Functional and mutational landscapes of BRCA1 for homology-directed repair and therapy resistance
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Title
Functional and mutational landscapes of BRCA1 for homology-directed repair and therapy resistance
Authors
Keywords
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Journal
eLife
Volume 6, Issue -, Pages -
Publisher
eLife Sciences Organisation, Ltd.
Online
2017-04-11
DOI
10.7554/elife.21350
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Note: Only part of the references are listed.- Compromised BRCA1–PALB2 interaction is associated with breast cancer risk
- (2017) T K Foo et al. ONCOGENE
- Human BRCA1–BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection
- (2016) Ruth M Densham et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Human BRCA1–BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection
- (2016) Ruth M Densham et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Deciphering the BRCA1 Tumor Suppressor Network
- (2015) Qinqin Jiang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Heterozygous PALB2 c.1592delT mutation channels DNA double-strand break repair into error-prone pathways in breast cancer patients
- (2015) K Obermeier et al. ONCOGENE
- Patterns and functional implications of rare germline variants across 12 cancer types
- (2015) Charles Lu et al. Nature Communications
- CtIP-mediated resection is essential for viability and can operate independently of BRCA1
- (2014) Federica Polato et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Two Decades After BRCA: Setting Paradigms in Personalized Cancer Care and Prevention
- (2014) F. J. Couch et al. SCIENCE
- Cancer Suppression by the Chromosome Custodians, BRCA1 and BRCA2
- (2014) A. R. Venkitaraman SCIENCE
- The interaction between CtIP and BRCA1 is not essential for resection-mediated DNA repair or tumor suppression
- (2013) Colleen R. Reczek et al. JOURNAL OF CELL BIOLOGY
- Mechanisms of resistance to therapies targeting BRCA-mutant cancers
- (2013) Christopher J Lord et al. NATURE MEDICINE
- A High-Throughput Functional Complementation Assay for Classification of BRCA1 Missense Variants
- (2013) P. Bouwman et al. Cancer Discovery
- A Classification Model for BRCA2 DNA Binding Domain Missense Variants Based on Homology-Directed Repair Activity
- (2012) L. Guidugli et al. CANCER RESEARCH
- A guide for functional analysis ofBRCA1variants of uncertain significance
- (2012) Gaël A. Millot et al. HUMAN MUTATION
- Analysis of BRCA1 Variants in Double-Strand Break Repair by Homologous Recombination and Single-Strand Annealing
- (2012) William I. Towler et al. HUMAN MUTATION
- PALB2 Interacts with KEAP1 To Promote NRF2 Nuclear Accumulation and Function
- (2012) J. Ma et al. MOLECULAR AND CELLULAR BIOLOGY
- Links between genome integrity and BRCA1 tumor suppression
- (2012) Mischa L. Li et al. TRENDS IN BIOCHEMICAL SCIENCES
- BRCA1 RING Function Is Essential for Tumor Suppression but Dispensable for Therapy Resistance
- (2011) Rinske Drost et al. CANCER CELL
- BRCA1 Tumor Suppression Depends on BRCT Phosphoprotein Binding, But Not Its E3 Ligase Activity
- (2011) R. Shakya et al. SCIENCE
- Identification of Breast Tumor Mutations in BRCA1 That Abolish Its Function in Homologous DNA Recombination
- (2010) D. J.R. Ransburgh et al. CANCER RESEARCH
- 53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks
- (2010) Samuel F. Bunting et al. CELL
- Purified human BRCA2 stimulates RAD51-mediated recombination
- (2010) Ryan B. Jensen et al. NATURE
- Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis
- (2010) Mary Ellen Moynahan et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA
- (2010) Jie Liu et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- PALB2 Links BRCA1 and BRCA2 in the DNA-Damage Response
- (2009) Feng Zhang et al. CURRENT BIOLOGY
- Structural basis for recruitment of BRCA2 by PALB2
- (2009) Antony W Oliver et al. EMBO REPORTS
- Expression of human BRCA1 variants in mouse ES cells allows functional analysis of BRCA1 mutations
- (2009) Suhwan Chang et al. JOURNAL OF CLINICAL INVESTIGATION
- PALB2 Functionally Connects the Breast Cancer Susceptibility Proteins BRCA1 and BRCA2
- (2009) F. Zhang et al. MOLECULAR CANCER RESEARCH
- The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress
- (2009) Joanna R. Morris et al. NATURE
- BRCA1 and its toolbox for the maintenance of genome integrity
- (2009) Michael S.Y. Huen et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- PALB2 is an integral component of the BRCA complex required for homologous recombination repair
- (2009) S. M. H. Sy et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The basal-like mammary carcinomas induced by Brca1 or Bard1 inactivation implicate the BRCA1/BARD1 heterodimer in tumor suppression
- (2008) R. Shakya et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- E3 ligase activity of BRCA1 is not essential for mammalian cell viability or homology-directed repair of double-strand DNA breaks
- (2008) L. J. Reid et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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