In Vitro Models to Study Human Lung Development, Disease and Homeostasis

The function of heparan sulfate during branching morphogenesis

(2017) Vaishali N. Patel et al.   MATRIX BIOLOGY

In vitro exposure system for study of aerosolized influenza virus

(2017) Hannah M. Creager et al.   VIROLOGY

Mechanisms of Lung Fibrosis Resolution

(2016) Stephan W. Glasser et al.   AMERICAN JOURNAL OF PATHOLOGY

Diversity of Interstitial Lung Fibroblasts Is Regulated by Platelet-Derived Growth Factor Receptor α Kinase Activity

(2016) Jenna Green et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Lung surfactant: Function and composition in the context of development and respiratory physiology

(2016) Wolfgang Bernhard   ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER

The development of a tissue-engineered tracheobronchial epithelial model using a bilayered collagen-hyaluronate scaffold

(2016) Cian O'Leary et al.   BIOMATERIALS

Comparative biology of decellularized lung matrix: Implications of species mismatch in regenerative medicine

(2016) Jenna L. Balestrini et al.   BIOMATERIALS

Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells

(2016) Hongmei Mou et al.   Cell Stem Cell

BMP signaling and cellular dynamics during regeneration of airway epithelium from basal progenitors

(2016) Tomomi Tadokoro et al.   DEVELOPMENT

A three-dimensional study of alveologenesis in mouse lung

(2016) Kelsey Branchfield et al.   DEVELOPMENTAL BIOLOGY

hPSC-derived lung and intestinal organoids as models of human fetal tissue

(2016) Megan Aurora et al.   DEVELOPMENTAL BIOLOGY

Designer matrices for intestinal stem cell and organoid culture

(2016) Nikolce Gjorevski et al.   NATURE

Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system

(2016) Michael J Workman et al.   NATURE MEDICINE

An interactive three-dimensional digital atlas and quantitative database of human development

(2016) Bernadette S. de Bakker et al.   SCIENCE

Pulmonary neuroendocrine cells function as airway sensors to control lung immune response

(2016) K. Branchfield et al.   SCIENCE

Airway acidification initiates host defense abnormalities in cystic fibrosis mice

(2016) V. S. Shah et al.   SCIENCE

Establishing Proximal and Distal Regional Identities in Murine and Human Tissue-Engineered Lung and Trachea

(2016) Andrew Trecartin et al.   TISSUE ENGINEERING PART C-METHODS

Enhanced Re-Endothelialization of Decellularized Rat Lungs

(2016) Collin T. Stabler et al.   TISSUE ENGINEERING PART C-METHODS

Klebsiella pneumoniae Siderophores Induce Inflammation, Bacterial Dissemination, and HIF-1α Stabilization during Pneumonia

(2016) Victoria I. Holden et al.   mBio

Development of a Three-Dimensional Bioengineering Technology to Generate Lung Tissue for Personalized Disease Modeling

(2016) Dan C. Wilkinson et al.   Stem Cells Translational Medicine

A bioengineered niche promotes in vivo engraftment and maturation of pluripotent stem cell derived human lung organoids

(2016) Briana R Dye et al.   eLife

Bioengineering Lungs for Transplantation

(2016) Sarah E. Gilpin et al.   Thoracic Surgery Clinics

Directed Induction of Functional Multi-ciliated Cells in Proximal Airway Epithelial Spheroids from Human Pluripotent Stem Cells

(2016) Satoshi Konishi et al.   Stem Cell Reports

HIV Impairs Lung Epithelial Integrity and Enters the Epithelium to Promote Chronic Lung Inflammation

(2016) Kieran A. Brune et al.   PLoS One

An Optimised Human Cell Culture Model for Alveolar Epithelial Transport

(2016) Hui Ren et al.   PLoS One

Junctional abnormalities in human airway epithelial cells expressing F508del CFTR

(2015) Samuel A. Molina et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Coming to terms with tissue engineering and regenerative medicine in the lung

(2015) Y. S. Prakash et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Cilia Dysfunction in Lung Disease

(2015) Ann E. Tilley et al.   Annual Review of Physiology

Injury Induces Direct Lineage Segregation of Functionally Distinct Airway Basal Stem/Progenitor Cell Subpopulations

(2015) Ana Pardo-Saganta et al.   Cell Stem Cell

The pulmonary mesenchyme directs lung development

(2015) David McCulley et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Localized Smooth Muscle Differentiation Is Essential for Epithelial Bifurcation during Branching Morphogenesis of the Mammalian Lung

(2015) Hye Young Kim et al.   DEVELOPMENTAL CELL

Synthetic matrices reveal contributions of ECM biophysical and biochemical properties to epithelial morphogenesis

(2015) Nduka O. Enemchukwu et al.   JOURNAL OF CELL BIOLOGY

Hedgehog actively maintains adult lung quiescence and regulates repair and regeneration

(2015) Tien Peng et al.   NATURE

Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis

(2015) Minoru Takasato et al.   NATURE

Engineering pulmonary vasculature in decellularized rat and human lungs

(2015) Xi Ren et al.   NATURE BIOTECHNOLOGY

Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro

(2015) Kambez H Benam et al.   NATURE METHODS

Mechanically patterning the embryonic airway epithelium

(2015) Victor D. Varner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human cerebral organoids recapitulate gene expression programs of fetal neocortex development

(2015) J. Gray Camp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mimicking the niche of lung epithelial stem cells and characterization of several effectors of their in vitro behavior

(2015) Ahmed E. Hegab et al.   Stem Cell Research

Generation of Distal Airway Epithelium from Multipotent Human Foregut Stem Cells

(2015) Nicholas R.F. Hannan et al.   STEM CELLS AND DEVELOPMENT

Plasticity of Hopx+ type I alveolar cells to regenerate type II cells in the lung

(2015) Rajan Jain et al.   Nature Communications

Functional Gene Correction for Cystic Fibrosis in Lung Epithelial Cells Generated from Patient iPSCs

(2015) Amy L. Firth et al.   Cell Reports

Notch2 Is Required for Inflammatory Cytokine-Driven Goblet Cell Metaplasia in the Lung

(2015) Henry Danahay et al.   Cell Reports

In vitro generation of human pluripotent stem cell derived lung organoids

(2015) Briana R Dye et al.   eLife

Generation of tissue-engineered small intestine using embryonic stem cell-derived human intestinal organoids

(2015) S. R. Finkbeiner et al.   Biology Open

Transcriptome-wide Analysis Reveals Hallmarks of Human Intestine Development and Maturation In Vitro and In Vivo

(2015) Stacy R. Finkbeiner et al.   Stem Cell Reports

Targeted Correction and Restored Function of the CFTR Gene in Cystic Fibrosis Induced Pluripotent Stem Cells

(2015) Ana M. Crane et al.   Stem Cell Reports

Cigarette smoke alters primary human bronchial epithelial cell differentiation at the air-liquid interface

(2015) Andrea C. Schamberger et al.   Scientific Reports

Comparative decellularization and recellularization of normal versus emphysematous human lungs

(2014) Darcy E. Wagner et al.   BIOMATERIALS

Airway branching has conserved needs for local parasympathetic innervation but not neurotransmission

(2014) Danielle V Bower et al.   BMC BIOLOGY

Lung Stem Cell Differentiation in Mice Directed by Endothelial Cells via a BMP4-NFATc1-Thrombospondin-1 Axis

(2014) Joo-Hyeon Lee et al.   CELL

Modeling human lung development and disease using pluripotent stem cells

(2014) H.-W. Snoeck   DEVELOPMENT

Cellular and physical mechanisms of branching morphogenesis

(2014) Victor D. Varner et al.   DEVELOPMENT

Lung development: orchestrating the generation and regeneration of a complex organ

(2014) M. Herriges et al.   DEVELOPMENT

Local and global dynamics of the basement membrane during branching morphogenesis require protease activity and actomyosin contractility

(2014) Jill S. Harunaga et al.   DEVELOPMENTAL BIOLOGY

Modelling human development and disease in pluripotent stem-cell-derived gastric organoids

(2014) Kyle W. McCracken et al.   NATURE

Alveolar progenitor and stem cells in lung development, renewal and cancer

(2014) Tushar J. Desai et al.   NATURE

Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury

(2014) Andrew E. Vaughan et al.   NATURE

Preclinical research: Make mouse studies work

(2014) Steve Perrin   NATURE

Lung regeneration: mechanisms, applications and emerging stem cell populations

(2014) Darrell N Kotton et al.   NATURE MEDICINE

An in vivo model of human small intestine using pluripotent stem cells

(2014) Carey L Watson et al.   NATURE MEDICINE

Perfusion decellularization of whole organs

(2014) Jacques P Guyette et al.   Nature Protocols

Cystic fibrosis genetics: from molecular understanding to clinical application

(2014) Garry R. Cutting   NATURE REVIEWS GENETICS

Remodelling the extracellular matrix in development and disease

(2014) Caroline Bonnans et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Impaired mucus detachment disrupts mucociliary transport in a piglet model of cystic fibrosis

(2014) M. J. Hoegger et al.   SCIENCE

A novel electrospun biphasic scaffold provides optimal three-dimensional topography forin vitroco-culture of airway epithelial and fibroblast cells

(2014) G E Morris et al.   Biofabrication

Generation of Alveolar Epithelial Spheroids via Isolated Progenitor Cells from Human Pluripotent Stem Cells

(2014) Shimpei Gotoh et al.   Stem Cell Reports

Chemosensory Functions for Pulmonary Neuroendocrine Cells

(2013) Xiaoling Gu et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Animal models of disease: Pre-clinical animal models of cancer and their applications and utility in drug discovery

(2013) Bruce A. Ruggeri et al.   BIOCHEMICAL PHARMACOLOGY

Alveolar epithelial differentiation of human induced pluripotent stem cells in a rotating bioreactor

(2013) Mahboobe Ghaedi et al.   BIOMATERIALS

Functional Repair of CFTR by CRISPR/Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis Patients

(2013) Gerald Schwank et al.   Cell Stem Cell

Human iPS cell–derived alveolar epithelium repopulates lung extracellular matrix

(2013) Mahboobe Ghaedi et al.   JOURNAL OF CLINICAL INVESTIGATION

Type 2 alveolar cells are stem cells in adult lung

(2013) Christina E. Barkauskas et al.   JOURNAL OF CLINICAL INVESTIGATION

Dedifferentiation of committed epithelial cells into stem cells in vivo

(2013) Purushothama Rao Tata et al.   NATURE

Efficient generation of lung and airway epithelial cells from human pluripotent stem cells

(2013) Sarah X L Huang et al.   NATURE BIOTECHNOLOGY

Lung epithelial branching program antagonizes alveolar differentiation

(2013) D. R. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sox9 plays multiple roles in the lung epithelium during branching morphogenesis

(2013) B. E. Rockich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Generation of Multipotent Foregut Stem Cells from Human Pluripotent Stem Cells

(2013) Nicholas R.F. Hannan et al.   Stem Cell Reports

Acellular Normal and Fibrotic Human Lung Matrices as a Culture System forIn VitroInvestigation

(2012) Adam J. Booth et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Dynamic Regulation of Platelet-Derived Growth Factor Receptor α Expression in Alveolar Fibroblasts during Realveolarization

(2012) Leiling Chen et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Ciliated Cells of Pseudostratified Airway Epithelium Do Not Become Mucous Cells after Ovalbumin Challenge

(2012) Ana Pardo-Saganta et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Efficient Derivation of Purified Lung and Thyroid Progenitors from Embryonic Stem Cells

(2012) Tyler A. Longmire et al.   Cell Stem Cell

Generation of Multipotent Lung and Airway Progenitors from Mouse ESCs and Patient-Specific Cystic Fibrosis iPSCs

(2012) Hongmei Mou et al.   Cell Stem Cell

Building and maintaining the epithelium of the lung

(2012) Craig R. Rackley et al.   JOURNAL OF CLINICAL INVESTIGATION

Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein

(2012) Amy P Wong et al.   NATURE BIOTECHNOLOGY

Ivacaftor

(2012) Pamela B. Davis et al.   NATURE REVIEWS DRUG DISCOVERY

Congenital Diaphragmatic Hernia

(2012) Juan A Tovar   Orphanet Journal of Rare Diseases

A Human Disease Model of Drug Toxicity–Induced Pulmonary Edema in a Lung-on-a-Chip Microdevice

(2012) Dongeun Huh et al.   Science Translational Medicine

A Nonhuman Primate Model of Lung Regeneration: Detergent-Mediated Decellularization and Initial In Vitro Recellularization with Mesenchymal Stem Cells

(2012) Ryan W. Bonvillain et al.   TISSUE ENGINEERING PART A

ROCK Inhibitor and Feeder Cells Induce the Conditional Reprogramming of Epithelial Cells

(2011) Xuefeng Liu et al.   AMERICAN JOURNAL OF PATHOLOGY

The effect of stromal components on the modulation of the phenotype of human bronchial epithelial cells in 3D culture

(2011) Steven C. Pageau et al.   BIOMATERIALS

Notch and Basal Cells Take Center Stage during Airway Epithelial Regeneration

(2011) Jeffrey A. Whitsett et al.   Cell Stem Cell

Notch-Dependent Differentiation of Adult Airway Basal Stem Cells

(2011) Jason R. Rock et al.   Cell Stem Cell

Paracellular Permeability of Bronchial Epithelium is Controlled by CFTR

(2011) Nelly Weiser et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The three R’s of lung health and disease: repair, remodeling, and regeneration

(2011) Michael F. Beers et al.   JOURNAL OF CLINICAL INVESTIGATION

Generation of anterior foregut endoderm from human embryonic and induced pluripotent stem cells

(2011) Michael D Green et al.   NATURE BIOTECHNOLOGY

Generating human intestinal tissue from pluripotent stem cells in vitro

(2011) Kyle W McCracken et al.   Nature Protocols

Preparing for the First Breath: Genetic and Cellular Mechanisms in Lung Development

(2010) Edward E. Morrisey et al.   DEVELOPMENTAL CELL

The building blocks of mammalian lung development

(2010) Emma L. Rawlins   DEVELOPMENTAL DYNAMICS

Patterning and plasticity in development of the respiratory lineage

(2010) Eric T. Domyan et al.   DEVELOPMENTAL DYNAMICS

The intrinsic innervation of the lung is derived from neural crest cells as shown by optical projection tomography in Wnt1-Cre;YFP reporter mice

(2010) Lucy J. Freem et al.   JOURNAL OF ANATOMY

HTII-280, a Biomarker Specific to the Apical Plasma Membrane of Human Lung Alveolar Type II Cells

(2010) Robert F. Gonzalez et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Cystic fibrosis transmembrane conductance regulator trafficking modulates the barrier function of airway epithelial cell monolayers

(2010) Pierre LeSimple et al.   JOURNAL OF PHYSIOLOGY-LONDON

Extracellular matrix-derived products modulate endothelial and progenitor cell migration and proliferation in vitro and stimulate regenerative healing in vivo

(2010) Ekaterina Vorotnikova et al.   MATRIX BIOLOGY

Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro

(2010) Jason R. Spence et al.   NATURE

Regeneration and orthotopic transplantation of a bioartificial lung

(2010) Harald C Ott et al.   NATURE MEDICINE

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Tissue-Engineered Lungs for in Vivo Implantation

(2010) T. H. Petersen et al.   SCIENCE

The Role of Scgb1a1+ Clara Cells in the Long-Term Maintenance and Repair of Lung Airway, but Not Alveolar, Epithelium

(2009) Emma L. Rawlins et al.   Cell Stem Cell

The Id2+ distal tip lung epithelium contains individual multipotent embryonic progenitor cells

(2009) E. L. Rawlins et al.   DEVELOPMENT

Chronic Hypoxia and Rat Lung Development: Analysis by Morphometry and Directed Microarray

(2009) William E Truog et al.   PEDIATRIC RESEARCH

Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770

(2009) F. Van Goor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Basal cells as stem cells of the mouse trachea and human airway epithelium

(2009) J. R. Rock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Simplified cell culture method for the diagnosis of atypical primary ciliary dyskinesia

(2009) M Pifferi et al.   THORAX

Animal models of acute lung injury

(2008) Gustavo Matute-Bello et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Novel human bronchial epithelial cell lines for cystic fibrosis research

(2008) M. L. Fulcher et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The branching programme of mouse lung development

(2008) Ross J. Metzger et al.   NATURE

Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo

(2008) Evert Kroon et al.   NATURE BIOTECHNOLOGY

Characterization of Side Population Cells from Human Airway Epithelium

(2008) Tillie-Louise Hackett et al.   STEM CELLS

Murine models of pulmonary fibrosis

(2007) Bethany B. Moore et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY