Broadening substrate specificity of a chain-extending ketosynthase through a single active-site mutation

Genetic engineering of modular PKSs: from combinatorial biosynthesis to synthetic biology

(2016) Kira J. Weissman   NATURAL PRODUCT REPORTS

Substrate Flexibility of a Mutated Acyltransferase Domain and Implications for Polyketide Biosynthesis

(2015) Kenny Bravo-Rodriguez et al.   CHEMISTRY & BIOLOGY

Reinvigorating natural product combinatorial biosynthesis with synthetic biology

(2015) Eunji Kim et al.   Nature Chemical Biology

The Phyre2 web portal for protein modeling, prediction and analysis

(2015) Lawrence A Kelley et al.   Nature Protocols

Engineering a Polyketide Synthase for In Vitro Production of Adipic Acid

(2015) Andrew Hagen et al.   ACS Synthetic Biology

Acyl-Chain Elongation Drives Ketosynthase Substrate Selectivity intrans-Acyltransferase Polyketide Synthases

(2014) Matthew Jenner et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structure of a modular polyketide synthase

(2014) Somnath Dutta et al.   NATURE

A Close Look at a Ketosynthase from a Trans-Acyltransferase Modular Polyketide Synthase

(2014) Darren C. Gay et al.   STRUCTURE

Multifactorial Control of Iteration Events in a Modular Polyketide Assembly Line

(2013) Benjamin Busch et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

High-level semi-synthetic production of the potent antimalarial artemisinin

(2013) C. J. Paddon et al.   NATURE

Vinylogous chain branching catalysed by a dedicated polyketide synthase module

(2013) Tom Bretschneider et al.   NATURE

Promiscuity of a modular polyketide synthase towards natural and non-natural extender units

(2013) Irina Koryakina et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The Cell Wall-Associated Mycolactone Polyketide Synthases Are Necessary but Not Sufficient for Mycolactone Biosynthesis

(2013) Jessica L. Porter et al.   PLoS One

Amino acid-accepting ketosynthase domain from a trans-AT polyketide synthase exhibits high selectivity for predicted intermediate

(2013) Christoph Kohlhaas et al.   Chemical Science

Quantitative full time course analysis of nonlinear enzyme cycling kinetics

(2013) Wenxiang Cao et al.   Scientific Reports

Substrate Specificity in Ketosynthase Domains fromtrans-AT Polyketide Synthases

(2012) Matthew Jenner et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Metabolic engineering is key to a sustainable chemical industry

(2011) Annabel C. Murphy   NATURAL PRODUCT REPORTS

The Biosynthetic Logic of Polyketide Diversity

(2009) Christian Hertweck   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Transfer, stable maintenance and expression of the mycolactone polyketide megasynthase mls genes in a recombination-impaired Mycobacterium marinum

(2009) J. L. Porter et al.   MICROBIOLOGY-SGM

Mycolactones: immunosuppressive and cytotoxic polyketides produced by aquatic mycobacteria

(2008) Hui Hong et al.   NATURAL PRODUCT REPORTS

Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection

(2008) TuAnh Nguyen et al.   NATURE BIOTECHNOLOGY