The Hv1 proton channel responds to mechanical stimuli

Voltage-Gated Proton Channels as Novel Drug Targets: From NADPH Oxidase Regulation to Sperm Biology

(2015) Tamara Seredenina et al.   ANTIOXIDANTS & REDOX SIGNALING

Protrusive and Contractile Forces of Spreading Human Neutrophils

(2015) Steven J. Henry et al.   BIOPHYSICAL JOURNAL

Mapping the Gating and Permeation Pathways in the Voltage-Gated Proton Channel Hv1

(2015) Adam Chamberlin et al.   JOURNAL OF MOLECULAR BIOLOGY

A specialized molecular motion opens the Hv1 voltage-gated proton channel

(2015) Laetitia Mony et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Resting state of the human proton channel dimer in a lipid bilayer

(2015) Qufei Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A specialized molecular motion opens the Hv1 voltage-gated proton channel

(2015) Laetitia Mony et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Interrogation of the intersubunit interface of the open Hv1 proton channel with a probe of allosteric coupling

(2015) Liang Hong et al.   Scientific Reports

Mechanosensitive Gating of Kv Channels

(2015) Catherine E. Morris et al.   PLoS One

Hv1 Proton Channel Opening Is Preceded by a Voltage-independent Transition

(2014) Carlos A. Villalba-Galea   BIOPHYSICAL JOURNAL

Long α helices projecting from the membrane as the dimer interface in the voltage-gated H+channel

(2014) Yuichiro Fujiwara et al.   JOURNAL OF GENERAL PHYSIOLOGY

Structural mechanism of voltage-dependent gating in an isolated voltage-sensing domain

(2014) Qufei Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

X-ray crystal structure of voltage-gated proton channel

(2014) Kohei Takeshita et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells

(2014) Medha M. Pathak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In pursuit of an inhibitory drug for the proton channel

(2014) Amaury Pupo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhanced activation of an amino-terminally truncated isoform of the voltage-gated proton channel HVCN1 enriched in malignant B cells

(2014) Elayne Hondares et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Moving gating charges through the gating pore in a Kv channel voltage sensor

(2014) J. J. Lacroix et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular determinants of Hv1 proton channel inhibition by guanidine derivatives

(2014) Liang Hong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular mechanism of voltage sensing in voltage-gated proton channels

(2013) Carlos Gonzalez et al.   JOURNAL OF GENERAL PHYSIOLOGY

Subunit Interactions during Cooperative Opening of Voltage-Gated Proton Channels

(2013) Feng Qiu et al.   NEURON

Voltage-Sensing Domain of Voltage-Gated Proton Channel Hv1 Shares Mechanism of Block with Pore Domains

(2013) Liang Hong et al.   NEURON

Kv1.1 Channels Act as Mechanical Brake in the Senses of Touch and Pain

(2013) Jizhe Hao et al.   NEURON

Voltage-Gated Proton Channels: Molecular Biology, Physiology, and Pathophysiology of the HV Family

(2013) Thomas E. DeCoursey   PHYSIOLOGICAL REVIEWS

Vaginal pH and Microbicidal Lactic Acid When Lactobacilli Dominate the Microbiota

(2013) Deirdre E. O’Hanlon et al.   PLoS One

Hydrophobic plug functions as a gate in voltage-gated proton channels

(2013) A. Chamberlin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasma membrane tension orchestrates membrane trafficking, cytoskeletal remodeling, and biochemical signaling during phagocytosis

(2013) T. A. Masters et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ionic Regulation of Cell Volume Changes and Cell Death after Ischemic Stroke

(2013) Mingke Song et al.   Translational Stroke Research

Membrane Tension Maintains Cell Polarity by Confining Signals to the Leading Edge during Neutrophil Migration

(2012) Andrew R. Houk et al.   CELL

Clinicopathological and Biological Significance of Human Voltage-gated Proton Channel Hv1 Protein Overexpression in Breast Cancer

(2012) Yifan Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gating of the designed trimeric/tetrameric voltage-gated H+channel

(2012) Yuichiro Fujiwara et al.   JOURNAL OF PHYSIOLOGY-LONDON

Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel

(2012) Xu Zhang et al.   NATURE

The voltage-gated proton channel Hv1 enhances brain damage from ischemic stroke

(2012) Long-Jun Wu et al.   NATURE NEUROSCIENCE

Mechanistic basis for low threshold mechanosensitivity in voltage-dependent K+ channels

(2012) D. Schmidt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The cytoplasmic coiled-coil mediates cooperative gating temperature sensitivity in the voltage-gated H+ channel Hv1

(2012) Yuichiro Fujiwara et al.   Nature Communications

Specific expression of the human voltage-gated proton channel Hv1 in highly metastatic breast cancer cells, promotes tumor progression and metastasis

(2011) Yifan Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Water wires in atomistic models of the Hv1 proton channel

(2011) Mona L. Wood et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The crystal structure of a voltage-gated sodium channel

(2011) Jian Payandeh et al.   NATURE

Acid Extrusion from Human Spermatozoa Is Mediated by Flagellar Voltage-Gated Proton Channel

(2010) Polina V. Lishko et al.   CELL

The Role and Structure of the Carboxyl-terminal Domain of the Human Voltage-gated Proton Channel Hv1

(2010) Shu Jie Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Function of the HVCN1 proton channel in airway epithelia and a naturally occurring mutation, M91T

(2010) David Iovannisci et al.   JOURNAL OF GENERAL PHYSIOLOGY

Hydration properties of mechanosensitive channel pores define the energetics of gating

(2010) A Anishkin et al.   JOURNAL OF PHYSICS-CONDENSED MATTER

Zinc inhibition of monomeric and dimeric proton channels suggests cooperative gating

(2010) Boris Musset et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mechanosensitivity of Nav1.5, a voltage-sensitive sodium channel

(2010) Arthur Beyder et al.   JOURNAL OF PHYSIOLOGY-LONDON

HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species

(2010) Melania Capasso et al.   NATURE IMMUNOLOGY

An aqueous H+ permeation pathway in the voltage-gated proton channel Hv1

(2010) I Scott Ramsey et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Gating Charge Transfer Center in Voltage Sensors

(2010) X. Tao et al.   SCIENCE

Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels

(2010) B. Coste et al.   SCIENCE

Identification of Thr29as a Critical Phosphorylation Site That Activates the Human Proton ChannelHvcn1in Leukocytes

(2009) Boris Musset et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Temperature dependence of proton permeation through a voltage-gated proton channel

(2009) Miyuki Kuno et al.   JOURNAL OF GENERAL PHYSIOLOGY

Strong cooperativity between subunits in voltage-gated proton channels

(2009) Carlos Gonzalez et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The opening of the two pores of the Hv1 voltage-gated proton channel is tuned by cooperativity

(2009) Francesco Tombola et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Voltage-Gated Proton Channel Hv1 Has Two Pores, Each Controlled by One Voltage Sensor

(2008) Francesco Tombola et al.   NEURON

A pH-stabilizing role of voltage-gated proton channels in IgE-mediated activation of human basophils

(2008) B. Musset et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multimeric nature of voltage-gated proton channels

(2008) Hans P. Koch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dimeric subunit stoichiometry of the human voltage-dependent proton channel Hv1

(2008) S.-Y. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA