Regulation of oxidative response and extracellular polysaccharide synthesis by a diadenylate cyclase in S treptococcus mutans

The PAMP c-di-AMP Is Essential for Listeria monocytogenes Growth in Rich but Not Minimal Media due to a Toxic Increase in (p)ppGpp

(2015) Aaron T. Whiteley et al.   Cell Host & Microbe

DisA and c-di-AMP act at the intersection between DNA-damage response and stress homeostasis in exponentially growing Bacillus subtilis cells

(2015) Carolina Gándara et al.   DNA REPAIR

Structural and Biochemical Analysis of the Essential Diadenylate Cyclase CdaA fromListeria monocytogenes

(2015) Jonathan Rosenberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An HD-domain phosphodiesterase mediates cooperative hydrolysis of c-di-AMP to affect bacterial growth and virulence

(2015) TuAnh Ngoc Huynh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Streptococcus mutans-derived extracellular matrix in cariogenic oral biofilms

(2015) Marlise I. Klein et al.   Frontiers in Cellular and Infection Microbiology

Functional analysis of the sporulation-specific diadenylate cyclase CdaS in Bacillus thuringiensis

(2015) Cao Zheng et al.   Frontiers in Microbiology

Unexpected Complex Formation between Coralyne and Cyclic Diadenosine Monophosphate Providing a Simple Fluorescent Turn-on Assay to Detect This Bacterial Second Messenger

(2014) Jie Zhou et al.   ANALYTICAL CHEMISTRY

Regulated proteolysis of the alternative sigma factor SigX in Streptococcus mutans: implication in the escape from competence

(2014) Gaofeng Dong et al.   BMC MICROBIOLOGY

The Cyclic Dinucleotide c-di-AMP Is an Allosteric Regulator of Metabolic Enzyme Function

(2014) Kamakshi Sureka et al.   CELL

Identification of bromophenol thiohydantoin as an inhibitor of DisA, a c-di-AMP synthase, from a 1000 compound library, using the coralyne assay

(2014) Yue Zheng et al.   CHEMICAL COMMUNICATIONS

Crystal structure of a c-di-AMP riboswitch reveals an internally pseudo-dimeric RNA

(2014) C. P. Jones et al.   EMBO JOURNAL

Effects of simulated microgravity onStreptococcus mutansphysiology and biofilm structure

(2014) Xingqun Cheng et al.   FEMS MICROBIOLOGY LETTERS

DhhP, a Cyclic di-AMP Phosphodiesterase of Borrelia burgdorferi, Is Essential for Cell Growth and Virulence

(2014) Meiping Ye et al.   INFECTION AND IMMUNITY

Role of the Streptococcus mutans CRISPR-Cas Systems in Immunity and Cell Physiology

(2014) M. A. Serbanescu et al.   JOURNAL OF BACTERIOLOGY

Control of the Diadenylate Cyclase CdaS inBacillus subtilis

(2014) Felix M. P. Mehne et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Detection of cyclic di-AMP using a competitive ELISA with a unique pneumococcal cyclic di-AMP binding protein

(2014) Adam J. Underwood et al.   JOURNAL OF MICROBIOLOGICAL METHODS

Deletion of the cyclic di-AMP phosphodiesterase gene (cnpB) inMycobacterium tuberculosisleads to reduced virulence in a mouse model of infection

(2014) Jun Yang et al.   MOLECULAR MICROBIOLOGY

Structural insights into recognition of c-di-AMP by the ydaO riboswitch

(2014) Ang Gao et al.   Nature Chemical Biology

c-di-AMP binds the ydaO riboswitch in two pseudo-symmetry–related pockets

(2014) Aiming Ren et al.   Nature Chemical Biology

Two-Step Synthesis and Hydrolysis of Cyclic di-AMP in Mycobacterium tuberculosis

(2014) Kasi Manikandan et al.   PLoS One

A Biochemical Characterization of the DNA Binding Activity of the Response Regulator VicR from Streptococcus mutans

(2014) Eduardo Ayala et al.   PLoS One

Cyclic-di-GMP and cyclic-di-AMP activate the NLRP3 inflammasome

(2013) Ali A Abdul-Sater et al.   EMBO REPORTS

Cyclic Di-AMP Impairs Potassium Uptake Mediated by a Cyclic Di-AMP Binding Protein in Streptococcus pneumoniae

(2013) Y. Bai et al.   JOURNAL OF BACTERIOLOGY

Listeria monocytogenes Multidrug Resistance Transporters and Cyclic Di-AMP, Which Contribute to Type I Interferon Induction, Play a Role in Cell Wall Stress

(2013) M. Kaplan Zeevi et al.   JOURNAL OF BACTERIOLOGY

Growth Phase and pH Influence Peptide Signaling for Competence Development in Streptococcus mutans

(2013) Q. Guo et al.   JOURNAL OF BACTERIOLOGY

Involvement of gshAB in the Interspecies Competition within Oral Biofilm

(2013) X. Zheng et al.   JOURNAL OF DENTAL RESEARCH

Biofilm infections, their resilience to therapy and innovative treatment strategies

(2013) U. Römling et al.   JOURNAL OF INTERNAL MEDICINE

Cyclic di-GMP: the First 25 Years of a Universal Bacterial Second Messenger

(2013) U. Romling et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Riboswitches in eubacteria sense the second messenger c-di-AMP

(2013) James W Nelson et al.   Nature Chemical Biology

Cyclic di-AMP: another second messenger enters the fray

(2013) Rebecca M. Corrigan et al.   NATURE REVIEWS MICROBIOLOGY

Mutation in the C-Di-AMP Cyclase dacA Affects Fitness and Resistance of Methicillin Resistant Staphylococcus aureus

(2013) Vanina Dengler et al.   PLoS One

Cyclic di-AMP Is Critical for Listeria monocytogenes Growth, Cell Wall Homeostasis, and Establishment of Infection

(2013) C. E. Witte et al.   mBio

Heat Resistance and Salt Hypersensitivity in Lactococcus lactis Due to Spontaneous Mutation ofllmg_1816(gdpP) Induced by High-Temperature Growth

(2012) William M. Smith et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Regulation of Bacteriocin Production and Cell Death by the VicRK Signaling System in Streptococcus mutans

(2012) D. B. Senadheera et al.   JOURNAL OF BACTERIOLOGY

Cyclic Di-AMP Homeostasis inBacillus subtilis

(2012) Felix M. P. Mehne et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DarR, a TetR-like Transcriptional Factor, Is a Cyclic Di-AMP-responsive Repressor inMycobacterium smegmatis

(2012) Lei Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mycobacterium tuberculosis Rv3586 (DacA) Is a Diadenylate Cyclase That Converts ATP or ADP into c-di-AMP

(2012) Yinlan Bai et al.   PLoS One

The Exopolysaccharide Matrix Modulates the Interaction between 3D Architecture and Virulence of a Mixed-Species Oral Biofilm

(2012) Jin Xiao et al.   PLoS Pathogens

Cloning-Independent and Counterselectable Markerless Mutagenesis System in Streptococcus mutans

(2011) Zhoujie Xie et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

c-di-AMP reports DNA integrity during sporulation in Bacillus subtilis

(2011) Yaara Oppenheimer-Shaanan et al.   EMBO REPORTS

Gene Regulation in S. mutans

(2011) E.G. Smith et al.   JOURNAL OF DENTAL RESEARCH

Analysis of the role of Bacillus subtilis σM in β-lactam resistance reveals an essential role for c-di-AMP in peptidoglycan homeostasis

(2011) Yun Luo et al.   MOLECULAR MICROBIOLOGY

CovR-Controlled Global Regulation of Gene Expression in Streptococcus mutans

(2011) Alexander Dmitriev et al.   PLoS One

Genome-wide essential gene identification in Streptococcus sanguinis

(2011) Ping Xu et al.   Scientific Reports

c-di-AMP Is a New Second Messenger in Staphylococcus aureus with a Role in Controlling Cell Size and Envelope Stress

(2011) Rebecca M. Corrigan et al.   PLoS Pathogens

Genomic Island TnSmu2 of Streptococcus mutans Harbors a Nonribosomal Peptide Synthetase-Polyketide Synthase Gene Cluster Responsible for the Biosynthesis of Pigments Involved in Oxygen and H2O2 Tolerance

(2010) C. Wu et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

The characterization of conserved binding motifs and potential target genes for M. tuberculosis MtrAB reveals a link between the two-component system and the drug resistance of M. smegmatis

(2010) Yuqing Li et al.   BMC MICROBIOLOGY

c-di-AMP Secreted by Intracellular Listeria monocytogenes Activates a Host Type I Interferon Response

(2010) J. J. Woodward et al.   SCIENCE

ClpP of Streptococcus mutans Differentially Regulates Expression of Genomic Islands, Mutacin Production, and Antibiotic Tolerance

(2009) P. Chattoraj et al.   JOURNAL OF BACTERIOLOGY

The effect of c-di-GMP (3′–5′-cyclic diguanylic acid) on the biofilm formation and adherence of Streptococcus mutans

(2009) Wenjuan Yan et al.   MICROBIOLOGICAL RESEARCH

Role of phosphoglucosamine mutase on virulence properties ofStreptococcus mutans

(2009) X. D. Liu et al.   Oral microbiology and immunology

Identification of theStreptococcus gordonii glmMgene encoding phosphoglucosamine mutase and its role in bacterial cell morphology, biofilm formation, and sensitivity to antibiotics

(2008) Kisaki Shimazu et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Structural Biochemistry of a Bacterial Checkpoint Protein Reveals Diadenylate Cyclase Activity Regulated by DNA Recombination Intermediates

(2008) Gregor Witte et al.   MOLECULAR CELL

Great Times for Small Molecules: c-di-AMP, a Second Messenger Candidate in Bacteria and Archaea

(2008) U. Romling   Science Signaling