Human brown adipose tissue as a target for obesity management; beyond cold-induced thermogenesis
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Title
Human brown adipose tissue as a target for obesity management; beyond cold-induced thermogenesis
Authors
Keywords
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Journal
Obesity Reviews
Volume 18, Issue 11, Pages 1227-1242
Publisher
Wiley
Online
2017-07-14
DOI
10.1111/obr.12584
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Related references
Note: Only part of the references are listed.- Hot heads & cool bodies: The conundrums of human brown adipose tissue (BAT) activity research
- (2017) Lonneke Bahler et al. European Journal of Internal Medicine
- Thyroid hormones and browning of adipose tissue
- (2017) Juliane Weiner et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Brown adipose tissue does not seem to mediate metabolic adaptation to overfeeding in men
- (2017) Courtney M. Peterson et al. Obesity
- Factors involved in white-to-brown adipose tissue conversion and in thermogenesis: a review
- (2017) T. Montanari et al. Obesity Reviews
- Variable Cold-Induced Brown Adipose Tissue Response to Thyroid Hormone Status
- (2017) Alina Gavrila et al. THYROID
- Mirabegron for the treatment of overactive bladder: a review of efficacy, safety and tolerability with a focus on male, elderly and antimuscarinic poor-responder populations, and patients with OAB in Asia
- (2017) Christopher R Chapple et al. Expert Review of Clinical Pharmacology
- Metabolic activity of brown, “beige,” and white adipose tissues in response to chronic adrenergic stimulation in male mice
- (2016) Sébastien M. Labbé et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Activation and recruitment of brown adipose tissue by cold exposure and food ingredients in humans
- (2016) Masayuki Saito et al. BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
- Brown Adipose Tissue Exhibits a Glucose-Responsive Thermogenic Biorhythm in Humans
- (2016) Paul Lee et al. Cell Metabolism
- Glucocorticoids Acutely Increase Brown Adipose Tissue Activity in Humans, Revealing Species-Specific Differences in UCP-1 Regulation
- (2016) Lynne E. Ramage et al. Cell Metabolism
- Eulogy for the Metabolic Clinical Investigator?
- (2016) Adrian Vella et al. DIABETES
- Combatting type 2 diabetes by turning up the heat
- (2016) Patrick Schrauwen et al. DIABETOLOGIA
- MECHANISMS IN ENDOCRINOLOGY: Brown adipose tissue in humans: regulation and metabolic significance
- (2016) Moe Thuzar et al. EUROPEAN JOURNAL OF ENDOCRINOLOGY
- Brown adipose tissue is involved in diet-induced thermogenesis and whole-body fat utilization in healthy humans
- (2016) M Hibi et al. INTERNATIONAL JOURNAL OF OBESITY
- Diabetes mellitus statistics on prevalence and mortality: facts and fallacies
- (2016) Paul Zimmet et al. Nature Reviews Endocrinology
- Brown adipose tissue as a secretory organ
- (2016) Francesc Villarroya et al. Nature Reviews Endocrinology
- Control of brown and beige fat development
- (2016) Wenshan Wang et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Thyroid Hormone Activates Brown Adipose Tissue and Increases Non-Shivering Thermogenesis - A Cohort Study in a Group of Thyroid Carcinoma Patients
- (2016) Evie P. M. Broeders et al. PLoS One
- Activation of Human Brown Adipose Tissue by a β3-Adrenergic Receptor Agonist
- (2015) Aaron M. Cypess et al. Cell Metabolism
- Brown and Beige Fat: Physiological Roles beyond Heat Generation
- (2015) Shingo Kajimura et al. Cell Metabolism
- The impact of low-protein high-carbohydrate diets on aging and lifespan
- (2015) David G. Le Couteur et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Brown and Beige Fat: Molecular Parts of a Thermogenic Machine
- (2015) Paul Cohen et al. DIABETES
- Short-term Cold Acclimation Recruits Brown Adipose Tissue in Obese Humans
- (2015) Mark J.W. Hanssen et al. DIABETES
- Chronic ephedrine administration decreases brown adipose tissue activity in a randomised controlled human trial: implications for obesity
- (2015) Andrew L. Carey et al. DIABETOLOGIA
- Low brown adipose tissue activity in endurance-trained compared with lean sedentary men
- (2015) M J Vosselman et al. INTERNATIONAL JOURNAL OF OBESITY
- Characterization of brown adipose tissue by water-fat separated magnetic resonance imaging
- (2015) Thobias Romu et al. JOURNAL OF MAGNETIC RESONANCE IMAGING
- Brown adipose tissue - not as hot as we thought
- (2015) Michael D. Jensen JOURNAL OF PHYSIOLOGY-LONDON
- Clonal analyses and gene profiling identify genetic biomarkers of the thermogenic potential of human brown and white preadipocytes
- (2015) Ruidan Xue et al. NATURE MEDICINE
- Genetic and functional characterization of clonally derived adult human brown adipocytes
- (2015) Kosaku Shinoda et al. NATURE MEDICINE
- Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus
- (2015) Mark J W Hanssen et al. NATURE MEDICINE
- FTO Obesity Variant Circuitry and Adipocyte Browning in Humans
- (2015) Melina Claussnitzer et al. NEW ENGLAND JOURNAL OF MEDICINE
- The thermogenic responses to overfeeding and cold are differentially regulated
- (2015) Courtney M. Peterson et al. Obesity
- Brown adipose tissue: what have we learned since its recent identification in human adults
- (2015) Bruno Halpern et al. Arquivos Brasileiros de Endocrinologia e Metabologia
- Meteorin-like Is a Hormone that Regulates Immune-Adipose Interactions to Increase Beige Fat Thermogenesis
- (2014) Rajesh R. Rao et al. CELL
- What We Talk About When We Talk About Fat
- (2014) Evan D. Rosen et al. CELL
- The Browning of White Adipose Tissue: Some Burning Issues
- (2014) Jan Nedergaard et al. Cell Metabolism
- Irisin and FGF21 Are Cold-Induced Endocrine Activators of Brown Fat Function in Humans
- (2014) Paul Lee et al. Cell Metabolism
- Temperature-Acclimated Brown Adipose Tissue Modulates Insulin Sensitivity in Humans
- (2014) Paul Lee et al. DIABETES
- The effects of thyroid hormones on brown adipose tissue in humans: a PET-CT study
- (2014) Qiongyue Zhang et al. DIABETES-METABOLISM RESEARCH AND REVIEWS
- Presence of Brown Adipose Tissue in an Adolescent With Severe Primary Hypothyroidism
- (2014) Mimi S. Kim et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Increased Brown Adipose Tissue Oxidative Capacity in Cold-Acclimated Humans
- (2014) Denis P. Blondin et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Effects of glucocorticoids on human brown adipocytes
- (2014) Johanna L Barclay et al. JOURNAL OF ENDOCRINOLOGY
- Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013
- (2014) Marie Ng et al. LANCET
- Twelve-year weight change, waist circumference change and incident obesity: The Australian diabetes, obesity and lifestyle study
- (2014) Stephanie K. Tanamas et al. Obesity
- Effect of Intermittent Cold Exposure on Brown Fat Activation, Obesity, and Energy Homeostasis in Mice
- (2014) Yann Ravussin et al. PLoS One
- Meta-Analysis Reveals the Association of Common Variants in the Uncoupling Protein (UCP) 1–3 Genes with Body Mass Index Variability
- (2014) Letícia A. Brondani et al. PLoS One
- Brown adipose tissue activity after a high-calorie meal in humans
- (2013) Maarten J Vosselman et al. AMERICAN JOURNAL OF CLINICAL NUTRITION
- Retinoic acid has different effects on UCP1 expression in mouse and human adipocytes
- (2013) Maria Murholm et al. BMC CELL BIOLOGY
- A Classical Brown Adipose Tissue mRNA Signature Partly Overlaps with Brite in the Supraclavicular Region of Adult Humans
- (2013) Naja Zenius Jespersen et al. Cell Metabolism
- Overfeeding Over 24 Hours Does Not Activate Brown Adipose Tissue in Humans
- (2013) Mathias Schlögl et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Hyperthyroidism Increases Brown Fat Metabolism in Humans
- (2013) Minna Lahesmaa et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Recruited brown adipose tissue as an antiobesity agent in humans
- (2013) Takeshi Yoneshiro et al. JOURNAL OF CLINICAL INVESTIGATION
- Cold acclimation recruits human brown fat and increases nonshivering thermogenesis
- (2013) Anouk A.J.J. van der Lans et al. JOURNAL OF CLINICAL INVESTIGATION
- 15O PET Measurement of Blood Flow and Oxygen Consumption in Cold-Activated Human Brown Fat
- (2013) O. Muzik et al. JOURNAL OF NUCLEAR MEDICINE
- Bi-directional interconversion of brite and white adipocytes
- (2013) Matthias Rosenwald et al. NATURE CELL BIOLOGY
- Tracking adipogenesis during white adipose tissue development, expansion and regeneration
- (2013) Qiong A Wang et al. NATURE MEDICINE
- Evidence for two types of brown adipose tissue in humans
- (2013) Martin E Lidell et al. NATURE MEDICINE
- PPARγ signaling and metabolism: the good, the bad and the future
- (2013) Maryam Ahmadian et al. NATURE MEDICINE
- Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat
- (2013) Aaron M Cypess et al. NATURE MEDICINE
- Blunted metabolic responses to cold and insulin stimulation in brown adipose tissue of obese humans
- (2013) Janne Orava et al. Obesity
- Brown adipose tissue in humans: Therapeutic potential to combat obesity
- (2013) Andrew L. Carey et al. PHARMACOLOGY & THERAPEUTICS
- Thermogenic Ability of Uncoupling Protein 1 in Beige Adipocytes in Mice
- (2013) Yuko Okamatsu-Ogura et al. PLoS One
- UCP1 in Brite/Beige Adipose Tissue Mitochondria Is Functionally Thermogenic
- (2013) Irina G. Shabalina et al. Cell Reports
- Nonpungent capsaicin analogs (capsinoids) increase energy expenditure through the activation of brown adipose tissue in humans
- (2012) Takeshi Yoneshiro et al. AMERICAN JOURNAL OF CLINICAL NUTRITION
- Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human
- (2012) Jun Wu et al. CELL
- PPARγ agonists Induce a White-to-Brown Fat Conversion through Stabilization of PRDM16 Protein
- (2012) Haruya Ohno et al. Cell Metabolism
- In Vivo Identification of Bipotential Adipocyte Progenitors Recruited by β3-Adrenoceptor Activation and High-Fat Feeding
- (2012) Yun-Hee Lee et al. Cell Metabolism
- Brown Adipose Tissue
- (2012) Charmaine S. Tam et al. CIRCULATION
- A sympathetic view of human obesity
- (2012) Elisabeth A. Lambert et al. CLINICAL AUTONOMIC RESEARCH
- Proarrhythmic Safety of Repeat Doses of Mirabegron in Healthy Subjects: A Randomized, Double-Blind, Placebo-, and Active-Controlled Thorough QT Study
- (2012) M Malik et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Systemic -Adrenergic Stimulation of Thermogenesis Is Not Accompanied by Brown Adipose Tissue Activity in Humans
- (2012) M. J. Vosselman et al. DIABETES
- Ephedrine activates brown adipose tissue in lean but not obese humans
- (2012) A. L. Carey et al. DIABETOLOGIA
- Increase in Brown Adipose Tissue Activity after Weight Loss in Morbidly Obese Subjects
- (2012) G. H. E. J. Vijgen et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans
- (2012) Véronique Ouellet et al. JOURNAL OF CLINICAL INVESTIGATION
- A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
- (2012) Pontus Boström et al. NATURE
- Human BAT Possesses Molecular Signatures That Resemble Beige/Brite Cells
- (2012) Louis Z. Sharp et al. PLoS One
- Cold but not sympathomimetics activates human brown adipose tissue in vivo
- (2012) A. M. Cypess et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Not so hot: Optimal housing temperatures for mice to mimic the thermal environment of humans
- (2012) John R. Speakman et al. Molecular Metabolism
- Triiodothyronine induces UCP-1 expression and mitochondrial biogenesis in human adipocytes
- (2011) Joo-Young Lee et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Implications of nonshivering thermogenesis for energy balance regulation in humans
- (2011) Wouter D. van Marken Lichtenbelt et al. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
- Different Metabolic Responses of Human Brown Adipose Tissue to Activation by Cold and Insulin
- (2011) Janne Orava et al. Cell Metabolism
- Brown adipose tissue activity controls triglyceride clearance
- (2011) Alexander Bartelt et al. NATURE MEDICINE
- Brown Adipose Tissue in Morbidly Obese Subjects
- (2011) Guy H. E. J. Vijgen et al. PLoS One
- Short-term endurance training does not alter the oxidative capacity of human subcutaneous adipose tissue
- (2010) Donny M. Camera et al. EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
- Metabolic consequences of the presence or absence of the thermogenic capacity of brown adipose tissue in mice (and probably in humans)
- (2010) B Cannon et al. INTERNATIONAL JOURNAL OF OBESITY
- Adaptive thermogenesis in humans
- (2010) M Rosenbaum et al. INTERNATIONAL JOURNAL OF OBESITY
- Outdoor Temperature, Age, Sex, Body Mass Index, and Diabetic Status Determine the Prevalence, Mass, and Glucose-Uptake Activity of18F-FDG-Detected BAT in Humans
- (2010) Veronique Ouellet et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Transdifferentiation properties of adipocytes in the adipose organ
- (2009) Saverio Cinti AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- UCP1 Ablation Induces Obesity and Abolishes Diet-Induced Thermogenesis in Mice Exempt from Thermal Stress by Living at Thermoneutrality
- (2009) Helena M. Feldmann et al. Cell Metabolism
- High Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans: Effects of Cold Exposure and Adiposity
- (2009) M. Saito et al. DIABETES
- Novel pharmacological approaches to combat obesity and insulin resistance: targeting skeletal muscle with ‘exercise mimetics’
- (2009) A. L. Carey et al. DIABETOLOGIA
- Multiple thermoregulatory effectors with independent central controls
- (2009) Robin M. McAllen et al. EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
- The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue
- (2009) Maria Cristina Zingaretti et al. FASEB JOURNAL
- Chronic Peroxisome Proliferator-activated Receptor γ (PPARγ) Activation of Epididymally Derived White Adipocyte Cultures Reveals a Population of Thermogenically Competent, UCP1-containing Adipocytes Molecularly Distinct from Classic Brown Adipocytes
- (2009) Natasa Petrovic et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Thyroid Hormone Induced Brown Adipose Tissue and Amelioration of Diabetes in a Patient with Extreme Insulin Resistance
- (2009) Monica C. Skarulis et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Functional Brown Adipose Tissue in Healthy Adults
- (2009) Kirsi A. Virtanen et al. NEW ENGLAND JOURNAL OF MEDICINE
- Cold-Activated Brown Adipose Tissue in Healthy Men
- (2009) Wouter D. van Marken Lichtenbelt et al. NEW ENGLAND JOURNAL OF MEDICINE
- Identification and Importance of Brown Adipose Tissue in Adult Humans
- (2009) Aaron M. Cypess et al. NEW ENGLAND JOURNAL OF MEDICINE
- The discovery of drugs for obesity, the metabolic effects of leptin and variable receptor pharmacology: perspectives from β3-adrenoceptor agonists
- (2008) Jonathan R. S. Arch NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
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