Heparan sulfate, an endogenous TLR4 agonist, promotes acute GVHD after allogeneic stem cell transplantation

Low Risk of Chronic Graft-versus-Host Disease and Relapse Associated with T Cell–Depleted Peripheral Blood Stem Cell Transplantation for Acute Myelogenous Leukemia in First Remission: Results of the Blood and Marrow Transplant Clinical Trials Network Protocol 0303

(2011) Steven M. Devine et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Inhibition of IL-32 activation by  -1 antitrypsin suppresses alloreactivity and increases survival in an allogeneic murine marrow transplantation model

(2011) A. M. Marcondes et al.   BLOOD

PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models

(2011) K Dredge et al.   BRITISH JOURNAL OF CANCER

Danger signals activating innate immunity in graft-versus-host disease

(2011) Robert Zeiser et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Alpha-1-antitrypsin monotherapy reduces graft-versus-host disease after experimental allogeneic bone marrow transplantation

(2011) I. Tawara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting the TLR9–MyD88 pathway in the regulation of adaptive immune responses

(2010) Xiaopei Huang et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Prevention of GVHD without losing GVL effect: windows of opportunity

(2010) Ping Zhang et al.   IMMUNOLOGIC RESEARCH

Graft-versus-Host Disease Is Independent of Innate Signaling Pathways Triggered by Pathogens in Host Hematopoietic Cells

(2010) H. Li et al.   JOURNAL OF IMMUNOLOGY

Heparanase upregulates Th2 cytokines, ameliorating experimental autoimmune encephalitis

(2010) Menachem Bitan et al.   MOLECULAR IMMUNOLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Heparanase Promotes Engraftment and Prevents Graft versus Host Disease in Stem Cell Transplantation

(2010) Menachem Bitan et al.   PLoS One

Regulation of Adaptive Immunity by the Innate Immune System

(2010) A. Iwasaki et al.   SCIENCE

Allogeneic immunotherapy to optimize the graft-versus-tumor effect: concepts and controversies

(2010) Steven C Goldstein et al.   Expert Review of Hematology

Hyaluronan Mediates Ozone-induced Airway Hyperresponsiveness in Mice

(2009) Stavros Garantziotis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Graft-versus-host disease

(2009) James LM Ferrara et al.   LANCET

Alpha1-Antitrypsin Deficiency

(2009) Edwin K. Silverman et al.   NEW ENGLAND JOURNAL OF MEDICINE

A critical role for direct TLR2-MyD88 signaling in CD8 T-cell clonal expansion and memory formation following vaccinia viral infection

(2008) M. Quigley et al.   BLOOD

TLR agonists regulate alloresponses and uncover a critical role for donor APCs in allogeneic bone marrow rejection

(2008) P. A. Taylor et al.   BLOOD

Heparanase prevents the development of type 1 diabetes in non‐obese diabetic mice by regulating T‐cell activation and cytokines production

(2008) Menachem Bitan et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Curative and   cell regenerative effects of  1-antitrypsin treatment in autoimmune diabetic NOD mice

(2008) M. Koulmanda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

 1-Antitrypsin monotherapy induces immune tolerance during islet allograft transplantation in mice

(2008) E. C. Lewis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA