Article
Chemistry, Medicinal
Waseem El-Huneidi, Khuloud Bajbouj, Jibran Sualeh Muhammad, Arya Vinod, Jasmin Shafarin, Ghalia Khoder, Mohamed A. Saleh, Jalal Taneera, Eman Abu-Gharbieh
Summary: Carnosic acid inhibits proliferation and survival of human gastric cancer cells in a dose-dependent manner by suppressing the phosphorylation/activation of Akt and mTOR, and enhancing cleavage of PARP as well as downregulating survivin expression.
Article
Biochemistry & Molecular Biology
Shuai Wang, Jian-Tao Shi, Xing-Rong Wang, Hong-Xia Mu, Xue-Ting Wang, Kai-Yan Xu, Qing-Shan Wang, Shi-Wu Chen
Summary: The PI3K/AKT/mTOR signaling pathway plays a significant role in tumor cell growth, proliferation, migration, invasion, and angiogenesis. In this study, a series of 3-amino-1H-indazole derivatives were synthesized and evaluated for their anti-proliferative activities against various cancer cells. Compound W24 exhibited broad-spectrum antiproliferative activity and inhibited cell migration and invasion. Mechanism studies revealed that W24 affected DNA synthesis, induced cell cycle arrest and apoptosis, and caused intracellular changes in HGC-27 cells. Furthermore, W24 showed low toxicity and good pharmacokinetic properties in vivo. Therefore, 3-amino-1H-indazole derivatives may serve as potential inhibitors for the PI3K/AKT/mTOR signaling pathway and anti-gastric cancer agents.
BIOORGANIC CHEMISTRY
(2023)
Article
Environmental Sciences
Xiaomin Liu, Jinsheng Liu, Bing Yan, Zhuo Quan, Xiaolong Wang, Yujing Ma, Abdullah A. Alarfaj, Lei Yan
Summary: Breast cancer is a significant health issue for women, and its treatment has been a research focus. This study discovered that periplocin has anticancer properties against breast cancer by inhibiting the PI3K/Akt/mTOR pathway, leading to apoptosis and cell cycle arrest in breast cancer cells.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Medicine, Research & Experimental
Alex Zohmachhuana, Malsawmdawngliana, F. Lalnunmawia, Vabeiryureilai Mathipi, K. Lalrinzuali, N. Senthil Kumar
Summary: The aim of this study was to evaluate the phytochemical content, antioxidant and anti-cancer activities of different parts of Curcuma aeruginosa Roxb. The methanol extracts from C. aeruginosa showed cytotoxicity against lung adenocarcinoma and cervical cancer cells, induced DNA damage, and up-regulated caspase activity. Additionally, bioactive compounds identified from the plant have been found to possess anti-cancer properties.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Ahmed M. Fathi, Shaimaa Waz, Eman Alaaeldin, Nisreen D. M. Toni, Azza A. K. El-Sheikh, Ahmed M. Sayed, Usama Ramadan Abdelmohsen, Maiiada H. Nazmy
Summary: Blackberry leaves have anti-inflammatory and antioxidant activities. In this study, site-specific delivery of blackberry leaves extract loaded AgNPs to hepatocytes in ischemia-reperfusion injury (IRI) was achieved, and the possible molecular mechanisms were verified. The results showed that pre-treatment with BBE protected against liver damage caused by I/R by reducing oxidative stress and promoting the activation of the anti-apoptotic signaling pathway.
Article
Biochemistry & Molecular Biology
Lei Li, Riyue Feng, Yang Li, Xiao Yu, Yuhao Liu, Yahui Zhao, Zhihua Liu
Summary: This study identified that mutant caspase-8 exerts tumor-promoting properties and is associated with a worse prognosis in esophageal squamous cell carcinoma (ESCC). Mutant caspase-8 loses its inhibitory effect on tumor growth and gains a new function of protecting against oxidative stress via the mTOR/SQSTM1/Keap1/Nrf2 axis. Caspase-8 status may serve as a new prognostic factor for survival in ESCC patients.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Anatomy & Morphology
Ying Wang, Yongjun Li, Dongxia Liu
Summary: This study aimed to investigate the role of erythropoietin in atherosclerosis and explore whether the underlying mechanism is associated with the PI3K/AKT/mTOR pathway. The results showed that erythropoietin significantly increased the incidence of hemorrhage in atherosclerotic plaques and up-regulated the expression levels of related proteins. Please note that these findings are the conclusion of this study.
Article
Oncology
Jida Guo, Shengqiang Zhang, Jun Wang, Pengfei Zhang, Tong Lu, Linyou Zhang
Summary: This study demonstrates the inhibitory effect of Hinokiflavone (HF) on the growth and progression of esophageal squamous cell carcinoma (ESCC). The underlying mechanism involves blocking the PI3K/AKT/mTOR signaling pathway, resulting in suppressed cell proliferation and induced apoptosis. HF could potentially serve as a complementary/alternative agent in the treatment of ESCC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Maryam Akbarzadeh, Ainaz Mihanfar, Shabnam Akbarzadeh, Bahman Yousefi, Maryam Majidinia
Summary: The PI3K/AKT/mTOR signaling pathway plays a crucial role in cancer and has been found to interact with miRNAs, which is important for understanding cancer biology.
Article
Veterinary Sciences
Jingsong Liu, Xueming Zhang, Shengnan Yue, Jingcheng Fu, Jin Chen, Ruochao Huang, Pengyuan Shang, Kai Zhong, Shuang Guo, Xianqin Jiao, Guangming Zha, Liqiang Han, Guoyu Yang, Heping Li, Yueying Wang
Summary: The study demonstrates that EPO promotes proliferation of MAC-T cells and has a better anti-inflammatory effect in cells treated with LPS, showing anti-apoptotic and anti-autophagic effects as well. These beneficial effects are dependent on the regulation of the PI3K/Akt/mTOR signaling pathway.
RESEARCH IN VETERINARY SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Ren-Fen Ma, Hu Liu, Xue-Chun Zhao, Peipei Shan, Ping Sun, Jun-Juan Xue, Guodong Wei, Hua Zhang
Summary: Phytochemical investigation of Daphne genkwa resulted in the discovery of 25 meroterpenoids, with 20 compounds being reported for the first time. Compound 8a exhibited remarkable cytotoxicity against various cancer cell lines and was found to inhibit proliferation, metastasis, induce apoptosis, and arrest the cell cycle of A549 cells. Mechanistic studies revealed that the antitumor activity of compound 8a is mediated through the inhibition of the PI3K/Akt/mTOR signaling pathway.
BIOORGANIC CHEMISTRY
(2023)
Article
Oncology
Haowei Wang, Yujia Chen, Qinzi Yuan, Lixia Chen, Peiling Dai, Xuenong Li
Summary: This study found that HRK is lowly expressed in colorectal cancer tissues. For the first time, it was shown that HRK promotes apoptosis and inhibits proliferation of colorectal cancer cells by inhibiting the PI3K/AKT/mTOR signaling pathway. HRK represents a potential target for the treatment of colorectal cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Genetics & Heredity
Liu Ye, Xin Liu, Kai Jin, Yingjie Niu, Qisheng Zuo, Jiuzhou Song, Wei Han, Guohong Chen, Bichun Li
Summary: This study demonstrates that insulin reduces apoptosis and ferroptosis and enhances cell proliferation in a dose-dependent manner via the PI3K-AKT-mTOR signaling pathway in PGCs.
Article
Cell Biology
Liqun Yang, Zhigang Dong, Shuyu Li, Tieliang Chen
Summary: This study aimed to explore the influence of endothelial cell-specific molecule 1 (ESM1) expression on colorectal cancer (CRC) cells and analyze its possible mechanism. ESM1 overexpression was found to promote tumor angiogenesis in CRC and accelerate tumor progression. The study also revealed that ESM1 may promote angiogenesis in CRC by activating the PI3K/Akt/mTOR pathway.
Article
Biotechnology & Applied Microbiology
Fangfang Liu, Lumin Tang, Mengyu Tao, Chuang Cui, Di He, Longxia Li, Yahui Liao, Yamin Gao, Jing He, Fan Sun, Houwen Lin, He Li
Summary: This study found that Stichoposide C has anti-proliferation and pro-apoptosis effects in ovarian cancer cells, and can induce autophagy. Mechanistically, STC induces autophagy by inhibiting the AKT/mTOR pathway in ovarian cancer cells. In addition, STC inhibited the growth of ovarian cancer cells in both in vitro and in vivo experiments. These results suggest that STC may be a potential therapeutic agent for ovarian cancer.
ONCOTARGETS AND THERAPY
(2022)
Review
Health Care Sciences & Services
Susi Afrianti Rahayu, Sunu Widianto, Irma Ruslina Defi, Rizky Abdulah
Summary: Chronic diseases are a global health issue. Patients with chronic diseases need interprofessional care teams involving general practitioners, medical specialists, nurses, and pharmacists. Pharmacists play an important role in these teams by providing drug information, acting as a consultant, and improving patient outcomes. The success of therapy for chronic diseases relies on partnership, coordination, cooperation, decision-making, and therapeutic outcomes within the interprofessional healthcare team.
JOURNAL OF MULTIDISCIPLINARY HEALTHCARE
(2021)
Review
Health Care Sciences & Services
Neily Zakiyah, Febby Purwadi, Widya N. Insani, Rizky Abdulah, Irma M. Puspitasari, Melisa Barliana, Ronny Lesmana, Amaliya Amaliya, Auliya A. Suwantika
Summary: This study systematically evaluated the effectiveness and safety of alternative tobacco and nicotine products in reducing smoking and aiding smoking cessation. The findings suggest that EC, snus, and NRT can moderately reduce daily cigarette consumption and assist smoking cessation with fewer adverse events. Further research is needed to investigate long-term outcomes, safety, and effectiveness of these products to inform smoking reduction and cessation policies.
JOURNAL OF MULTIDISCIPLINARY HEALTHCARE
(2021)
Article
Chemistry, Medicinal
Melisa Intan Barliana, Ajeng Diantini, Anas Subarnas, Rizky Abdulah
Summary: This study investigated the antiproliferative mechanism of the active compound kaempferol-3-O-rhamnoside from Indonesian herbal medicine Schima wallichii against Jurkat cells. The results showed that kaempferol-3-O-rhamnoside had antiproliferative activity and inhibited Jurkat cell proliferation through the stimulation of phosphorylated Jun amino-terminal kinase.
NATURAL PRODUCTS JOURNAL
(2022)
Review
Health Care Sciences & Services
Abdurahman Ridho, Sofa D. Alfian, Job F. M. van Boven, Jutti Levita, Esin Aki Yalcin, Ly Le, Jan-Willem Alffenaar, Eelko Hak, Rizky Abdulah, Ivan S. Pradipta
Summary: Digital health technology interventions show promise in improving medication adherence and treatment outcomes in patients with tuberculosis. However, the effects of different interventions vary in terms of direction and extent of improvement.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Public, Environmental & Occupational Health
Auliya A. Suwantika, Inge Dhamanti, Yulianto Suharto, Fredrick D. Purba, Rizky Abdulah
Summary: The study shows that social distancing measures through school closures, workforce, and community contact reductions are cost-saving, and extending the duration of social distancing tends to increase both the savings and the number of averted deaths.
TRAVEL MEDICINE AND INFECTIOUS DISEASE
(2022)
Review
Health Care Sciences & Services
Gabriella J. Caren, Deni Iskandar, Dian A. E. Pitaloka, Rizky Abdulah, Auliya A. Suwantika
Summary: The COVID-19 pandemic has disrupted TB treatment in Indonesia, leading to a potential decrease in funding, interruptions in TB services, lower quality of care, and impacts on monitoring activities. Lessons from other countries, such as combining COVID-19 and TB screening and utilizing telemedicine, can provide useful strategies for managing TB during the pandemic.
JOURNAL OF MULTIDISCIPLINARY HEALTHCARE
(2022)
Review
Infectious Diseases
Dian Ayu Eka Pitaloka, Mas Rizky Anggun A. A. Syamsunarno, Rizky Abdulah, Lidya Chaidir
Summary: Poor sensitivity of sputum conversion for monitoring TB treatment has led to the urgent need for identifying a non-sputum-based biomarker. Recent studies on omics-related research have contributed to the identification of surrogate markers and prediction of future reactivation risk in pulmonary TB. However, proper validation through longitudinal studies is crucial before utilizing these biomarkers in clinical practice.
INFECTION AND DRUG RESISTANCE
(2022)
Review
Oncology
Alistia Ilmiah Fahira, Riezki Amalia, Melisa Intan Barliana, Vesara Ardhe Gatera, Rizky Abdulah
Summary: Cancer is a leading cause of morbidity and mortality worldwide, and different types of cancer require different treatments. Polyethyleneimine (PEI) shows promise as a co-delivery system for anticancer therapy, but its clinical safety needs further evaluation.
BREAST CANCER-TARGETS AND THERAPY
(2022)
Review
Health Care Sciences & Services
Pungki Afifah Asyraf, Ivanna Fauziyah Kusnadi, Jonathan Stefanus, Miski Aghnia Khairinisa, Rizky Abdulah
Summary: Drug hypersensitivity is an inflammatory or immune reaction caused by drugs, which can have severe consequences if not properly treated. Sulfonamide drugs have a broad spectrum antimicrobial effect, but they can also cause adverse reactions in some individuals. This review identifies the symptoms, associated genes, and different allergic reactions that can be caused by sulfonamide hypersensitivity.
DRUG HEALTHCARE AND PATIENT SAFETY
(2022)
Article
Health Care Sciences & Services
Ivanny O. Y. Sinaga, Melisa Barliana, Ivan Surya Pradipta, Aulia Iskandarsyah, Rizky Abdulah, Sofa D. Alfian
Summary: This study found a positive association between depression and the incidence of multimorbidity in the general population in Indonesia, with higher prevalence of depression with increasing age. Respondents with depressive symptoms were more likely to report multimorbidity.
JOURNAL OF MULTIDISCIPLINARY HEALTHCARE
(2022)
Article
Pharmacology & Pharmacy
Rudi Hendra, Rohimatul Khodijah, Muhammad Almurdani, Yuli Haryani, Ari Satia Nugraha, Neni Frimayanti, Hilwan Yuda Teruna, Rizky Abdulah
Summary: This study investigated the activity of Stenochlaena palustris, a traditional medicinal plant. The results showed that the ethyl acetate extract of this plant exhibited potential free radical scavenging and antiplasmodial activities, without toxicity.
ADVANCES IN PHARMACOLOGICAL AND PHARMACEUTICAL SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Felix Zulhendri, Ronny Lesmana, Steven Tandean, Andreas Christoper, Kavita Chandrasekaran, Ilham Irsyam, Auliya A. Suwantika, Rizky Abdulah, Nasrul Wathoni
Summary: Recent research has shown that propolis has potential as a raw material for pharmaceuticals and nutraceuticals due to its anti-inflammatory properties. This review examines the latest experimental evidence on the anti-inflammatory properties of propolis from 2017 to 2022. The evidence suggests that propolis possesses various mechanisms to regulate inflammation and create an anti-inflammatory environment. It inhibits and downregulates pro-inflammatory cytokines and associated signaling pathways, and also reduces the migration of immune cells.
Article
Biochemistry & Molecular Biology
Mohammad Adam Mustapa, Ikhsan Guswenrivo, Ade Zurohtun, Nur Kusaira Khairul Ikram, Muchtaridi Muchtaridi
Summary: This research study focused on developing essential oil-based repellent activity tests against Aedes aegypti mosquitoes. The steam distillation method was used to isolate essential oils, and 10% essential oil repellents were tested on volunteers' arms using virus-free Aedes aegypti mosquitoes. The analysis of essential oil activities and aroma components was conducted using headspace repellent and GC-MS methods. The results showed that patchouli and cinnamon had the highest average repellent power, and the chemical compounds in these oils have the potential to be environmentally friendly mosquito repellents.
Article
Cardiac & Cardiovascular Systems
Qisty A. Khoiry, Sofa D. Alfian, Rizky Abdulah
Summary: Main factors associated with low awareness of hypertension treatment are modifiable, such as older age, irregular blood pressure control, depressive symptoms, insomnia, and low satisfaction with health care. Surprisingly, individuals with high religiosity are more likely to have low awareness of hypertension treatment.
Article
Gastroenterology & Hepatology
Shigemasa Suzuki, Norio Kubo, Nobuhiro Hosoi, Takashi Ooki, Naoki Matsumura, Ryusuke Aihara, Akira Mogi, Yasuo Hosouchi, Yasuji Nishida, Takeshi Hatanaka, Yoshiki Tanaka, Hiroshi Saeki, Ken Shirabe
Summary: This case report describes the successful management of postoperative pancreatic fistula (PF) using endoscopic ultrasound (EUS)-guided transduodenal drainage. The patient developed fluid retention after surgery and was treated with multiple drainage procedures before achieving complete recovery.
CASE REPORTS IN GASTROENTEROLOGY
(2022)