Deletion of the cyclic di-AMP phosphodiesterase gene (cnpB) inMycobacterium tuberculosisleads to reduced virulence in a mouse model of infection

Two-Step Synthesis and Hydrolysis of Cyclic di-AMP in Mycobacterium tuberculosis

(2014) Kasi Manikandan et al.   PLoS One

Cyclic-di-GMP and cyclic-di-AMP activate the NLRP3 inflammasome

(2013) Ali A Abdul-Sater et al.   EMBO REPORTS

Two DHH Subfamily 1 Proteins in Streptococcus pneumoniae Possess Cyclic Di-AMP Phosphodiesterase Activity and Affect Bacterial Growth and Virulence

(2013) Y. Bai et al.   JOURNAL OF BACTERIOLOGY

Cyclic Di-AMP Impairs Potassium Uptake Mediated by a Cyclic Di-AMP Binding Protein in Streptococcus pneumoniae

(2013) Y. Bai et al.   JOURNAL OF BACTERIOLOGY

The Vitamin B6 Biosynthesis Pathway in Streptococcus pneumoniae Is Controlled by Pyridoxal 5'-Phosphate and the Transcription Factor PdxR and Has an Impact on Ear Infection

(2013) S. El Qaidi et al.   JOURNAL OF BACTERIOLOGY

Functional Characterization of Core Components of the Bacillus subtilis Cyclic-Di-GMP Signaling Pathway

(2013) X. Gao et al.   JOURNAL OF BACTERIOLOGY

Radiation-sensitive Gene A (RadA) Targets DisA, DNA Integrity Scanning Protein A, to Negatively Affect Cyclic Di-AMP Synthesis Activity inMycobacterium smegmatis

(2013) Lei Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclic di-GMP: the First 25 Years of a Universal Bacterial Second Messenger

(2013) U. Romling et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Riboswitches in eubacteria sense the second messenger c-di-AMP

(2013) James W Nelson et al.   Nature Chemical Biology

Cyclic di-AMP: another second messenger enters the fray

(2013) Rebecca M. Corrigan et al.   NATURE REVIEWS MICROBIOLOGY

Streptococcus pyogenes c-di-AMP Phosphodiesterase, GdpP, Influences SpeB Processing and Virulence

(2013) Kyu Hong Cho et al.   PLoS One

Systematic identification of conserved bacterial c-di-AMP receptor proteins

(2013) R. M. Corrigan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type I Interferon Suppresses Type II Interferon-Triggered Human Anti-Mycobacterial Responses

(2013) R. M. B. Teles et al.   SCIENCE

STING-Dependent Recognition of Cyclic di-AMP Mediates Type I Interferon Responses during Chlamydia trachomatis Infection

(2013) J. R. Barker et al.   mBio

Cyclic di-AMP Is Critical for Listeria monocytogenes Growth, Cell Wall Homeostasis, and Establishment of Infection

(2013) C. E. Witte et al.   mBio

Heat Resistance and Salt Hypersensitivity in Lactococcus lactis Due to Spontaneous Mutation ofllmg_1816(gdpP) Induced by High-Temperature Growth

(2012) William M. Smith et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Mycobacterium Tuberculosis Activates the DNA-Dependent Cytosolic Surveillance Pathway within Macrophages

(2012) Paolo S. Manzanillo et al.   Cell Host & Microbe

Listeria monocytogenes Strain-Specific Impairment of the TetR Regulator Underlies the Drastic Increase in Cyclic di-AMP Secretion and Beta Interferon-Inducing Ability

(2012) Takeshi Yamamoto et al.   INFECTION AND IMMUNITY

Hyperinduction of Host Beta Interferon by a Listeria monocytogenes Strain Naturally Overexpressing the Multidrug Efflux Pump MdrT

(2012) Kierstyn T. Schwartz et al.   INFECTION AND IMMUNITY

Evidence for Cyclic Di-GMP-Mediated Signaling in Bacillus subtilis

(2012) Yun Chen et al.   JOURNAL OF BACTERIOLOGY

Cyclic Di-AMP Homeostasis inBacillus subtilis

(2012) Felix M. P. Mehne et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DarR, a TetR-like Transcriptional Factor, Is a Cyclic Di-AMP-responsive Repressor inMycobacterium smegmatis

(2012) Lei Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamic Roles of Type I and Type II IFNs in Early Infection with Mycobacterium tuberculosis

(2012) L. Desvignes et al.   JOURNAL OF IMMUNOLOGY

The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response

(2012) Kislay Parvatiyar et al.   NATURE IMMUNOLOGY

Innate sensing of bacterial cyclic dinucleotides: more than just STING

(2012) Andrew G Bowie   NATURE IMMUNOLOGY

Mycobacterium tuberculosis Rv3586 (DacA) Is a Diadenylate Cyclase That Converts ATP or ADP into c-di-AMP

(2012) Yinlan Bai et al.   PLoS One

Methicillin Resistance Alters the Biofilm Phenotype and Attenuates Virulence in Staphylococcus aureus Device-Associated Infections

(2012) Clarissa Pozzi et al.   PLoS Pathogens

Loss of Function of the GdpP Protein Leads to Joint β-Lactam/Glycopeptide Tolerance in Staphylococcus aureus

(2011) J. M. Griffiths et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Two DHH Subfamily 1 Proteins Contribute to Pneumococcal Virulence and Confer Protection against Pneumococcal Disease

(2011) L. E. Cron et al.   INFECTION AND IMMUNITY

MPYS Is Required for IFN Response Factor 3 Activation and Type I IFN Production in the Response of Cultured Phagocytes to Bacterial Second Messengers Cyclic-di-AMP and Cyclic-di-GMP

(2011) L. Jin et al.   JOURNAL OF IMMUNOLOGY

Dysregulation of serine biosynthesis contributes to the growth defect of a Mycobacterium tuberculosis crp mutant

(2011) Guangchun Bai et al.   MOLECULAR MICROBIOLOGY

Analysis of the role of Bacillus subtilis σM in β-lactam resistance reveals an essential role for c-di-AMP in peptidoglycan homeostasis

(2011) Yun Luo et al.   MOLECULAR MICROBIOLOGY

STING is a direct innate immune sensor of cyclic di-GMP

(2011) Dara L. Burdette et al.   NATURE

Characterization of NrnA homologs from Mycobacterium tuberculosis and Mycoplasma pneumoniae

(2011) G. Postic et al.   RNA

c-di-AMP Is a New Second Messenger in Staphylococcus aureus with a Role in Controlling Cell Size and Envelope Stress

(2011) Rebecca M. Corrigan et al.   PLoS Pathogens

A mecA-Negative Strain of Methicillin-Resistant Staphylococcus aureus with High-Level  -Lactam Resistance Contains Mutations in Three Genes

(2010) R. Banerjee et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Cyclic AMP signalling in mycobacteria: redirecting the conversation with a common currency

(2010) Guangchun Bai et al.   CELLULAR MICROBIOLOGY

TheN-Ethyl-N-Nitrosourea-InducedGoldenticketMouse Mutant Reveals an Essential Function ofStingin theIn VivoInterferon Response toListeria monocytogenesand Cyclic Dinucleotides

(2010) John-Demian Sauer et al.   INFECTION AND IMMUNITY

Systematic analysis of cyclic di-GMP signalling enzymes and their role in biofilm formation and virulence in Yersinia pestis

(2010) Alexander G. Bobrov et al.   MOLECULAR MICROBIOLOGY

Analysis of a Borrelia burgdorferi phosphodiesterase demonstrates a role for cyclic-di-guanosine monophosphate in motility and virulence

(2010) Syed Z. Sultan et al.   MOLECULAR MICROBIOLOGY

An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis

(2010) Matthew P. R. Berry et al.   NATURE

Identification, Activity and Disulfide Connectivity of C-di-GMP Regulating Proteins in Mycobacterium tuberculosis

(2010) Kajal Gupta et al.   PLoS One

c-di-AMP Secreted by Intracellular Listeria monocytogenes Activates a Host Type I Interferon Response

(2010) J. J. Woodward et al.   SCIENCE

A Mycobacterial Cyclic AMP Phosphodiesterase That Moonlights as a Modifier of Cell Wall Permeability

(2009) Marjetka Podobnik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

YybT Is a Signaling Protein That Contains a Cyclic Dinucleotide Phosphodiesterase Domain and a GGDEF Domain with ATPase Activity

(2009) Feng Rao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclic AMP intoxication of macrophages by a Mycobacterium tuberculosis adenylate cyclase

(2009) Nisheeth Agarwal et al.   NATURE

NOD2, RIP2 and IRF5 Play a Critical Role in the Type I Interferon Response to Mycobacterium tuberculosis

(2009) Amit K. Pandey et al.   PLoS Pathogens

HD-GYP domain proteins regulate biofilm formation and virulence inPseudomonas aeruginosa

(2008) Robert P. Ryan et al.   ENVIRONMENTAL MICROBIOLOGY

cAMP levels withinMycobacterium tuberculosisandMycobacterium bovisBCG increase upon infection of macrophages

(2008) Guangchun Bai et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Protein tyrosine phosphatase PtpA is not required forMycobacterium tuberculosisgrowth in mice

(2008) Christoph Grundner et al.   FEMS MICROBIOLOGY LETTERS

Role of Cyclic Di-GMP during El Tor Biotype Vibrio cholerae Infection: Characterization of the In Vivo-Induced Cyclic Di-GMP Phosphodiesterase CdpA

(2008) R. Tamayo et al.   INFECTION AND IMMUNITY

A Phosphate-binding Histidine of Binuclear Metallophosphodiesterase Enzymes Is a Determinant of 2′,3′-Cyclic Nucleotide Phosphodiesterase Activity

(2008) Niroshika Keppetipola et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Biochemistry of a Bacterial Checkpoint Protein Reveals Diadenylate Cyclase Activity Regulated by DNA Recombination Intermediates

(2008) Gregor Witte et al.   MOLECULAR CELL

Mycothiol biosynthesis is essential for ethionamide susceptibility inMycobacterium tuberculosis

(2008) Catherine Vilchèze et al.   MOLECULAR MICROBIOLOGY

Great Times for Small Molecules: c-di-AMP, a Second Messenger Candidate in Bacteria and Archaea

(2008) U. Romling   Science Signaling