Polyphenols as Therapeutic Molecules in Alzheimer’s Disease Through Modulating Amyloid Pathways

Emerging Therapeutics for Alzheimer's Disease

(2014) Karen Chiang et al.   Annual Review of Pharmacology and Toxicology

Molecular Structures of Amyloid and Prion Fibrils: Consensus versus Controversy

(2013) Robert Tycko et al.   ACCOUNTS OF CHEMICAL RESEARCH

Intrinsic Structural Heterogeneity and Long-Term Maturation of Amyloid β Peptide Fibrils

(2013) Jianqiang Ma et al.   ACS Chemical Neuroscience

Tanshinones Inhibit Amyloid Aggregation by Amyloid-β Peptide, Disaggregate Amyloid Fibrils, and Protect Cultured Cells

(2013) Qiuming Wang et al.   ACS Chemical Neuroscience

3D NMR structure of a complex between the amyloid beta peptide (1–40) and the polyphenol ε-viniferin glucoside: Implications in Alzheimer's disease

(2013) Tristan Richard et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Anthocyanin-rich Purple Wheat Prolongs the Life Span of Caenorhabditis elegans Probably by Activating the DAF-16/FOXO Transcription Factor

(2013) Wei Chen et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Clinical Trials in Predementia Stages of Alzheimer Disease

(2013) Jagan A. Pillai et al.   MEDICAL CLINICS OF NORTH AMERICA

Previously not recognized deletion in presenilin-1 (p.Leu174del.) in a patient with early-onset familial Alzheimer's disease

(2013) H.O. Tiedt et al.   NEUROSCIENCE LETTERS

Treatment Strategies Targeting Amyloid  -Protein

(2013) D. Schenk et al.   Cold Spring Harbor Perspectives in Medicine

An Azobenzene Photoswitch Sheds Light on Turn Nucleation in Amyloid-β Self-Assembly

(2012) Todd M. Doran et al.   ACS Chemical Neuroscience

A Key Role for Lysine Residues in Amyloid β-Protein Folding, Assembly, and Toxicity

(2012) Sharmistha Sinha et al.   ACS Chemical Neuroscience

Activation of α-secretase by curcumin-aminoacid conjugates

(2012) Ramesh B. Narasingapa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cholinestrase inhibitory effects of geranylated flavonoids from Paulownia tomentosa fruits

(2012) Jung Keun Cho et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Comparative study of the binding pockets of mammalian proprotein convertases and its implications for the design of specific small molecule inhibitors

(2012) Sun Tian et al.   International Journal of Biological Sciences

Anti-inflammatory Activity of a Honey Flavonoid Extract on Lipopolysaccharide-Activated N13 Microglial Cells

(2012) Manila Candiracci et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Liberation of Copper from Amyloid Plaques: Making a Risk Factor Useful for Alzheimer’s Disease Treatment

(2012) Jie Geng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Review of Theoretical Studies for Prediction of Neurodegenerative Inhibitors

(2012) F. Prado-Prado et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Recent Advances in α-Synuclein Functions, Advanced Glycation, and Toxicity: Implications for Parkinson’s Disease

(2012) Erika Guerrero et al.   MOLECULAR NEUROBIOLOGY

The binding of resveratrol to monomer and fibril amyloid beta

(2012) Jin-Fang Ge et al.   NEUROCHEMISTRY INTERNATIONAL

Phlorotannin-rich Ecklonia cava reduces the production of beta-amyloid by modulating alpha- and gamma-secretase expression and activity

(2012) Il-Jun Kang et al.   NEUROTOXICOLOGY

Dietary Polyphenols as Modulators of Brain Functions: Biological Actions and Molecular Mechanisms Underpinning Their Beneficial Effects

(2012) David Vauzour   Oxidative Medicine and Cellular Longevity

“Clicked” Sugar–Curcumin Conjugate: Modulator of Amyloid-β and Tau Peptide Aggregation at Ultralow Concentrations

(2011) Sukanta Dolai et al.   ACS Chemical Neuroscience

A Safe, Blood-Brain Barrier Permeable Triphenylmethane Dye Inhibits Amyloid-β Neurotoxicity by Generating Nontoxic Aggregates

(2011) H. Edward Wong et al.   ACS Chemical Neuroscience

Beta-secretase as a target for Alzheimer’s disease drug discovery: an overview of in vitro methods for characterization of inhibitors

(2011) Francesca Mancini et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Exploring the inhibitory activity of short-chain phospholipids against amyloid fibrillogenesis of hen egg-white lysozyme

(2011) Steven S.-S. Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Protective effect of ε-viniferin on β-amyloid peptide aggregation investigated by electrospray ionization mass spectrometry

(2011) Tristan Richard et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Polyphenol contents and radical scavenging capacities of red maple (Acer rubrum L.) extracts

(2011) Mariana Royer et al.   FOOD AND CHEMICAL TOXICOLOGY

The Role of Pro, Gly Lys, and Arg Containing Peptides on Amyloid-Beta Aggregation

(2011) Seema Jagota et al.   International Journal of Peptide Research and Therapeutics

Protective Effects of Anthocyanins against Amyloid β-Peptide-Induced Damage in Neuro-2A Cells

(2011) Ping-Hsiao Shih et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Apricot Carotenoids Possess Potent Anti-amyloidogenic Activity in Vitro

(2011) Shigeru Katayama et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Aggregation properties of a short peptide that mediates amyloid fibril formation in model proteins unrelated to disease

(2011) Nitin Chaudhary et al.   JOURNAL OF BIOSCIENCES

Targets for AD treatment: conflicting messages from γ-secretase inhibitors

(2011) Kumar Sambamurti et al.   JOURNAL OF NEUROCHEMISTRY

Conformational transition in the substrate binding domain of β-secretase exploited by NMA and its implication in inhibitor recognition: BACE1–myricetin a case study

(2011) Sandipan Chakraborty et al.   NEUROCHEMISTRY INTERNATIONAL

Regulation of alpha-secretase ADAM10 expression and activity

(2011) Kristina Endres et al.   EXPERIMENTAL BRAIN RESEARCH

Structure−Activity Relationships in Peptide Modulators of β-Amyloid Protein Aggregation: Variation in α,α-Disubstitution Results in Altered Aggregate Size and Morphology

(2010) Cyrus K. Bett et al.   ACS Chemical Neuroscience

Effects of Peptides Derived from Terminal Modifications of the Aβ Central Hydrophobic Core on Aβ Fibrillization

(2010) Cyrus K. Bett et al.   ACS Chemical Neuroscience

Dual Effect of Amino Modified Polystyrene Nanoparticles on Amyloid β Protein Fibrillation

(2010) Celia Cabaleiro-Lago et al.   ACS Chemical Neuroscience

Engineered polyketide biosynthesis and biocatalysis in Escherichia coli

(2010) Xue Gao et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Potential therapeutic agents against Alzheimer’s disease from natural sources

(2010) So-Young Park   ARCHIVES OF PHARMACAL RESEARCH

A Disulfide-Linked Amyloid-β Peptide Dimer Forms a Protofibril-like Oligomer through a Distinct Pathway from Amyloid Fibril Formation

(2010) Takahiro Yamaguchi et al.   BIOCHEMISTRY

Molecular docking studies of phlorotannins from Eisenia bicyclis with BACE1 inhibitory activity

(2010) Hyun Ah Jung et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A critical review of methods for characterisation of polyphenolic compounds in fruits and vegetables

(2010) Ioana Ignat et al.   FOOD CHEMISTRY

Soy isoflavones as potential inhibitors of Alzheimer ß-amyloid fibril aggregation in vitro

(2010) Caroline Henry-Vitrac et al.   FOOD RESEARCH INTERNATIONAL

Bioavailability of the Polyphenols: Status and Controversies

(2010) Massimo D’Archivio et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Systematic Analysis of the Content of 502 Polyphenols in 452 Foods and Beverages: An Application of the Phenol-Explorer Database

(2010) Jara Pérez-Jiménez et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Alzheimer's disease: strategies for disease modification

(2010) Martin Citron   NATURE REVIEWS DRUG DISCOVERY

New evidences on Tau–DNA interactions and relevance to neurodegeneration

(2010) Vasudevaraju Padmaraju et al.   NEUROCHEMISTRY INTERNATIONAL

Anti-amyloidogenic property of leaf aqueous extract of Caesalpinia crista

(2010) B.N. Ramesh et al.   NEUROSCIENCE LETTERS

Polyphenols: Chemistry, Dietary Sources, Metabolism, and Nutritional Significance

(2010) Laura Bravo   NUTRITION REVIEWS

Regulation of β cleavage of amyloid precursor protein

(2010) Jun-Feng Wang et al.   Neuroscience Bulletin

Identification and Characterization of Polyphenolic Antioxidants Using On-Line Liquid Chromatography, Electrochemistry, and Electrospray Ionization Tandem Mass Spectrometry

(2009) Camilla Zettersten et al.   ANALYTICAL CHEMISTRY

Carboxymethylated-κ-casein: A convenient tool for the identification of polyphenolic inhibitors of amyloid fibril formation

(2009) John A. Carver et al.   BIOORGANIC & MEDICINAL CHEMISTRY

New stilbene dimers against amyloid fibril formation

(2009) Céline Rivière et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Polyphenols: food sources, properties and applications - a review

(2009) Hasna El Gharras   INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY

Advanced separation methods of food anthocyanins, isoflavones and flavanols

(2009) Josep Valls et al.   JOURNAL OF CHROMATOGRAPHY A

(−)-Epigallocatechin-3-Gallate (EGCG) Maintains κ-Casein in Its Pre-Fibrillar State without Redirecting Its Aggregation Pathway

(2009) Sean A. Hudson et al.   JOURNAL OF MOLECULAR BIOLOGY

A traditional medicinal herbPaeonia suffruticosaand its active constituent 1,2,3,4,6-penta-O-galloyl-β-d-glucopyranose have potent anti-aggregation effects on Alzheimer’s amyloid β proteinsin vitroandin vivo

(2009) Hironori Fujiwara et al.   JOURNAL OF NEUROCHEMISTRY

Consumption of Grape Seed Extract Prevents Amyloid-β Deposition and Attenuates Inflammation in Brain of an Alzheimer’s Disease Mouse

(2009) Yan-Jiang Wang et al.   NEUROTOXICITY RESEARCH

Resveratrol inhibits beta-amyloid oligomeric cytotoxicity but does not prevent oligomer formation

(2009) Ying Feng et al.   NEUROTOXICOLOGY

Polyphenol-induced dissociation of various amyloid fibrils results in a methionine-independent formation of ROS

(2008) Hila Shoval et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Beta-Secretase: Structure, Function, and Evolution

(2008) Chitra Venugopal et al.   CNS & Neurological Disorders-Drug Targets

Neuroprotective Effects of the Citrus Flavanones against H2O2-Induced Cytotoxicity in PC12 Cells

(2008) Sam-Long Hwang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Structure−Activity Relationships of Flavonoids in the Cellular Antioxidant Activity Assay

(2008) Kelly L. Wolfe et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Challenges for Research on Polyphenols from Foods in Alzheimer’s Disease: Bioavailability, Metabolism, and Cellular and Molecular Mechanisms

(2008) Manjeet Singh et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Amyloid and tau imaging, neuronal losses and function in mild cognitive impairment

(2008) J. R. Barrio et al.   Journal of Nutrition Health & Aging

Localization of the noncovalent binding site between amyloid-β-peptide and oleuropein using electrospray ionization FT-ICR mass spectrometry

(2008) Fotini N. Bazoti et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Crystal Structure of an Active Form of BACE1, an Enzyme Responsible for Amyloid   Protein Production

(2008) H. Shimizu et al.   MOLECULAR AND CELLULAR BIOLOGY

The ADAM metalloproteinases

(2008) D EDWARDS et al.   MOLECULAR ASPECTS OF MEDICINE

Biomarker discovery in neurodegenerative diseases: A proteomic approach

(2008) Min Shi et al.   NEUROBIOLOGY OF DISEASE

The Polyphenol Piceid Destabilizes Preformed Amyloid Fibrils and Oligomers In Vitro: Hypothesis on Possible Molecular Mechanisms

(2008) Céline Rivière et al.   NEUROCHEMICAL RESEARCH

Structural requirements for the flavonoid fisetin in inhibiting fibril formation of amyloid β protein

(2008) Tatsuhiro Akaishi et al.   NEUROSCIENCE LETTERS

Efficient Inhibition of the Alzheimer's Disease  -Secretase by Membrane Targeting

(2008) L. Rajendran et al.   SCIENCE

New polyphenols active on β-amyloid aggregation

(2007) Céline Rivière et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS