Enhancing SHP-1 expression with 5-azacytidine may inhibit STAT3 activation and confer sensitivity in lestaurtinib (CEP-701)-resistant FLT3-ITD positive acute myeloid leukemia

Silencing of Suppressor of Cytokine Signaling-3 due to Methylation Results in Phosphorylation of STAT3 in Imatinib Resistant BCR-ABL Positive Chronic Myeloid Leukemia Cells

(2014) Hamid AN Al-Jamal et al.   Asian Pacific Journal of Cancer Prevention

The promoter of miR-663 is hypermethylated in Chinese pediatric acute myeloid leukemia (AML)

(2013) Tao Yan-Fang et al.   BMC Medical Genetics

Methylation profiling ofSOCS1,SOCS2,SOCS3,CISHandSHP1in Philadelphia-negative myeloproliferative neoplasm

(2013) Min Yue Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Aberrant DNA methyltransferase expression in pancreatic ductal adenocarcinoma development and progression

(2013) Jun Gao et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Epigenetic mechanisms of protein tyrosine phosphatase 6 suppression in diffuse large B-cell lymphoma: implications for epigenetic therapy

(2013) T E Witzig et al.   LEUKEMIA

Inhibition of STAT3 signaling and induction of SHP1 mediate antiangiogenic and antitumor activities of ergosterol peroxide in U266 multiple myeloma cells

(2012) Yun-Hee Rhee et al.   BMC CANCER

Platelet factor 4 induces cell apoptosis by inhibition of STAT3 via up-regulation of SOCS3 expression in multiple myeloma

(2012) P. Liang et al.   HAEMATOLOGICA

Gfi-1 inhibits the expression of eosinophil major basic protein (MBP) during G-CSF-induced neutrophilic differentiation

(2012) Qingquan Liu et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

5-Aza-2′-deoxycytidine Leads to Reduced Embryo Implantation and Reduced Expression of DNA Methyltransferases and Essential Endometrial Genes

(2012) Yu-Bin Ding et al.   PLoS One

Stat3 signaling in acute myeloid leukemia: ligand-dependent and -independent activation and induction of apoptosis by a novel small-molecule Stat3 inhibitor

(2011) M. S. Redell et al.   BLOOD

SHP-1 expression accounts for resistance to imatinib treatment in Philadelphia chromosome-positive cells derived from patients with chronic myeloid leukemia

(2011) N. Esposito et al.   BLOOD

FLT3 inhibitors: a story of the old and the new

(2011) Amir Fathi et al.   CURRENT OPINION IN HEMATOLOGY

Pacritinib (SB1518), a JAK2/FLT3 inhibitor for the treatment of acute myeloid leukemia

(2011) S Hart et al.   Blood Cancer Journal

Mechanisms of resistance against PKC412 in resistant FLT3-ITD positive human acute myeloid leukemia cells

(2010) Friedrich Stölzel et al.   ANNALS OF HEMATOLOGY

Inhibition of DNA methyltransferase induces G2 cell cycle arrest and apoptosis in human colorectal cancer cells via inhibition of JAK2/STAT3/STAT5 signalling

(2010) Hua Xiong et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Clinical significance of HSP27 expression in colorectal cancer

(2010) Xu   Molecular Medicine Reports

DNMT3AMutations in Acute Myeloid Leukemia

(2010) Timothy J. Ley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Role of the protein tyrosine phosphatase SHP-1 in Interleukin-6 regulation of prostate cancer cells

(2010) Helena Tassidis et al.   PROSTATE

Structure of DNMT1-DNA Complex Reveals a Role for Autoinhibition in Maintenance DNA Methylation

(2010) J. Song et al.   SCIENCE

Enhanced activation of STAT pathways and overexpression of survivin confer resistance to FLT3 inhibitors and could be therapeutic targets in AML

(2009) J. Zhou et al.   BLOOD

Targeting DNA Methylation

(2009) J.-P. J. Issa et al.   CLINICAL CANCER RESEARCH

FLT3 inhibition and mechanisms of drug resistance in mutant FLT3-positive AML

(2009) Ellen Weisberg et al.   DRUG RESISTANCE UPDATES

Differential Methylation Pattern of ID4, SFRP1, and SHP1 between Acute Myeloid Leukemia and Chronic Myeloid Leukemia

(2009) Kyung-Ok Uhm et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

RUNX1T1 is overexpressed in imatinib mesylate-resistant cells

(2009) Binato   Molecular Medicine Reports

EXPRESSION OF PTEN AND SHP1, INVESTIGATED FROM TISSUE MICROARRAYS IN PEDIATRIC ACUTE LYMPHOBLASTIC, LEUKEMIA

(2009) Fredrika Gauffin et al.   PEDIATRIC HEMATOLOGY AND ONCOLOGY

Demethylating agents in myeloid malignancies

(2008) Guillermo Garcia-Manero   CURRENT OPINION IN ONCOLOGY

Stat3 contributes to resistance toward BCR-ABL inhibitors in a bone marrow microenvironment model of drug resistance

(2008) Nadine N. Bewry et al.   MOLECULAR CANCER THERAPEUTICS