Biofilm infections, their resilience to therapy and innovative treatment strategies

Chronic wounds and the medical biofilm paradigm

(2014) R.D. Wolcott et al.   Journal of Wound Care

Correlative Time-Resolved Fluorescence Microscopy To Assess Antibiotic Diffusion-Reaction in Biofilms

(2012) S. Daddi Oubekka et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Ajoene, a Sulfur-Rich Molecule from Garlic, Inhibits Genes Controlled by Quorum Sensing

(2012) Tim Holm Jakobsen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Nitric Oxide Regulation of Cyclic di-GMP Synthesis and Hydrolysis in Shewanella woodyi

(2012) Niu Liu et al.   BIOCHEMISTRY

RETRACTED: A Self-Produced Trigger for Biofilm Disassembly that Targets Exopolysaccharide

(2012) Ilana Kolodkin-Gal et al.   CELL

You’ve come a long way: c-di-GMP signaling

(2012) Holger Sondermann et al.   CURRENT OPINION IN MICROBIOLOGY

Drug Discovery of Antimicrobial Photosensitizers Using Animal Models

(2012) Sulbha K. Sharma et al.   CURRENT PHARMACEUTICAL DESIGN

Immunoprophylaxis and immunotherapy ofStaphylococcus epidermidisinfections: challenges and prospects

(2012) Lieve Van Mellaert et al.   Expert Review of Vaccines

Towards diagnostic guidelines for biofilm-associated infections

(2012) Luanne Hall-Stoodley et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Hyperinduction of Host Beta Interferon by a Listeria monocytogenes Strain Naturally Overexpressing the Multidrug Efflux Pump MdrT

(2012) Kierstyn T. Schwartz et al.   INFECTION AND IMMUNITY

Pneumococcal Interactions with Epithelial Cells Are Crucial for Optimal Biofilm Formation and ColonizationIn VitroandIn Vivo

(2012) Laura R. Marks et al.   INFECTION AND IMMUNITY

Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorum-sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model

(2012) L. D. Christensen et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Cyclic Diguanylate Inversely Regulates Motility and Aggregation in Clostridium difficile

(2012) E. B. Purcell et al.   JOURNAL OF BACTERIOLOGY

The Phosphodiesterase DipA (PA5017) Is Essential for Pseudomonas aeruginosa Biofilm Dispersion

(2012) A. B. Roy et al.   JOURNAL OF BACTERIOLOGY

Stringent Response Regulation of Biofilm Formation in Vibrio cholerae

(2012) H. He et al.   JOURNAL OF BACTERIOLOGY

Nitric Oxide Modulates Bacterial Biofilm Formation through a Multicomponent Cyclic-di-GMP Signaling Network

(2012) Lars Plate et al.   MOLECULAR CELL

Signaling-mediated bacterial persister formation

(2012) Nicole M Vega et al.   Nature Chemical Biology

ppGpp: magic beyond RNA polymerase

(2012) Zachary D. Dalebroux et al.   NATURE REVIEWS MICROBIOLOGY

Sensing the messenger: The diverse ways that bacteria signal through c-di-GMP

(2012) Petya Violinova Krasteva et al.   PROTEIN SCIENCE

When the PilZ don’t work: effectors for cyclic di-GMP action in bacteria

(2012) Robert P. Ryan et al.   TRENDS IN MICROBIOLOGY

Bacteriophages  MR299-2 and  NH-4 Can Eliminate Pseudomonas aeruginosa in the Murine Lung and on Cystic Fibrosis Lung Airway Cells

(2012) D. Alemayehu et al.   mBio

Cellular Levels and Binding of c-di-GMP Control Subcellular Localization and Activity of the Vibrio cholerae Transcriptional Regulator VpsT

(2012) Nicholas J. Shikuma et al.   PLoS Pathogens

Methicillin Resistance Alters the Biofilm Phenotype and Attenuates Virulence in Staphylococcus aureus Device-Associated Infections

(2012) Clarissa Pozzi et al.   PLoS Pathogens

A New Small Molecule Specifically Inhibits the Cariogenic Bacterium Streptococcus mutans in Multispecies Biofilms

(2011) Chang Liu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Toxin-Antitoxin Systems Influence Biofilm and Persister Cell Formation and the General Stress Response

(2011) Xiaoxue Wang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Role of (p)ppGpp in Biofilm Formation by Enterococcus faecalis

(2011) Luis E. Chávez de Paz et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Diamidinium and iminium aromatics as new aggregators of the bacterial signaling molecule, c-di-GMP

(2011) Ilana Kelsey et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Biofilm formation by Salmonella enterica serovar Typhimurium colonizing solid tumours

(2011) Katja Crull et al.   CELLULAR MICROBIOLOGY

c-di-GMP can form remarkably stable G-quadruplexes at physiological conditions in the presence of some planar intercalators

(2011) Shizuka Nakayama et al.   CHEMICAL COMMUNICATIONS

Antibiotics as Signal Molecules

(2011) Diego Romero et al.   CHEMICAL REVIEWS

Biofilm Elimination on Intravascular Catheters: Important Considerations for the Infectious Disease Practitioner

(2011) R. M. Donlan   CLINICAL INFECTIOUS DISEASES

c-di-AMP reports DNA integrity during sporulation in Bacillus subtilis

(2011) Yaara Oppenheimer-Shaanan et al.   EMBO REPORTS

Cyclic di-GMP, an established secondary messenger still speeding up

(2011) Ute Römling   ENVIRONMENTAL MICROBIOLOGY

Bacteriophage therapy: potential uses in the control of antibiotic-resistant pathogens

(2011) Ben Burrowes et al.   Expert Review of Anti-Infective Therapy

Combating biofilms

(2011) Liang Yang et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Scenery ofStaphylococcusimplant infections in orthopedics

(2011) Lucio Montanaro et al.   Future Microbiology

Cyclic Dimeric GMP Signaling Regulates Intracellular Aggregation, Sessility, and Growth of Ehrlichia chaffeensis

(2011) Yumi Kumagai et al.   INFECTION AND IMMUNITY

Direct Evaluation of Pseudomonas aeruginosa Biofilm Mediators in a Chronic Infection Model

(2011) Matthew S. Byrd et al.   INFECTION AND IMMUNITY

Antibiotic-Induced Biofilm Formation

(2011) Jeffrey B. Kaplan   INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS

Biofilms in drinking water and their role as reservoir for pathogens

(2011) Jost Wingender et al.   INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH

Unusual Heme-Binding PAS Domain from YybT Family Proteins

(2011) F. Rao et al.   JOURNAL OF BACTERIOLOGY

Systematic Analysis of Diguanylate Cyclases That Promote Biofilm Formation by Pseudomonas fluorescens Pf0-1

(2011) P. D. Newell et al.   JOURNAL OF BACTERIOLOGY

Identification and Characterization of CdgB, a Diguanylate Cyclase Involved in Developmental Processes in Streptomyces coelicolor

(2011) N. T. Tran et al.   JOURNAL OF BACTERIOLOGY

Brucella melitensis Cyclic di-GMP Phosphodiesterase BpdA Controls Expression of Flagellar Genes

(2011) E. Petersen et al.   JOURNAL OF BACTERIOLOGY

Cancer Immunotherapy Comes of Age

(2011) Suzanne L. Topalian et al.   JOURNAL OF CLINICAL ONCOLOGY

Conservative Change to the Phosphate Moiety of Cyclic Diguanylic Monophosphate Remarkably Affects Its Polymorphism and Ability To Bind DGC, PDE, and PilZ Proteins

(2011) Jingxin Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The overlapping host responses to bacterial cyclic dinucleotides

(2011) Ali A. Abdul-Sater et al.   MICROBES AND INFECTION

Analysis of the role of Bacillus subtilis σM in β-lactam resistance reveals an essential role for c-di-AMP in peptidoglycan homeostasis

(2011) Yun Luo et al.   MOLECULAR MICROBIOLOGY

Physicochemical regulation of biofilm formation

(2011) Lars D. Renner et al.   MRS BULLETIN

STING is a direct innate immune sensor of cyclic di-GMP

(2011) Dara L. Burdette et al.   NATURE

Metabolite-enabled eradication of bacterial persisters by aminoglycosides

(2011) Kyle R. Allison et al.   NATURE

Antitoxin MqsA helps mediate the bacterial general stress response

(2011) Xiaoxue Wang et al.   Nature Chemical Biology

Dispersal of Group A Streptococcal Biofilms by the Cysteine Protease SpeB Leads to Increased Disease Severity in a Murine Model

(2011) Kristie L. Connolly et al.   PLoS One

Differential Control of Yersinia pestis Biofilm Formation In Vitro and in the Flea Vector by Two c-di-GMP Diguanylate Cyclases

(2011) Yi-Cheng Sun et al.   PLoS One

The RelA/SpoT Homolog (RSH) Superfamily: Distribution and Functional Evolution of ppGpp Synthetases and Hydrolases across the Tree of Life

(2011) Gemma C. Atkinson et al.   PLoS One

Streptococcus pneumoniae in Biofilms Are Unable to Cause Invasive Disease Due to Altered Virulence Determinant Production

(2011) Carlos J. Sanchez et al.   PLoS One

Bacterial persistence by RNA endonucleases

(2011) Etienne Maisonneuve et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Active Starvation Responses Mediate Antibiotic Tolerance in Biofilms and Nutrient-Limited Bacteria

(2011) D. Nguyen et al.   SCIENCE

H2S: A Universal Defense Against Antibiotics in Bacteria

(2011) K. Shatalin et al.   SCIENCE

Bis-(3′,5′)-cyclic dimeric adenosine monophosphate: Strong Th1/Th2/Th17 promoting mucosal adjuvant

(2011) Thomas Ebensen et al.   VACCINE

c-di-AMP Is a New Second Messenger in Staphylococcus aureus with a Role in Controlling Cell Size and Envelope Stress

(2011) Rebecca M. Corrigan et al.   PLoS Pathogens

Cyclic di-nucleotides: new era for small molecules as adjuvants

(2011) Rimma Libanova et al.   Microbial Biotechnology

Persister Cells

(2010) Kim Lewis   Annual Review of Microbiology

Modulation of Pseudomonas aeruginosa Biofilm Dispersal by a Cyclic-Di-GMP Phosphodiesterase with a Putative Hypoxia-Sensing Domain

(2010) S. An et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

ppGpp analogues inhibit synthetase activity of Rel proteins from Gram-negative and Gram-positive bacteria

(2010) Ezequiel Wexselblatt et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Cyclic AMP signalling in mycobacteria: redirecting the conversation with a common currency

(2010) Guangchun Bai et al.   CELLULAR MICROBIOLOGY

Engineering a novel c-di-GMP-binding protein for biofilm dispersal

(2010) Qun Ma et al.   ENVIRONMENTAL MICROBIOLOGY

Molecular biology of surface colonization by Listeria monocytogenes: an additional facet of an opportunistic Gram-positive foodborne pathogen

(2010) Sandra Renier et al.   ENVIRONMENTAL MICROBIOLOGY

Pseudomonas aeruginosabiofilms in cystic fibrosis

(2010) Niels Høiby et al.   Future Microbiology

TheN-Ethyl-N-Nitrosourea-InducedGoldenticketMouse Mutant Reveals an Essential Function ofStingin theIn VivoInterferon Response toListeria monocytogenesand Cyclic Dinucleotides

(2010) John-Demian Sauer et al.   INFECTION AND IMMUNITY

Cyclic di-GMP Signaling Regulates Invasion by Ehrlichia chaffeensis of Human Monocytes

(2010) Y. Kumagai et al.   JOURNAL OF BACTERIOLOGY

(p)ppGpp and drug resistance

(2010) Jun Wu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

ppGpp Conjures Bacterial Virulence

(2010) Z. D. Dalebroux et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Systematic analysis of cyclic di-GMP signalling enzymes and their role in biofilm formation and virulence in Yersinia pestis

(2010) Alexander G. Bobrov et al.   MOLECULAR MICROBIOLOGY

Discretely calibrated regulatory loops controlled by ppGpp partition gene induction across the ‘feast to famine’ gradient in Escherichia coli

(2010) Matthew F. Traxler et al.   MOLECULAR MICROBIOLOGY

Staphylococcus epidermidis Esp inhibits Staphylococcus aureus biofilm formation and nasal colonization

(2010) Tadayuki Iwase et al.   NATURE

A 96-well-plate–based optical method for the quantitative and qualitative evaluation of Pseudomonas aeruginosa biofilm formation and its application to susceptibility testing

(2010) Mathias Müsken et al.   Nature Protocols

How antibiotics kill bacteria: from targets to networks

(2010) Michael A. Kohanski et al.   NATURE REVIEWS MICROBIOLOGY

Amyloid fibers provide structural integrity to Bacillus subtilis biofilms

(2010) D. Romero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

D-Amino Acids Trigger Biofilm Disassembly

(2010) I. Kolodkin-Gal et al.   SCIENCE

Asymmetrical Distribution of the Second Messenger c-di-GMP upon Bacterial Cell Division

(2010) M. Christen et al.   SCIENCE

c-di-AMP Secreted by Intracellular Listeria monocytogenes Activates a Host Type I Interferon Response

(2010) J. J. Woodward et al.   SCIENCE

The member of the cyclic di-nucleotide family bis-(3′, 5′)-cyclic dimeric inosine monophosphate exerts potent activity as mucosal adjuvant

(2010) Rimma Libanova et al.   VACCINE

Comprehensive identification of essential Staphylococcus aureus genes using Transposon-Mediated Differential Hybridisation (TMDH)

(2009) Roy R Chaudhuri et al.   BMC GENOMICS

Evolving concepts in biofilm infections

(2009) Luanne Hall-Stoodley et al.   CELLULAR MICROBIOLOGY

A controlled clinical trial of a therapeutic bacteriophage preparation in chronic otitis due to antibiotic-resistantPseudomonas aeruginosa; a preliminary report of efficacy

(2009) A. Wright et al.   CLINICAL OTOLARYNGOLOGY

Characteristics of Biofilms from Urinary Tract Catheters and Presence of Biofilm-Related Components in Escherichia coli

(2009) Xiaoda Wang et al.   CURRENT MICROBIOLOGY

Structure, function and contribution of polysaccharide intercellular adhesin (PIA) to Staphylococcus epidermidis biofilm formation and pathogenesis of biomaterial-associated infections

(2009) Holger Rohde et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

The synthesis and function of the alarmone (p)ppGpp in firmicutes

(2009) Christiane Wolz et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

The Molecular Alarmone (p)ppGpp Mediates Stress Responses, Vancomycin Tolerance, and Virulence in Enterococcus faecalis

(2009) J. Abranches et al.   JOURNAL OF BACTERIOLOGY

Pseudomonas aeruginosa Rugose Small-Colony Variants Have Adaptations That Likely Promote Persistence in the Cystic Fibrosis Lung

(2009) M. Starkey et al.   JOURNAL OF BACTERIOLOGY

Nitric Oxide Signaling in Pseudomonas aeruginosa Biofilms Mediates Phosphodiesterase Activity, Decreased Cyclic Di-GMP Levels, and Enhanced Dispersal

(2009) N. Barraud et al.   JOURNAL OF BACTERIOLOGY

YybT Is a Signaling Protein That Contains a Cyclic Dinucleotide Phosphodiesterase Domain and a GGDEF Domain with ATPase Activity

(2009) Feng Rao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP

(2009) Sarah M. McWhirter et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Second messenger signalling governsEscherichia colibiofilm induction upon ribosomal stress

(2009) Alex Boehm et al.   MOLECULAR MICROBIOLOGY

Small-molecule inhibitors target Escherichia coli amyloid biogenesis and biofilm formation

(2009) Lynette Cegelski et al.   Nature Chemical Biology

Structural and mechanistic determinants of c-di-GMP signalling

(2009) Tilman Schirmer et al.   NATURE REVIEWS MICROBIOLOGY

Molecular Mechanisms of HipA-Mediated Multidrug Tolerance and Its Neutralization by HipB

(2009) M. A. Schumacher et al.   SCIENCE

c-di-GMP as a vaccine adjuvant enhances protection against systemic methicillin-resistant Staphylococcus aureus (MRSA) infection

(2009) Dong-Liang Hu et al.   VACCINE

Nitric oxide-mediated dispersal in single- and multi-species biofilms of clinically and industrially relevant microorganisms

(2009) Nicolas Barraud et al.   Microbial Biotechnology

Bacterial Toxin–Antitoxin Systems: More Than Selfish Entities?

(2009) Laurence Van Melderen et al.   PLoS Genetics

Type 1 Fimbriae, a Colonization Factor of Uropathogenic Escherichia coli, Are Controlled by the Metabolic Sensor CRP-cAMP

(2009) Claudia M. Müller et al.   PLoS Pathogens

(p)ppGpp: Still Magical?

(2008) Katarzyna Potrykus et al.   Annual Review of Microbiology

TheAnaplasma phagocytophilumPleC Histidine Kinase and PleD Diguanylate Cyclase Two-Component System and Role of Cyclic Di-GMP in Host Cell Infection

(2008) Tzung-Huei Lai et al.   JOURNAL OF BACTERIOLOGY

Bacteria Possessing Two RelA/SpoT-Like Proteins Have Evolved a Specific Stringent Response Involving the Acyl Carrier Protein-SpoT Interaction

(2008) A. Battesti et al.   JOURNAL OF BACTERIOLOGY

Interplay between Cyclic AMP-Cyclic AMP Receptor Protein and Cyclic di-GMP Signaling in Vibrio cholerae Biofilm Formation

(2008) J. C. N. Fong et al.   JOURNAL OF BACTERIOLOGY

Protective Action of ppGpp in Microcin J25-Sensitive Strains

(2008) M. F. Pomares et al.   JOURNAL OF BACTERIOLOGY

Structural Biochemistry of a Bacterial Checkpoint Protein Reveals Diadenylate Cyclase Activity Regulated by DNA Recombination Intermediates

(2008) Gregor Witte et al.   MOLECULAR CELL

Large-scale transposon mutagenesis ofMycoplasma pulmonis

(2008) Christopher T. French et al.   MOLECULAR MICROBIOLOGY

Fine structure of the promoter-  region 1.2 interaction

(2008) S. P. Haugen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Great Times for Small Molecules: c-di-AMP, a Second Messenger Candidate in Bacteria and Archaea

(2008) U. Romling   Science Signaling

Targeting non-multiplying organisms as a way to develop novel antimicrobials

(2008) Anthony R.M. Coates et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

c-di-GMP is an effective immunomodulator and vaccine adjuvant against pneumococcal infection

(2008) Abiodun D. Ogunniyi et al.   VACCINE

Bacterial and Fungal Biofilm Infections

(2007) A. Simon Lynch et al.   Annual Review of Medicine