Stereocontrol within polyketide assembly lines

Substrate structure–activity relationships guide rational engineering of modular polyketide synthase ketoreductases

(2016) Constance B. Bailey et al.   CHEMICAL COMMUNICATIONS

Biosynthesis of polyketides by trans-AT polyketide synthases

(2016) Eric J. N. Helfrich et al.   NATURAL PRODUCT REPORTS

Divergent Mechanistic Routes for the Formation ofgem-Dimethyl Groups in the Biosynthesis of Complex Polyketides

(2015) Sean Poust et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enzymology of Pyran Ring A Formation in Salinomycin Biosynthesis

(2015) Hanna Luhavaya et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Molecular Dynamics Studies of Modular Polyketide Synthase Ketoreductase Stereospecificity

(2015) Mauro L. Mugnai et al.   BIOCHEMISTRY

The use of ene adducts to study and engineer enoyl-thioester reductases

(2015) Raoul G Rosenthal et al.   Nature Chemical Biology

antiSMASH 3.0—a comprehensive resource for the genome mining of biosynthetic gene clusters

(2015) Tilmann Weber et al.   NUCLEIC ACIDS RESEARCH

Structural and evolutionary relationships of “AT-less” type I polyketide synthase ketosynthases

(2015) Jeremy R. Lohman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Double-Hotdog with a New Trick: Structure and Mechanism of the trans-Acyltransferase Polyketide Synthase Enoyl-isomerase

(2014) Darren C. Gay et al.   ACS Chemical Biology

Acyl-Chain Elongation Drives Ketosynthase Substrate Selectivity intrans-Acyltransferase Polyketide Synthases

(2014) Matthew Jenner et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Elucidation of the Cryptic Epimerase Activity of Redox-Inactive Ketoreductase Domains from Modular Polyketide Synthases by Tandem Equilibrium Isotope Exchange

(2014) Ashish Garg et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural and functional studies of a trans -acyltransferase polyketide assembly line enzyme that catalyzes stereoselective α- and β-ketoreduction

(2014) Shawn K. Piasecki et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

A Close Look at a Ketosynthase from a Trans-Acyltransferase Modular Polyketide Synthase

(2014) Darren C. Gay et al.   STRUCTURE

Evolutionary Origins of the Multienzyme Architecture of Giant Fungal Fatty Acid Synthase

(2014) Habib S.T. Bukhari et al.   STRUCTURE

Structural Studies of an A2-Type Modular Polyketide Synthase Ketoreductase Reveal Features Controlling α-Substituent Stereochemistry

(2013) Jianting Zheng et al.   ACS Chemical Biology

The Missing Linker: A Dimerization Motif Located within Polyketide Synthase Modules

(2013) Jianting Zheng et al.   ACS Chemical Biology

An Enzymatic Domain for the Formation of Cyclic Ethers in Complex Polyketides

(2013) Petra Pöplau et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Crystal structure of (R)-3-hydroxybutyryl-CoA dehydrogenase PhaB from Ralstonia eutropha

(2013) Jieun Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structure and Stereospecificity of the Dehydratase Domain from the Terminal Module of the Rifamycin Polyketide Synthase

(2013) Darren Gay et al.   BIOCHEMISTRY

Structural and Stereochemical Analysis of a Modular Polyketide Synthase Ketoreductase Domain Required for the Generation of a cis-Alkene

(2013) Shilah A. Bonnett et al.   CHEMISTRY & BIOLOGY

Cyanobacterial Polyketide Synthase Docking Domains: A Tool for Engineering Natural Product Biosynthesis

(2013) Jonathan R. Whicher et al.   CHEMISTRY & BIOLOGY

Coupled Methyl Group Epimerization and Reduction by Polyketide Synthase Ketoreductase Domains. Ketoreductase-Catalyzed Equilibrium Isotope Exchange

(2013) Ashish Garg et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Trapping the dynamic acyl carrier protein in fatty acid biosynthesis

(2013) Chi Nguyen et al.   NATURE

Direct evidence for a covalent ene adduct intermediate in NAD(P)H-dependent enzymes

(2013) Raoul G Rosenthal et al.   Nature Chemical Biology

Substrate Specificity in Ketosynthase Domains fromtrans-AT Polyketide Synthases

(2012) Matthew Jenner et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Crystal structure of hexanoyl-CoA bound to β-ketoacyl reductase FabG4 ofMycobacterium tuberculosis

(2012) Debajyoti Dutta et al.   BIOCHEMICAL JOURNAL

The structures of type I polyketide synthases

(2012) Adrian T. Keatinge-Clay   NATURAL PRODUCT REPORTS

Divergence of multimodular polyketide synthases revealed by a didomain structure

(2012) Jianting Zheng et al.   Nature Chemical Biology

The status of type I polyketide synthase ketoreductases

(2012) Jianting Zheng et al.   MedChemComm

Structural and Functional Analysis of C2-Type Ketoreductases from Modular Polyketide Synthases

(2011) Jianting Zheng et al.   JOURNAL OF MOLECULAR BIOLOGY

The Stereochemistry of Complex Polyketide Biosynthesis by Modular Polyketide Synthases

(2011) David H. Kwan et al.   MOLECULES

Mutagenesis of a Modular Polyketide Synthase Enoylreductase Domain Reveals Insights into Catalysis and Stereospecificity

(2010) David H. Kwan et al.   ACS Chemical Biology

Stereospecificity of the Dehydratase Domain of the Erythromycin Polyketide Synthase

(2010) Chiara R. Valenzano et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biosynthesis of polyketides by trans-AT polyketide synthases

(2010) Jörn Piel   NATURAL PRODUCT REPORTS

Crystal Structures of Dehydratase Domains from the Curacin Polyketide Biosynthetic Pathway

(2010) David L. Akey et al.   STRUCTURE

Structural and Functional Analysis of A-Type Ketoreductases from the Amphotericin Modular Polyketide Synthase

(2010) Jianting Zheng et al.   STRUCTURE

Functionally Distinct Modules Operate Two Consecutive α,β→β,γ Double-Bond Shifts in the Rhizoxin Polyketide Assembly Line

(2009) Björn Kusebauch et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Biochemical Basis for Stereochemical Control in Polyketide Biosynthesis

(2009) Chiara R. Valenzano et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Medium- and short-chain dehydrogenase/reductase gene and protein families

(2008) K. L. Kavanagh et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Prediction and Manipulation of the Stereochemistry of Enoylreduction in Modular Polyketide Synthases

(2008) David H. Kwan et al.   CHEMISTRY & BIOLOGY

Crystal Structure of the Erythromycin Polyketide Synthase Dehydratase

(2008) Adrian Keatinge-Clay   JOURNAL OF MOLECULAR BIOLOGY

Biosynthesis of polyketide synthase extender units

(2008) Yolande A. Chan et al.   NATURAL PRODUCT REPORTS

Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection

(2008) TuAnh Nguyen et al.   NATURE BIOTECHNOLOGY