Probiotics, prebiotics, synbiotics and insulin sensitivity

Role of the Gut Microbiome in the Pathogenesis of Obesity and Obesity-Related Metabolic Dysfunction

(2017) Kristien E. Bouter et al.   GASTROENTEROLOGY

Akkermansia MuciniphilaProtects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation inApoe−/−MiceCLINICAL PERSPECTIVE

(2016) Jin Li et al.   CIRCULATION

Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: A randomized, double-blind, placebo-controlled trial

(2016) M. Karamali et al.   DIABETES & METABOLISM

Inactivating Variants in ANGPTL4 and Risk of Coronary Artery Disease

(2016) Frederick E. Dewey et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Intestinal Microbiota in Metabolic Disease

(2016) Anni Woting et al.   Nutrients

Probiotics and Prebiotics: Present Status and Future Perspectives on Metabolic Disorders

(2016) Ji Yoo et al.   Nutrients

Increased gut hormones and insulin sensitivity index following a 3-d intervention with a barley kernel-based product: a randomised cross-over study in healthy middle-aged subjects

(2015) Anne C. Nilsson et al.   BRITISH JOURNAL OF NUTRITION

Genetic and environmental control of host-gut microbiota interactions

(2015) Elin Org et al.   GENOME RESEARCH

Akkermansia muciniphilaand improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology

(2015) Maria Carlota Dao et al.   GUT

The Consumption of Synbiotic Bread ContainingLactobacillus sporogenesand Inulin Affects Nitric Oxide and Malondialdehyde in Patients with Type 2 Diabetes Mellitus: Randomized, Double-Blind, Placebo-Controlled Trial

(2015) Fereashteh Bahmani et al.   JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION

Contrasting effects of fresh and fermented kimchi consumption on gut microbiota composition and gene expression related to metabolic syndrome in obese Korean women

(2015) Kyungsun Han et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Akkermansia muciniphila inversely correlates with the onset of inflammation, altered adipose tissue metabolism and metabolic disorders during obesity in mice

(2015) Marc Schneeberger et al.   Scientific Reports

Probiotics in obese pregnancy do not reduce maternal fasting glucose: a double-blind, placebo-controlled, randomized trial (Probiotics in Pregnancy Study)

(2014) Karen L Lindsay et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Synbiotic supplementation in nonalcoholic fatty liver disease: a randomized, double-blind, placebo-controlled pilot study

(2014) Tannaz Eslamparast et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Effects of Daily Consumption of Synbiotic Bread on Insulin Metabolism and Serum High-Sensitivity C-Reactive Protein among Diabetic Patients: A Double-Blind, Randomized, Controlled Clinical Trial

(2014) Maryam Tajadadi-Ebrahimi et al.   ANNALS OF NUTRITION AND METABOLISM

Effects of synbiotic supplementation on insulin resistance in subjects with the metabolic syndrome: a randomised, double-blind, placebo-controlled pilot study

(2014) Tannaz Eslamparast et al.   BRITISH JOURNAL OF NUTRITION

Microbiota-Generated Metabolites Promote Metabolic Benefits via Gut-Brain Neural Circuits

(2014) Filipe De Vadder et al.   CELL

Short-Chain Fatty Acid Receptor and Its Contribution to Glucagon-Like Peptide-1 Release

(2014) Izumi Kaji et al.   DIGESTION

The effects of probiotic bacteria on glycaemic control in overweight men and women: a randomised controlled trial

(2014) K L Ivey et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Freeze-dried powdered yacon: effects of FOS on serum glucose, lipids and intestinal transit in the elderly

(2014) M. M. A. Scheid et al.   EUROPEAN JOURNAL OF NUTRITION

Effect of Probiotic Lactobacillus salivarius UBL S22 and Prebiotic Fructo-oligosaccharide on Serum Lipids, Inflammatory Markers, Insulin Sensitivity, and Gut Bacteria in Healthy Young Volunteers

(2014) Hemalatha Rajkumar et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Consumption of Synbiotic Bread Decreases Triacylglycerol and VLDL Levels While Increasing HDL Levels in Serum from Patients with Type-2 Diabetes

(2014) Hossein Shakeri et al.   LIPIDS

Lactobacillus gasseri SBT2055 reduces postprandial and fasting serum non-esterified fatty acid levels in Japanese hypertriacylglycerolemic subjects

(2014) Akihiro Ogawa et al.   Lipids in Health and Disease

Resistant starch type 4-enriched diet lowered blood cholesterols and improved body composition in a double blind controlled cross-over intervention

(2014) Sailendra N. Nichenametla et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Nutrient Control of Energy Homeostasis via Gut-Brain Neural Circuits

(2014) Gilles Mithieux   NEUROENDOCRINOLOGY

The impact of oligofructose on stimulation of gut hormones, appetite regulation and adiposity

(2014) Norlida M. Daud et al.   Obesity

Efficacy of increased resistant starch consumption in human type 2 diabetes

(2014) C L Bodinham et al.   Endocrine Connections

ANGPTL4 expression induced by butyrate and rosiglitazone in human intestinal epithelial cells utilizes independent pathways

(2013) Agata Korecka et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Beneficial Effects of Fresh and Fermented Kimchi in Prediabetic Individuals

(2013) So-Yeon An et al.   ANNALS OF NUTRITION AND METABOLISM

Effects of synbiotic food consumption on metabolic status of diabetic patients: A double-blind randomized cross-over controlled clinical trial

(2013) Zatollah Asemi et al.   CLINICAL NUTRITION

Global estimates of diabetes prevalence for 2013 and projections for 2035

(2013) L. Guariguata et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

An increase in theAkkermansiaspp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice

(2013) Na-Ri Shin et al.   GUT

ANGPTL4 is produced by entero-endocrine cells in the human intestinal tract

(2013) Sheril Alex et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Beneficial Metabolic Effects of a Probiotic via Butyrate-induced GLP-1 Hormone Secretion

(2013) Hariom Yadav et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Beneficial effects of Lactobacillus plantarum on glycemia and homocysteine levels in postmenopausal women with metabolic syndrome

(2013) Fabíola Málaga Barreto et al.   NUTRITION

Oligofructose-enriched inulin improves some inflammatory markers and metabolic endotoxemia in women with type 2 diabetes mellitus: A randomized controlled clinical trial

(2013) Parvin Dehghan et al.   NUTRITION

Hypocaloric diet supplemented with probiotic cheese improves body mass index and blood pressure indices of obese hypertensive patients - a randomized double-blind placebo-controlled pilot study

(2013) Khaider K Sharafedtinov et al.   Nutrition Journal

Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity

(2013) A. Everard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glucagon-like peptide 1 and appetite

(2013) Megan J. Dailey et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The prebiotic source influences the growth, biochemical features and survival under simulated gastrointestinal conditions of the probiotic Lactobacillus acidophilus

(2012) Filomena Nazzaro et al.   ANAEROBE

Probiotic Mechanisms of Action

(2012) Miriam Bermudez-Brito et al.   ANNALS OF NUTRITION AND METABOLISM

Probiotics as potential biotherapeutics in the management of type 2 diabetes - prospects and perspectives

(2012) Harsh Panwar et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Effect of daily consumption of probiotic yoghurt on insulin resistance in pregnant women: a randomized controlled trial

(2012) Z Asemi et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Transfer of Intestinal Microbiota From Lean Donors Increases Insulin Sensitivity in Individuals With Metabolic Syndrome

(2012) Anne Vrieze et al.   GASTROENTEROLOGY

Insight into the prebiotic concept: lessons from an exploratory, double blind intervention study with inulin-type fructans in obese women

(2012) Evelyne M Dewulf et al.   GUT

Gut Hormones and Appetite Control: A Focus on PYY and GLP-1 as Therapeutic Targets in Obesity

(2012) Akila De Silva et al.   Gut and Liver

Short-Chain Fatty Acids Suppress Lipopolysaccharide-Induced Production of Nitric Oxide and Proinflammatory Cytokines Through Inhibition of NF-κB Pathway in RAW264.7 Cells

(2012) Tengfei Liu et al.   INFLAMMATION

Metabolites of Lactobacillus plantarum 2142 Prevent Oxidative Stress-Induced Overexpression of Proinflammatory Cytokines in IPEC-J2 Cell Line

(2012) Erzsebet Paszti-Gere et al.   INFLAMMATION

Resistant Starch from High-Amylose Maize Increases Insulin Sensitivity in Overweight and Obese Men

(2012) Kevin C. Maki et al.   JOURNAL OF NUTRITION

Probiotics to Adolescents With Obesity

(2012) Rikke Juul Gøbel et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Effect of the consumption of a new symbiotic shake on glycemia and cholesterol levels in elderly people with type 2 diabetes mellitus

(2012) Camila Moroti et al.   Lipids in Health and Disease

A metagenome-wide association study of gut microbiota in type 2 diabetes

(2012) Junjie Qin et al.   NATURE

Do probiotics act more efficiently in foods than in supplements?

(2012) Aziz Homayoni Rad et al.   NUTRITION

The inclusion of a partial meal replacement with or without inulin to a calorie restricted diet contributes to reach recommended intakes of micronutrients and decrease plasma triglycerides: A randomized clinical trial in obese Mexican women.

(2012) Alma Rosa Tovar et al.   Nutrition Journal

Butyrate and Propionate Protect against Diet-Induced Obesity and Regulate Gut Hormones via Free Fatty Acid Receptor 3-Independent Mechanisms

(2012) Hua V. Lin et al.   PLoS One

Evaluation of clinical safety and tolerance of a Lactobacillus reuteri NCIMB 30242 supplement capsule: A randomized control trial

(2012) Mitchell L. Jones et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Short chain fatty acids and their receptors: new metabolic targets

(2012) Brian T. Layden et al.   Translational Research

Energy-balance studies reveal associations between gut microbes, caloric load, and nutrient absorption in humans

(2011) Reiner Jumpertz et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Interaction Between Obesity and the Gut Microbiota: Relevance in Nutrition

(2011) Nathalie M. Delzenne et al.   Annual Review of Nutrition

Responses of Gut Microbiota and Glucose and Lipid Metabolism to Prebiotics in Genetic Obese and Diet-Induced Leptin-Resistant Mice

(2011) Amandine Everard et al.   DIABETES

Bacterial monocultures, propionate, butyrate and H2O2 modulate the expression, secretion and structure of the fasting-induced adipose factor in gut epithelial cell lines

(2011) Charlotte Grootaert et al.   ENVIRONMENTAL MICROBIOLOGY

Recommendations for the viability assessment of probiotics as concentrated cultures and in food matrices

(2011) Claude P. Champagne et al.   INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY

Probiotic yogurt improves antioxidant status in type 2 diabetic patients

(2011) Hanie S. Ejtahed et al.   NUTRITION

Fermented kimchi reduces body weight and improves metabolic parameters in overweight and obese patients

(2011) Eun Kyoung Kim et al.   NUTRITION RESEARCH

Effects of Lactobacillus acidophilus NCFM on insulin sensitivity and the systemic inflammatory response in human subjects

(2010) Anne Sofie Andreasen et al.   BRITISH JOURNAL OF NUTRITION

Angptl4 Protects against Severe Proinflammatory Effects of Saturated Fat by Inhibiting Fatty Acid Uptake into Mesenteric Lymph Node Macrophages

(2010) Laeticia Lichtenstein et al.   Cell Metabolism

Induction of Cardiac Angptl4 by Dietary Fatty Acids Is Mediated by Peroxisome Proliferator-Activated Receptor β/δ and Protects Against Fatty Acid–Induced Oxidative Stress

(2010) Anastasia Georgiadi et al.   CIRCULATION RESEARCH

Molecular Characterisation of the Faecal Microbiota in Patients with Type II Diabetes

(2010) Xiaokang Wu et al.   CURRENT MICROBIOLOGY

Metabolic Effects of a Diet with Inulin-Enriched Pasta in Healthy Young Volunteers

(2010) F. Russo et al.   CURRENT PHARMACEUTICAL DESIGN

Resistant starch improves insulin sensitivity in metabolic syndrome

(2010) K. L. Johnston et al.   DIABETIC MEDICINE

Germ-free C57BL/6J mice are resistant to high-fat-diet-induced insulin resistance and have altered cholesterol metabolism

(2010) Sylvie Rabot et al.   FASEB JOURNAL

Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids

(2010) Mohamed S. Zaibi et al.   FEBS LETTERS

Suppressive effect of short-chain fatty acids on production of proinflammatory mediators by neutrophils

(2010) Marco A.R. Vinolo et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Inulin-type fructans with prebiotic properties counteract GPR43 overexpression and PPARγ-related adipogenesis in the white adipose tissue of high-fat diet-fed mice

(2010) Evelyne M. Dewulf et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Do nutrient-gut-microbiota interactions play a role in human obesity, insulin resistance and type 2 diabetes?

(2010) M. Diamant et al.   Obesity Reviews

Gut Microbiota in Human Adults with Type 2 Diabetes Differs from Non-Diabetic Adults

(2010) Nadja Larsen et al.   PLoS One

Weight loss during oligofructose supplementation is associated with decreased ghrelin and increased peptide YY in overweight and obese adults

(2009) Jill A Parnell et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Gut microbiota fermentation of prebiotics increases satietogenic and incretin gut peptide production with consequences for appetite sensation and glucose response after a meal

(2009) Patrice D Cani et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Yacon syrup: Beneficial effects on obesity and insulin resistance in humans

(2009) Susana Genta et al.   CLINICAL NUTRITION

Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability

(2009) P. D. Cani et al.   GUT

Short-chain fatty acids act as antiinflammatory mediatorsby regulating prostaglandin E2 and cytokines

(2009) Mary Ann Cox et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Probiotics and dietary counselling contribute to glucose regulation during and after pregnancy: a randomised controlled trial

(2008) Kirsi Laitinen et al.   BRITISH JOURNAL OF NUTRITION

Diet-Induced Obesity Is Linked to Marked but Reversible Alterations in the Mouse Distal Gut Microbiome

(2008) Peter J. Turnbaugh et al.   Cell Host & Microbe

Intestinal Gluconeogenesis Is a Key Factor for Early Metabolic Changes after Gastric Bypass but Not after Gastric Lap-Band in Mice

(2008) Stephanie Troy et al.   Cell Metabolism

Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice

(2008) P. D. Cani et al.   DIABETES

Activation of G Protein-Coupled Receptor 43 in Adipocytes Leads to Inhibition of Lipolysis and Suppression of Plasma Free Fatty Acids

(2008) Hongfei Ge et al.   ENDOCRINOLOGY

Probiotics and prebiotics – Progress and challenges

(2008) Gregor Reid   INTERNATIONAL DAIRY JOURNAL

A core gut microbiome in obese and lean twins

(2008) Peter J. Turnbaugh et al.   NATURE

Butyrate and trichostatin A attenuate nuclear factor κB activation and tumor necrosis factor α secretion and increase prostaglandin E2 secretion in human peripheral blood mononuclear cells

(2008) Makoto Usami et al.   NUTRITION RESEARCH