DhhP, a Cyclic di-AMP Phosphodiesterase of Borrelia burgdorferi, Is Essential for Cell Growth and Virulence

Study of the Response Regulator Rrp1 Reveals Its Regulatory Role in Chitobiose Utilization and Virulence of Borrelia burgdorferi

(2013) Ching Wooen Sze et al.   INFECTION AND IMMUNITY

Manganese and Zinc Regulate Virulence Determinants in Borrelia burgdorferi

(2013) Bryan Troxell et al.   INFECTION AND IMMUNITY

Cyclic Di-GMP Receptor PlzA Controls Virulence Gene Expression through RpoS in Borrelia burgdorferi

(2013) Ming He et al.   INFECTION AND IMMUNITY

Two DHH Subfamily 1 Proteins in Streptococcus pneumoniae Possess Cyclic Di-AMP Phosphodiesterase Activity and Affect Bacterial Growth and Virulence

(2013) Y. Bai et al.   JOURNAL OF BACTERIOLOGY

Cyclic Di-AMP Impairs Potassium Uptake Mediated by a Cyclic Di-AMP Binding Protein in Streptococcus pneumoniae

(2013) Y. Bai et al.   JOURNAL OF BACTERIOLOGY

Cyclic di-GMP: the First 25 Years of a Universal Bacterial Second Messenger

(2013) U. Romling et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Cyclic di-AMP: another second messenger enters the fray

(2013) Rebecca M. Corrigan et al.   NATURE REVIEWS MICROBIOLOGY

Streptococcus pyogenes c-di-AMP Phosphodiesterase, GdpP, Influences SpeB Processing and Virulence

(2013) Kyu Hong Cho et al.   PLoS One

Systematic identification of conserved bacterial c-di-AMP receptor proteins

(2013) R. M. Corrigan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STING-Dependent Recognition of Cyclic di-AMP Mediates Type I Interferon Responses during Chlamydia trachomatis Infection

(2013) J. R. Barker et al.   mBio

Cyclic di-AMP Is Critical for Listeria monocytogenes Growth, Cell Wall Homeostasis, and Establishment of Infection

(2013) C. E. Witte et al.   mBio

The Unique Paradigm of Spirochete Motility and Chemotaxis

(2012) Nyles W. Charon et al.   Annual Review of Microbiology

Heat Resistance and Salt Hypersensitivity in Lactococcus lactis Due to Spontaneous Mutation ofllmg_1816(gdpP) Induced by High-Temperature Growth

(2012) William M. Smith et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Nucleotide, c-di-GMP, c-di-AMP, cGMP, cAMP, (p)ppGpp signaling in bacteria and implications in pathogenesis

(2012) Dimpy Kalia et al.   CHEMICAL SOCIETY REVIEWS

Two DHH Subfamily 1 Proteins Contribute to Pneumococcal Virulence and Confer Protection against Pneumococcal Disease

(2012) L. E. Cron et al.   INFECTION AND IMMUNITY

Changes in Bacterial Growth Rate Govern Expression of the Borrelia burgdorferi OspC and Erp Infection-Associated Surface Proteins

(2012) B. L. Jutras et al.   JOURNAL OF BACTERIOLOGY

Cyclic Di-AMP Homeostasis inBacillus subtilis

(2012) Felix M. P. Mehne et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DarR, a TetR-like Transcriptional Factor, Is a Cyclic Di-AMP-responsive Repressor inMycobacterium smegmatis

(2012) Lei Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Of ticks, mice and men: understanding the dual-host lifestyle of Lyme disease spirochaetes

(2012) Justin D. Radolf et al.   NATURE REVIEWS MICROBIOLOGY

Loss of Function of the GdpP Protein Leads to Joint β-Lactam/Glycopeptide Tolerance in Staphylococcus aureus

(2011) J. M. Griffiths et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Analysis of the HD-GYP Domain Cyclic Dimeric GMP Phosphodiesterase Reveals a Role in Motility and the Enzootic Life Cycle of Borrelia burgdorferi

(2011) Syed Z. Sultan et al.   INFECTION AND IMMUNITY

The Hybrid Histidine Kinase Hk1 Is Part of a Two-Component System That Is Essential for Survival of Borrelia burgdorferi in Feeding Ixodes scapularis Ticks

(2011) Melissa J. Caimano et al.   INFECTION AND IMMUNITY

Unusual Heme-Binding PAS Domain from YybT Family Proteins

(2011) F. Rao et al.   JOURNAL OF BACTERIOLOGY

Multiplex PCR as a tool for validating plasmid content of Borrelia burgdorferi

(2011) Ignas Bunikis et al.   JOURNAL OF MICROBIOLOGICAL METHODS

The diguanylate cyclase, Rrp1, regulates critical steps in the enzootic cycle of the Lyme disease spirochetes

(2011) Jessica L. Kostick et al.   MOLECULAR MICROBIOLOGY

Analysis of the role of Bacillus subtilis σM in β-lactam resistance reveals an essential role for c-di-AMP in peptidoglycan homeostasis

(2011) Yun Luo et al.   MOLECULAR MICROBIOLOGY

The myriad roles of cyclic AMP in microbial pathogens: from signal to sword

(2011) Kathleen A. McDonough et al.   NATURE REVIEWS MICROBIOLOGY

c-di-AMP Is a New Second Messenger in Staphylococcus aureus with a Role in Controlling Cell Size and Envelope Stress

(2011) Rebecca M. Corrigan et al.   PLoS Pathogens

Cyclic di-GMP is Essential for the Survival of the Lyme Disease Spirochete in Ticks

(2011) Ming He et al.   PLoS Pathogens

Ligand-Binding PAS Domains in a Genomic, Cellular, and Structural Context

(2010) Jonathan T. Henry et al.   Annual Review of Microbiology

Gene Regulation inBorrelia burgdorferi

(2010) D. Scott Samuels   Annual Review of Microbiology

Role of the Surface Lipoprotein BBA07 in the Enzootic Cycle of Borrelia burgdorferi

(2010) H. Xu et al.   INFECTION AND IMMUNITY

Systematic analysis of cyclic di-GMP signalling enzymes and their role in biofilm formation and virulence in Yersinia pestis

(2010) Alexander G. Bobrov et al.   MOLECULAR MICROBIOLOGY

Analysis of a Borrelia burgdorferi phosphodiesterase demonstrates a role for cyclic-di-guanosine monophosphate in motility and virulence

(2010) Syed Z. Sultan et al.   MOLECULAR MICROBIOLOGY

A post-translational, c-di-GMP-dependent mechanism regulating flagellar motility

(2010) Xin Fang et al.   MOLECULAR MICROBIOLOGY

cAMP, c-di-GMP, c-di-AMP and now cGMP: bacteria use them all!

(2010) Mark Gomelsky   MOLECULAR MICROBIOLOGY

c-di-AMP Secreted by Intracellular Listeria monocytogenes Activates a Host Type I Interferon Response

(2010) J. J. Woodward et al.   SCIENCE

Comprehensive identification of essential Staphylococcus aureus genes using Transposon-Mediated Differential Hybridisation (TMDH)

(2009) Roy R Chaudhuri et al.   BMC GENOMICS

Identification and molecular characterization of a cyclic-di-GMP effector protein, PlzA (BB0733): additional evidence for the existence of a functional cyclic-di-GMP regulatory network in the Lyme disease spirochete,Borrelia burgdorferi

(2009) John C. Freedman et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

YybT Is a Signaling Protein That Contains a Cyclic Dinucleotide Phosphodiesterase Domain and a GGDEF Domain with ATPase Activity

(2009) Feng Rao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BosR (BB0647) governs virulence expression in Borrelia burgdorferi

(2009) Zhiming Ouyang et al.   MOLECULAR MICROBIOLOGY

The BosR regulatory protein of Borrelia burgdorferi interfaces with the RpoS regulatory pathway and modulates both the oxidative stress response and pathogenic properties of the Lyme disease spirochete

(2009) Jenny A. Hyde et al.   MOLECULAR MICROBIOLOGY

Principles of c-di-GMP signalling in bacteria

(2009) Regine Hengge   NATURE REVIEWS MICROBIOLOGY

Essential Role of the Response Regulator Rrp2 in the Infectious Cycle of Borrelia burgdorferi

(2008) B. K. Boardman et al.   INFECTION AND IMMUNITY

Transcriptional interplay among the regulators Rrp2, RpoN and RpoS in Borrelia burgdorferi

(2008) Z. Ouyang et al.   MICROBIOLOGY-SGM

Structural Biochemistry of a Bacterial Checkpoint Protein Reveals Diadenylate Cyclase Activity Regulated by DNA Recombination Intermediates

(2008) Gregor Witte et al.   MOLECULAR CELL

Abrogation ofospABconstitutively activates the Rrp2-RpoN-RpoS pathway (sigmaN-sigmaS cascade) inBorrelia burgdorferi

(2008) Ming He et al.   MOLECULAR MICROBIOLOGY

Large-scale transposon mutagenesis ofMycoplasma pulmonis

(2008) Christopher T. French et al.   MOLECULAR MICROBIOLOGY

Great Times for Small Molecules: c-di-AMP, a Second Messenger Candidate in Bacteria and Archaea

(2008) U. Romling   Science Signaling