标题
Physiological Aging: Links Among Adipose Tissue Dysfunction, Diabetes, and Frailty
作者
关键词
-
出版物
PHYSIOLOGY
Volume 32, Issue 1, Pages 9-19
出版商
American Physiological Society
发表日期
2016-12-08
DOI
10.1152/physiol.00012.2016
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice
- (2016) Carolyn M. Roos et al. AGING CELL
- Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors
- (2016) Yi Zhu et al. AGING CELL
- Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue
- (2016) Marissa J. Schafer et al. DIABETES
- Insulin resistance and sarcopenia: mechanistic links between common co-morbidities
- (2016) Mark E Cleasby et al. JOURNAL OF ENDOCRINOLOGY
- Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
- (2016) Darren J. Baker et al. NATURE
- Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice
- (2016) Michael B. Stout et al. Aging-US
- The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
- (2015) Yi Zhu et al. AGING CELL
- Promoting Health and Longevity through Diet: From Model Organisms to Humans
- (2015) Luigi Fontana et al. CELL
- Antigen- and Cytokine-Driven Accumulation of Regulatory T Cells in Visceral Adipose Tissue of Lean Mice
- (2015) Dmitriy Kolodin et al. Cell Metabolism
- IL-1 family members in the pathogenesis and treatment of metabolic disease: Focus on adipose tissue inflammation and insulin resistance
- (2015) Dov B. Ballak et al. CYTOKINE
- Stewing in Not-So-Good Juices: Interactions of Skeletal Muscle With Adipose Secretions: Figure 1
- (2015) David E. Kelley et al. DIABETES
- Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity
- (2015) Allyson K. Palmer et al. DIABETES
- Human Adipocytes Induce Inflammation and Atrophy in Muscle Cells During Obesity
- (2015) Vanessa Pellegrinelli et al. DIABETES
- Role of insulin in the regulation of human skeletal muscle protein synthesis and breakdown: a systematic review and meta-analysis
- (2015) Haitham Abdulla et al. DIABETOLOGIA
- Clinical strategies and animal models for developing senolytic agents
- (2015) James L. Kirkland et al. EXPERIMENTAL GERONTOLOGY
- Sodium nitrite supplementation improves motor function and skeletal muscle inflammatory profile in old male mice
- (2015) Jamie N. Justice et al. JOURNAL OF APPLIED PHYSIOLOGY
- Intramyocellular Lipid and Impaired Myofiber Contraction in Normal Weight and Obese Older Adults
- (2015) Seung J. Choi et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Prostate cancer: 4 big questions
- (2015) Richard Hodson NATURE
- Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
- (2015) Jianhui Chang et al. NATURE MEDICINE
- Inflammation and the depot-specific secretome of human preadipocytes
- (2015) Yi Zhu et al. Obesity
- JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age
- (2015) Ming Xu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Growth hormone in adipose dysfunction and senescence
- (2015) Michael B. Stout et al. Oncotarget
- Transcriptome profiling reveals divergent expression shifts in brown and white adipose tissue from long-lived GHRKO mice
- (2015) Michael B. Stout et al. Oncotarget
- Targeting senescent cells enhances adipogenesis and metabolic function in old age
- (2015) Ming Xu et al. eLife
- Ageing, adipose tissue, fatty acids and inflammation
- (2014) Chathyan Pararasa et al. BIOGERONTOLOGY
- The Frailty Syndrome: Clinical measurements and basic underpinnings in humans and animals
- (2014) M. Jane Mohler et al. EXPERIMENTAL GERONTOLOGY
- Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases
- (2014) C. Franceschi et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Obesity accelerates epigenetic aging of human liver
- (2014) S. Horvath et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Pro-inflammatory capacity of classically activated monocytes relates positively to muscle mass and strength
- (2013) Karel G. M. Beenakker et al. AGING CELL
- Associations between body composition and gait-speed decline: results from the Health, Aging, and Body Composition study
- (2013) Kristen M Beavers et al. AMERICAN JOURNAL OF CLINICAL NUTRITION
- The Hallmarks of Aging
- (2013) Carlos López-Otín et al. CELL
- Mechanisms and Metabolic Implications of Regional Differences among Fat Depots
- (2013) Tamara Tchkonia et al. Cell Metabolism
- Changes in Adipose Tissue Macrophages and T Cells During Aging
- (2013) Sanjay K. Garg et al. CRITICAL REVIEWS IN IMMUNOLOGY
- Frailty and Safety
- (2013) Angela M. Abbatecola et al. DRUG SAFETY
- Macrophages, fat, and the emergence of immunometabolism
- (2013) Anthony W. Ferrante JOURNAL OF CLINICAL INVESTIGATION
- Cellular senescence and the senescent secretory phenotype: therapeutic opportunities
- (2013) Tamara Tchkonia et al. JOURNAL OF CLINICAL INVESTIGATION
- Frailty in elderly people
- (2013) Andrew Clegg et al. LANCET
- Pro-Inflammatory macrophages increase in skeletal muscle of high fat-Fed mice and correlate with metabolic risk markers in humans
- (2013) Lisbeth N. Fink et al. Obesity
- Metformin improves healthspan and lifespan in mice
- (2013) Alejandro Martin-Montalvo et al. Nature Communications
- Chronic inflammation role in the obesity-diabetes association: a case-cohort study
- (2013) Vivian C Luft et al. Diabetology & Metabolic Syndrome
- Clinical frailty and long-term mortality in elderly subjects with diabetes
- (2012) Francesco Cacciatore et al. ACTA DIABETOLOGICA
- Diabetes in Older Adults
- (2012) M. S. Kirkman et al. DIABETES CARE
- Translating advances from the basic biology of aging into clinical application
- (2012) James L. Kirkland EXPERIMENTAL GERONTOLOGY
- Peripheral fat loss and decline in adipogenesis in older humans
- (2012) Giuseppe Caso et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- The cellular and signaling networks linking the immune system and metabolism in disease
- (2012) Olivia Osborn et al. NATURE MEDICINE
- Role and potential mechanisms of anabolic resistance in sarcopenia
- (2012) Prashanth H. Haran et al. Journal of Cachexia Sarcopenia and Muscle
- Inflammation and mortality in a frail mouse model
- (2011) Fred Ko et al. AGE
- Lack of Interleukin-1 Receptor I (IL-1RI) Protects Mice From High-Fat Diet-Induced Adipose Tissue Inflammation Coincident With Improved Glucose Homeostasis
- (2011) F. C. McGillicuddy et al. DIABETES
- Skeletal Muscle Power
- (2011) Kieran F. Reid et al. EXERCISE AND SPORT SCIENCES REVIEWS
- Low serum IL-6 is associated with high 6-minute walking performance in asymptomatic women aged 20 to 70years
- (2011) Hubert Blain et al. EXPERIMENTAL GERONTOLOGY
- Gait Speed and Survival in Older Adults
- (2011) Stephanie Studenski JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Aging Is Associated with an Increase in T Cells and Inflammatory Macrophages in Visceral Adipose Tissue
- (2011) C. N. Lumeng et al. JOURNAL OF IMMUNOLOGY
- Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
- (2011) Darren J. Baker et al. NATURE
- Fat tissue, aging, and cellular senescence
- (2010) Tamara Tchkonia et al. AGING CELL
- The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression
- (2010) Jean-Philippe Coppé et al. Annual Review of Pathology-Mechanisms of Disease
- The Inflammasome-Mediated Caspase-1 Activation Controls Adipocyte Differentiation and Insulin Sensitivity
- (2010) Rinke Stienstra et al. Cell Metabolism
- Diet-induced obesity alters signalling pathways and induces atrophy and apoptosis in skeletal muscle in a prediabetic rat model
- (2010) Balindiwe Sishi et al. EXPERIMENTAL PHYSIOLOGY
- Prevalence and 10-Year Outcomes of Frailty in Older Adults in Relation to Deficit Accumulation
- (2010) Xiaowei Song et al. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
- Aging, Depot Origin, and Preadipocyte Gene Expression
- (2010) Mark J. Cartwright et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- The metabolic syndrome in older persons: a loosely defined constellation of symptoms or a distinct entity?
- (2009) John E. Morley et al. AGE AND AGEING
- Age-related changes in total and regional fat distribution
- (2009) Jennifer L. Kuk et al. AGEING RESEARCH REVIEWS
- Inflammation and impaired adipogenesis in hypertrophic obesity in man
- (2009) Birgit Gustafson et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Functional analyses reveal the greater potency of preadipocytes compared with adipocytes as endothelial cell activator under normoxia, hypoxia, and TNFα exposure
- (2009) Isabelle Mack et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Impaired Preadipocyte Differentiation in Human Abdominal Obesity: Role of Wnt, Tumor Necrosis Factor- , and Inflammation
- (2009) P. Isakson et al. DIABETES
- Age-Associated Increase in Cytokine Production During Systemic Inflammation: Adipose Tissue as a Major Source of IL-6
- (2009) M. E. Starr et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Two-Year Body Composition Analyses of Long-Lived GHR Null Mice
- (2009) D. E. Berryman et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Nonlinear Multisystem Physiological Dysregulation Associated With Frailty in Older Women: Implications for Etiology and Treatment
- (2009) L. P. Fried et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells
- (2009) Kazuyo Moro et al. NATURE
- A crucial role for adipose tissue p53 in the regulation of insulin resistance
- (2009) Tohru Minamino et al. NATURE MEDICINE
- Connecting obesity, aging and diabetes
- (2009) Rexford S. Ahima NATURE MEDICINE
- Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters
- (2009) Markus Feuerer et al. NATURE MEDICINE
- Regional Anatomic and Age Effects on Cell Function of Human Adipose-Derived Stem Cells
- (2008) Bret M. Schipper et al. ANNALS OF PLASTIC SURGERY
- Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
- (2008) Jean-Philippe Coppé et al. PLOS BIOLOGY
- Insulin resistance associated to obesity: the link TNF-alpha
- (2008) Iria Nieto-Vazquez et al. ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
- Insulin resistance induced by tumor necrosis factor-α in myocytes and brown adipocytes12
- (2007) M. Lorenzo et al. JOURNAL OF ANIMAL SCIENCE
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