Exercise, heat shock proteins and insulin resistance

Aerobic capacity mediates susceptibility for the transition from steatosis to steatohepatitis

(2017) E. Matthew Morris et al.   JOURNAL OF PHYSIOLOGY-LONDON

Cytosolic proteostasis through importing of misfolded proteins into mitochondria

(2017) Linhao Ruan et al.   NATURE

Effects of heated hydrotherapy on muscle HSP70 and glucose metabolism in old and young vervet monkeys

(2016) Kylie Kavanagh et al.   CELL STRESS & CHAPERONES

Waon Therapy for Managing Chronic Heart Failure　– Results From a Multicenter Prospective Randomized WAON-CHF Study –

(2016) Chuwa Tei et al.   CIRCULATION JOURNAL

Deficiency in the Heat Stress Response Could Underlie Susceptibility to Metabolic Disease

(2016) Robert S. Rogers et al.   DIABETES

Modeling type 2 diabetes-like hyperglycemia in C. elegans on a microdevice

(2016) Guoli Zhu et al.   Integrative Biology

Heat shock proteins and exercise adaptations. Our knowledge thus far and the road still ahead

(2016) Darren C. Henstridge et al.   JOURNAL OF APPLIED PHYSIOLOGY

Passive heat therapy improves endothelial function, arterial stiffness and blood pressure in sedentary humans

(2016) Vienna E. Brunt et al.   JOURNAL OF PHYSIOLOGY-LONDON

An acute bout of whole body passive hyperthermia increases plasma leptin, but does not alter glucose or insulin responses in obese type 2 diabetics and healthy adults

(2016) Eric Rivas et al.   JOURNAL OF THERMAL BIOLOGY

Endoplasmic reticulum stress in obesity and obesity-related disorders: An expanded view

(2016) Michael J. Pagliassotti et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Obese type 2 diabetics have a blunted hypotensive response to acute hyperthermia therapy that does not affect the perception of thermal stress or physiological strain compared to healthy adults

(2016) Eric Rivas et al.   PHYSIOLOGY & BEHAVIOR

The transcriptional coactivator PGC1α protects against hyperthermic stress via cooperation with the heat shock factor HSF1

(2016) L Xu et al.   Cell Death & Disease

Identification of matrine as a promising novel drug for hepatic steatosis and glucose intolerance with HSP72 as an upstream target

(2015) Xiao-Yi Zeng et al.   BRITISH JOURNAL OF PHARMACOLOGY

Hepatic Acetyl CoA Links Adipose Tissue Inflammation to Hepatic Insulin Resistance and Type 2 Diabetes

(2015) Rachel J. Perry et al.   CELL

Glucose regulates heat shock factor 1 transcription activity via mTOR pathway in HCC cell lines

(2015) Wanli Ma et al.   CELL BIOLOGY INTERNATIONAL

Celastrol Protects against Obesity and Metabolic Dysfunction through Activation of a HSF1-PGC1α Transcriptional Axis

(2015) Xinran Ma et al.   Cell Metabolism

Role of the unfolded protein response, GRP78 and GRP94 in organ homeostasis

(2015) Genyuan Zhu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity

(2015) Sanda Win et al.   JOURNAL OF HEPATOLOGY

Daily heat stress treatment rescues denervation-activated mitochondrial clearance and atrophy in skeletal muscle

(2015) Yuki Tamura et al.   JOURNAL OF PHYSIOLOGY-LONDON

The Chaperone Balance Hypothesis: The Importance of the Extracellular to Intracellular HSP70 Ratio to Inflammation-Driven Type 2 Diabetes, the Effect of Exercise, and the Implications for Clinical Management

(2015) Mauricio Krause et al.   MEDIATORS OF INFLAMMATION

Oral supplementations with l-glutamine or l-alanyl-l-glutamine do not change metabolic alterations induced by long-term high-fat diet in the B6.129F2/J mouse model of insulin resistance

(2015) Patricia Martins Bock et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Chia (Salvia hispanica L.) enhances HSP, PGC-1α expressions and improves glucose tolerance in diet-induced obese rats

(2015) Rafaela da Silva Marineli et al.   NUTRITION

Intercellular chaperone transmission via exosomes contributes to maintenance of protein homeostasis at the organismal level

(2015) Toshihide Takeuchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The PPARα-FGF21 Hormone Axis Contributes to Metabolic Regulation by the Hepatic JNK Signaling Pathway

(2014) Santiago Vernia et al.   Cell Metabolism

Activating HSP72 in Rodent Skeletal Muscle Increases Mitochondrial Number and Oxidative Capacity and Decreases Insulin Resistance

(2014) Darren C. Henstridge et al.   DIABETES

Inducing Muscle Heat Shock Protein 70 Improves Insulin Sensitivity and Muscular Performance in Aged Mice

(2014) Marnie G. Silverstein et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Obesity depresses the anti-inflammatory HSP70 pathway, contributing to NAFLD progression

(2014) Fábio Cangeri Di Naso et al.   Obesity

JNK interaction with Sab mediates ER stress induced inhibition of mitochondrial respiration and cell death

(2014) S Win et al.   Cell Death & Disease

Chaperoning to the metabolic party: The emerging therapeutic role of heat-shock proteins in obesity and type 2 diabetes

(2014) Darren C. Henstridge et al.   Molecular Metabolism

Exercise reduces cellular stress related to skeletal muscle insulin resistance

(2013) Mariana Aguiar de Matos et al.   CELL STRESS & CHAPERONES

HSP72 Is a Mitochondrial Stress Sensor Critical for Parkin Action, Oxidative Metabolism, and Insulin Sensitivity in Skeletal Muscle

(2013) Brian G. Drew et al.   DIABETES

Mycobacterium tuberculosis-Induced Neutrophil Extracellular Traps Activate Human Macrophages

(2013) Clara Braian et al.   Journal of Innate Immunity

Silencing of Lipid Metabolism Genes through IRE1α-Mediated mRNA Decay Lowers Plasma Lipids in Mice

(2012) Jae-Seon So et al.   Cell Metabolism

Divergence of intracellular and extracellular HSP72 in type 2 diabetes: does fat matter?

(2012) Josianne Rodrigues-Krause et al.   CELL STRESS & CHAPERONES

Influence of exercise on NA- and Hsp72-induced release of IFNγ by the peritoneal suspension of macrophages and lymphocytes from genetically obese Zucker rats

(2012) L. Martín-Cordero et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Aging Does Not Reduce Heat Shock Protein 70 in the Absence of Chronic Insulin Resistance

(2012) K. Kavanagh et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

(2012) Claudio Hetz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

JNK Expression by Macrophages Promotes Obesity-Induced Insulin Resistance and Inflammation

(2012) M. S. Han et al.   SCIENCE

JNK modulates FOXO3a for the expression of the mitochondrial death and mitophagy marker BNIP3 in pathological hypertrophy and in heart failure

(2012) A H Chaanine et al.   Cell Death & Disease

Absolute amounts and diffusibility of HSP72, HSP25, and αB-crystallin in fast- and slow-twitch skeletal muscle fibers of rat

(2011) Noni T. Larkins et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The Unfolded Protein Response Mediates Adaptation to Exercise in Skeletal Muscle through a PGC-1α/ATF6α Complex

(2011) Jun Wu et al.   Cell Metabolism

Oleate Blocks Palmitate-Induced Abnormal Lipid Distribution, Endoplasmic Reticulum Expansion and Stress, and Insulin Resistance in Skeletal Muscle

(2011) Gong Peng et al.   ENDOCRINOLOGY

Constitutive Role for IRE1α-XBP1 Signaling Pathway in the Insulin-Mediated Hepatic Lipogenic Program

(2011) Jie Ning et al.   ENDOCRINOLOGY

HSP70 mediates dissociation and reassociation of the 26S proteasome during adaptation to oxidative stress

(2011) Tilman Grune et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mild heat stress induces mitochondrial biogenesis in C2C12 myotubes

(2011) Chien-Ting Liu et al.   JOURNAL OF APPLIED PHYSIOLOGY

Altered chromatin architecture underlies progressive impairment of the heat shock response in mouse models of Huntington disease

(2011) John Labbadia et al.   JOURNAL OF CLINICAL INVESTIGATION

The unfolded protein response is activated in skeletal muscle by high-fat feeding: potential role in the downregulation of protein synthesis

(2010) Louise Deldicque et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The Effects of Repeated Thermal Therapy on Quality of Life in Patients with Type II Diabetes Mellitus

(2010) Richard Beever   JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE

Acute heat treatment improves insulin-stimulated glucose uptake in aged skeletal muscle

(2010) Anisha A. Gupte et al.   JOURNAL OF APPLIED PHYSIOLOGY

The relationship between heat shock protein 72 expression in skeletal muscle and insulin sensitivity is dependent on adiposity

(2010) Darren C. Henstridge et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Exercise training and experimental diabetes modulate heat shock protein response in brain

(2010) Z. Lappalainen et al.   SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS

HSP72 Protects Cells from ER Stress-induced Apoptosis via Enhancement of IRE1α-XBP1 Signaling through a Physical Interaction

(2010) Sanjeev Gupta et al.   PLOS BIOLOGY

Different effect of glutamine on macrophage tumor necrosis factor-alpha release and heat shock protein 72 expression in vitro and in vivo

(2009) M. Liang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Lipoic acid increases heat shock protein expression and inhibits stress kinase activation to improve insulin signaling in skeletal muscle from high-fat-fed rats

(2009) Anisha A. Gupte et al.   JOURNAL OF APPLIED PHYSIOLOGY

Rats selectively bred for low aerobic capacity have reduced hepatic mitochondrial oxidative capacity and susceptibility to hepatic steatosis and injury

(2009) John P. Thyfault et al.   JOURNAL OF PHYSIOLOGY-LONDON

UPR Pathways Combine to Prevent Hepatic Steatosis Caused by ER Stress-Mediated Suppression of Transcriptional Master Regulators

(2008) D. Thomas Rutkowski et al.   DEVELOPMENTAL CELL

Endoplasmic Reticulum Stress Is Reduced in Tissues of Obese Subjects After Weight Loss

(2008) M. F. Gregor et al.   DIABETES

Heat Treatment Improves Glucose Tolerance and Prevents Skeletal Muscle Insulin Resistance in Rats Fed a High-Fat Diet

(2008) A. A. Gupte et al.   DIABETES

Role of JNK Translocation to Mitochondria Leading to Inhibition of Mitochondria Bioenergetics in Acetaminophen-induced Liver Injury

(2008) Naoko Hanawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Trained Men Display Increased Basal Heat Shock Protein Content of Skeletal Muscle

(2008) JAMES P. MORTON et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Mild Electrical Stimulation with Heat Shock Ameliorates Insulin Resistance via Enhanced Insulin Signaling

(2008) Saori Morino et al.   PLoS One

HSP72 protects against obesity-induced insulin resistance

(2008) J. Chung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Hepatic Lipogenesis by the Transcription Factor XBP1

(2008) A.-H. Lee et al.   SCIENCE

Heat shock protein 72 : release and biological significance during exercise

(2007) Martin Whitham   Frontiers in Bioscience-Landmark

Activation and Dysregulation of the Unfolded Protein Response in Nonalcoholic Fatty Liver Disease

(2007) Puneet Puri et al.   GASTROENTEROLOGY