ClusterCAD: a computational platform for type I modular polyketide synthase design

Insights into Substrate Modification by Dehydratases from Type I Polyketide Synthases

(2017) Alexandre Faille et al.   JOURNAL OF MOLECULAR BIOLOGY

SBSPKSv2: structure-based sequence analysis of polyketide synthases and non-ribosomal peptide synthetases

(2017) Shradha Khater et al.   NUCLEIC ACIDS RESEARCH

SeMPI: a genome-based secondary metabolite prediction and identification web server

(2017) Paul F. Zierep et al.   NUCLEIC ACIDS RESEARCH

Alteration of Polyketide Stereochemistry from anti to syn by a Ketoreductase Domain Exchange in a Type I Modular Polyketide Synthase Subunit

(2016) Clara H. Eng et al.   BIOCHEMISTRY

Broadening substrate specificity of a chain-extending ketosynthase through a single active-site mutation

(2016) Annabel C. Murphy et al.   CHEMICAL COMMUNICATIONS

On-line enzymatic tailoring of polyketides and peptides in thiotemplate systems

(2016) Srividhya Sundaram et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Bio-based production of fuels and industrial chemicals by repurposing antibiotic-producing type I modular polyketide synthases: opportunities and challenges

(2016) Satoshi Yuzawa et al.   JOURNAL OF ANTIBIOTICS

Stereocontrol within polyketide assembly lines

(2016) Adrian T. Keatinge-Clay   NATURAL PRODUCT REPORTS

Evaluating Ketoreductase Exchanges as a Means of Rationally Altering Polyketide Stereochemistry

(2015) Thibault Annaval et al.   CHEMBIOCHEM

Uncovering the Formation and Selection of Benzylmalonyl-CoA from the Biosynthesis of Splenocin and Enterocin Reveals a Versatile Way to Introduce Amino Acids into Polyketide Carbon Scaffolds

(2015) Chenchen Chang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Minimum Information about a Biosynthetic Gene cluster

(2015) Marnix H Medema et al.   Nature Chemical Biology

antiSMASH 3.0—a comprehensive resource for the genome mining of biosynthetic gene clusters

(2015) Tilmann Weber et al.   NUCLEIC ACIDS RESEARCH

In Vitro Analysis of Carboxyacyl Substrate Tolerance in the Loading and First Extension Modules of Borrelidin Polyketide Synthase

(2014) Andrew Hagen et al.   BIOCHEMISTRY

SSpro/ACCpro 5: almost perfect prediction of protein secondary structure and relative solvent accessibility using profiles, machine learning and structural similarity

(2014) C. N. Magnan et al.   BIOINFORMATICS

Elucidation of the Cryptic Epimerase Activity of Redox-Inactive Ketoreductase Domains from Modular Polyketide Synthases by Tandem Equilibrium Isotope Exchange

(2014) Ashish Garg et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure of a modular polyketide synthase

(2014) Somnath Dutta et al.   NATURE

Structural rearrangements of a polyketide synthase module during its catalytic cycle

(2014) Jonathan R. Whicher et al.   NATURE

Coupled Methyl Group Epimerization and Reduction by Polyketide Synthase Ketoreductase Domains. Ketoreductase-Catalyzed Equilibrium Isotope Exchange

(2013) Ashish Garg et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Engineering the acyltransferase substrate specificity of assembly line polyketide synthases

(2013) B. J. Dunn et al.   Journal of the Royal Society Interface

The structures of type I polyketide synthases

(2012) Adrian T. Keatinge-Clay   NATURAL PRODUCT REPORTS

Divergence of multimodular polyketide synthases revealed by a didomain structure

(2012) Jianting Zheng et al.   Nature Chemical Biology

The status of type I polyketide synthase ketoreductases

(2012) Jianting Zheng et al.   MedChemComm

Beyond ethylmalonyl-CoA: The functional role of crotonyl-CoAcarboxylase/reductase homologs in expanding polyketide diversity

(2011) Micheal C. Wilson et al.   NATURAL PRODUCT REPORTS

BLAST+: architecture and applications

(2009) Christiam Camacho et al.   BMC BIOINFORMATICS

A Polylinker Approach to Reductive Loop Swaps in Modular Polyketide Synthases

(2008) Laurenz Kellenberger et al.   CHEMBIOCHEM

Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection

(2008) TuAnh Nguyen et al.   NATURE BIOTECHNOLOGY