The chemistry and biology of guanidine natural products

Elucidation of the Teixobactin Pharmacophore

(2016) Hyunjun Yang et al.   ACS Chemical Biology

Guanidine Synthesis: Use of Amidines as Guanylating Agents

(2016) Mattijs Baeten et al.   ADVANCED SYNTHESIS & CATALYSIS

Cyclic Guanidine Compounds from Toxic Newts Support the Hypothesis that Tetrodotoxin is Derived from a Monoterpene

(2016) Yuta Kudo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Synthesis of Axinellamines A and B

(2016) Zhiqiang Ma et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Investigating the Toxicity of the Aeruginosin Chlorosulfopeptides by Chemical Synthesis

(2016) Manuel Scherer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Construction of Vicinal Quaternary Stereogenic Centers by Enantioselective Direct Mannich-Type Reaction Using a Chiral Bis(guanidino)iminophosphorane Catalyst

(2016) Tadahiro Takeda et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Sulfoxidation Catalyzed by a Bisguanidinium Diphosphatobisperoxotungstate Ion Pair

(2016) Xinyi Ye et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Synthesis of 11-Saxitoxinethanoic Acid and Evaluation of its Inhibitory Activity on Voltage-Gated Sodium Channels

(2016) Chao Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Copper/Guanidine-Catalyzed Asymmetric Alkynylation of Isatins

(2016) Quangang Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dual Targeting of Cell Wall Precursors by Teixobactin Leads to Cell Lysis

(2016) Tomoyuki Homma et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Enduracididine, a rare amino acid component of peptide antibiotics: Natural products and synthesis

(2016) Darcy J Atkinson et al.   Beilstein Journal of Organic Chemistry

Asymmetric α-amination of β-keto esters using a guanidine–bisurea bifunctional organocatalyst

(2016) Minami Odagi et al.   Beilstein Journal of Organic Chemistry

A chiral analog of the bicyclic guanidine TBD: synthesis, structure and Brønsted base catalysis

(2016) Mariano Goldberg et al.   Beilstein Journal of Organic Chemistry

Evidence for an iterative module in chain elongation on the azalomycin polyketide synthase

(2016) Hui Hong et al.   Beilstein Journal of Organic Chemistry

Synthesis and biological evaluation of analogues of the potent ADAM8 inhibitor cyclo(RLsKDK) for the treatment of inflammatory diseases and cancer metastasis

(2016) Victor Yim et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Structure-based design, synthesis, and biological evaluation of Leu-Arg dipeptide analogs as novel hepsin inhibitors

(2016) Hongmok Kwon et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Rational design, synthesis and in vitro evaluation of allylidene hydrazinecarboximidamide derivatives as BACE-1 inhibitors

(2016) Priti Jain et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Bromotyrosine-derived metabolites from an Indonesian marine sponge in the family Aplysinellidae (Order Verongiida)

(2016) Jingqiu Dai et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Bromopyrrole Alkaloids from Okinawan Marine Sponges Agelas spp.

(2016) Naonobu Tanaka et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Structural and Mechanistic Insights into s-Block Bimetallic Catalysis: Sodium Magnesiate-Catalyzed Guanylation of Amines

(2016) Marco De Tullio et al.   CHEMISTRY-A EUROPEAN JOURNAL

Total Synthesis and Functional Evaluation of Fourteen Derivatives of Lysocin E: Importance of Cationic, Hydrophobic, and Aromatic Moieties for Antibacterial Activity

(2016) Takuya Kaji et al.   CHEMISTRY-A EUROPEAN JOURNAL

The praying mantis (Mantodea) as predator of the poisonous red-spotted newt Notophthalmus viridescens (Amphibia: Urodela: Salamandridae)

(2016) Dietrich Mebs et al.   CHEMOECOLOGY

Arginine modified polymeric micelles as a novel drug delivery system with enhanced endocytosis efficiency

(2016) Song Luo et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Tetrodotoxin

(2016) Max N. Lorentz et al.   CURRENT BIOLOGY

N-Arylation of Amidines and Guanidines: An Update

(2016) Grigory Kantin et al.   CURRENT ORGANIC CHEMISTRY

Deep Extraction Desulfurization with a Novel Guanidinium-Based Strong Magnetic Room-Temperature Ionic Liquid

(2016) Tian Yao et al.   ENERGY & FUELS

Low dose extended exposure to saxitoxin and its potential neurodevelopmental effects: A review

(2016) Katie O’Neill et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

A General and Mild Copper(I)-Catalyzed Three-Component Reaction of Cyanamides, Amines, and Diaryl­iodonium Triflates

(2016) Jihui Li et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Photochemical Reductive C-C Coupling with a Guanidine Electron Donor

(2016) Sven Wiesner et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

The genetics, biosynthesis and regulation of toxic specialized metabolites of cyanobacteria

(2016) Leanne A. Pearson et al.   HARMFUL ALGAE

A review of the phylogeny, ecology and toxin production of bloom-forming Aphanizomenon spp. and related species within the Nostocales (cyanobacteria)

(2016) Samuel Cirés et al.   HARMFUL ALGAE

Antimicrobial activity and cytotoxicity of piperazinium- and guanidinium-based ionic liquids

(2016) Jing Yu et al.   JOURNAL OF HAZARDOUS MATERIALS

Structure-Based Design of an Iminoheterocyclic β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE) Inhibitor that Lowers Central Aβ in Nonhuman Primates

(2016) Mihirbaran Mandal et al.   JOURNAL OF MEDICINAL CHEMISTRY

Robenidine Analogues as Gram-Positive Antibacterial Agents

(2016) Rebecca J. Abraham et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mimicking of Arginine by Functionalized Nω-Carbamoylated Arginine As a New Broadly Applicable Approach to Labeled Bioactive Peptides: High Affinity Angiotensin, Neuropeptide Y, Neuropeptide FF, and Neurotensin Receptor Ligands As Examples

(2016) Max Keller et al.   JOURNAL OF MEDICINAL CHEMISTRY

Peptide–Boronic Acid Inhibitors of Flaviviral Proteases: Medicinal Chemistry and Structural Biology

(2016) Christoph Nitsche et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of the 3-Imino-1,2,4-thiadiazinane 1,1-Dioxide Derivative Verubecestat (MK-8931)–A β-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor for the Treatment of Alzheimer’s Disease

(2016) Jack D. Scott et al.   JOURNAL OF MEDICINAL CHEMISTRY

Exploring the N-Terminal Region of C-X-C Motif Chemokine 12 (CXCL12): Identification of Plasma-Stable Cyclic Peptides As Novel, Potent C-X-C Chemokine Receptor Type 4 (CXCR4) Antagonists

(2016) Salvatore Di Maro et al.   JOURNAL OF MEDICINAL CHEMISTRY

Haliclonadiamine Derivatives and 6-epi-Monanchorin from the Marine Sponge Halichondria panicea Collected at Iriomote Island

(2016) Delfly B. Abdjul et al.   JOURNAL OF NATURAL PRODUCTS

Variochelins, Lipopeptide Siderophores from Variovorax boronicumulans Discovered by Genome Mining

(2016) Colette Kurth et al.   JOURNAL OF NATURAL PRODUCTS

Synthesis of Peramine, an Anti-insect Defensive Alkaloid Produced by Endophytic Fungi of Cool Season Grasses

(2016) Matthew R. Nelli et al.   JOURNAL OF NATURAL PRODUCTS

Dragmacidins G and H, Bisindole Alkaloids Tethered by a Guanidino Ethylthiopyrazine Moiety, from a Lipastrotethya sp. Marine Sponge

(2016) Yuki Hitora et al.   JOURNAL OF NATURAL PRODUCTS

The Halicylindramides, Farnesoid X Receptor Antagonizing Depsipeptides from a Petrosia sp. Marine Sponge Collected in Korea

(2016) Dongyup Hahn et al.   JOURNAL OF NATURAL PRODUCTS

Cytotoxic Guanidine Alkaloids from a French Polynesian Monanchora n. sp. Sponge

(2016) Amr El-Demerdash et al.   JOURNAL OF NATURAL PRODUCTS

Analogues of Marine Guanidine Alkaloids Are in Vitro Effective against Trypanosoma cruzi and Selectively Eliminate Leishmania (L.) infantum Intracellular Amastigotes

(2016) Ligia F. Martins et al.   JOURNAL OF NATURAL PRODUCTS

Chemical Diversity, Origin, and Analysis of Phycotoxins

(2016) Silas Anselm Rasmussen et al.   JOURNAL OF NATURAL PRODUCTS

Synthesis of Chiral Bicyclic Guanidinium Salts using Di(imidazole-1-yl)methanimine

(2016) Aleksej Turočkin et al.   JOURNAL OF ORGANIC CHEMISTRY

Phosphoryl Transfer Processes Promoted by a Trifunctional Calix[4]arene Inspired by DNA Topoisomerase I

(2016) Riccardo Salvio et al.   JOURNAL OF ORGANIC CHEMISTRY

15N NMR Spectroscopy, X-ray and Neutron Diffraction, Quantum-Chemical Calculations, and UV/vis-Spectrophotometric Titrations as Complementary Techniques for the Analysis of Pyridine-Supported Bicyclic Guanidine Superbases

(2016) Ryan J. Schwamm et al.   JOURNAL OF ORGANIC CHEMISTRY

Iron Trichloride and Air Mediated Guanylation of Acylthioureas. An Ecological Route to Acylguanidines: Scope and Mechanistic Insights

(2016) Simon Pape et al.   JOURNAL OF ORGANIC CHEMISTRY

A Green Light-Triggerable RGD Peptide for Photocontrolled Targeted Drug Delivery: Synthesis and Photolysis Studies

(2016) Albert Gandioso et al.   JOURNAL OF ORGANIC CHEMISTRY

Paralytic shellfish toxin biosynthesis in cyanobacteria and dinoflagellates: A molecular overview

(2016) Da-Zhi Wang et al.   Journal of Proteomics

Defining the Catechol–Cation Synergy for Enhanced Wet Adhesion to Mineral Surfaces

(2016) Michael V. Rapp et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

11-Step Total Synthesis of Araiosamines

(2016) Maoqun Tian et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of the Paralytic Shellfish Poisons (+)-Gonyautoxin 2, (+)-Gonyautoxin 3, and (+)-11,11-Dihydroxysaxitoxin

(2016) John V. Mulcahy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pentanidium- and Bisguanidinium-Catalyzed Enantioselective Alkylations Using Silylamide as Brønsted Probase

(2016) Bo Teng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Distal Stereocontrol Using Guanidinylated Peptides as Multifunctional Ligands: Desymmetrization of Diarylmethanes via Ullman Cross-Coupling

(2016) Byoungmoo Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cell-Penetrating, Guanidinium-Rich Oligophosphoesters: Effective and Versatile Molecular Transporters for Drug and Probe Delivery

(2016) Colin J. McKinlay et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis of Mannopeptimycins α and β

(2016) Bo Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Novel Acylguanidine-Based Inhibitor of HIV-1

(2016) Philip Mwimanzi et al.   JOURNAL OF VIROLOGY

Induction of ionic smectic C phases: a systematic study of alkyl-linked guanidinium-based liquid crystals

(2016) Nina Trbojevic et al.   LIQUID CRYSTALS

Guanidine Alkaloids from the Marine Sponge Monanchora pulchra Show Cytotoxic Properties and Prevent EGF-Induced Neoplastic Transformation in Vitro

(2016) Sergey Dyshlovoy et al.   Marine Drugs

Alkaloids from the Sponge Stylissa carteri Present Prospective Scaffolds for the Inhibition of Human Immunodeficiency Virus 1 (HIV-1)

(2016) Aubrie O’Rourke et al.   Marine Drugs

The Bacterial (Vibrio alginolyticus) Production of Tetrodotoxin in the Ribbon Worm Lineus longissimus—Just a False Positive?

(2016) Malin Strand et al.   Marine Drugs

Marine Natural Products from New Caledonia—A Review

(2016) Sofia-Eléna Motuhi et al.   Marine Drugs

Polycyclic Guanidine Alkaloids from Poecilosclerida Marine Sponges

(2016) Estelle Sfecci et al.   Marine Drugs

New Insights on the Mode of Action of Microcystins in Animal Cells - A Review

(2016) Elisabete Valério et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Mechanisms of Microcystin-induced Cytotoxicity and Apoptosis

(2016) Liang Chen et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

A New Indole Alkaloid from the Toad Venom of Bufo bufo gargarizans

(2016) Ying-Hui Dai et al.   MOLECULES

Military Importance of Natural Toxins and Their Analogs

(2016) Vladimír Pitschmann et al.   MOLECULES

The chemistry and biology of guanidine natural products

(2016) Roberto G. S. Berlinck et al.   NATURAL PRODUCT REPORTS

Asymmetric synthesis of crambescin A–C carboxylic acids and their inhibitory activity on voltage-gated sodium channels

(2016) Atsuo Nakazaki et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Stereoselective Synthesis of Cyclic Guanidines by Directed Diamination of Unactivated Alkenes

(2016) Artur K. Mailyan et al.   ORGANIC LETTERS

A Synthetic Strategy for Saxitoxin Skeleton by a Cascade Bromocyclization: Total Synthesis of (+)-Decarbamoyl-α-saxitoxinol

(2016) Sohei Ueno et al.   ORGANIC LETTERS

Synthesis of Cyclic Guanidines via Silver-Catalyzed Intramolecular Alkene Hydroamination Reactions of N-Allylguanidines

(2016) Zachary J. Garlets et al.   ORGANIC LETTERS

Kinetic Resolution of Oxaziridines via Chiral Bifunctional Guanidine-Catalyzed Enantioselective α-Hydroxylation of β-Keto Esters

(2016) Xiaobin Lin et al.   ORGANIC LETTERS

Total Synthesis of Teixobactin

(2016) Andrew M. Giltrap et al.   ORGANIC LETTERS

Metagenomic Analysis of the Sponge Discodermia Reveals the Production of the Cyanobacterial Natural Product Kasumigamide by ‘Entotheonella’

(2016) Yu Nakashima et al.   PLoS One

An optimized guanidination method for large-scale proteomic studies

(2016) Juanying Ye et al.   PROTEOMICS

Guanidinyl benzothiazole derivatives: Synthesis and structure activity relationship studies of a novel series of potential antimicrobial and antioxidants

(2016) Mahesh Bhat et al.   RESEARCH ON CHEMICAL INTERMEDIATES

One-Pot Synthesis of C 2 Symmetric and Asymmetric N,N′,N′′-Substituted Guanidines from Aryl Isothiocyanates and Amines

(2016) Wong Phakhodee et al.   SYNLETT

Facile Guanidine Formation under Mild Acidic Conditions

(2016) Kosuke Namba et al.   SYNLETT

Synthesis, applications and mechanistic investigations of C2 symmetric guanidinium salts

(2016) Matthew T. Allingham et al.   TETRAHEDRON

Determinative role of ring size and substituents in highly selective synthesis of functionalized bicyclic guanidine and tetra substituted thiophene derivatives based on salt adducts afforded by cyclic thioureas and ketene dithioacetal

(2016) Abdolali Alizadeh et al.   TETRAHEDRON

Mellpaladines and dopargimine, novel neuroactive guanidine alkaloids from a Palauan Didemnidae tunicate

(2016) Hajime Uchimasu et al.   TETRAHEDRON

Simple and efficient methodology to prepare guanidines from 1,3-disubstituted thioureas

(2016) Márcio V. Costa et al.   TETRAHEDRON LETTERS

Ultrasound-assisted synthesis of substituted guanidines from thioureas

(2016) Mookda Pattarawarapan et al.   TETRAHEDRON LETTERS

The voltage-gated sodium ion channel inhibitory activities of a new tetrodotoxin analogue, 4,4a-anhydrotetrodotoxin, and three other analogues evaluated by colorimetric cell-based assay

(2016) Shogo Saruhashi et al.   TOXICON

Biological toxins of potential bioterrorism risk: Current status of detection and identification technology

(2016) Brigitte G. Dorner et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Total synthesis of teixobactin

(2016) Kang Jin et al.   Nature Communications

Ionic liquids derived from organosuperbases: en route to superionic liquids

(2016) Janusz Nowicki et al.   RSC Advances

Biosynthetic route towards saxitoxin and shunt pathway

(2016) Shigeki Tsuchiya et al.   Scientific Reports

Toxicity and population structure of the Rough-Skinned Newt (Taricha granulosa) outside the range of an arms race with resistant predators

(2016) Michael T.J. Hague et al.   Ecology and Evolution

Cobalt-Catalyzed Intermolecular Oxidative Isocyanide Insertion with Two Amines: An Approach to Guanidines

(2015) Tong-Hao Zhu et al.   ADVANCED SYNTHESIS & CATALYSIS

Homoarginine, arginine, and relatives: analysis, metabolism, transport, physiology, and pathology

(2015) Dimitrios Tsikas et al.   AMINO ACIDS

Homoarginine in the renal and cardiovascular systems

(2015) Stefan Pilz et al.   AMINO ACIDS

Guanidinoacetic acid as a performance-enhancing agent

(2015) Sergej M. Ostojic   AMINO ACIDS

Total Synthesis of the Posttranslationally Modified Polyazole Peptide Antibiotic Plantazolicin A

(2015) Hiroki Wada et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Total Synthesis of (−)-Martinellic Acid

(2015) Mukesh Pappoppula et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An Amidinohydrolase Provides the Missing Link in the Biosynthesis of Amino Marginolactone Antibiotics

(2015) Hui Hong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Small Cause, Great Impact: Modification of the Guanidine Group in the RGD Motif Controls Integrin Subtype Selectivity

(2015) Tobias G. Kapp et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biosynthesis of the CarbamoylatedD-Gulosamine Moiety of Streptothricins: Involvement of a Guanidino-N-glycosyltransferase and anN-Acetyl-D-gulosamine Deacetylase

(2015) Zhengyan Guo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The marine spongeAgelas citrinaas a source of the new pyrrole–imidazole alkaloids citrinamines A–D andN-methylagelongine

(2015) Christine Cychon et al.   Beilstein Journal of Organic Chemistry

Streptomyces wadayamensis MppP Is a Pyridoxal 5′-Phosphate-Dependent l-Arginine α-Deaminase, γ-Hydroxylase in the Enduracididine Biosynthetic Pathway

(2015) Lanlan Han et al.   BIOCHEMISTRY

Mono-guanidine heterolipid based SMEDDS: A promising tool for cytosolic delivery of antineoplastics

(2015) Harshad Shete et al.   BIOMATERIALS

Synthesis, structure activity relationship, radiolabeling and preclinical evaluation of high affinity ligands for the ion channel of the N-methyl-d-aspartate receptor as potential imaging probes for positron emission tomography

(2015) Pieter J. Klein et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Guanidinium compounds with sub-micromolar activities against Mycobacterium tuberculosis . Synthesis, characterization and biological evaluations

(2015) Hugues Massimba-Dibama et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Anti-plasmodial activity of bradykinin and analogs

(2015) Adriana F. Silva et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Rethinking the old antiviral drug moroxydine: Discovery of novel analogues as anti-hepatitis C virus (HCV) agents

(2015) Andrea Magri et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Predictably Convergent Evolution of Sodium Channels in the Arms Race between Predators and Prey

(2015) Edmund D. Brodie III et al.   BRAIN BEHAVIOR AND EVOLUTION

Recent development of synthetic preparation methods for guanidines via transition metal catalysis

(2015) Wen-Xiong Zhang et al.   CHEMICAL COMMUNICATIONS

Guanidinium iodide-catalyzed oxidative α-nitroalkylation of β-ketoamides

(2015) Koji Yasui et al.   CHEMICAL COMMUNICATIONS

Netamines O-S, Five New Tricyclic Guanidine Alkaloids from the Madagascar SpongeBiemna laboutei, and Their Antimalarial Activities

(2015) Emmanuelle Gros et al.   CHEMISTRY & BIODIVERSITY

Synthesis of a Tricyclic Bisguanidine Compound Structurally Related to Saxitoxin and its Identification in Paralytic Shellfish Toxin-Producing Microorganisms

(2015) Shigeki Tsuchiya et al.   CHEMISTRY-A EUROPEAN JOURNAL

The Guanidinium Unit in the Catalysis of Phosphoryl Transfer Reactions: From Molecular Spacers to Nanostructured Supports

(2015) Riccardo Salvio   CHEMISTRY-A EUROPEAN JOURNAL

Chiral Iminophosphoranes-An Emerging Class of Superbase Organocatalysts

(2015) Henryk Krawczyk et al.   CHEMISTRY-A EUROPEAN JOURNAL

Bicyclic Guanidine Catalyzed Asymmetric Tandem Isomerization Intramolecular-Diels-Alder Reaction: The First Catalytic Enantioselective Total Synthesis of (+)-alpha-Yohimbine

(2015) Wei Feng et al.   Chemistry-An Asian Journal

First evidence of accumulation in cyanobacteria of guanidinoacetate, a precursor of the toxin cylindrospermopsin

(2015) Ángel Barón-Sola et al.   CHEMOSPHERE

The synthesis of indolo[2,3-b]quinoline derivatives with a guanidine group: Highly selective cytotoxic agents

(2015) Katarzyna Sidoryk et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Advanced physiological roles of guanidinoacetic acid

(2015) Sergej M. Ostojic   EUROPEAN JOURNAL OF NUTRITION

Synthetic Strategies for Preparing Bicyclic Guanidines

(2015) Barbora Lemrová et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Puffer fish and its consumption: To eat or not to eat?

(2015) Inês Panão et al.   FOOD REVIEWS INTERNATIONAL

Is there more than one way to skin a newt? Convergent toxin resistance in snakes is not due to a common genetic mechanism

(2015) C R Feldman et al.   HEREDITY

2-Debromonagelamide U, 2-Debromomukanadin G, and 2-Debromonagelamide P from Marine Sponge Agelas sp.

(2015) Jun'ichi Kobayashi et al.   HETEROCYCLES

Saxitoxin and the Ochre Sea Star: Molecule of Keystone Significance and a Classic Keystone Species

(2015) Ryan P. Ferrer et al.   INTEGRATIVE AND COMPARATIVE BIOLOGY

An overview on the origin and production of tetrodotoxin, a potent neurotoxin

(2015) S. Jal et al.   JOURNAL OF APPLIED MICROBIOLOGY

Creation of Customized Bioactivity within a 14-Membered Macrolide Scaffold: Design, Synthesis, and Biological Evaluation Using a Family-18 Chitinase

(2015) Akihiro Sugawara et al.   JOURNAL OF MEDICINAL CHEMISTRY

α2-Adrenoceptor Antagonists: Synthesis, Pharmacological Evaluation, and Molecular Modeling Investigation of Pyridinoguanidine, Pyridino-2-aminoimidazoline and Their Derivatives

(2015) Brendan Kelly et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Selective, Cell-Permeable Nonphosphorylated Bicyclic Peptidyl Inhibitor against Peptidyl–Prolyl Isomerase Pin1

(2015) Bisheng Jiang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design of Specific Serine Protease Inhibitors Based on a Versatile Peptide Scaffold: Conversion of a Urokinase Inhibitor to a Plasma Kallikrein Inhibitor

(2015) Peng Xu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure–Activity Relationships of Novel Tryptamine-Based Inhibitors of Bacterial Transglycosylase

(2015) Izidor Sosič et al.   JOURNAL OF MEDICINAL CHEMISTRY

N′-3-(Trifluoromethyl)phenyl Derivatives of N-Aryl-N′-methylguanidines as Prospective PET Radioligands for the Open Channel of the N-Methyl-d-aspartate (NMDA) Receptor: Synthesis and Structure–Affinity Relationships

(2015) Gregory R. Naumiec et al.   JOURNAL OF MEDICINAL CHEMISTRY

Combinatorial Libraries As a Tool for the Discovery of Novel, Broad-Spectrum Antibacterial Agents Targeting the ESKAPE Pathogens

(2015) Renee Fleeman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Voltage-Gated Sodium Channels: Structure, Function, Pharmacology, and Clinical Indications

(2015) Manuel de Lera Ruiz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Anti-parasitic Guanidine and Pyrimidine Alkaloids from the Marine Sponge Monanchora arbuscula

(2015) Mario F. C. Santos et al.   JOURNAL OF NATURAL PRODUCTS

Plantadeprate A, a Tricyclic Monoterpene Zwitterionic Guanidium, and Related Derivatives from the Seeds of Plantago depressa

(2015) Xiu-Mian Zheng et al.   JOURNAL OF NATURAL PRODUCTS

Antipodal Crambescin A2 Homologues from the Marine Sponge Pseudaxinella reticulata. Antifungal Structure–Activity Relationships

(2015) Matthew T. Jamison et al.   JOURNAL OF NATURAL PRODUCTS

Mechanistic Insights into Bicyclic Guanidine-Catalyzed Reactions from Microscopic and Macroscopic Perspectives

(2015) Hansong Xue et al.   JOURNAL OF ORGANIC CHEMISTRY

Halocyclization of Unsaturated Guanidines Mediated by Koser’s Reagent and Lithium Halides

(2015) Marion Daniel et al.   JOURNAL OF ORGANIC CHEMISTRY

Total Synthesis and Reassignment of the Structures of the Antimicrobial Lipodepsipeptides Circulocin γ and δ

(2015) James R. Cochrane et al.   JOURNAL OF ORGANIC CHEMISTRY

Chiral Bifunctional Guanidine-Catalyzed Enantioselective Aza-Henry Reaction of Isatin-Derived Ketimines

(2015) Bing Fang et al.   JOURNAL OF ORGANIC CHEMISTRY

The Mechanism of Action of Lysobactin

(2015) Wonsik Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tumor Acidity-Sensitive Polymeric Vector for Active Targeted siRNA Delivery

(2015) Chun-Yang Sun et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Crambescin C1 Exerts a Cytoprotective Effect on HepG2 Cells through Metallothionein Induction

(2015) María Roel et al.   Marine Drugs

Tetrodotoxin, an Extremely Potent Marine Neurotoxin: Distribution, Toxicity, Origin and Therapeutical Uses

(2015) Jorge Lago et al.   Marine Drugs

Gene duplication, loss and selection in the evolution of saxitoxin biosynthesis in alveolates

(2015) Shauna A. Murray et al.   MOLECULAR PHYLOGENETICS AND EVOLUTION

Unconventional Bifunctional Lewis-Brønsted Acid Activation Mode in Bicyclic Guanidine-Catalyzed Conjugate Addition Reactions

(2015) Bokun Cho et al.   MOLECULES

A Mild and Regioselective Ring-Opening of Aziridines with Acid Anhydride Using TBD or PS-TBD as a Catalyst

(2015) Satoru Matsukawa et al.   MOLECULES

A concise synthesis of (+)-batzelladine B from simple pyrrole-based starting materials

(2015) Brendan T. Parr et al.   NATURE

A new antibiotic kills pathogens without detectable resistance

(2015) Losee L. Ling et al.   NATURE

Catalyst free C–N bond formation by the reaction of amines with diimides: bulky guanidines

(2015) Ashim Baishya et al.   NEW JOURNAL OF CHEMISTRY

A Highly Stereoselective and Scalable Synthesis of l-allo-Enduracididine

(2015) William Craig et al.   ORGANIC LETTERS

De Novo Asymmetric Synthesis of (+)-Monanchorin

(2015) Yuzhi Ma et al.   ORGANIC LETTERS

Synthesis and Biological Evaluation of a Teixobactin Analogue

(2015) Yahya E. Jad et al.   ORGANIC LETTERS

Mechanistic Considerations of the Catalytic Guanylation Reaction of Amines with Carbodiimides for Guanidine Synthesis

(2015) Ling Xu et al.   ORGANOMETALLICS

Ecliptamines A–D, four new guanidine alkaloids from Eclipta prostrata L.

(2015) Akinori Tabata et al.   Phytochemistry Letters

Guanidinium-based sulfonic acid as a new Brønsted acid organocatalyst in organic synthesis in water

(2015) Mozhdeh Seyyedhamzeh et al.   RESEARCH ON CHEMICAL INTERMEDIATES

An Efficient Route to N-Monosubstituted Guanidino-Lactams

(2015) Matteo Zanda et al.   SYNTHESIS-STUTTGART

Total synthesis of tubastrine and 3-dehydroxy tubastrine by microwave-assisted cross-coupling reactions

(2015) Marianne Lorentzen et al.   TETRAHEDRON

Syntheses of cyclic guanidine-containing natural products

(2015) Yuyong Ma et al.   TETRAHEDRON

Agelamadin F and tauroacidin E, bromopyrrole alkaloids from an Okinawan marine sponge Agelas sp.

(2015) Taishi Kusama et al.   TETRAHEDRON LETTERS

1,4-addition reaction of 5H-oxazol-4-ones to vinyl ketones catalyzed by chiral guanidines

(2015) Akane Morita et al.   TETRAHEDRON LETTERS

Synthesis of the cyclic prenylguanidine nitensidine E using a palladium-catalyzed carbenylative amination

(2015) Mitsuru Kitamura et al.   TETRAHEDRON LETTERS

Highly enantioselective and diastereoselective conjugate addition of 5H-oxazol-4-ones to 2-chloroacrylonitrile catalyzed by chiral guanidines

(2015) Tomonori Misaki et al.   TETRAHEDRON LETTERS

Design and synthesis of a chiral seven-membered ring guanidine organocatalyst applied to asymmetric vinylogous aldol reactions

(2015) Roya Mirabdolbaghi et al.   TETRAHEDRON-ASYMMETRY

Identification of tetrodotoxin-producing bacteria from goby Yongeichthys criniger

(2015) Fen Wei et al.   TOXICON

Natural Product Biosynthetic Diversity and Comparative Genomics of the Cyanobacteria

(2015) Elke Dittmann et al.   TRENDS IN MICROBIOLOGY

Marine alkaloid Monanchocidin a overcomes drug resistance by induction of autophagy and lysosomal membrane permeabilization

(2015) Sergey A. Dyshlovoy et al.   Oncotarget

No Evidence for a Culturable Bacterial Tetrodotoxin Producer in Pleurobranchaea maculata (Gastropoda: Pleurobranchidae) and Stylochoplana sp. (Platyhelminthes: Polycladida)

(2015) Lauren Salvitti et al.   Toxins

Facile Synthesis of Guanidine Functionalised Building Blocks

(2015) Shane M. Hickey et al.   Asian Journal of Organic Chemistry

Development of Guanidine-Bisurea Bifunctional Organocatalyst Bearing Chirality at the Inner and Outer Sides of the Urea Groups, and Application to Enantioselective α-Hydroxylation of Pyranoindolizine Intermediate for Camptothecin Synthesis

(2015) Minami Odagi et al.   Symmetry-Basel

NovelN-(2,2′-disubstituted-2H-cromenyl)-N′,N″-disubstituted Guanidine Derivatives as anS-Nitrosoglutathion Reductase Inhibitor

(2015) Gee-Hyung Lee et al.   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

Evolutionary history of a complex adaptation: Tetrodotoxin resistance in salamanders

(2014) Charles T. Hanifin et al.   EVOLUTION

Integrating phylogeny, geographic niche partitioning and secondary metabolite synthesis in bloom-forming Planktothrix

(2014) Rainer Kurmayer et al.   ISME Journal

Total Synthesis of Clavatadine A

(2014) Stephanie J. Conn et al.   JOURNAL OF NATURAL PRODUCTS

Experimental and computational studies of ring-opening polymerization of ethylene brassylate macrolactone and copolymerization with ε-caprolactone and TBD-guanidine organic catalyst

(2014) Ana Pascual et al.   JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY

Synthesis and identification of proposed biosynthetic intermediates of saxitoxin in the cyanobacterium Anabaena circinalis (TA04) and the dinoflagellate Alexandrium tamarense (Axat-2)

(2014) Shigeki Tsuchiya et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Seven new microcystin variants discovered from a nativeMicrocystis aeruginosastrain - unambiguous assignment of product ions by tandem mass spectrometry

(2014) Yulin Qi et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Asymmetric syntheses of sceptrin and massadine and evidence for biosynthetic enantiodivergence

(2014) Z. Ma et al.   SCIENCE

Diversity and Biosynthetic Potential of Culturable Microbes Associated with Toxic Marine Animals

(2013) Rocky Chau et al.   Marine Drugs

Synthesis of crambescin B carboxylic acid, a potent inhibitor of voltage-gated sodium channels

(2013) Atsuo Nakazaki et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Enantiomeric Natural Products: Occurrence and Biogenesis

(2012) Jennifer M. Finefield et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A macrolactonization approach to the total synthesis of the antimicrobial cyclic depsipeptide LI-F04a and diastereoisomeric analogues

(2012) James R Cochrane et al.   Beilstein Journal of Organic Chemistry

Effects of Cyclic Lipodepsipeptide Structural Modulation on Stability, Antibacterial Activity, and Human Cell Toxicity

(2012) Nina Bionda et al.   ChemMedChem

A Synthetic Route to the Saxitoxin Skeleton: Synthesis of Decarbamoyl α-Saxitoxinol, an Analogue of Saxitoxin Produced by the Cyanobacterium Lyngbya wollei

(2011) Yusuke Sawayama et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Araiosamines A−D: Tris-bromoindole Cyclic Guanidine Alkaloids from the Marine SpongeClathria (Thalysias) araiosa

(2011) Xiaomei Wei et al.   JOURNAL OF ORGANIC CHEMISTRY

Total Synthesis of (+)-Decarbamoylsaxitoxin and (+)-Gonyautoxin 3

(2010) Osamu Iwamoto et al.   ORGANIC LETTERS

Total Synthesis and Assignment of the Side Chain Stereochemistry of LI-F04a: An Antimicrobial Cyclic Depsipeptide

(2010) James R. Cochrane et al.   ORGANIC LETTERS

Biosynthetic Intermediate Analysis and Functional Homology Reveal a Saxitoxin Gene Cluster in Cyanobacteria

(2008) R. Kellmann et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Clavatadine A, A Natural Product with Selective Recognition and Irreversible Inhibition of Factor XIa†

(2008) Malcolm S. Buchanan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Isolation and Structure Elucidation of New and Unusual Saxitoxin Analogues from Mussels

(2008) Carmela Dell’Aversano et al.   JOURNAL OF NATURAL PRODUCTS