Obesity-associated variants within FTO form long-range functional connections with IRX3

Arcuate NPY Controls Sympathetic Output and BAT Function via a Relay of Tyrosine Hydroxylase Neurons in the PVN

(2013) Yan-Chuan Shi et al.   Cell Metabolism

Long-Range Chromatin Contacts in Embryonic Stem Cells Reveal a Role for Pluripotency Factors and Polycomb Proteins in Genome Organization

(2013) Matthew Denholtz et al.   Cell Stem Cell

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(2013) Ralph Stadhouders et al.   Nature Protocols

Adult Onset Global Loss of the Fto Gene Alters Body Composition and Metabolism in the Mouse

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Genetic Risk Factors for Type 2 Diabetes: A Trans-Regulatory Genetic Architecture?

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GABAergic RIP-Cre Neurons in the Arcuate Nucleus Selectively Regulate Energy Expenditure

(2012) Dong Kong et al.   CELL

Extensive Promoter-Centered Chromatin Interactions Provide a Topological Basis for Transcription Regulation

(2012) Guoliang Li et al.   CELL

Kif7 regulates Gli2 through Sufu-dependent and -independent functions during skin development and tumorigenesis

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Regulatory variation in a TBX5 enhancer leads to isolated congenital heart disease

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Determining long-range chromatin interactions for selected genomic sites using 4C-seq technology: From fixation to computation

(2012) Erik Splinter et al.   METHODS

Enrichment of cis-regulatory gene expression SNPs and methylation quantitative trait loci among bipolar disorder susceptibility variants

(2012) E R Gamazon et al.   MOLECULAR PSYCHIATRY

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(2012) Jesse R. Dixon et al.   NATURE

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Iroquois homeobox gene 3 establishes fast conduction in the cardiac His-Purkinje network

(2011) S.-S. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Dynamic Architecture of Hox Gene Clusters

(2011) D. Noordermeer et al.   SCIENCE

A User's Guide to the Encyclopedia of DNA Elements (ENCODE)

(2011)   PLOS BIOLOGY

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

(2010) Elizabeth K Speliotes et al.   NATURE GENETICS

Overexpression of Fto leads to increased food intake and results in obesity

(2010) Chris Church et al.   NATURE GENETICS

Switch from Stress Response to Homeobox Transcription Factors in Adipose Tissue After Profound Fat Loss

(2010) Simon N. Dankel et al.   PLoS One

The Fat Mass and Obesity Associated Gene FTO Functions in the Brain to Regulate Postnatal Growth in Mice

(2010) Xue Gao et al.   PLoS One

Critical Role for Hypothalamic mTOR Activity in Energy Balance

(2009) Hiroyuki Mori et al.   Cell Metabolism

Regulation and Function of FTO mRNA Expression in Human Skeletal Muscle and Subcutaneous Adipose Tissue

(2009) L. G. Grunnet et al.   DIABETES

Circos: An information aesthetic for comparative genomics

(2009) M. Krzywinski et al.   GENOME RESEARCH

Inactivation of the Fto gene protects from obesity

(2009) Julia Fischer et al.   NATURE

Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3

(2009) A. Ragvin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome

(2009) E. Lieberman-Aiden et al.   SCIENCE

Regulation of Fto/Ftm gene expression in mice and humans

(2008) George Stratigopoulos et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Fat Mass-and Obesity-Associated (FTO) Gene Variant Is Associated With Obesity: Longitudinal Analyses in Two Cohort Studies and Functional Test

(2008) L. Qi et al.   DIABETES

Inverse relationship between obesity and FTO gene expression in visceral adipose tissue in humans

(2008) N. Klöting et al.   DIABETOLOGIA