Brown adipose tissue as a secretory organ

Metabolic activity of brown, “beige,” and white adipose tissues in response to chronic adrenergic stimulation in male mice

(2016) Sébastien M. Labbé et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Exercise-induced increase in IL-6 level enhances GLUT4 expression and insulin sensitivity in mouse skeletal muscle

(2016) Shin-ichi Ikeda et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

AgRP Neurons Control Systemic Insulin Sensitivity via Myostatin Expression in Brown Adipose Tissue

(2016) Sophie M. Steculorum et al.   CELL

A Secreted Slit2 Fragment Regulates Adipose Tissue Thermogenesis and Metabolic Function

(2016) Katrin J. Svensson et al.   Cell Metabolism

Proinflammatory cytokine interleukin-1β suppresses cold-induced thermogenesis in adipocytes

(2016) Tsuyoshi Goto et al.   CYTOKINE

Endocannabinoid regulation in white and brown adipose tissue following thermogenic activation

(2016) Lucia M. Krott et al.   JOURNAL OF LIPID RESEARCH

Autocrine effect of vascular endothelial growth factor-A is essential for mitochondrial function in brown adipocytes

(2016) Kiana Mahdaviani et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Human 'brite/beige' adipocytes develop from capillary networks and their implantation improves metabolic homeostasis in mice

(2016) So Yun Min et al.   NATURE MEDICINE

Brown adipose tissue transplantation ameliorates polycystic ovary syndrome

(2016) Xiaoxue Yuan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Searching for Classical Brown Fat in Humans: Development of a Novel Human Fetal Brown Stem Cell Model

(2016) Alessandra Di Franco et al.   STEM CELLS

The Gq signalling pathway inhibits brown and beige adipose tissue

(2016) Katarina Klepac et al.   Nature Communications

Insulin-independent reversal of type 1 diabetes in nonobese diabetic mice with brown adipose tissue transplant

(2015) Subhadra C. Gunawardana et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Activated Type 2 Innate Lymphoid Cells Regulate Beige Fat Biogenesis

(2015) Min-Woo Lee et al.   CELL

A Creatine-Driven Substrate Cycle Enhances Energy Expenditure and Thermogenesis in Beige Fat

(2015) Lawrence Kazak et al.   CELL

Adiponectin Enhances Cold-Induced Browning of Subcutaneous Adipose Tissue via Promoting M2 Macrophage Proliferation

(2015) Xiaoyan Hui et al.   Cell Metabolism

Pharmacologic Effects of FGF21 Are Independent of the “Browning” of White Adipose Tissue

(2015) Murielle M. Véniant et al.   Cell Metabolism

Human Brown Adipose Tissue: What We Have Learned So Far

(2015) Matthias J. Betz et al.   DIABETES

A Novel Role for Subcutaneous Adipose Tissue in Exercise-Induced Improvements in Glucose Homeostasis

(2015) Kristin I. Stanford et al.   DIABETES

BMP4 and BMP Antagonists Regulate Human White and Beige Adipogenesis

(2015) Birgit Gustafson et al.   DIABETES

Brown Adipose Tissue Transplantation Reverses Obesity in Ob/Ob Mice

(2015) Xiaomeng Liu et al.   ENDOCRINOLOGY

Functional brown adipose tissue limits cardiomyocyte injury and adverse remodeling in catecholamine-induced cardiomyopathy

(2015) Robrecht Thoonen et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Fibroblast growth factor-21, energy balance and obesity

(2015) Marta Giralt et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Adipokines in health and disease

(2015) Mathias Fasshauer et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans

(2015) Andrew J. Whittle et al.   Nature Communications

Serum FGF21 levels are associated with brown adipose tissue activity in humans

(2015) Mark J.W. Hanssen et al.   Scientific Reports

Discrete Aspects of FGF21 In Vivo Pharmacology Do Not Require UCP1

(2015) Ricardo J. Samms et al.   Cell Reports

Estrogens increase expression of bone morphogenetic protein 8b in brown adipose tissue of mice

(2015) Aldo Grefhorst et al.   Biology of Sex Differences

Genetic disruption of uncoupling protein 1 in mice renders brown adipose tissue a significant source of FGF21 secretion

(2015) Susanne Keipert et al.   Molecular Metabolism

Brown and white adipose tissues: intrinsic differences in gene expression and response to cold exposure in mice

(2014) Meritxell Rosell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Nuclear factor-κB is a common upstream signal for growth differentiation factor-5 expression in brown adipocytes exposed to pro-inflammatory cytokines and palmitate

(2014) Eiichi Hinoi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

FGF21 expression and release in muscle cells: involvement of MyoD and regulation by mitochondria-driven signalling

(2014) Francesc Ribas et al.   BIOCHEMICAL JOURNAL

Contrasting effects of cold acclimation versus obesogenic diets on chemerin gene expression in brown and brite adipose tissues

(2014) Ida R. Hansen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Bone morphogenetic proteins: A powerful osteoinductive compound with non-negligible side effects and limitations

(2014) Ahmad Oryan et al.   BIOFACTORS

BMP-9 as a potent brown adipogenic inducer with anti-obesity capacity

(2014) Mario Meng-Chiang Kuo et al.   BIOMATERIALS

Eosinophils and Type 2 Cytokine Signaling in Macrophages Orchestrate Development of Functional Beige Fat

(2014) Yifu Qiu et al.   CELL

Meteorin-like Is a Hormone that Regulates Immune-Adipose Interactions to Increase Beige Fat Thermogenesis

(2014) Rajesh R. Rao et al.   CELL

ANGPTL8/Betatrophin Does Not Control Pancreatic Beta Cell Expansion

(2014) Viktoria Gusarova et al.   CELL

The Browning of White Adipose Tissue: Some Burning Issues

(2014) Jan Nedergaard et al.   Cell Metabolism

Irisin and FGF21 Are Cold-Induced Endocrine Activators of Brown Fat Function in Humans

(2014) Paul Lee et al.   Cell Metabolism

Inorganic Nitrate Promotes the Browning of White Adipose Tissue Through the Nitrate-Nitrite-Nitric Oxide Pathway

(2014) Lee D. Roberts et al.   DIABETES

Circulating FGF21 Is Liver Derived and Enhances Glucose Uptake During Refeeding and Overfeeding

(2014) K. R. Markan et al.   DIABETES

Peripheral cannabinoid 1 receptor blockade activates brown adipose tissue and diminishes dyslipidemia and obesity

(2014) Mariëtte R. Boon et al.   FASEB JOURNAL

Processing, signaling, and physiological function of chemerin

(2014) Andreas Mattern et al.   IUBMB LIFE

20 YEARS OF LEPTIN: Leptin at 20: an overview

(2014) Jeffrey Friedman   JOURNAL OF ENDOCRINOLOGY

Gpr1 is an active chemerin receptor influencing glucose homeostasis in obese mice

(2014) Jillian L Rourke et al.   JOURNAL OF ENDOCRINOLOGY

Follistatin promotes adipocyte differentiation, browning, and energy metabolism

(2014) Melissa Braga et al.   JOURNAL OF LIPID RESEARCH

Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity

(2014) Jonathan R. Brestoff et al.   NATURE

Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptors

(2014) Thorsten Gnad et al.   NATURE

Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin

(2014) Jan Mauer et al.   NATURE IMMUNOLOGY

The brown fat–enriched secreted factor Nrg4 preserves metabolic homeostasis through attenuation of hepatic lipogenesis

(2014) Guo-Xiao Wang et al.   NATURE MEDICINE

Role of IL-6 in Exercise Training- and Cold-Induced UCP1 Expression in Subcutaneous White Adipose Tissue

(2014) Jakob G. Knudsen et al.   PLoS One

Brown adipose tissue derived VEGF-A modulates cold tolerance and energy expenditure

(2014) Kai Sun et al.   Molecular Metabolism

Prostaglandin E2signals white-to-brown adipogenic differentiation

(2014) Verónica García-Alonso et al.   Adipocyte

BMP4 and BMP7 induce the white-to-brown transition of primary human adipose stem cells

(2013) Manuela Elsen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Role of bone morphogenetic protein 4 in the differentiation of brown fat-like adipocytes

(2013) Ruidan Xue et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Skeletal muscle mitochondrial uncoupling drives endocrine cross-talk through the induction of FGF21 as a myokine

(2013) Susanne Keipert et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Emerging roles of Lipasin as a critical lipid regulator

(2013) Ren Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of brown adipogenesis by the Tgf-β family: Involvement of Srebp1c in Tgf-β- and Activin-induced inhibition of adipogenesis

(2013) Hirofumi Yoshida et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Bone morphogenic proteins signaling in adipogenesis and energy homeostasis

(2013) Salvatore Modica et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

RETRACTED: Betatrophin: A Hormone that Controls Pancreatic β Cell Proliferation

(2013) Peng Yi et al.   CELL

A Classical Brown Adipose Tissue mRNA Signature Partly Overlaps with Brite in the Supraclavicular Region of Adult Humans

(2013) Naja Zenius Jespersen et al.   Cell Metabolism

Brown adipose tissue transplantation improves whole-body energy metabolism

(2013) Xiaomeng Liu et al.   CELL RESEARCH

Growth Differentiation Factor-5 Promotes Brown Adipogenesis in Systemic Energy Expenditure

(2013) E. Hinoi et al.   DIABETES

Inducible Brown Adipose Tissue, or Beige Fat, Is Anabolic for the Skeleton

(2013) Sima Rahman et al.   ENDOCRINOLOGY

Fat depot-specific mRNA expression of novel loci associated with waist–hip ratio

(2013) D Schleinitz et al.   INTERNATIONAL JOURNAL OF OBESITY

Fibroblast growth factor-21 is expressed in neonatal and pheochromocytoma-induced adult human brown adipose tissue

(2013) Elayne Hondares et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat

(2013) Tim J. Schulz et al.   NATURE

Adipose tissue browning and metabolic health

(2013) Alexander Bartelt et al.   Nature Reviews Endocrinology

Inhibition of in vitro and in vivo brown fat differentiation program by myostatin

(2013) Melissa Braga et al.   Obesity

Enhanced sympathetic activity in mice with brown adipose tissue transplantation (transBATation)

(2013) Zheng Zhu et al.   PHYSIOLOGY & BEHAVIOR

BMP4-mediated brown fat-like changes in white adipose tissue alter glucose and energy homeostasis

(2013) Shu-Wen Qian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

UCP1 in Brite/Beige Adipose Tissue Mitochondria Is Functionally Thermogenic

(2013) Irina G. Shabalina et al.   Cell Reports

Increased Mitochondrial Activity in BMP7-Treated Brown Adipocytes, Due to Increased CPT1- and CD36-Mediated Fatty Acid Uptake

(2012) Kristy L. Townsend et al.   ANTIOXIDANTS & REDOX SIGNALING

Lipasin, thermoregulated in brown fat, is a novel but atypical member of the angiopoietin-like protein family

(2012) Zhiyao Fu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

BMP8B Increases Brown Adipose Tissue Thermogenesis through Both Central and Peripheral Actions

(2012) Andrew J. Whittle et al.   CELL

Mechanism of Fatty-Acid-Dependent UCP1 Uncoupling in Brown Fat Mitochondria

(2012) Andriy Fedorenko et al.   CELL

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

(2012) Jun Wu et al.   CELL

Reversal of Type 1 Diabetes in Mice by Brown Adipose Tissue Transplant

(2012) S. C. Gunawardana et al.   DIABETES

A New Role for Lipocalin Prostaglandin D Synthase in the Regulation of Brown Adipose Tissue Substrate Utilization

(2012) S. Virtue et al.   DIABETES

A Novel Therapeutic Approach to Treating Obesity through Modulation of TGFβ Signaling

(2012) Alan Koncarevic et al.   ENDOCRINOLOGY

Peroxisome Proliferator-Activated Receptors-α and -γ, and cAMP-Mediated Pathways, Control Retinol-Binding Protein-4 Gene Expression in Brown Adipose Tissue

(2012) Meritxell Rosell et al.   ENDOCRINOLOGY

Bone morphogenetic protein 7 (BMP7) reverses obesity and regulates appetite through a central mTOR pathway

(2012) Kristy L. Townsend et al.   FASEB JOURNAL

FGF21 regulates PGC-1  and browning of white adipose tissues in adaptive thermogenesis

(2012) f. M. Fisher et al.   GENES & DEVELOPMENT

Brown adipose tissue regulates glucose homeostasis and insulin sensitivity

(2012) Kristin I. Stanford et al.   JOURNAL OF CLINICAL INVESTIGATION

Blockade of the Activin Receptor IIB Activates Functional Brown Adipogenesis and Thermogenesis by Inducing Mitochondrial Oxidative Metabolism

(2012) B. Fournier et al.   MOLECULAR AND CELLULAR BIOLOGY

Human BAT Possesses Molecular Signatures That Resemble Beige/Brite Cells

(2012) Louis Z. Sharp et al.   PLoS One

Recruited vs. nonrecruited molecular signatures of brown, “brite,” and white adipose tissues

(2011) Tomas B. Waldén et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Protection from Obesity and Diabetes by Blockade of TGF-β/Smad3 Signaling

(2011) Hariom Yadav et al.   Cell Metabolism

Different Metabolic Responses of Human Brown Adipose Tissue to Activation by Cold and Insulin

(2011) Janne Orava et al.   Cell Metabolism

Evaluation of macrophage plasticity in brown and white adipose tissue

(2011) M. Teresa Ortega et al.   CELLULAR IMMUNOLOGY

Emerging Roles for the Transforming Growth Factor-β Superfamily in Regulating Adiposity and Energy Expenditure

(2011) Nader Zamani et al.   ENDOCRINE REVIEWS

Thermogenic Activation Induces FGF21 Expression and Release in Brown Adipose Tissue

(2011) Elayne Hondares et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FGF-21 as a biomarker for muscle-manifesting mitochondrial respiratory chain deficiencies: a diagnostic study

(2011) Anu Suomalainen et al.   LANCET NEUROLOGY

Unknown

(2011) Dionysios Chartoumpekis et al.   MOLECULAR MEDICINE

Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis

(2011) Khoa D. Nguyen et al.   NATURE

Eosinophils Sustain Adipose Alternatively Activated Macrophages Associated with Glucose Homeostasis

(2011) D. Wu et al.   SCIENCE

Hepatic FGF21 Expression Is Induced at Birth via PPARα in Response to Milk Intake and Contributes to Thermogenic Activation of Neonatal Brown Fat

(2010) Elayne Hondares et al.   Cell Metabolism

Increased Fibroblast Growth Factor 21 in Obesity and Nonalcoholic Fatty Liver Disease

(2010) Jody Dushay et al.   GASTROENTEROLOGY

Sympathetic and sensory innervation of brown adipose tissue

(2010) T J Bartness et al.   INTERNATIONAL JOURNAL OF OBESITY

Transplantation of adipose tissue and stem cells: role in metabolism and disease

(2010) Thien T. Tran et al.   Nature Reviews Endocrinology

Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat

(2010) T. J. Schulz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclooxygenase-2 Controls Energy Homeostasis in Mice by de Novo Recruitment of Brown Adipocytes

(2010) A. Vegiopoulos et al.   SCIENCE

Hypoxia-Independent Angiogenesis in Adipose Tissues during Cold Acclimation

(2009) Yuan Xue et al.   Cell Metabolism

Transcriptional control of brown adipocyte development and physiological function--of mice and men

(2009) P. Seale et al.   GENES & DEVELOPMENT

Deletion of Tumor Necrosis Factor-α Receptor 1 (TNFR1) Protects against Diet-induced Obesity by Means of Increased Thermogenesis

(2009) Talita Romanatto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chronic Peroxisome Proliferator-activated Receptor γ (PPARγ) Activation of Epididymally Derived White Adipocyte Cultures Reveals a Population of Thermogenically Competent, UCP1-containing Adipocytes Molecularly Distinct from Classic Brown Adipocytes

(2009) Natasa Petrovic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Brown Adipose Tissue in Healthy Adults

(2009) Kirsi A. Virtanen et al.   NEW ENGLAND JOURNAL OF MEDICINE

New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure

(2008) Yu-Hua Tseng et al.   NATURE