its association with protein misfolding diseases

(2014) Tuomas P. J. Knowles et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein by Small Molecules as a Potential Therapeutic Strategy for Parkinson’s Disease

(2014) Gergely Tóth et al.   PLoS One

In vivo modulation of hypoxia-inducible signaling by topographical helix mimetics

(2014) B. B. Lao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Potential pharmacological chaperones targeting cancer-associated MCL-1 and Parkinson disease-associated  -synuclein

(2014) M. Oh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

α-Helix mimetics: Outwards and upwards

(2013) Madura K.P. Jayatunga et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Inhibition of α-helix-mediated protein–protein interactions using designed molecules

(2013) Valeria Azzarito et al.   Nature Chemistry

Super-secondary structure peptidomimetics: design and synthesis of an α–α hairpin analogue

(2013) Laura Nevola et al.   SUPRAMOLECULAR CHEMISTRY

The Amyloid State of Proteins in Human Diseases

(2012) David Eisenberg et al.   CELL

Enaminone-Based Mimics of Extended and Hydrophilic α-Helices

(2012) Marc J. Adler et al.   CHEMISTRY-A EUROPEAN JOURNAL

Aggregation of islet amyloid polypeptide: from physical chemistry to cell biology

(2012) Ping Cao et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Small Molecules That Target Protein Misfolding

(2012) Lori Krim Gavrin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Amphiphilic α-helix mimetics based on a benzoylurea scaffold

(2012) Sam Thompson et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Pyrrolinone–Pyrrolidine Oligomers as Universal Peptidomimetics

(2011) Arjun Raghuraman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Double-sided α-helix mimetics

(2011) Sam Thompson et al.   TETRAHEDRON

Protein-induced photophysical changes to the amyloid indicator dye thioflavin T

(2010) L. S. Wolfe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthetic α-Helix Mimetics as Agonists and Antagonists of Islet Amyloid Polypeptide Aggregation

(2009) Ishu Saraogi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Helix Stabilization Precedes Aqueous and Bilayer-Catalyzed Fiber Formation in Islet Amyloid Polypeptide

(2009) Jessica A. Williamson et al.   JOURNAL OF MOLECULAR BIOLOGY