STAT3 as a possible therapeutic target in human malignancies: lessons from acute myeloid leukemia
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Title
STAT3 as a possible therapeutic target in human malignancies: lessons from acute myeloid leukemia
Authors
Keywords
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Journal
Expert Review of Hematology
Volume 8, Issue 1, Pages 29-41
Publisher
Informa UK Limited
Online
2014-11-06
DOI
10.1586/17474086.2015.971005
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Note: Only part of the references are listed.- A STAT3-mediated metabolic switch is involved in tumour transformation and STAT3 addiction
- (2016) Marco Demaria et al. Aging-US
- Differences in proliferative capacity of primary human acute myelogenous leukaemia cells are associated with altered gene expression profiles and can be used for subclassification of patients
- (2015) H. Reikvam et al. CELL PROLIFERATION
- CXXC5 (Retinoid-Inducible Nuclear Factor, RINF) is a Potential Therapeutic Target in High-Risk Human Acute Myeloid Leukemia
- (2015) Andrey Astori et al. Oncotarget
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- (2015) Håkon Reikvam et al. Oncotarget
- Dual Aurora A and JAK2 kinase blockade effectively suppresses malignant transformation
- (2015) Hua Yang et al. Oncotarget
- Stimulation of the B-cell receptor activates the JAK2/STAT3 signaling pathway in chronic lymphocytic leukemia cells
- (2014) U. Rozovski et al. BLOOD
- Reduced phosphorylation of Stat3 at Ser-727 mediated by casein kinase 2 — Protein phosphatase 2A enhances Stat3 Tyr-705 induced tumorigenic potential of glioma cells
- (2014) Tapashi Mandal et al. CELLULAR SIGNALLING
- Tumor aerobic glycolysis: new insights into therapeutic strategies with targeted delivery
- (2014) Meghna Talekar et al. EXPERT OPINION ON BIOLOGICAL THERAPY
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- (2014) Yongwook Choi et al. Molecular Oncology
- Toward a new STATe: The role of STATs in mitochondrial function
- (2014) Jeremy A. Meier et al. SEMINARS IN IMMUNOLOGY
- Activity of a heptad of transcription factors is associated with stem cell programs and clinical outcome in acute myeloid leukemia
- (2013) E. Diffner et al. BLOOD
- Leukemia cell-targeted STAT3 silencing and TLR9 triggering generate systemic antitumor immunity
- (2013) D. M. S. Hossain et al. BLOOD
- Antileukaemic effect of PI3K-mTOR inhibitors in acute myeloid leukaemia-gene expression profiles reveal CDC25B expression as determinate of pharmacological effect
- (2013) Håkon Reikvam et al. BRITISH JOURNAL OF HAEMATOLOGY
- BCL-2 Inhibition Targets Oxidative Phosphorylation and Selectively Eradicates Quiescent Human Leukemia Stem Cells
- (2013) Eleni D. Lagadinou et al. Cell Stem Cell
- STAT3 interacts with Skp2/p27/p21 pathway to regulate the motility and invasion of gastric cancer cells
- (2013) Zheng Wei et al. CELLULAR SIGNALLING
- Regulation of STAT signaling by acetylation
- (2013) Shougang Zhuang CELLULAR SIGNALLING
- The STAT3 Inhibitor Stattic Impairs Cardiomyocyte Mitochondrial Function Through Increased Reactive Oxygen Species Formation
- (2013) Kerstin Boengler et al. CURRENT PHARMACEUTICAL DESIGN
- Reciprocal Regulation of Protein Kinase and Pyruvate Kinase Activities of Pyruvate Kinase M2 by Growth Signals
- (2013) Xueliang Gao et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Aggressive acute myeloid leukemia in PU.1/p53 double-mutant mice
- (2013) P Basova et al. ONCOGENE
- Novel Mechanism of Inhibition of Dendritic Cells Maturation by Mesenchymal Stem Cells via Interleukin-10 and the JAK1/STAT3 Signaling Pathway
- (2013) Wen-hua Liu et al. PLoS One
- STAT3 Phosphorylation at Tyrosine 705 and Serine 727 Differentially Regulates Mouse ESC Fates
- (2013) Guanyi Huang et al. STEM CELLS
- Residual disease detected by multidimensional flow cytometry signifies high relapse risk in patients with de novo acute myeloid leukemia: a report from Children's Oncology Group
- (2012) M. R. Loken et al. BLOOD
- FACS analysis of Stat3/5 signaling reveals sensitivity to G-CSF and IL-6 as a significant prognostic factor in pediatric AML: a Children's Oncology Group report
- (2012) M. S. Redell et al. BLOOD
- Phase 2 study of the JAK kinase inhibitor ruxolitinib in patients with refractory leukemias, including postmyeloproliferative neoplasm acute myeloid leukemia
- (2012) A. Eghtedar et al. BLOOD
- Mouse hematopoietic cell-targeted STAT3 deletion: stem/progenitor cell defects, mitochondrial dysfunction, ROS overproduction, and a rapid aging-like phenotype
- (2012) C. Mantel et al. BLOOD
- Acetylation modulates the STAT signaling code
- (2012) Martin Wieczorek et al. CYTOKINE & GROWTH FACTOR REVIEWS
- Targeting of polo-like kinases and their cross talk with Aurora kinases – possible therapeutic strategies in human acute myeloid leukemia?
- (2012) Galina Tsykunova et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Phospho-Ser727 of STAT3 regulates STAT3 activity by enhancing dephosphorylation of phospho-Tyr705 largely through TC45
- (2012) Ryohei Wakahara et al. GENES TO CELLS
- The Import of the Transcription Factor STAT3 into Mitochondria Depends on GRIM-19, a Component of the Electron Transport Chain
- (2012) Prasad Tammineni et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cytokine Response Is Determined by Duration of Receptor and Signal Transducers and Activators of Transcription 3 (STAT3) Activation
- (2012) David A. Braun et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- GRIM-19-mediated translocation of STAT3 to mitochondria is necessary for TNF-induced necroptosis
- (2012) Nataly Shulga et al. JOURNAL OF CELL SCIENCE
- Discovery of New Inhibitors of Cdc25B Dual Specificity Phosphatases by Structure-Based Virtual Screening
- (2012) Antonio Lavecchia et al. JOURNAL OF MEDICINAL CHEMISTRY
- Serine 727 phosphorylation of STAT3: An early change in mouse hepatocarcinogenesis induced by neonatal treatment with diethylnitrosamine
- (2012) Masaaki Miyakoshi et al. MOLECULAR CARCINOGENESIS
- Cytoplasmic STAT3 Represses Autophagy by Inhibiting PKR Activity
- (2012) Shensi Shen et al. MOLECULAR CELL
- Pyruvate Kinase M2 Regulates Gene Transcription by Acting as a Protein Kinase
- (2012) Xueliang Gao et al. MOLECULAR CELL
- SomaticSTAT3Mutations in Large Granular Lymphocytic Leukemia
- (2012) Hanna L.M. Koskela et al. NEW ENGLAND JOURNAL OF MEDICINE
- Spi-1/PU.1 activates transcription through clustered DNA occupancy in erythroleukemia
- (2012) Maya Ridinger-Saison et al. NUCLEIC ACIDS RESEARCH
- STAT3 Is Activated by JAK2 Independent of Key Oncogenic Driver Mutations in Non-Small Cell Lung Carcinoma
- (2012) Brendan D. Looyenga et al. PLoS One
- Anti-Angiogenic Activity of a Small Molecule STAT3 Inhibitor LLL12
- (2012) Hemant K. Bid et al. PLoS One
- The many faces of Janus kinase
- (2011) Matthew M. Seavey et al. BIOCHEMICAL PHARMACOLOGY
- Stat3 signaling in acute myeloid leukemia: ligand-dependent and -independent activation and induction of apoptosis by a novel small-molecule Stat3 inhibitor
- (2011) M. S. Redell et al. BLOOD
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- (2011) Håkon Reikvam et al. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
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- (2011) Camilla Pilati et al. JOURNAL OF EXPERIMENTAL MEDICINE
- The surface molecule signature of primary human acute myeloid leukemia (AML) cells is highly associated with NPM1 mutation status
- (2011) G Tsykunova et al. LEUKEMIA
- Correlation analysis of p53 protein isoforms with NPM1/FLT3 mutations and therapy response in acute myeloid leukemia
- (2011) N Ånensen et al. ONCOGENE
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- (2011) J Skavland et al. Blood Cancer Journal
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- The level of glycolytic metabolism in acute myeloid leukemia blasts at diagnosis is prognostic for clinical outcome
- (2010) Patries M. Herst et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet
- (2009) H. Dohner et al. BLOOD
- Heat Shock Protein 90 – a Potential Target in the Treatment of Human Acute Myelogenous Leukemia
- (2009) H. Reikvam et al. CURRENT CANCER DRUG TARGETS
- STAT3-Stathmin Interactions Control Microtubule Dynamics in Migrating T-cells
- (2009) Navin K. Verma et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia Genome
- (2009) Elaine R. Mardis et al. NEW ENGLAND JOURNAL OF MEDICINE
- Stat3 promotes the development of erythroleukemia by inducing Pu.1 expression and inhibiting erythroid differentiation
- (2009) S Hegde et al. ONCOGENE
- Function of Mitochondrial Stat3 in Cellular Respiration
- (2009) J. Wegrzyn et al. SCIENCE
- MicroRNA expression in acute myeloid leukemia
- (2009) Guido Marcucci et al. Current Hematologic Malignancy Reports
- Epigenetic regulation of signal transducer and activator of transcription 3 in acute myeloid leukemia
- (2008) Sampa Ghoshal (Gupta) et al. LEUKEMIA RESEARCH
- Distinct microRNA expression profiles in acute myeloid leukemia with common translocations
- (2008) Z. Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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