Hypothalamic AMPK: a canonical regulator of whole-body energy balance

Role of estradiol in intrinsic hindbrain AMPK regulation of hypothalamic AMPK, metabolic neuropeptide, and norepinephrine activity and food intake in the female rat

(2016) F.S.H. Alenazi et al.   NEUROSCIENCE

AMP-activated protein kinase mediates mitochondrial fission in response to energy stress

(2016) E. Q. Toyama et al.   SCIENCE

The role of AMP-activated protein kinase in the androgenic potentiation of cannabinoid-induced changes in energy homeostasis

(2015) Amanda Borgquist et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Differential regulation by AMP and ADP of AMPK complexes containing different   subunit isoforms

(2015) F. A. Ross et al.   BIOCHEMICAL JOURNAL

Repurposing metformin: an old drug with new tricks in its binding pockets

(2015) R. Pryor et al.   BIOCHEMICAL JOURNAL

Neural Control of Energy Balance: Translating Circuits to Therapies

(2015) Laurent Gautron et al.   CELL

Beyond Energy Homeostasis: the Expanding Role of AMP-Activated Protein Kinase in Regulating Metabolism

(2015) David Carling et al.   Cell Metabolism

Neuronal Regulation of Energy Homeostasis: Beyond the Hypothalamus and Feeding

(2015) Michael J. Waterson et al.   Cell Metabolism

MicroRNA-455 regulates brown adipogenesis via a novel HIF1an-AMPK-PGC1  signaling network

(2015) H. Zhang et al.   EMBO REPORTS

Pregnancy Induces Resistance to the Anorectic Effect of Hypothalamic Malonyl-CoA and the Thermogenic Effect of Hypothalamic AMPK Inhibition in Female Rats

(2015) Pablo B. Martínez de Morentin et al.   ENDOCRINOLOGY

Leptin Receptor Signaling in the Hypothalamus Regulates Hepatic Autonomic Nerve Activity via Phosphatidylinositol 3-Kinase and AMP-Activated Protein Kinase

(2015) M. Tanida et al.   JOURNAL OF NEUROSCIENCE

Hypoxia, AMPK activation and uterine artery vasoreactivity

(2015) K. L. Skeffington et al.   JOURNAL OF PHYSIOLOGY-LONDON

Brain lipid sensing and the neural control of energy balance

(2015) Christophe Magnan et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota

(2015) Kristoffer Forslund et al.   NATURE

AMPK and PFKFB3 mediate glycolysis and survival in response to mitophagy during mitotic arrest

(2015) Elena Doménech et al.   NATURE CELL BIOLOGY

Cognitive and autonomic determinants of energy homeostasis in obesity

(2015) Denis Richard   Nature Reviews Endocrinology

Estrogens and the control of energy homeostasis: a brain perspective

(2015) Miguel López et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Regulation of brown fat by AMP-activated protein kinase

(2015) Andrea D. van Dam et al.   TRENDS IN MOLECULAR MEDICINE

ANGPTL4 mediates shuttling of lipid fuel to brown adipose tissue during sustained cold exposure

(2015) Wieneke Dijk et al.   eLife

Hypothalamic CaMKKβ mediates glucagon anorectic effect and its diet-induced resistance

(2015) Mar Quiñones et al.   Molecular Metabolism

Coinjection of CCK and leptin reduces food intake via increased CART/TRH and reduced AMPK phosphorylation in the hypothalamus

(2014) Sayaka Akieda-Asai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The brain and brown fat

(2014) Cristina Contreras et al.   ANNALS OF MEDICINE

AMP-Activated Protein Kinase: Maintaining Energy Homeostasis at the Cellular and Whole-Body Levels

(2014) D. Grahame Hardie   Annual Review of Nutrition

Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells

(2014) Simon A. Hawley et al.   BIOCHEMICAL JOURNAL

Central Neural Regulation of Brown Adipose Tissue Thermogenesis and Energy Expenditure

(2014) Shaun F. Morrison et al.   Cell Metabolism

Estradiol Regulates Brown Adipose Tissue Thermogenesis via Hypothalamic AMPK

(2014) Pablo B. Martínez de Morentin et al.   Cell Metabolism

Metformin: From Mechanisms of Action to Therapies

(2014) Marc Foretz et al.   Cell Metabolism

AMPK—Sensing Energy while Talking to Other Signaling Pathways

(2014) D. Grahame Hardie   Cell Metabolism

Hypoglycemia-Activated GLUT2 Neurons of the Nucleus Tractus Solitarius Stimulate Vagal Activity and Glucagon Secretion

(2014) Christophe M. Lamy et al.   Cell Metabolism

GLP-1 Agonism Stimulates Brown Adipose Tissue Thermogenesis and Browning Through Hypothalamic AMPK

(2014) D. Beiroa et al.   DIABETES

Olanzapine-Activated AMPK Signaling in the Dorsal Vagal Complex Is Attenuated by Histamine H1 Receptor Agonist in Female Rats

(2014) Meng He et al.   ENDOCRINOLOGY

Nicotine Improves Obesity and Hepatic Steatosis and ER Stress in Diet-Induced Obese Male Rats

(2014) Patricia Seoane-Collazo et al.   ENDOCRINOLOGY

Convergence of IPMK and LKB1-AMPK Signaling Pathways on Metformin Action

(2014) Sookhee Bang et al.   MOLECULAR ENDOCRINOLOGY

PAS Kinase Is a Nutrient and Energy Sensor in Hypothalamic Areas Required for the Normal Function of AMPK and mTOR/S6K1

(2014) Verónica Hurtado-Carneiro et al.   MOLECULAR NEUROBIOLOGY

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

(2014) Anila K. Madiraju et al.   NATURE

Thiamine deficiency induces anorexia by inhibiting hypothalamic AMPK

(2014) M. Liu et al.   NEUROSCIENCE

The LKB1-AMPK Pathway—Friend or Foe in Cancer?

(2013) D. Grahame Hardie   CANCER CELL

AMP Is a True Physiological Regulator of AMP-Activated Protein Kinase by Both Allosteric Activation and Enhancing Net Phosphorylation

(2013) Graeme J. Gowans et al.   Cell Metabolism

Hypothalamic Ceramide Levels Regulated by CPT1C Mediate the Orexigenic Effect of Ghrelin

(2013) S. Ramirez et al.   DIABETES

Metformin Lowers Plasma Triglycerides by Promoting VLDL-Triglyceride Clearance by Brown Adipose Tissue in Mice

(2013) J. J. Geerling et al.   DIABETES

The Role of Estrogens in Control of Energy Balance and Glucose Homeostasis

(2013) Franck Mauvais-Jarvis et al.   ENDOCRINE REVIEWS

An increase in theAkkermansiaspp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice

(2013) Na-Ri Shin et al.   GUT

Olanzapine depot formulation in rat: a step forward in modelling antipsychotic-induced metabolic adverse effects

(2013) Silje Skrede et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Glucose Regulates Hypothalamic Long-chain Fatty Acid Metabolism via AMP-activated Kinase (AMPK) in Neurons and Astrocytes

(2013) Bouchra Taïb et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemoproteomic Analysis of Intertissue and Interspecies Isoform Diversity of AMP-activated Protein Kinase (AMPK)

(2013) Jiang Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMPK, insulin resistance, and the metabolic syndrome

(2013) Neil B. Ruderman et al.   JOURNAL OF CLINICAL INVESTIGATION

Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

(2013) Russell A. Miller et al.   NATURE

Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat

(2013) Tim J. Schulz et al.   NATURE

Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin

(2013) Morgan D Fullerton et al.   NATURE MEDICINE

Differential effects of central ghrelin on fatty acid metabolism in hypothalamic ventral medial and arcuate nuclei

(2013) Su Gao et al.   PHYSIOLOGY & BEHAVIOR

Involvement of Hypothalamic AMP-Activated Protein Kinase in Leptin-Induced Sympathetic Nerve Activation

(2013) Mamoru Tanida et al.   PLoS One

Energy balance regulation by thyroid hormones at central level

(2013) Miguel López et al.   TRENDS IN MOLECULAR MEDICINE

AMPK  Modulation in Cancer Progression: Multilayer Integrative Analysis of the Whole Transcriptome in Asian Gastric Cancer

(2012) Y. H. Kim et al.   CANCER RESEARCH

BMP8B Increases Brown Adipose Tissue Thermogenesis through Both Central and Peripheral Actions

(2012) Andrew J. Whittle et al.   CELL

p70S6 Kinase Phosphorylates AMPK on Serine 491 to Mediate Leptin's Effect on Food Intake

(2012) Yossi Dagon et al.   Cell Metabolism

Nicotine Induces Negative Energy Balance Through Hypothalamic AMP-Activated Protein Kinase

(2012) P. B. Martinez de Morentin et al.   DIABETES

Fructose-Induced Hypothalamic AMPK Activation Stimulates Hepatic PEPCK and Gluconeogenesis due to Increased Corticosterone Levels

(2012) Andrezza Kinote et al.   ENDOCRINOLOGY

Targeted estrogen delivery reverses the metabolic syndrome

(2012) Brian Finan et al.   NATURE MEDICINE

Unraveling the brain regulation of appetite: lessons from genetics

(2012) Giles S H Yeo et al.   NATURE NEUROSCIENCE

Leptin revisited: its mechanism of action and potential for treating diabetes

(2012) Roberto Coppari et al.   NATURE REVIEWS DRUG DISCOVERY

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cold tolerance, cold-induced hyperphagia, and nonshivering thermogenesis are normal in α1-AMPK−/− mice

(2011) Jake D. Bauwens et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Interscapular brown adipose tissue metabolic reprogramming during cold acclimation: Interplay of HIF-1α and AMPKα

(2011) Milica Vucetic et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Hunger States Switch a Flip-Flop Memory Circuit via a Synaptic AMPK-Dependent Positive Feedback Loop

(2011) Yunlei Yang et al.   CELL

Distinct Hypothalamic Neurons Mediate Estrogenic Effects on Energy Homeostasis and Reproduction

(2011) Yong Xu et al.   Cell Metabolism

Intracellular Signals Mediating the Food Intake-Suppressive Effects of Hindbrain Glucagon-like Peptide-1 Receptor Activation

(2011) Matthew R. Hayes et al.   Cell Metabolism

Desnutrin/ATGL Is Regulated by AMPK and Is Required for a Brown Adipose Phenotype

(2011) Maryam Ahmadian et al.   Cell Metabolism

Participation of Hindbrain AMP-Activated Protein Kinase in Glucoprivic Feeding

(2011) A.-J. Li et al.   DIABETES

The Central Sirtuin 1/p53 Pathway Is Essential for the Orexigenic Action of Ghrelin

(2011) D. A. Velasquez et al.   DIABETES

Deletion ofLkb1in Pro-Opiomelanocortin Neurons Impairs Peripheral Glucose Homeostasis in Mice

(2011) Marc Claret et al.   DIABETES

Adrenergic Regulation of AMP-activated Protein Kinase in Brown Adipose Tissuein Vivo

(2011) Thomas Pulinilkunnil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of mammalian AMPK and its regulation by ADP

(2011) Bing Xiao et al.   NATURE

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

AMP-activated protein kinase: nature's energy sensor

(2011) David Carling et al.   Nature Chemical Biology

Leptin and the Central Nervous System Control of Glucose Metabolism

(2011) Gregory J. Morton et al.   PHYSIOLOGICAL REVIEWS

AMP-activated protein kinase is physiologically regulated by inositol polyphosphate multikinase

(2011) S. Bang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypothalamic AMP-activated protein kinase as a mediator of whole body energy balance

(2011) Pablo Blanco Martínez de Morentin et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

AMPK Is a Direct Adenylate Charge-Regulated Protein Kinase

(2011) J. S. Oakhill et al.   SCIENCE

Endogenous Leptin Signaling in the Caudal Nucleus Tractus Solitarius and Area Postrema Is Required for Energy Balance Regulation

(2010) Matthew R. Hayes et al.   Cell Metabolism

Hypothalamic Angptl4/Fiaf Is a Novel Regulator of Food Intake and Body Weight

(2010) H.-K. Kim et al.   DIABETES

Hypothalamic AMP-Activated Protein Kinase Regulates Glucose Production

(2010) C. S. Yang et al.   DIABETES

Hypothalamic Nutrient Sensing Activates a Forebrain-Hindbrain Neuronal Circuit to Regulate Glucose Production In Vivo

(2010) C. K. L. Lam et al.   DIABETES

Metformin regulates the incretin receptor axis via a pathway dependent on peroxisome proliferator-activated receptor-α in mice

(2010) A. Maida et al.   DIABETOLOGIA

Adenosine 5′-Monophosphate-Activated Protein Kinase-Mammalian Target of Rapamycin Cross Talk Regulates Brown Adipocyte Differentiation

(2010) Rocio Vila-Bedmar et al.   ENDOCRINOLOGY

Ghrelin effects on neuropeptides in the rat hypothalamus depend on fatty acid metabolism actions on BSX but not on gender

(2010) Ricardo Lage et al.   FASEB JOURNAL

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

(2010) Marc Foretz et al.   JOURNAL OF CLINICAL INVESTIGATION

Globular adiponectin regulates energy homeostasis through AMP-activated protein kinase–acetyl-CoA carboxylase (AMPK/ACC) pathway in the hypothalamus

(2010) Jun-Ping Wen et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance

(2010) Miguel López et al.   NATURE MEDICINE

Differential effects of exercise and dietary docosahexaenoic acid on molecular systems associated with control of allostasis in the hypothalamus and hippocampus

(2010) F. Gomez-Pinilla et al.   NEUROSCIENCE

Profound Obesity Secondary to Hyperphagia in Mice Lacking Kinase Suppressor of Ras 2

(2010) Jean-Pierre Revelli et al.   Obesity

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

AMP-activated protein kinase and nitric oxide regulate the glucose sensitivity of ventromedial hypothalamic glucose-inhibited neurons

(2009) Beth Ann Murphy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Central lactate metabolism suppresses food intake via the hypothalamic AMP kinase/malonyl-CoA signaling pathway

(2009) Seung Hun Cha et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

KSR2 Is an Essential Regulator of AMP Kinase, Energy Expenditure, and Insulin Sensitivity

(2009) Diane L. Costanzo-Garvey et al.   Cell Metabolism

PKA phosphorylates and inactivates AMPKα to promote efficient lipolysis

(2009) Nabil Djouder et al.   EMBO JOURNAL

AMPK β1 Deletion Reduces Appetite, Preventing Obesity and Hepatic Insulin Resistance

(2009) Nicolas Dzamko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuronal Protein Tyrosine Phosphatase 1B Deficiency Results in Inhibition of Hypothalamic AMPK and Isoform-Specific Activation of AMPK in Peripheral Tissues

(2009) B. Xue et al.   MOLECULAR AND CELLULAR BIOLOGY

Central AMPK contributes to sleep homeostasis in mice

(2009) Sachiko Chikahisa et al.   NEUROPHARMACOLOGY

Structure of the LKB1-STRAD-MO25 Complex Reveals an Allosteric Mechanism of Kinase Activation

(2009) E. Zeqiraj et al.   SCIENCE

Hypothalamic CaMKK2 Contributes to the Regulation of Energy Balance

(2008) Kristin A. Anderson et al.   Cell Metabolism

Hypothalamic Fatty Acid Metabolism Mediates the Orexigenic Action of Ghrelin

(2008) Miguel López et al.   Cell Metabolism

Downregulation of AMP-activated protein kinase by Cidea-mediated ubiquitination and degradation in brown adipose tissue

(2008) Jingzong Qi et al.   EMBO JOURNAL

Acute Effects of Glucagon-Like Peptide-1 on Hypothalamic Neuropeptide and AMP Activated Kinase Expression in Fasted Rats

(2008) Sanghee SEO et al.   ENDOCRINE JOURNAL

Central Resistin Regulates Hypothalamic and Peripheral Lipid Metabolism in a Nutritional-Dependent Fashion

(2008) María J. Vázquez et al.   ENDOCRINOLOGY

Glucocorticoids Increase Neuropeptide Y and Agouti-Related Peptide Gene Expression via Adenosine Monophosphate-Activated Protein Kinase Signaling in the Arcuate Nucleus of Rats

(2008) Hiroshi Shimizu et al.   ENDOCRINOLOGY

Dorsal Hindbrain 5′-Adenosine Monophosphate-Activated Protein Kinase as an Intracellular Mediator of Energy Balance

(2008) Matthew R. Hayes et al.   ENDOCRINOLOGY

Intracerebroventricular injection of citrate inhibits hypothalamic AMPK and modulates feeding behavior and peripheral insulin signaling

(2008) Graziela R Stoppa et al.   JOURNAL OF ENDOCRINOLOGY

UCP2 mediates ghrelin’s action on NPY/AgRP neurons by lowering free radicals

(2008) Zane B. Andrews et al.   NATURE

New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure

(2008) Yu-Hua Tseng et al.   NATURE

The Orexigenic Effect of Ghrelin Is Mediated through Central Activation of the Endogenous Cannabinoid System

(2008) Blerina Kola et al.   PLoS One

AMPK: a metabolic gauge regulating whole-body energy homeostasis

(2008) Ricardo Lage et al.   TRENDS IN MOLECULAR MEDICINE