Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 25, Issue 22, Pages 5372-5376Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2015.09.029
Keywords
HCV; Amidinourea; Guanidine; Hepatitis C life cycle; RNA replication
Categories
Funding
- Compagnia San Paolo (Italy)
- Medical Research Council - United Kingdom
- Royal Society of Chemistry - United Kingdom
- MRC [MC_UU_12014/2] Funding Source: UKRI
- Medical Research Council [MC_UU_12014/2] Funding Source: researchfish
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The discovery of a novel class of HCV inhibitors is described. The new amidinourea compounds were designed as isosteric analogues of the antiviral drug moroxydine. The two derivatives 11g and 11h showed excellent HCV inhibition activity and viability and proved to inhibit a step(s) of the RNA replication. The new compounds have been synthesized in only three synthetic steps from cheap building blocks and in high yields, thus turning to be promising drug candidates in the development of cheaper HCV treatments. (C) 2015 Elsevier Ltd. All rights reserved.
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