A neutrophil inhibitory pepducin derived from FPR1 expected to target FPR1 signaling hijacks the closely related FPR2 instead

Structural changes of the ligand and of the receptor alters the receptor preference for neutrophil activating peptides starting with a formylmethionyl group

(2015) Huamei Forsman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Antibacterial Activity of Pepducins, Allosterical Modulators of Formyl Peptide Receptor Signaling

(2014) M. Winther et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Development and Characterization of Pepducins as Gs-biased Allosteric Agonists

(2014) Richard Carr et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Pepducin Derived from the Third Intracellular Loop of FPR2 Is a Partial Agonist for Direct Activation of This Receptor in Neutrophils But a Full Agonist for Cross-Talk Triggered Reactivation of FPR2

(2014) Michael Gabl et al.   PLoS One

The leukocyte chemotactic receptor FPR2, but not the closely related FPR1, is sensitive to cell-penetrating pepducins with amino acid sequences descending from the third intracellular receptor loop

(2013) Huamei Forsman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Ligand-specific conformational change of the G-protein-coupled receptor ALX/FPR2 determines proresolving functional responses

(2013) S. N. Cooray et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Turning Receptors On and Off with Intracellular Pepducins: New Insights into G-protein-coupled Receptor Drug Development

(2012) Katie O'Callaghan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Characterization and Inhibitory Profile of Formyl Peptide Receptor 2 Selective Peptides Descending from a PIP2-Binding Domain of Gelsolin

(2012) H. Forsman et al.   JOURNAL OF IMMUNOLOGY

G protein-coupled receptor modulation with pepducins: moving closer to the clinic

(2011) Patricia Dimond et al.   Annals of the New York Academy of Sciences

Full characterization of GPCR monomer–dimer dynamic equilibrium by single molecule imaging

(2011) Rinshi S. Kasai et al.   JOURNAL OF CELL BIOLOGY

What Formyl Peptide Receptors, if Any, Are Triggered by Compound 43 and Lipoxin A4 ?

(2011) H. Forsman et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Activation of human monocytes by a formyl peptide receptor 2-derived pepducin

(2010) Ha Young Lee et al.   FEBS LETTERS

Therapeutic anti-inflammatory potential of formyl-peptide receptor agonists

(2010) Neil Dufton et al.   PHARMACOLOGY & THERAPEUTICS

Insider access: pepducin symposium explores a new approach to GPCR modulation

(2009) Jacquelyn Miller et al.   Annals of the New York Academy of Sciences

Dimerization in GPCR mobility and signaling

(2009) Martin J Lohse   CURRENT OPINION IN PHARMACOLOGY

International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the Formyl Peptide Receptor (FPR) Family

(2009) R. D. Ye et al.   PHARMACOLOGICAL REVIEWS

Lipoxin A4Metabolites/Analogues from Two Commercial Sources have No Effects on TNF-α-mediated Priming or Activation through the Neutrophil Formyl Peptide Receptors

(2009) H. Forsman et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Changes in the ratio between FPR and FPRL1 triggered superoxide production in human neutrophils—A tool in analysing receptor specific events

(2007) Huamei Fu et al.   JOURNAL OF IMMUNOLOGICAL METHODS