Lung regeneration: mechanisms, applications and emerging stem cell populations

Lung Stem Cell Differentiation in Mice Directed by Endothelial Cells via a BMP4-NFATc1-Thrombospondin-1 Axis

(2014) Joo-Hyeon Lee et al.   CELL

Alveolar progenitor and stem cells in lung development, renewal and cancer

(2014) Tushar J. Desai et al.   NATURE

Reconstructing lineage hierarchies of the distal lung epithelium using single-cell RNA-seq

(2014) Barbara Treutlein et al.   NATURE

Cell Therapy Trials for Lung Diseases: Progress and Cautions

(2013) Daniel J. Weiss et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

β-Catenin in the Alveolar Epithelium Protects from Lung Fibrosis after Intratracheal Bleomycin

(2013) Harikrishna Tanjore et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Evidence for Scgb1a1+Cells in the Generation of p63+Cells in the Damaged Lung Parenchyma

(2013) Dahai Zheng et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Development and Regeneration of Sox2+ Endoderm Progenitors Are Regulated by a HDAC1/2-Bmp4/Rb1 Regulatory Pathway

(2013) Yi Wang et al.   DEVELOPMENTAL CELL

Human iPS cell–derived alveolar epithelium repopulates lung extracellular matrix

(2013) Mahboobe Ghaedi et al.   JOURNAL OF CLINICAL INVESTIGATION

Type 2 alveolar cells are stem cells in adult lung

(2013) Christina E. Barkauskas et al.   JOURNAL OF CLINICAL INVESTIGATION

Coordination of heart and lung co-development by a multipotent cardiopulmonary progenitor

(2013) Tien Peng et al.   NATURE

The meaning, the sense and the significance: translating the science of mesenchymal stem cells into medicine

(2013) Paolo Bianco et al.   NATURE MEDICINE

Sox9 plays multiple roles in the lung epithelium during branching morphogenesis

(2013) B. E. Rockich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endogenous Distal Airway Progenitor Cells, Lung Mechanics, and Disproportionate Lobar Growth Following Long-Term Postpneumonectomy in Mice

(2013) Philip Eisenhauer et al.   STEM CELLS

Maintenance and Repair of the Lung Endothelium Does Not Involve Contributions from Marrow-Derived Endothelial Precursor Cells

(2012) Sarah J. Ohle et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Ciliated Cells of Pseudostratified Airway Epithelium Do Not Become Mucous Cells after Ovalbumin Challenge

(2012) Ana Pardo-Saganta et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Efficient Derivation of Purified Lung and Thyroid Progenitors from Embryonic Stem Cells

(2012) Tyler A. Longmire et al.   Cell Stem Cell

Generation of Multipotent Lung and Airway Progenitors from Mouse ESCs and Patient-Specific Cystic Fibrosis iPSCs

(2012) Hongmei Mou et al.   Cell Stem Cell

Different assemblies of Notch receptors coordinate the distribution of the major bronchial Clara, ciliated and neuroendocrine cells

(2012) M. Morimoto et al.   DEVELOPMENT

Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein

(2012) Amy P Wong et al.   NATURE BIOTECHNOLOGY

Evidence for Adult Lung Growth in Humans

(2012) James P. Butler et al.   NEW ENGLAND JOURNAL OF MEDICINE

Regeneration of Alveolar Type I and II Cells from Scgb1a1-Expressing Cells following Severe Pulmonary Damage Induced by Bleomycin and Influenza

(2012) Dahai Zheng et al.   PLoS One

Neuroepithelial body microenvironment is a niche for a distinct subset of Clara-like precursors in the developing airways

(2012) A. Guha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence for type II cells as cells of origin of K-Ras-induced distal lung adenocarcinoma

(2012) X. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stem cells of the adult lung: their development and role in homeostasis, regeneration, and disease

(2012) Carolien Wansleeben et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Distal Airway Stem Cells Yield Alveoli In Vitro and during Lung Regeneration following H1N1 Influenza Infection

(2011) Pooja A. Kumar et al.   CELL

Endothelial-Derived Angiocrine Signals Induce and Sustain Regenerative Lung Alveolarization

(2011) Bi-Sen Ding et al.   CELL

Notch-Dependent Differentiation of Adult Airway Basal Stem Cells

(2011) Jason R. Rock et al.   Cell Stem Cell

Notch signaling prevents mucous metaplasia in mouse conducting airways during postnatal development

(2011) Po-Nien Tsao et al.   DEVELOPMENT

Signaling through BMP receptors promotes respiratory identity in the foregut via repression of Sox2

(2011) E. T. Domyan et al.   DEVELOPMENT

Mouse ES and iPS cells can form similar definitive endoderm despite differences in imprinted genes

(2011) Constantina Christodoulou et al.   JOURNAL OF CLINICAL INVESTIGATION

The three R’s of lung health and disease: repair, remodeling, and regeneration

(2011) Michael F. Beers et al.   JOURNAL OF CLINICAL INVESTIGATION

Parabronchial smooth muscle constitutes an airway epithelial stem cell niche in the mouse lung after injury

(2011) Thomas Volckaert et al.   JOURNAL OF CLINICAL INVESTIGATION

Integrin α6β4 identifies an adult distal lung epithelial population with regenerative potential in mice

(2011) Harold A. Chapman et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells

(2011) Kosuke Yusa et al.   NATURE

Generation of anterior foregut endoderm from human embryonic and induced pluripotent stem cells

(2011) Michael D Green et al.   NATURE BIOTECHNOLOGY

Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition

(2011) J. R. Rock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Initial Binding and Recellularization of Decellularized Mouse Lung Scaffolds with Bone Marrow-Derived Mesenchymal Stromal Cells

(2011) Amanda B. Daly et al.   TISSUE ENGINEERING PART A

Comparative Assessment of Detergent-Based Protocols for Mouse Lung De-Cellularization and Re-Cellularization

(2011) John M. Wallis et al.   TISSUE ENGINEERING PART C-METHODS

Tracheal Basal Cells

(2010) Brook B. Cole et al.   AMERICAN JOURNAL OF PATHOLOGY

Sox2 Activates Cell Proliferation and Differentiation in the Respiratory Epithelium

(2010) David H. Tompkins et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Tissue engineered human tracheas for in vivo implantation

(2010) Silvia Baiguera et al.   BIOMATERIALS

Canonical Notch signaling in the developing lung is required for determination of arterial smooth muscle cells and selection of Clara versus ciliated cell fate

(2010) M. Morimoto et al.   JOURNAL OF CELL SCIENCE

Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells

(2010) S. Tamir Rashid et al.   JOURNAL OF CLINICAL INVESTIGATION

Regeneration and orthotopic transplantation of a bioartificial lung

(2010) Harald C Ott et al.   NATURE MEDICINE

Inhibition of Wnt/ -catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis

(2010) W. R. Henderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence of an epithelial stem/progenitor cell hierarchy in the adult mouse lung

(2010) J. L. McQualter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased pulmonary Wnt (wingless/integrated)-signaling in patients with sarcoidosis

(2010) Bettina Levänen et al.   RESPIRATORY MEDICINE

Tissue-Engineered Lungs for in Vivo Implantation

(2010) T. H. Petersen et al.   SCIENCE

Generation of Transgene-Free Lung Disease-Specific Human Induced Pluripotent Stem Cells Using a Single Excisable Lentiviral Stem Cell Cassette

(2010) Aba Somers et al.   STEM CELLS

What's in a Name?

(2010) Arnold I. Caplan   TISSUE ENGINEERING PART A

Influence of Acellular Natural Lung Matrix on Murine Embryonic Stem Cell Differentiation and Tissue Formation

(2010) Joaquin Cortiella et al.   TISSUE ENGINEERING PART A

Matrix modulation of compensatory lung regrowth and progenitor cell proliferation in mice

(2009) A. M. Hoffman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

β-Catenin Is Not Necessary for Maintenance or Repair of the Bronchiolar Epithelium

(2009) Anna C. Zemke et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Directed Expression of Cre in Alveolar Epithelial Type 1 Cells

(2009) Per Flodby et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The Role of Scgb1a1+ Clara Cells in the Long-Term Maintenance and Repair of Lung Airway, but Not Alveolar, Epithelium

(2009) Emma L. Rawlins et al.   Cell Stem Cell

The Id2+ distal tip lung epithelium contains individual multipotent embryonic progenitor cells

(2009) E. L. Rawlins et al.   DEVELOPMENT

Notch signaling controls the balance of ciliated and secretory cell fates in developing airways

(2009) P.-N. Tsao et al.   DEVELOPMENT

Multiple roles for Sox2 in the developing and adult mouse trachea

(2009) J. Que et al.   DEVELOPMENT

Wnt2/2b and β-Catenin Signaling Are Necessary and Sufficient to Specify Lung Progenitors in the Foregut

(2009) Ashley M. Goss et al.   DEVELOPMENTAL CELL

Sox2 Is Required for Maintenance and Differentiation of Bronchiolar Clara, Ciliated, and Goblet Cells

(2009) David H. Tompkins et al.   PLoS One

Stem cells are dispensable for lung homeostasis but restore airways after injury

(2009) A. Giangreco et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

 -Catenin promotes respiratory progenitor identity in mouse foregut

(2009) K. S. Harris-Johnson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Basal cells as stem cells of the mouse trachea and human airway epithelium

(2009) J. R. Rock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular kinetics and modeling of bronchioalveolar stem cell response during lung regeneration

(2008) R. D. Nolen-Walston et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Ciliated epithelial cell lifespan in the mouse trachea and lung

(2008) Emma L. Rawlins et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Differentiation of Embryonic Stem Cells to Clinically Relevant Populations: Lessons from Embryonic Development

(2008) Charles E. Murry et al.   CELL

Clinical transplantation of a tissue-engineered airway

(2008) Paolo Macchiarini et al.   LANCET

The branching programme of mouse lung development

(2008) Ross J. Metzger et al.   NATURE

A Gata6-Wnt pathway required for epithelial stem cell development and airway regeneration

(2008) Yuzhen Zhang et al.   NATURE GENETICS

Functional Wnt Signaling Is Increased in Idiopathic Pulmonary Fibrosis

(2008) Melanie Königshoff et al.   PLoS One

Generation and Regeneration of Cells of the Liver and Pancreas

(2008) K. S. Zaret et al.   SCIENCE