Article
Food Science & Technology
Paulina Patalas-Krawczyk, Dominika Malinska, Jaroslaw Walczak, Gilles Kratzer, Monika Prill, Bernadeta Michalska, Karolina Drabik, Bjorn Titz, Yvan Eb-Levadoux, Thomas Schneider, Jedrzej Szymanski, Julia Hoeng, Manuel C. Peitsch, Jerzy Duszynski, Joanna Szczepanowska, Marco Van der Toorn, Carole Mathis, Mariusz R. Wieckowski
Summary: Mitochondria play an important role in responding to stress factors, and alkaloids from tobacco plants such as nicotine, anatabine, and anabasine can modulate mitochondrial activities differently in mouse brain and liver tissues. These alkaloids affect mitochondrial bioenergetics parameters, including oxygen consumption and swelling rates, with potential toxic effects observed in liver mitochondria. The observed effects are likely independent of nicotinic acetylcholine receptors based on quantitative proteomic analysis.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Xavier R. Chapa-Dubocq, Keishla M. Rodriguez-Graciani, Nelson Escobales, Sabzali Javadov
Summary: Mitochondria, known as the powerhouse of the cell, regulate various cellular processes including ion homeostasis, energy production, and cell death. The inner mitochondrial membrane (IMM) plays a critical role in controlling mitochondrial metabolism and function. The volume of the mitochondrial matrix, regulated by ion transport mechanisms, influences IMM remodeling and can affect mitochondrial respiration and cell survival. Despite extensive research, the mechanisms underlying changes in matrix volume and IMM remodeling in response to energy and oxidative stressors remain poorly understood. This review summarizes previous studies and discusses the interplay between matrix volume regulation and IMM remodeling.
Review
Biochemistry & Molecular Biology
Hagai Rottenberg
Summary: It is widely reported that the mitochondrial membrane potential, increment ψm, is reduced in aging animals. It was recently suggested that the lower increment ψm in aged animals modulates mitochondrial bioenergetics and that this effect is a major cause of aging since artificially increased increment ψm in C. elegans increased lifespan. The activation of the voltage-gated mitochondrial permeability transition pore (mPTP) is the main cause of the increase in depolarized mitochondria in aged cells, inhibiting oxidative phosphorylation, releasing calcium and mROS, and depleting NAD(+), thereby accelerating degenerative diseases and aging. The reported lifespan extension by artificially generated increment ψm in C. elegans is best explained by inhibition of the voltage-gated mPTP.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Giampaolo Morciano, Natalia Naumova, Piotr Koprowski, Sara Valente, Vilma A. Sardao, Yaiza Potes, Alessandro Rimessi, Mariusz R. Wieckowski, Paulo J. Oliveira
Summary: This review summarizes the intriguing phenomenon of the mitochondrial permeability transition pore (mPTP) in cell biology. Despite almost 50 years of research, the mechanisms of mPTP are still not definitively understood. From initially being considered an in vitro artifact to now being recognized for its physiological and pathological implications, the journey of mPTP research has been long and complex.
BIOLOGICAL REVIEWS
(2021)
Article
Pharmacology & Pharmacy
Tatiana A. Fedotcheva, Olga P. Sheichenko, Nadezhda I. Fedotcheva
Summary: Agrimoniin, a polyphenol with antioxidant and anticancer activities, has been found to influence mitochondrial functions through various pathways, including apoptosis activation and mitochondrial function stimulation.
Article
Multidisciplinary Sciences
Vincenzo Algieri, Cristina Algieri, Loredana Maiuolo, Antonio De Nino, Alessandra Pagliarani, Matteo Antonio Tallarida, Fabiana Trombetti, Salvatore Nesci
Summary: The study identified two 1,5-disubstituted 1,2,3-triazole derivatives that inhibit the opening of the mitochondrial permeability transition pore without affecting mitochondrial respiration.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Cristina Algieri, Fabiana Trombetti, Alessandra Pagliarani, Micaela Fabbri, Salvatore Nesci
Summary: The study found that gadolinium has a strong inhibitory effect on both the mitochondrial Ca2+-activated F1FO-ATPase and the PTP, strengthening the link between the two. This provides new insights into the biological effects of Gd3+.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Eilam Palzur, Doron Edelman, Reem Sakas, Jean Francois Soustiel
Summary: The study demonstrates that etifoxine exerts significant neuroprotective effects after traumatic brain injury by restoring mitochondrial function and improving behavioral and cognitive outcomes. This suggests that etifoxine may be a promising candidate for further clinical trials in TBI patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Cristina Algieri, Chiara Bernardini, Saverio Marchi, Maurizio Forte, Matteo Antonio Tallarida, Franca Bianchi, Debora La Mantia, Vincenzo Algieri, Rosita Stanzione, Maria Cotugno, Paola Costanzo, Fabiana Trombetti, Loredana Maiuolo, Monica Forni, Antonio De Nino, Flavio Di Nonno, Sebastiano Sciarretta, Massimo Volpe, Speranza Rubattu, Salvatore Nesci
Summary: Small molecules of triazole derivatives (Tzs) rescue compromised cardiovascular cells by preventing mitochondrial dysfunction. The protective effect of Tzs on mitochondria and cell metabolism was confirmed, leading to improved cell viability. These findings have important implications for the treatment of cardiovascular diseases.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
George Domingues, Jorge Moraes, Rodrigo Nunes da Fonseca, Eldo Campos
Summary: This study found that polyP enhances the activity of electron transport chain enzymes and F1Fo ATP synthase in tick embryos during embryonic development. Long and medium polyP chains (polyP(15) and polyP(65)) increased the activity of complex I, complex II, complex III, and F1Fo ATP synthase, while short polyP chains (polyP(3)) had no effect. The study also demonstrated that PPX activity is stimulated in low-energy conditions and is decreased when inhibitors of complexes I-III and F1Fo ATP synthase are added in energized mitochondria. Furthermore, polyP causes mitochondrial swelling by increasing the effects of calcium on the mitochondrial permeability transition pore.
ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Salvatore Nesci, Cristina Algieri, Fabiana Trombetti, Vittoria Ventrella, Micaela Fabbri, Alessandra Pagliarani
Summary: The study reveals that H2S affects the activity of specific enzymes in mitochondria, leading to respiratory chain inhibition and reduced membrane potential, thereby impacting oxidative phosphorylation process.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Cell Biology
Artyom Y. Baev, Andrey Y. Vinokurov, Irina N. Novikova, Viktor V. Dremin, Elena V. Potapova, Andrey Y. Abramov
Summary: Neurodegenerative disorders are devastating diseases characterized by the loss of neurons in specific brain regions. Recent research has identified genes, toxins, and risk factors associated with these diseases, and has found similarities in the involvement of mitochondria, oxidative stress, and abnormal calcium signaling in neurons and astrocytes.
Review
Pharmacology & Pharmacy
Faustino Mollinedo, Consuelo Gajate
Summary: Edelfosine, an ether lipid, selectively induces apoptosis in tumor cells by interacting with cholesterol-rich lipid rafts, endoplasmic reticulum (ER), and mitochondria. Its mechanism involves recruitment of death receptors and ER stress signaling through lipid rafts in hematological cancer cells, and ER stress response in solid tumor cells. The involvement of lipid rafts and/or ER in edelfosine-induced apoptosis requires a mitochondrial-dependent step leading to cell death. Overexpression of Bcl-2 or Bcl-xL blocks this process. Additionally, edelfosine redistributes lipid rafts to mitochondria and recruits F1FO-ATP synthase into cholesterol-rich lipid rafts to induce cell death.
Article
Biochemistry & Molecular Biology
Yisang Yoon, Hakjoo Lee, Marilen Federico, Shey-Shing Sheu
Summary: Mitochondrial permeability transition (MPT) is a phenomenon that leads to mitochondrial dysfunction and cell injury. The opening of a mega-channel called the permeability transition pore (PTP) is responsible for MPT. Mitochondrial fission and fusion play a role in regulating MPT. There may also exist a non-conventional form of MPT that is insensitive to certain inhibitors.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
(2023)
Article
Biochemistry & Molecular Biology
Maria Jose Perez, Rodrigo Ibarra-Garcia-Padilla, Maoping Tang, George A. Porter Jr, Gail V. W. Johnson, Rodrigo A. Quintanilla
Summary: The cleavage of tau protein by Caspase-3 negatively affects mitochondrial bioenergetics through the activation of mitochondrial permeability transition pore (mPTP), emphasizing the importance of this channel and its regulatory protein, cyclophilin D (CypD), in neuronal damage induced by tau pathology in Alzheimer's disease.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Editorial Material
Biochemical Research Methods
Ravichandran Ramasamy, Richard A. Friedman, Alexander Shekhtman, Ann Marie Schmidt
EXPERT REVIEW OF PROTEOMICS
(2019)
Editorial Material
Cardiac & Cardiovascular Systems
Gautham Yepuri, Ravichandran Ramasamy
CIRCULATION RESEARCH
(2019)
Editorial Material
Hematology
Henry H. Ruiz, Raquel Lopez Diez, Lakshmi Arivazahagan, Ravichandran Ramasamy, Ann Marie Schmidt
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Michael MacLean, Julia Derk, Henry H. Ruiz, Judyta K. Juranek, Ravichandran Ramasamy, Ann Marie Schmidt
NEUROCHEMISTRY INTERNATIONAL
(2019)
Meeting Abstract
Cardiac & Cardiovascular Systems
Riccardo Perfetti, Philana Rowell, Shoshana Shendelman, Francesca Lawson, Ravichandran Ramasamy
JOURNAL OF CARDIAC FAILURE
(2019)
Review
Endocrinology & Metabolism
Henry H. Ruiz, Ravichandran Ramasamy, Ann Marie Schmidt
Meeting Abstract
Endocrinology & Metabolism
R. Perfetti, G. Yeppuri, N. Quadri, R. Ramasamy, S. Shendelman
METABOLISM-CLINICAL AND EXPERIMENTAL
(2020)
Article
Cardiac & Cardiovascular Systems
Lakshmi Arivazhagan, Henry H. Ruiz, Robin A. Wilson, Michaele B. Manigrasso, Paul F. Gugger, Edward A. Fisher, Kathryn J. Moore, Ravichandran Ramasamy, Ann Marie Schmidt
CIRCULATION RESEARCH
(2020)
Article
Multidisciplinary Sciences
Monika Sharma, Ludovic Boytard, Tarik Hadi, Graeme Koelwyn, Russell Simon, Mireille Ouimet, Lena Seifert, Westley Spiro, Bo Yan, Susan Hutchison, Edward A. Fisher, Ravichandran Ramasamy, Bhama Ramkhelawon, Kathryn J. Moore
SCIENTIFIC REPORTS
(2020)
Review
Hematology
Bernard S. Kadosh, Michael S. Garshick, Juan Gaztanaga, Kathryn J. Moore, Jonathan D. Newman, Michael Pillinger, Ravichandran Ramasamy, Harmony R. Reynolds, Binita Shah, Judith Hochman, Glenn Fishman, Stuart D. Katz
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2020)
Article
Medicine, Research & Experimental
Laura Senatus, Raquel Lopez-Diez, Lander Egana-Gorrono, Jianhua Liu, Jiyuan Hu, Gurdip Daffu, Qing Li, Karishma Rahman, Yuliya Vengrenyuk, Tessa J. Barrett, M. Zahidunnabi Dewan, Liang Guo, Daniela Fuller, Aloke Finn, Renu Virmani, Huilin Li, Richard A. Friedman, Edward A. Fisher, Ravichandran Ramasamy, Ann Marie Schmidt
Review
Hematology
Divya Roy, Ravichandran Ramasamy, Ann Marie Schmidt
Summary: The SARS-CoV-2 pandemic continues to affect millions globally, with no definitive cures or preventative measures available. Identifying the pathobiological mechanisms is urgent to understand the increased risk and severity of infection.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Raquel Lopez-Diez, Lander Egana-Gorrono, Laura Senatus, Alexander Shekhtman, Ravichandran Ramasamy, Ann Marie Schmidt
Summary: This review highlights the cardiovascular complications of diabetes, efforts in glycemic control, and the potential benefits and drawbacks of intensive glycemic control. The role of epigenetics, gene expression, interferon networks, mitochondrial dysfunction in driving cardiovascular disorders in diabetes is discussed, along with updates on cardioprotective therapies for hyperglycemia. Ongoing research is providing new therapeutic opportunities in diabetes and cardiovascular diseases.
CURRENT CARDIOLOGY REPORTS
(2021)
Review
Cardiac & Cardiovascular Systems
Lander Egana-Gorrono, Raquel Lopez-Diez, Gautham Yepuri, Lisa S. Ramirez, Sergey Reverdatto, Paul F. Gugger, Alexander Shekhtman, Ravichandran Ramasamy, Ann Marie Schmidt
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2020)
Article
Endocrinology & Metabolism
Abdishakur Abdulle, Claire K. Inman, Abdelkarim Saleh, Mohamed Noshi, Divya Galani, Laila Abdelwareth, Habiba Alsafar, Abubaker Elfatih, Hefsa Al Shamsi, Raghib Ali, Huilin Li, Ravichandran Ramasamy, Ann Marie Schmidt, Mahmoud M. Benbarka, Mohamed H. Hassan
JOURNAL OF CLINICAL AND TRANSLATIONAL ENDOCRINOLOGY
(2019)