Evaluating Ketoreductase Exchanges as a Means of Rationally Altering Polyketide Stereochemistry

Narrowing the gap between the promise and reality of polyketide synthases as a synthetic biology platform

(2014) Sean Poust et al.   CURRENT OPINION IN BIOTECHNOLOGY

Elucidation of the Cryptic Epimerase Activity of Redox-Inactive Ketoreductase Domains from Modular Polyketide Synthases by Tandem Equilibrium Isotope Exchange

(2014) Ashish Garg et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural rearrangements of a polyketide synthase module during its catalytic cycle

(2014) Jonathan R. Whicher et al.   NATURE

The Missing Linker: A Dimerization Motif Located within Polyketide Synthase Modules

(2013) Jianting Zheng et al.   ACS Chemical Biology

Configurational Assignment of Secondary Hydroxyl Groups and Methyl Branches in Polyketide Natural Products through Bioinformatic Analysis of the Ketoreductase Domain

(2013) Andreas Kitsche et al.   CHEMBIOCHEM

Coupled Methyl Group Epimerization and Reduction by Polyketide Synthase Ketoreductase Domains. Ketoreductase-Catalyzed Equilibrium Isotope Exchange

(2013) Ashish Garg et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The structures of type I polyketide synthases

(2012) Adrian T. Keatinge-Clay   NATURAL PRODUCT REPORTS

Insights into the stereospecificity of ketoreduction in a modular polyketide synthase

(2011) David H. Kwan et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens

(2011) L. Laureti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Biosynthetic Logic of Polyketide Diversity

(2009) Christian Hertweck   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Biochemical Basis for Stereochemical Control in Polyketide Biosynthesis

(2009) Chiara R. Valenzano et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Polylinker Approach to Reductive Loop Swaps in Modular Polyketide Synthases

(2008) Laurenz Kellenberger et al.   CHEMBIOCHEM

Analysis of Specific Mutants in the Lasalocid Gene Cluster: Evidence for Enzymatic Catalysis of a Disfavoured Polyether Ring Closure

(2008) Luke Smith et al.   CHEMBIOCHEM