ATM loss leads to synthetic lethality in BRCA1 BRCT mutant mice associated with exacerbated defects in homology-directed repair
Published 2017 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
ATM loss leads to synthetic lethality in BRCA1 BRCT mutant mice associated with exacerbated defects in homology-directed repair
Authors
Keywords
-
Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 114, Issue 29, Pages 7665-7670
Publisher
Proceedings of the National Academy of Sciences
Online
2017-06-29
DOI
10.1073/pnas.1706392114
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Functional and mutational landscapes of BRCA1 for homology-directed repair and therapy resistance
- (2017) Rachel W Anantha et al. eLife
- ATM/ATR‐mediated phosphorylation of PALB2 promotes RAD51 function
- (2016) Johanna K Ahlskog et al. EMBO REPORTS
- HELB Is a Feedback Inhibitor of DNA End Resection
- (2016) Ján Tkáč et al. MOLECULAR CELL
- A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells
- (2016) Akshay K. Ahuja et al. Nature Communications
- Robust homology-directed repair within mouse mammary tissue is not specifically affected by Brca2 mutation
- (2016) Elizabeth M. Kass et al. Nature Communications
- Coordinated nuclease activities counteract Ku at single-ended DNA double-strand breaks
- (2016) Pauline Chanut et al. Nature Communications
- Mitochondrial dysfunction remodels one-carbon metabolism in human cells
- (2016) Xiaoyan Robert Bao et al. eLife
- A mechanism for the suppression of homologous recombination in G1 cells
- (2015) Alexandre Orthwein et al. NATURE
- REV7 counteracts DNA double-strand break resection and affects PARP inhibition
- (2015) Guotai Xu et al. NATURE
- ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1
- (2015) Amanda W. Kijas et al. NUCLEIC ACIDS RESEARCH
- Involvement of ATM in homologous recombination after end resection and RAD51 nucleofilament formation
- (2015) A. Bakr et al. NUCLEIC ACIDS RESEARCH
- Phosphopeptide interactions with BRCA1 BRCT domains: More than just a motif
- (2015) Qian Wu et al. PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
- Cell cycle-dependent inhibition of 53BP1 signaling by BRCA1
- (2015) Lin Feng et al. Cell Discovery
- CtIP-mediated resection is essential for viability and can operate independently of BRCA1
- (2014) Federica Polato et al. JOURNAL OF EXPERIMENTAL MEDICINE
- KAP-1 Promotes Resection of Broken DNA Ends Not Protected by -H2AX and 53BP1 in G1-Phase Lymphocytes
- (2014) A. T. Tubbs et al. MOLECULAR AND CELLULAR BIOLOGY
- Catalytic and Noncatalytic Roles of the CtIP Endonuclease in Double-Strand Break End Resection
- (2014) Nodar Makharashvili et al. MOLECULAR CELL
- BRCA1 Accelerates CtIP-Mediated DNA-End Resection
- (2014) Andrés Cruz-García et al. Cell Reports
- Ataxia Telangiectasia Mutated (ATM) Is Dispensable for Endonuclease I-SceI-induced Homologous Recombination in Mouse Embryonic Stem Cells
- (2013) Emilie Rass et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The interaction between CtIP and BRCA1 is not essential for resection-mediated DNA repair or tumor suppression
- (2013) Colleen R. Reczek et al. JOURNAL OF CELL BIOLOGY
- A Role for the MRN Complex in ATR Activation via TOPBP1 Recruitment
- (2013) Anja M. Duursma et al. MOLECULAR CELL
- A Cell Cycle-Dependent Regulatory Circuit Composed of 53BP1-RIF1 and BRCA1-CtIP Controls DNA Repair Pathway Choice
- (2013) Cristina Escribano-Díaz et al. MOLECULAR CELL
- The ATM protein kinase: regulating the cellular response to genotoxic stress and more
- (2013) Yosef Shiloh et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Double-strand break repair: 53BP1 comes into focus
- (2013) Stephanie Panier et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Co-operation of BRCA1 and POH1 relieves the barriers posed by 53BP1 and RAP80 to resection
- (2013) Andreas Kakarougkas et al. NUCLEIC ACIDS RESEARCH
- Double-strand break repair by homologous recombination in primary mouse somatic cells requires BRCA1 but not the ATM kinase
- (2013) E. M. Kass et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Stabilization of mutant BRCA1 protein confers PARP inhibitor and platinum resistance
- (2013) N. Johnson et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- 53BP1: pro choice in DNA repair
- (2013) Michal Zimmermann et al. TRENDS IN CELL BIOLOGY
- RPA Accumulation during Class Switch Recombination Represents 5′–3′ DNA-End Resection during the S–G2/M Phase of the Cell Cycle
- (2013) Arito Yamane et al. Cell Reports
- The Interaction of CtIP and Nbs1 Connects CDK and ATM to Regulate HR–Mediated Double-Strand Break Repair
- (2013) Hailong Wang et al. PLoS Genetics
- Abstract 5588: A phase I, open label, dose escalation study of an oral mammalian target of rapamycin inhibitor INK128 administered once daily in patients with advanced malignancies
- (2012) Jeffrey R. Infante et al. CANCER RESEARCH
- Playing the End Game: DNA Double-Strand Break Repair Pathway Choice
- (2012) J. Ross Chapman et al. MOLECULAR CELL
- Activation of DSB Processing Requires Phosphorylation of CtIP by ATR
- (2012) Shaun E. Peterson et al. MOLECULAR CELL
- Loss of 53BP1 Causes PARP Inhibitor Resistance in Brca1 -Mutated Mouse Mammary Tumors
- (2012) Janneke E. Jaspers et al. Cancer Discovery
- Lymphoid tumours and breast cancer in ataxia telangiectasia; substantial protective effect of residual ATM kinase activity against childhood tumours
- (2011) A Reiman et al. BRITISH JOURNAL OF CANCER
- Factors determining DNA double-strand break repair pathway choice in G2 phase
- (2011) Atsushi Shibata et al. EMBO JOURNAL
- Correct End Use during End Joining of Multiple Chromosomal Double Strand Breaks Is Influenced by Repair Protein RAD50, DNA-dependent Protein Kinase DNA-PKcs, and Transcription Context
- (2011) Amanda Gunn et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The underlying mechanism for the PARP and BRCA synthetic lethality: Clearing up the misunderstandings
- (2011) Thomas Helleday Molecular Oncology
- BRCA1 Tumor Suppression Depends on BRCT Phosphoprotein Binding, But Not Its E3 Ligase Activity
- (2011) R. Shakya et al. SCIENCE
- 53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks
- (2010) Samuel F. Bunting et al. CELL
- 53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination
- (2010) Anne Bothmer et al. JOURNAL OF EXPERIMENTAL MEDICINE
- H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes
- (2010) Beth A. Helmink et al. NATURE
- Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis
- (2010) Mary Ellen Moynahan et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- 53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers
- (2010) Peter Bouwman et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Transient ATM Kinase Inhibition Disrupts DNA Damage-Induced Sister Chromatid Exchange
- (2010) J. S. White et al. Science Signaling
- ATM Limits Incorrect End Utilization during Non-Homologous End Joining of Multiple Chromosome Breaks
- (2010) Nicole Bennardo et al. PLoS Genetics
- ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2
- (2009) Andrea Beucher et al. EMBO JOURNAL
- CtIP Links DNA Double-Strand Break Sensing to Resection
- (2009) Zhongsheng You et al. MOLECULAR CELL
- A Selective Requirement for 53BP1 in the Biological Response to Genomic Instability Induced by Brca1 Deficiency
- (2009) Liu Cao et al. MOLECULAR CELL
- CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle
- (2009) Maximina H. Yun et al. NATURE
- Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks
- (2009) Emma Bolderson et al. NUCLEIC ACIDS RESEARCH
- Complementary functions of ATM and H2AX in development and suppression of genomic instability
- (2008) S. Zha et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started