The roles of lipid and glucose metabolism in modulation of β-amyloid, tau, and neurodegeneration in the pathogenesis of Alzheimer disease

Bridging Integrator 1 (BIN1) Protein Expression Increases in the Alzheimer's Disease Brain and Correlates with Neurofibrillary Tangle Pathology

(2018) Christopher J. Holler et al.   JOURNAL OF ALZHEIMERS DISEASE

Structural and Functional Brain Changes in Middle-Aged Type 2 Diabetic Patients: A Cross-Sectional Study

(2018) Natalia García-Casares et al.   JOURNAL OF ALZHEIMERS DISEASE

Long-Term Metformin Usage and Cognitive Function among Older Adults with Diabetes

(2018) Tze Pin Ng et al.   JOURNAL OF ALZHEIMERS DISEASE

Risk of Incident Alzheimer's Disease in Diabetic Patients: A Systematic Review of Prospective Trials

(2017) Daniel Kopf et al.   JOURNAL OF ALZHEIMERS DISEASE

Effect of pioglitazone medication on the incidence of dementia

(2015) Michael T. Heneka et al.   ANNALS OF NEUROLOGY

The impairment of cholesterol metabolism in Huntington disease

(2015) Valerio Leoni et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Cholesterol in myelin biogenesis and hypomyelinating disorders

(2015) Gesine Saher et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Neuroinflammation, mitochondrial defects and neurodegeneration in mucopolysaccharidosis III type C mouse model

(2015) Carla Martins et al.   BRAIN

Glial Lipid Droplets and ROS Induced by Mitochondrial Defects Promote Neurodegeneration

(2015) Lucy Liu et al.   CELL

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

(2015) Yaming Wang et al.   CELL

Hyperglycemia modulates extracellular amyloid-β concentrations and neuronal activity in vivo

(2015) Shannon L. Macauley et al.   JOURNAL OF CLINICAL INVESTIGATION

Cholesterol modulates open probability and desensitization of NMDA receptors

(2015) Miloslav Korinek et al.   JOURNAL OF PHYSIOLOGY-LONDON

A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial

(2015) Tiia Ngandu et al.   LANCET

Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation

(2015) Céline Galvagnion et al.   Nature Chemical Biology

GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration

(2015) Ethan A Winkler et al.   NATURE NEUROSCIENCE

Acyl-coenzyme A:cholesterol acyltransferase 1 blockage enhances autophagy in the neurons of triple transgenic Alzheimer's disease mouse and reduces human P301L-tau content at the presymptomatic stage

(2015) Yohei Shibuya et al.   NEUROBIOLOGY OF AGING

Human prefrontal cortex phospholipids containing docosahexaenoic acid increase during normal adult aging, whereas those containing arachidonic acid decrease

(2015) Sarah E. Norris et al.   NEUROBIOLOGY OF AGING

mTOR signaling in aging and neurodegeneration: At the crossroad between metabolism dysfunction and impairment of autophagy

(2015) Marzia Perluigi et al.   NEUROBIOLOGY OF DISEASE

The mediational effects of FDG hypometabolism on the association between cerebrospinal fluid biomarkers and neurocognitive function

(2015) N. Maritza Dowling et al.   NEUROIMAGE

Glucose indices are associated with cognitive and structural brain measures in young adults

(2015) G. Weinstein et al.   NEUROLOGY

Impaired vascular-mediated clearance of brain amyloid beta in Alzheimer’s disease: the role, regulation and restoration of LRP1

(2015) Anita Ramanathan et al.   Frontiers in Aging Neuroscience

High membrane protein oxidation in the human cerebral cortex

(2015) Matthias Granold et al.   Redox Biology

Increasing membrane cholesterol of neurons in culture recapitulates Alzheimer’s disease early phenotypes

(2015) Catherine Marquer et al.   Molecular Neurodegeneration

Spatial Patterns of Structural Brain Changes in Type 2 Diabetic Patients and Their Longitudinal Progression With Intensive Control of Blood Glucose

(2014) Guray Erus et al.   DIABETES CARE

Prevention of amyloid β-induced memory impairment by fluvastatin, associated with the decrease in amyloid β accumulation and oxidative stressin amyloid β injection mouse model

(2014) Hitomi Kurinami et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

The Emerging Link betweenO-GlcNAc and Alzheimer Disease

(2014) Yanping Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tau Pathology Induces Intraneuronal Cholesterol Accumulation

(2014) Frauke Glöckner et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Association of type 2 diabetes with brain atrophy and cognitive impairment

(2014) R. O. Roberts et al.   NEUROLOGY

Intracellular Clusterin Interacts with Brain Isoforms of the Bridging Integrator 1 and with the Microtubule-Associated Protein Tau in Alzheimer's Disease

(2014) Yuan Zhou et al.   PLoS One

Decreased CALM expression reduces Aβ42 to total Aβ ratio through clathrin-mediated endocytosis of γ-secretase

(2014) Kunihiko Kanatsu et al.   Nature Communications

Possible modification of Alzheimer’s disease by statins in midlife: interactions with genetic and non-genetic risk factors

(2014) Mitsuru Shinohara et al.   Frontiers in Aging Neuroscience

Brain Alterations and Clinical Symptoms of Dementia in Diabetes: Aβ/Tau-Dependent and Independent Mechanisms

(2014) Naoyuki Sato et al.   Frontiers in Endocrinology

Cell number changes in Alzheimer's disease relate to dementia, not to plaques and tangles

(2013) C. H. Andrade-Moraes et al.   BRAIN

Plasma A : A Possible Missing Link Between Alzheimer Disease and Diabetes

(2013) N. Sato et al.   DIABETES

Brain Atrophy in Type 2 Diabetes: Regional distribution and influence on cognition

(2013) C. Moran et al.   DIABETES CARE

Increased Risk of Cognitive Impairment in Patients With Diabetes Is Associated With Metformin

(2013) E. M. Moore et al.   DIABETES CARE

Deletion of Abca7 Increases Cerebral Amyloid-  Accumulation in the J20 Mouse Model of Alzheimer's Disease

(2013) W. S. Kim et al.   JOURNAL OF NEUROSCIENCE

Neuronal Clearance of Amyloid-  by Endocytic Receptor LRP1

(2013) T. Kanekiyo et al.   JOURNAL OF NEUROSCIENCE

Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology

(2013) J Chapuis et al.   MOLECULAR PSYCHIATRY

Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer’s disease

(2013) Carlos Cruchaga et al.   NATURE

Impaired glycemia increases disease progression in mild cognitive impairment

(2013) Jill K. Morris et al.   NEUROBIOLOGY OF AGING

Selective benefits of simvastatin in bitransgenic APPSwe,Ind/TGF-β1 mice

(2013) Panayiota Papadopoulos et al.   NEUROBIOLOGY OF AGING

The CAMKK2-AMPK Kinase Pathway Mediates the Synaptotoxic Effects of Aβ Oligomers through Tau Phosphorylation

(2013) Georges Mairet-Coello et al.   NEURON

BIN1 Is Decreased in Sporadic but Not Familial Alzheimer’s Disease or in Aging

(2013) Elizabeth B. C. Glennon et al.   PLoS One

ApoE influences amyloid-  (A ) clearance despite minimal apoE/A  association in physiological conditions

(2013) P. B. Verghese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bridging integrator 1 (BIN1): form, function, and Alzheimer's disease

(2013) Meng-Shan Tan et al.   TRENDS IN MOLECULAR MEDICINE

Roles of vascular and metabolic components in cognitive dysfunction of Alzheimer disease: short- and long-term modification by non-genetic risk factors

(2013) Naoyuki Sato et al.   Frontiers in Aging Neuroscience

Associations Between Serum Cholesterol Levels and Cerebral Amyloidosis

(2013) Bruce Reed et al.   JAMA Neurology

Accumulation of autophagosomes contributes to enhanced amyloidogenic APP processing under insulin-resistant conditions

(2012) Sung Min Son et al.   Autophagy

Role of Phosphatidylinositol Clathrin Assembly Lymphoid-Myeloid Leukemia (PICALM) in Intracellular Amyloid Precursor Protein (APP) Processing and Amyloid Plaque Pathogenesis

(2012) Qingli Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms Underlying the Rapid Peroxisome Proliferator-Activated Receptor- -Mediated Amyloid Clearance and Reversal of Cognitive Deficits in a Murine Model of Alzheimer's Disease

(2012) S. Mandrekar-Colucci et al.   JOURNAL OF NEUROSCIENCE

The Role of Clusterin in Alzheimer’s Disease: Pathways, Pathogenesis, and Therapy

(2012) Jin-Tai Yu et al.   MOLECULAR NEUROBIOLOGY

Dual Effects of Statins on Aß Metabolism: Upregulation of the Degradation of APP-CTF and Aß Clearance

(2012) Naoyuki Sato et al.   Neurodegenerative Diseases

HMG-CoA reductase inhibitors enhance phagocytosis by upregulating ATP-binding cassette transporter A7

(2011) Nobukiyo Tanaka et al.   ATHEROSCLEROSIS

Effects of streptozotocin-induced diabetes on tau phosphorylation in the rat brain

(2011) Zhongsen Qu et al.   BRAIN RESEARCH

Roles of ATP-Binding Cassette Transporter A7 in Cholesterol Homeostasis and Host Defense System

(2011) Nobukiyo Tanaka et al.   Journal of Atherosclerosis and Thrombosis

Apolipoprotein E in Alzheimer's disease and other neurological disorders

(2011) Philip B Verghese et al.   LANCET NEUROLOGY

GSK-3α/β kinases and amyloid production in vivo

(2011) Tomasz Jaworski et al.   NATURE

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

(2011) Paul Hollingworth et al.   NATURE GENETICS

The Revitalized Tau Hypothesis on Alzheimer's Disease

(2010) Ricardo B. Maccioni et al.   ARCHIVES OF MEDICAL RESEARCH

Reduction of Brain β-Amyloid (Aβ) by Fluvastatin, a Hydroxymethylglutaryl-CoA Reductase Inhibitor, through Increase in Degradation of Amyloid Precursor Protein C-terminal Fragments (APP-CTFs) and Aβ Clearance

(2010) Mitsuru Shinohara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AGEs/RAGE complex upregulates BACE1 via NF-κB pathway activation

(2010) Michela Guglielmotto et al.   NEUROBIOLOGY OF AGING

Insulin resistance is associated with the pathology of Alzheimer disease: The Hisayama Study

(2010) T. Matsuzaki et al.   NEUROLOGY

Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling

(2010) E. Kickstein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and A  deposition in an Alzheimer mouse model with diabetes

(2010) S. Takeda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of GSK-3 Ameliorates Aβ Pathology in an Adult-Onset Drosophila Model of Alzheimer's Disease

(2010) Oyinkan Sofola et al.   PLoS Genetics

Mechanisms of tau-induced neurodegeneration

(2009) Khalid Iqbal et al.   ACTA NEUROPATHOLOGICA

APOEpredicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging

(2009) John C. Morris et al.   ANNALS OF NEUROLOGY

Increased Tau Phosphorylation and Cleavage in Mouse Models of Type 1 and Type 2 Diabetes

(2009) Bhumsoo Kim et al.   ENDOCRINOLOGY

Metabolic links between diabetes and Alzheimer’s disease

(2009) Pamela A Maher et al.   Expert Review of Neurotherapeutics

Brain glucose transporters,O-GlcNAcylation and phosphorylation of tau in diabetes and Alzheimer’s disease

(2009) Ying Liu et al.   JOURNAL OF NEUROCHEMISTRY

Statins Reduce the Neurofibrillary Tangle Burden in a Mouse Model of Tauopathy

(2009) Moran Boimel et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Diabetes, microvascular pathology and Alzheimer disease

(2009) Raj N. Kalaria   Nature Reviews Neurology

Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

(2009) Guojun Bu   NATURE REVIEWS NEUROSCIENCE

The effects of apolipoprotein E on non-impaired cognitive functioning: A meta-analysis

(2009) Nick M. Wisdom et al.   NEUROBIOLOGY OF AGING

A novel GSK-3β inhibitor reduces Alzheimer's pathology and rescues neuronal loss in vivo

(2009) L. Serenó et al.   NEUROBIOLOGY OF DISEASE

Experimental Diabetes Mellitus Exacerbates Tau Pathology in a Transgenic Mouse Model of Alzheimer's Disease

(2009) Yazi D. Ke et al.   PLoS One

Fibrillar amyloid-  burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease

(2009) E. M. Reiman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct patterns of brain activity in young carriers of the APOE- 4 allele

(2009) N. Filippini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of the Amyloid Cascade in Apolipoprotein E4 Transgenic Mice Induces Lysosomal Activation and Neurodegeneration Resulting in Marked Cognitive Deficits

(2008) H. Belinson et al.   JOURNAL OF NEUROSCIENCE

Defective insulin signaling pathway and increased glycogen synthase kinase-3 activity in the brain of diabetic mice: Parallels with Alzheimer's disease and correction by insulin

(2008) C.G. Jolivalt et al.   JOURNAL OF NEUROSCIENCE RESEARCH