SHP-1 is a negative regulator of epithelial–mesenchymal transition in hepatocellular carcinoma

IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis

(2014) Matjaz Rokavec et al.   JOURNAL OF CLINICAL INVESTIGATION

IL-24 Induces Apoptosis of Chronic Lymphocytic Leukemia B Cells Engaged into the Cell Cycle through Dephosphorylation of STAT3 and Stabilization of p53 Expression

(2014) A. Sainz-Perez et al.   JOURNAL OF IMMUNOLOGY

Imbalance between MMP-2, 9 and TIMP-1 promote the invasion and metastasis of renal cell carcinoma via SKP2 signaling pathways

(2014) Hongsheng Lu et al.   TUMOR BIOLOGY

Capillarisin inhibits constitutive and inducible STAT3 activation through induction of SHP-1 and SHP-2 tyrosine phosphatases

(2013) Jong Hyun Lee et al.   CANCER LETTERS

Discovery of novel src homology region 2 domain-containing phosphatase 1 agonists from sorafenib for the treatment of hepatocellular carcinoma

(2013) Wei-Tien Tai et al.   HEPATOLOGY

Arsenite evokes IL-6 secretion, autocrine regulation of STAT3 signaling, and miR-21 expression, processes involved in the EMT and malignant transformation of human bronchial epithelial cells

(2013) Fei Luo et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

SHP-1 in Cell-Cycle Regulation

(2012) Pilar Lopez-Ruiz et al.   Anti-Cancer Agents in Medicinal Chemistry

Blockade of STAT3 activation by sorafenib derivatives through enhancing SHP-1 phosphatase activity

(2012) Kuen-Feng Chen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Src Homology Domain 2-containing Protein-tyrosine Phosphatase-1 (SHP-1) Binds and Dephosphorylates Gα-interacting, Vesicle-associated Protein (GIV)/Girdin and Attenuates the GIV-Phosphatidylinositol 3-Kinase (PI3K)-Akt Signaling Pathway

(2011) Yash Mittal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Roles of STAT3 and ZEB1 Proteins in E-cadherin Down-regulation and Human Colorectal Cancer Epithelial-Mesenchymal Transition

(2011) Hua Xiong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Signal transducer and activator of transcription 3 is a major kinase-independent target of sorafenib in hepatocellular carcinoma

(2011) Wei-Tien Tai et al.   JOURNAL OF HEPATOLOGY

STAT3 SIGNALING: Anticancer Strategies and Challenges

(2011) P. A. Johnston et al.   MOLECULAR INTERVENTIONS

A Gαi–GIV Molecular Complex Binds Epidermal Growth Factor Receptor and Determines Whether Cells Migrate or Proliferate

(2010) Pradipta Ghosh et al.   MOLECULAR BIOLOGY OF THE CELL

Mechanisms of the epithelial–mesenchymal transition by TGF-β

(2009) Michael K Wendt et al.   Future Oncology

GIV is a nonreceptor GEF for G i with a unique motif that regulates Akt signaling

(2009) M. Garcia-Marcos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Roles of TGFβ in metastasis

(2008) David Padua et al.   CELL RESEARCH

Sorafenib

(2008) Dene Simpson et al.   DRUGS

Soybean saponin inhibits tumor cell metastasis by modulating expressions of MMP-2, MMP-9 and TIMP- 2

(2007) Ji-Hye Kang et al.   CANCER LETTERS