Combatting type 2 diabetes by turning up the heat

ANT1-mediated fatty acid-induced uncoupling as a target for improving myocellular insulin sensitivity

(2016) Lauren M. Sparks et al.   DIABETOLOGIA

Metformin and the gastrointestinal tract

(2016) Laura J. McCreight et al.   DIABETOLOGIA

Resveratrol and obesity: Can resveratrol relieve metabolic disturbances?

(2015) Marlies de Ligt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Modified high-intensity interval training reduces liver fat and improves cardiac function in non-alcoholic fatty liver disease: a randomized controlled trial

(2015) K. Hallsworth et al.   CLINICAL SCIENCE

AMPK: positive and negative regulation, and its role in whole-body energy homeostasis

(2015) D Grahame Hardie   CURRENT OPINION IN CELL BIOLOGY

Exercise and Weight Loss Improve Muscle Mitochondrial Respiration, Lipid Partitioning, and Insulin Sensitivity After Gastric Bypass Surgery

(2015) Paul M. Coen et al.   DIABETES

Defects in Mitochondrial Efficiency and H2O2Emissions in Obese Women Are Restored to a Lean Phenotype With Aerobic Exercise Training

(2015) Adam R. Konopka et al.   DIABETES

Short-term Cold Acclimation Recruits Brown Adipose Tissue in Obese Humans

(2015) Mark J.W. Hanssen et al.   DIABETES

Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus

(2015) Mark J W Hanssen et al.   NATURE MEDICINE

Controlled-release mitochondrial protonophore reverses diabetes and steatohepatitis in rats

(2015) R. J. Perry et al.   SCIENCE

The Italian Diabetes and Exercise Study 2 (IDES-2): a long-term behavioral intervention for adoption and maintenance of a physically active lifestyle

(2015) Stefano Balducci et al.   Trials

Cold-activated brown adipose tissue in human adults: methodological issues

(2014) Anouk A. J. J. van der Lans et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

AMP-Activated Protein Kinase: Maintaining Energy Homeostasis at the Cellular and Whole-Body Levels

(2014) D. Grahame Hardie   Annual Review of Nutrition

Meteorin-like Is a Hormone that Regulates Immune-Adipose Interactions to Increase Beige Fat Thermogenesis

(2014) Rajesh R. Rao et al.   CELL

Metformin: From Mechanisms of Action to Therapies

(2014) Marc Foretz et al.   Cell Metabolism

AMPK—Sensing Energy while Talking to Other Signaling Pathways

(2014) D. Grahame Hardie   Cell Metabolism

β-Aminoisobutyric Acid Induces Browning of White Fat and Hepatic β-Oxidation and Is Inversely Correlated with Cardiometabolic Risk Factors

(2014) Lee D. Roberts et al.   Cell Metabolism

Brown Adipose Tissue Improves Whole-Body Glucose Homeostasis and Insulin Sensitivity in Humans

(2014) M. Chondronikola et al.   DIABETES

Temperature-Acclimated Brown Adipose Tissue Modulates Insulin Sensitivity in Humans

(2014) Paul Lee et al.   DIABETES

Glucose uptake in human brown adipose tissue is impaired upon fasting-induced insulin resistance

(2014) Mark J. W. Hanssen et al.   DIABETOLOGIA

The role of AMPK in controlling metabolism and mitochondrial biogenesis during exercise

(2014) Katarina Marcinko et al.   EXPERIMENTAL PHYSIOLOGY

Increased Brown Adipose Tissue Oxidative Capacity in Cold-Acclimated Humans

(2014) Denis P. Blondin et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Frequent Extreme Cold Exposure and Brown Fat and Cold-Induced Thermogenesis: A Study in a Monozygotic Twin

(2014) Maarten J. Vosselman et al.   PLoS One

Fatty acid-inducible ANGPTL4 governs lipid metabolic response to exercise

(2014) M. Catoire et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SIRT1 and other sirtuins in metabolism

(2014) Hung-Chun Chang et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Overexpression of PLIN5 in skeletal muscle promotes oxidative gene expression and intramyocellular lipid content without compromising insulin sensitivity

(2013) M. Bosma et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Reversal of Hypertriglyceridemia, Fatty Liver Disease, and Insulin Resistance by a Liver-Targeted Mitochondrial Uncoupler

(2013) Rachel J. Perry et al.   Cell Metabolism

Molecular mechanism of action of metformin: old or new insights?

(2013) Graham Rena et al.   DIABETOLOGIA

Both resistance training and aerobic training reduce hepatic fat content in type 2 diabetic subjects with nonalcoholic fatty liver disease (the RAED2 randomized trial)

(2013) Elisabetta Bacchi et al.   HEPATOLOGY

AMPK, insulin resistance, and the metabolic syndrome

(2013) Neil B. Ruderman et al.   JOURNAL OF CLINICAL INVESTIGATION

Recruited brown adipose tissue as an antiobesity agent in humans

(2013) Takeshi Yoneshiro et al.   JOURNAL OF CLINICAL INVESTIGATION

Cold acclimation recruits human brown fat and increases nonshivering thermogenesis

(2013) Anouk A.J.J. van der Lans et al.   JOURNAL OF CLINICAL INVESTIGATION

Blunted metabolic responses to cold and insulin stimulation in brown adipose tissue of obese humans

(2013) Janne Orava et al.   Obesity

Minimal Intensity Physical Activity (Standing and Walking) of Longer Duration Improves Insulin Action and Plasma Lipids More than Shorter Periods of Moderate to Vigorous Exercise (Cycling) in Sedentary Subjects When Energy Expenditure Is Comparable

(2013) Bernard M. F. M. Duvivier et al.   PLoS One

PGC-1α Improves Glucose Homeostasis in Skeletal Muscle in an Activity-Dependent Manner

(2012) Serge Summermatter et al.   DIABETES

Perilipin 2 Improves Insulin Sensitivity in Skeletal Muscle Despite Elevated Intramuscular Lipid Levels

(2012) M. Bosma et al.   DIABETES

Increase in Brown Adipose Tissue Activity after Weight Loss in Morbidly Obese Subjects

(2012) G. H. E. J. Vijgen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Brown adipose tissue regulates glucose homeostasis and insulin sensitivity

(2012) Kristin I. Stanford et al.   JOURNAL OF CLINICAL INVESTIGATION

Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans

(2012) Véronique Ouellet et al.   JOURNAL OF CLINICAL INVESTIGATION

Exercise and non-alcoholic fatty liver disease: A systematic review and meta-analysis

(2012) Shelley E. Keating et al.   JOURNAL OF HEPATOLOGY

PPARγ coactivator-1α contributes to exercise-induced regulation of intramuscular lipid droplet programming in mice and humans

(2012) Timothy R. Koves et al.   JOURNAL OF LIPID RESEARCH

Exercise-induced AMPK activity in skeletal muscle: Role in glucose uptake and insulin sensitivity

(2012) Martin Friedrichsen et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

The many faces of insulin-like peptide signalling in the brain

(2012) Ana M. Fernandez et al.   NATURE REVIEWS NEUROSCIENCE

Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans

(2011) Silvie Timmers et al.   Cell Metabolism

Different Metabolic Responses of Human Brown Adipose Tissue to Activation by Cold and Insulin

(2011) Janne Orava et al.   Cell Metabolism

Skeletal Muscle Triglycerides, Diacylglycerols, and Ceramides in Insulin Resistance: Another Paradox in Endurance-Trained Athletes?

(2011) F. Amati et al.   DIABETES

The lipid droplet coat protein perilipin 5 also localizes to muscle mitochondria

(2011) Madeleen Bosma et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Assessing Physical Activity Using Wearable Monitors

(2011) NANCY F. BUTTE et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Brown Adipose Tissue in Morbidly Obese Subjects

(2011) Guy H. E. J. Vijgen et al.   PLoS One

Paradoxical Increase in TAG and DAG Content Parallel the Insulin Sensitizing Effect of Unilateral DGAT1 Overexpression in Rat Skeletal Muscle

(2011) Silvie Timmers et al.   PLoS One

Control of Brown Adipose Tissue Glucose and Lipid Metabolism by PPARγ

(2011) William T. Festuccia et al.   Frontiers in Endocrinology

Exercise training increases mitochondrial content and ex vivo mitochondrial function similarly in patients with type 2 diabetes and in control individuals

(2010) E. Phielix et al.   DIABETOLOGIA

Effect of physical training on mitochondrial respiration and reactive oxygen species release in skeletal muscle in patients with obesity and type 2 diabetes

(2010) M. Hey-Mogensen et al.   DIABETOLOGIA

State of the epidemiological evidence on physical activity and cancer prevention

(2010) Christine M. Friedenreich et al.   EUROPEAN JOURNAL OF CANCER

Increased intramuscular lipid synthesis and low saturation relate to insulin sensitivity in endurance-trained athletes

(2010) Bryan C. Bergman et al.   JOURNAL OF APPLIED PHYSIOLOGY

Outdoor Temperature, Age, Sex, Body Mass Index, and Diabetic Status Determine the Prevalence, Mass, and Glucose-Uptake Activity of18F-FDG-Detected BAT in Humans

(2010) Veronique Ouellet et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Sedentary behavior, physical activity, and concentrations of insulin among US adults

(2010) Earl S. Ford et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Altered Intramuscular Lipid Metabolism Relates to Diminished Insulin Action in Men, but Not Women, in Progression to Diabetes

(2010) Leigh Perreault et al.   Obesity

Restoration of Muscle Mitochondrial Function and Metabolic Flexibility in Type 2 Diabetes by Exercise Training Is Paralleled by Increased Myocellular Fat Storage and Improved Insulin Sensitivity

(2009) R. C.R. Meex et al.   DIABETES

High Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans: Effects of Cold Exposure and Adiposity

(2009) M. Saito et al.   DIABETES

Deleterious Associations of Sitting Time and Television Viewing Time With Cardiometabolic Risk Biomarkers: Australian Diabetes, Obesity and Lifestyle (AusDiab) study 2004-2005

(2009) A. A. Thorp et al.   DIABETES CARE

Abnormal hepatic energy homeostasis in type 2 diabetes

(2009) Julia Szendroedi et al.   HEPATOLOGY

Functional Brown Adipose Tissue in Healthy Adults

(2009) Kirsi A. Virtanen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cold-Activated Brown Adipose Tissue in Healthy Men

(2009) Wouter D. van Marken Lichtenbelt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification and Importance of Brown Adipose Tissue in Adult Humans

(2009) Aaron M. Cypess et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inflexibility in Intramuscular Triglyceride Fractional Synthesis Distinguishes Prediabetes From Obesity in Humans

(2009) Leigh Perreault et al.   Obesity

Recent advances in adaptive thermogenesis: potential implications for the treatment of obesity

(2009) S. L. J. Wijers et al.   Obesity Reviews

Fatty liver, insulin resistance, and dyslipidemia

(2008) Martin Adiels et al.   Current Diabetes Reports

Physical Activity and the Metabolic Syndrome in Elderly German Men and Women: Results from the population-based KORA Survey

(2008) V. Hahn et al.   DIABETES CARE

Breaks in Sedentary Time: Beneficial associations with metabolic risk

(2008) G. N. Healy et al.   DIABETES CARE

Increased substrate oxidation and mitochondrial uncoupling in skeletal muscle of endurance-trained individuals

(2008) D. E. Befroy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Paradoxical effects of increased expression of PGC-1  on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism

(2008) C. S. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA