Ginkgolic Acid C 17:1, Derived from Ginkgo biloba Leaves, Suppresses Constitutive and Inducible STAT3 Activation through Induction of PTEN and SHP-1 Tyrosine Phosphatase

The STAT3 pathway as a therapeutic target in head and neck cancer: Barriers and innovations

(2016) Jessica L. Geiger et al.   ORAL ONCOLOGY

Ginkgetin Blocks Constitutive STAT3 Activation and Induces Apoptosis through Induction of SHP-1 and PTEN Tyrosine Phosphatases

(2016) Seung Ho Baek et al.   PHYTOTHERAPY RESEARCH

Enhancing SHP-1 expression with 5-azacytidine may inhibit STAT3 activation and confer sensitivity in lestaurtinib (CEP-701)-resistant FLT3-ITD positive acute myeloid leukemia

(2015) Hamid Ali Nagi Al-Jamal et al.   BMC CANCER

Cinobufagin exerts anti-proliferative and pro-apoptotic effects through the modulation ROS-mediated MAPKs signaling pathway

(2015) Seung Ho Baek et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Constitutive activation of STAT3 in breast cancer cells: A review

(2015) Kasturi Banerjee et al.   INTERNATIONAL JOURNAL OF CANCER

Molecular characterization of antitumor effects of the rhizome extract from Curcuma zedoaria on human esophageal carcinoma cells

(2015) YUNI ELSA HADISAPUTRI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

The Ying and Yang of STAT3 in Human Disease

(2015) Tiphanie P. Vogel et al.   JOURNAL OF CLINICAL IMMUNOLOGY

STAT3-Activating Cytokines: A Therapeutic Opportunity for Inflammatory Bowel Disease?

(2015) Paul M. Nguyen et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Ascochlorin, an isoprenoid antibiotic inhibits growth and invasion of hepatocellular carcinoma by targeting STAT3 signaling cascade through the induction of PIAS3

(2015) Xiaoyun Dai et al.   Molecular Oncology

SHP-1 is a negative regulator of epithelial–mesenchymal transition in hepatocellular carcinoma

(2015) L-C Fan et al.   ONCOGENE

Review of STAT3 (Signal Transducers and Activators of Transcription) in head and neck cancer

(2015) Shrikant Balasaheb Mali   ORAL ONCOLOGY

Ginkgolic acid suppresses the development of pancreatic cancer by inhibiting pathways driving lipogenesis

(2015) Jiguang Ma et al.   Oncotarget

Drug resistance in multiple myeloma: latest findings and new concepts on molecular mechanisms

(2015) Jahangir Abdi et al.   Oncotarget

Targeting the STAT3 signaling pathway in cancer: Role of synthetic and natural inhibitors

(2014) Kodappully Sivaraman Siveen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Small molecule 1′-acetoxychavicol acetate suppresses breast tumor metastasis by regulating the SHP-1/STAT3/MMPs signaling pathway

(2014) Jieqiong Wang et al.   BREAST CANCER RESEARCH AND TREATMENT

Bergamottin, a natural furanocoumarin obtained from grapefruit juice induces chemosensitization and apoptosis through the inhibition of STAT3 signaling pathway in tumor cells

(2014) Sung-Moo Kim et al.   CANCER LETTERS

STAT3, a key regulator of cell-to-cell communication in the heart

(2014) Arash Haghikia et al.   CARDIOVASCULAR RESEARCH

Treatment of patients with multiple myeloma over 65 yr: more tolerability or better response?

(2014) Pinar Tarkun et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Cyclosporin A affects the bioavailability of ginkgolic acids via inhibition of P-gp and BCRP

(2014) Li Li et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Thermal stability of ginkgolic acids from Ginkgo biloba and the effects of ginkgol C17:1 on the apoptosis and migration of SMMC7721 cells

(2014) Xiao-Ming Yang et al.   FITOTERAPIA

Development of a Novel Azaspirane That Targets the Janus Kinase-Signal Transducer and Activator of Transcription (STAT) Pathway in Hepatocellular Carcinomain Vitroandin Vivo

(2014) Chakrabhavi Dhananjaya Mohan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of STAT3 dimerization and acetylation by garcinol suppresses the growth of human hepatocellular carcinoma in vitro and in vivo

(2014) Gautam Sethi et al.   Molecular Cancer

STAT3 inhibitor WP1066 attenuates miRNA-21 to suppress human oral squamous cell carcinoma growth in vitro and in vivo

(2014) XUAN ZHOU et al.   ONCOLOGY REPORTS

STAT3 as a possible therapeutic target in human malignancies: lessons from acute myeloid leukemia

(2014) Øystein Bruserud et al.   Expert Review of Hematology

The Role of STAT3 in Non-Small Cell Lung Cancer

(2014) Daijiro Harada et al.   Cancers

Spectomycin B1 as a Novel SUMOylation Inhibitor That Directly Binds to SUMO E2

(2013) Mikako Hirohama et al.   ACS Chemical Biology

Sophoraflavanone G induces apoptosis of human cancer cells by targeting upstream signals of STATs

(2013) Byung-Hak Kim et al.   BIOCHEMICAL PHARMACOLOGY

Emodin inhibits growth and induces apoptosis in an orthotopic hepatocellular carcinoma model by blocking activation of STAT3

(2013) Aruljothi Subramaniam et al.   BRITISH JOURNAL OF PHARMACOLOGY

Emodin Suppresses Migration and Invasion through the Modulation of CXCR4 Expression in an Orthotopic Model of Human Hepatocellular Carcinoma

(2013) Kanjoormana Aryan Manu et al.   PLoS One

Role of STAT3 in Cancer Metastasis and Translational Advances

(2013) Mohammad Zahid Kamran et al.   Biomed Research International

STAT3 inhibition, a novel approach to enhancing targeted therapy in human cancers

(2012) XIAOCHUN WANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Inhibition of fatty acid synthase by ginkgolic acids from the leaves of Ginkgo biloba and their cytotoxic activity

(2012) Joonseok Oh et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

(2012) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Role of STAT3 in Transformation and Drug Resistance in CML

(2012) Rajesh R. Nair et al.   Frontiers in Oncology

Pathogenesis of Myeloma

(2011) Kenneth C. Anderson et al.   Annual Review of Pathology-Mechanisms of Disease

Celastrol inhibits proliferation and induces chemosensitization through down-regulation of NF-κB and STAT3 regulated gene products in multiple myeloma cells

(2011) Radhamani Kannaiyan et al.   BRITISH JOURNAL OF PHARMACOLOGY

Embelin suppresses STAT3 signaling, proliferation, and survival of multiple myeloma via the protein tyrosine phosphatase PTEN

(2011) Ji Young Heo et al.   CANCER LETTERS

γ-Tocotrienol is a novel inhibitor of constitutive and inducible STAT3 signalling pathway in human hepatocellular carcinoma: potential role as an antiproliferative, pro-apoptotic and chemosensitizing agent

(2010) Peramaiyan Rajendran et al.   BRITISH JOURNAL OF PHARMACOLOGY

Antitumor Effects of Ginkgolic Acid in Human Cancer Cell Occur via Cell Cycle Arrest and Decrease the Bcl-2/Bax Ratio to Induce Apoptosis

(2010) Chenchen Zhou et al.   CHEMOTHERAPY

Signal Transducer and Activator of Transcription-3, Inflammation, and Cancer

(2009) Bharat B. Aggarwal et al.   Annals of the New York Academy of Sciences

Ginkgolic Acid Inhibits Protein SUMOylation by Blocking Formation of the E1-SUMO Intermediate

(2009) Isao Fukuda et al.   CHEMISTRY & BIOLOGY

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE