Insights for Oxidative Stress and mTOR Signaling in Myocardial Ischemia/Reperfusion Injury under Diabetes

Executive Summary: Heart Disease and Stroke Statistics—2016 Update

(2016) Dariush Mozaffarian et al.   CIRCULATION

AMPK in cardiac fibrosis and repair: Actions beyond metabolic regulation

(2016) Evangelos P. Daskalopoulos et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

C1q/TNF-Related Protein 9 Protects Diabetic Rat Heart against Ischemia Reperfusion Injury: Role of Endoplasmic Reticulum Stress

(2016) Sanxing Bai et al.   Oxidative Medicine and Cellular Longevity

Metformin Protects H9C2 Cardiomyocytes from High-Glucose and Hypoxia/Reoxygenation Injury via Inhibition of Reactive Oxygen Species Generation and Inflammatory Responses: Role of AMPK and JNK

(2016) Mingyan Hu et al.   Journal of Diabetes Research

Cardiac mTOR rescues the detrimental effects of diet-induced obesity in the heart after ischemia-reperfusion

(2015) Toshinori Aoyagi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Inhibition of mammalian target of rapamycin protects against reperfusion injury in diabetic heart through STAT3 signaling

(2015) Anindita Das et al.   BASIC RESEARCH IN CARDIOLOGY

Endoplasmic reticulum stress and protein quality control in diabetic cardiomyopathy

(2015) Lifang Yang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Targeting molecules to medicine with mTOR, autophagy and neurodegenerative disorders

(2015) Kenneth Maiese   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Acute hyperglycemia abolishes cardioprotection by remote ischemic perconditioning

(2015) Tamás Baranyai et al.   Cardiovascular Diabetology

Oxidative stress, mitochondrial and proteostasis malfunction in adrenoleukodystrophy: A paradigm for axonal degeneration

(2015) Stéphane Fourcade et al.   FREE RADICAL BIOLOGY AND MEDICINE

Lin28a protects against cardiac ischaemia/reperfusion injury in diabetic mice through the insulin-PI3K-mTOR pathway

(2015) Mingming Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

C1q/Tumor Necrosis Factor-Related Protein 9 Protects against Acute Myocardial Injury through an Adiponectin Receptor I-AMPK-Dependent Mechanism

(2015) Takahiro Kambara et al.   MOLECULAR AND CELLULAR BIOLOGY

Troponin and Cardiac Events in Stable Ischemic Heart Disease and Diabetes

(2015) Brendan M. Everett et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lixisenatide in Patients with Type 2 Diabetes and Acute Coronary Syndrome

(2015) Marc A. Pfeffer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hydrogen sulfide attenuates high fat diet-induced cardiac dysfunction via the suppression of endoplasmic reticulum stress

(2015) Larry A. Barr et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Cardiac-specific overexpression of metallothionein attenuates myocardial remodeling and contractile dysfunction in l-NAME-induced experimental hypertension: Role of autophagy regulation

(2015) Lifang Yang et al.   TOXICOLOGY LETTERS

The Cardioprotection of the Insulin-Mediated PI3K/Akt/mTOR Signaling Pathway

(2014) Hong Yao et al.   American Journal of Cardiovascular Drugs

Targeted deletion of C1q/TNF-related protein 9 increases food intake, decreases insulin sensitivity, and promotes hepatic steatosis in mice

(2014) Zhikui Wei et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

MicroRNA-144 is a circulating effector of remote ischemic preconditioning

(2014) Jing Li et al.   BASIC RESEARCH IN CARDIOLOGY

Left ventricular diastolic dysfunction and myocardial stiffness in diabetic mice is attenuated by inhibition of dipeptidyl peptidase 4

(2014) N. Hamdani et al.   CARDIOVASCULAR RESEARCH

Arachidonate 12/15-Lipoxygenase–Induced Inflammation and Oxidative Stress Are Involved in the Development of Diabetic Cardiomyopathy

(2014) Hirofumi Suzuki et al.   DIABETES

Metformin Protects Against Systolic Overload–Induced Heart Failure Independent of AMP-Activated Protein Kinase α2

(2014) Xin Xu et al.   HYPERTENSION

Leptin induces cardiac fibrosis through galectin-3, mTOR and oxidative stress

(2014) Ernesto Martínez-Martínez et al.   JOURNAL OF HYPERTENSION

NAD+ and sirtuins in aging and disease

(2014) Shin-ichiro Imai et al.   TRENDS IN CELL BIOLOGY

Src-dependent impairment of autophagy by oxidative stress in a mouse model of Duchenne muscular dystrophy

(2014) Rituraj Pal et al.   Nature Communications

CTRP9 transgenic mice are protected from diet-induced obesity and metabolic dysfunction

(2013) Jonathan M. Peterson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Mitophagy Is Required for Acute Cardioprotection by Simvastatin

(2013) Allen M. Andres et al.   ANTIOXIDANTS & REDOX SIGNALING

Role of AMPK-mediated adaptive responses in human cells with mitochondrial dysfunction to oxidative stress

(2013) Shi-Bei Wu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Adiponectin knockout accentuates high fat diet-induced obesity and cardiac dysfunction: Role of autophagy

(2013) Rui Guo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Duration of Rapamycin Treatment Has Differential Effects on Metabolism in Mice

(2013) Yimin Fang et al.   Cell Metabolism

Mechanistic Target of Rapamycin Complex 2 Protects the Heart From Ischemic Damage

(2013) Mirko Völkers et al.   CIRCULATION

Endothelial Loss and Repair in the Vascular Complications of Diabetes

(2013) Richard E. Gilbert   CIRCULATION JOURNAL

Insulin Stimulates Mitochondrial Fusion and Function in Cardiomyocytes via the Akt-mTOR-NF B-Opa-1 Signaling Pathway

(2013) V. Parra et al.   DIABETES

Evaluation of Subclinical Left Ventricular Dysfunction in Diabetic Patients: Longitudinal Strain Velocities and Left Ventricular Dyssynchrony by Two-Dimensional Speckle Tracking Echocardiography Study

(2013) Arezoo Zoroufian et al.   ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES

Regulation of mTORC1 and its impact on gene expression at a glance

(2013) M. Laplante et al.   JOURNAL OF CELL SCIENCE

Acute hyperglycaemia enhances oxidative stress and aggravates myocardial ischaemia/reperfusion injury: role of thioredoxin-interacting protein

(2013) Hui Su et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

mTOR is a key modulator of ageing and age-related disease

(2013) Simon C. Johnson et al.   NATURE

A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS

(2013) Jiangwei Zhang et al.   NATURE CELL BIOLOGY

Glucose Regulation of Load‐Induced mTOR Signaling and ER Stress in Mammalian Heart

(2013) Shiraj Sen et al.   Journal of the American Heart Association

Cardiac mTOR protects the heart against ischemia-reperfusion injury

(2012) Toshinori Aoyagi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Suppression of autophagy is protective in high glucose-induced cardiomyocyte injury

(2012) Satoru Kobayashi et al.   Autophagy

Inhibition of CTRP9, a novel and cardiac-abundantly expressed cell survival molecule, by TNFα-initiated oxidative signaling contributes to exacerbated cardiac injury in diabetic mice

(2012) Hui Su et al.   BASIC RESEARCH IN CARDIOLOGY

Effects of diabetes on myocardial infarct size and cardioprotection by preconditioning and postconditioning

(2012) Takayuki Miki et al.   Cardiovascular Diabetology

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

The pathways of mitophagy for quality control and clearance of mitochondria

(2012) G Ashrafi et al.   CELL DEATH AND DIFFERENTIATION

Rheb is a Critical Regulator of Autophagy During Myocardial Ischemia

(2012) Sebastiano Sciarretta et al.   CIRCULATION

Association of Polymorphic Markers of the Catalase and Superoxide Dismutase Genes with Type 2 Diabetes Mellitus

(2012) Maivel H. Ghattas et al.   DNA AND CELL BIOLOGY

Time course of hydrogen peroxide-thioredoxin balance and its influence on the intracellular signalling in myocardial infarction

(2012) Paulo Cavalheiro Schenkel et al.   EXPERIMENTAL PHYSIOLOGY

CTRP9 Protein Protects against Myocardial Injury following Ischemia-Reperfusion through AMP-activated Protein Kinase (AMPK)-dependent Mechanism

(2012) Takahiro Kambara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapamycin protects against myocardial ischemia–reperfusion injury through JAK2–STAT3 signaling pathway

(2012) Anindita Das et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Matricellular Proteins in Cardiac Adaptation and Disease

(2012) Nikolaos G. Frangogiannis   PHYSIOLOGICAL REVIEWS

Cardiovascular Disease and mTOR Signaling

(2012) Zhao Zhong Chong et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Nox4-derived reactive oxygen species mediate cardiomyocyte injury in early type 1 diabetes

(2011) Rita M. Maalouf et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Diabetes Blockade of Sevoflurane Postconditioning Is Not Restored by Insulin in the Rat Heart

(2011) Benjamin Drenger et al.   ANESTHESIOLOGY

Visfatin exerts angiogenic effects on human umbilical vein endothelial cells through the mTOR signaling pathway

(2011) Joo-Won Park et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Azelnidipine prevents cardiac dysfunction in streptozotocin-diabetic rats by reducing intracellular calcium accumulation, oxidative stress and apoptosis

(2011) Vasundhara Kain et al.   Cardiovascular Diabetology

GSK-3β at the crossroads in the signalling of heart preconditioning: implication of mTOR and Wnt pathways

(2011) François Vigneron et al.   CARDIOVASCULAR RESEARCH

Hypercholesterolemia is associated with hyperactive cardiac mTORC1 and mTORC2 signaling

(2011) Hilary P. Glazer et al.   CELL CYCLE

Fine Tuning Our Cellular Factories: Sirtuins in Mitochondrial Biology

(2011) Lei Zhong et al.   Cell Metabolism

Cardiac Raptor Ablation Impairs Adaptive Hypertrophy, Alters Metabolic Gene Expression, and Causes Heart Failure in Mice

(2011) Pankaj Shende et al.   CIRCULATION

Long-term outcome after sirolimus-eluting stents versus bare metal stents in patients with Diabetes mellitus: a patient-level meta-analysis of randomized trials

(2011) Antoinette de Waha et al.   Clinical Research in Cardiology

Left ventricular systolic and diastolic function, remodelling, and clinical outcomes among patients with diabetes following myocardial infarction and the influence of direct renin inhibition with aliskiren

(2011) Amil M. Shah et al.   EUROPEAN JOURNAL OF HEART FAILURE

MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice

(2011) Denghong Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance

(2011) Rui-Hong Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

The cellular and molecular origin of reactive oxygen species generation during myocardial ischemia and reperfusion

(2011) Koen Raedschelders et al.   PHARMACOLOGY & THERAPEUTICS

Preconditioning Involves Selective Mitophagy Mediated by Parkin and p62/SQSTM1

(2011) Chengqun Huang et al.   PLoS One

Hyperactive S6K1 Mediates Oxidative Stress and Endothelial Dysfunction in Aging: Inhibition by Resveratrol

(2011) Angana G. Rajapakse et al.   PLoS One

Spinster is required for autophagic lysosome reformation and mTOR reactivation following starvation

(2011) Y. Rong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cigarette Smoke Components Induce Matrix Metalloproteinase-1 in Aortic Endothelial Cells through Inhibition of mTOR Signaling

(2011) Vincent Lemaître et al.   TOXICOLOGICAL SCIENCES

Aging and disease: connections to sirtuins

(2010) Gizem Donmez et al.   AGING CELL

AICAR treatment for 14 days normalizes obesity-induced dysregulation of TORC1 signaling and translational capacity in fasted skeletal muscle

(2010) Joshua C. Drake et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

PGC-1α Regulates Expression of Myocardial Mitochondrial Antioxidants and Myocardial Oxidative Stress After Chronic Systolic Overload

(2010) Zhongbing Lu et al.   ANTIOXIDANTS & REDOX SIGNALING

Reduced Cardioprotective Action of Adiponectin in High-Fat Diet–Induced Type II Diabetic Mice and Its Underlying Mechanisms

(2010) Wei Yi et al.   ANTIOXIDANTS & REDOX SIGNALING

Reperfusion Injury Salvage Kinase and Survivor Activating Factor Enhancement Prosurvival Signaling Pathways in Ischemic Postconditioning: Two Sides of the Same Coin

(2010) Derek J. Hausenloy et al.   ANTIOXIDANTS & REDOX SIGNALING

Diabetes mellitus abrogates erythropoietin-induced cardioprotection against ischemic-reperfusion injury by alteration of the RISK/GSK-3β signaling

(2010) Nehmat Ghaboura et al.   BASIC RESEARCH IN CARDIOLOGY

Metformin improves cardiac function in rats via activation of AMP-activated protein kinase

(2010) Xiao-Fang Wang et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Chronic Rapamycin Treatment Causes Glucose Intolerance and Hyperlipidemia by Upregulating Hepatic Gluconeogenesis and Impairing Lipid Deposition in Adipose Tissue

(2010) V. P. Houde et al.   DIABETES

Reversal of inducible nitric oxide synthase uncoupling unmasks tolerance to ischemia/reperfusion injury in the diabetic rat heart

(2010) Toru Okazaki et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Deficiency in AMP-activated protein kinase exaggerates high fat diet-induced cardiac hypertrophy and contractile dysfunction

(2010) Subat Turdi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Survivin: A novel player in insulin cardioprotection against myocardial ischemia/reperfusion injury

(2010) Rui Si et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cannabidiol Attenuates Cardiac Dysfunction, Oxidative Stress, Fibrosis, and Inflammatory and Cell Death Signaling Pathways in Diabetic Cardiomyopathy

(2010) Mohanraj Rajesh et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Ischemic post-conditioning reduces infarct size of the in vivo rat heart: role of PI3-K, mTOR, GSK-3β, and apoptosis

(2010) Claudia Wagner et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Cardioprotection by ischemic postconditioning is abolished in depressed rats: role of Akt and signal transducer and activator of transcription-3

(2010) Chuanjun Zhuo et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Redox-sensitive prosurvival and proapoptotic protein expression in the myocardial remodeling post-infarction in rats

(2010) Paulo Cavalheiro Schenkel et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Termination of autophagy and reformation of lysosomes regulated by mTOR

(2010) Li Yu et al.   NATURE

S-glutathionylation uncouples eNOS and regulates its cellular and vascular function

(2010) Chun-An Chen et al.   NATURE

Mammalian life-span determinant p66shcA mediates obesity-induced insulin resistance

(2010) S. C. Ranieri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxidative stress in skeletal muscle impairs mitochondrial respiration and limits exercise capacity in type 2 diabetic mice

(2009) Takashi Yokota et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Rapamycin inhibits mTORC1, but not completely

(2009) Carson C. Thoreen et al.   Autophagy

High glucose sensitizes adult cardiomyocytes to ischaemia/reperfusion injury through nitrative thioredoxin inactivation

(2009) R. Luan et al.   CARDIOVASCULAR RESEARCH

AMP-Activated Protein Kinase Deficiency Enhances Myocardial Ischemia/Reperfusion Injury but Has Minimal Effect on the Antioxidant/Antinitrative Protection of Adiponectin

(2009) Yajing Wang et al.   CIRCULATION

Endoplasmic Reticulum Stress in Diabetic Hearts Abolishes Erythropoietin-Induced Myocardial Protection by Impairment of Phospho–Glycogen Synthase Kinase-3β–Mediated Suppression of Mitochondrial Permeability Transition

(2009) Takayuki Miki et al.   DIABETES

Activation of the protective Survivor Activating Factor Enhancement (SAFE) pathway against reperfusion injury: Does it go beyond the RISK pathway?

(2009) Sandrine Lecour   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Polyol pathway impairs the function of SERCA and RyR in ischemic-reperfused rat hearts by increasing oxidative modifications of these proteins

(2009) Wai Ho Tang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Substrate-Specific Derangements in Mitochondrial Metabolism and Redox Balance in the Atrium of the Type 2 Diabetic Human Heart

(2009) Ethan J. Anderson et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The Pathologic Continuum of Diabetic Vascular Disease

(2009) Gabriela Orasanu et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

(2009) Chang Hwa Jung et al.   MOLECULAR BIOLOGY OF THE CELL

Aldose reductase mediates myocardial ischemia-reperfusion injury in part by opening mitochondrial permeability transition pore

(2008) Radha Ananthakrishnan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Changes in Risk Variables of Metabolic Syndrome Since Childhood in Pre-Diabetic and Type 2 Diabetic Subjects: The Bogalusa Heart Study

(2008) Q. M. Nguyen et al.   DIABETES CARE

The Role for Endoplasmic Reticulum Stress in Diabetes Mellitus

(2008) Décio L. Eizirik et al.   ENDOCRINE REVIEWS

mTOR-Raptor Binds and Activates SGK1 to Regulate p27 Phosphorylation

(2008) Feng Hong et al.   MOLECULAR CELL

Biomarkers in Heart Failure

(2008) Eugene Braunwald   NEW ENGLAND JOURNAL OF MEDICINE

Oxidative Stress Triggers Cardiac Fibrosis in the Heart of Diabetic Rats

(2007) Manuela Aragno et al.   ENDOCRINOLOGY