Chemical activation of adenylyl cyclase Rv1625c inhibits growth of Mycobacterium tuberculosis on cholesterol and modulates intramacrophage signaling

Bacterial subversion of cAMP signalling inhibits cathelicidin expression, which is required for innate resistance to Mycobacterium tuberculosis

(2017) Shashank Gupta et al.   JOURNAL OF PATHOLOGY

Inflammatory signaling in human tuberculosis granulomas is spatially organized

(2016) Mohlopheni J Marakalala et al.   NATURE MEDICINE

The association between sterilizing activity and drug distribution into tuberculosis lesions

(2015) Brendan Prideaux et al.   NATURE MEDICINE

Role of intragenic binding of cAMP responsive protein (CRP) in regulation of the succinate dehydrogenase genes Rv0249c-Rv0247c in TB complex mycobacteria

(2015) G. S. Knapp et al.   NUCLEIC ACIDS RESEARCH

Characterization of a cAMP responsive transcription factor, Cmr (Rv1675c), in TB complex mycobacteria reveals overlap with the DosR (DevR) dormancy regulon

(2015) Sridevi Ranganathan et al.   NUCLEIC ACIDS RESEARCH

Novel Inhibitors of Cholesterol Degradation in Mycobacterium tuberculosis Reveal How the Bacterium’s Metabolism Is Constrained by the Intracellular Environment

(2015) Brian C. VanderVen et al.   PLoS Pathogens

Expression of a Subset of Heat Stress Induced Genes of Mycobacterium tuberculosis Is Regulated by 3',5'-Cyclic AMP

(2014) Eira Choudhary et al.   PLoS One

Perspectives on host adaptation in response to Mycobacterium tuberculosis: Modulation of inflammation

(2014) Anca Dorhoi et al.   SEMINARS IN IMMUNOLOGY

IntracellularMycobacterium tuberculosisExploits Host-derived Fatty Acids to Limit Metabolic Stress

(2013) Wonsik Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclic AMP-dependent Protein Lysine Acylation in Mycobacteria Regulates Fatty Acid and Propionate Metabolism

(2013) Subhalaxmi Nambi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reversible acetylation regulates acetate and propionate metabolism in Mycobacterium smegmatis

(2013) J. D. Hayden et al.   MICROBIOLOGY-SGM

Cholesterol Catabolism by Mycobacterium tuberculosis Requires Transcriptional and Metabolic Adaptations

(2012) Jennifer E. Griffin et al.   CHEMISTRY & BIOLOGY

A screen for non-coding RNA in Mycobacterium tuberculosis reveals a cAMP-responsive RNA that is expressed during infection

(2012) Shaaretha Pelly et al.   GENE

Automation of the CHARMM General Force Field (CGenFF) II: Assignment of Bonded Parameters and Partial Atomic Charges

(2012) K. Vanommeslaeghe et al.   Journal of Chemical Information and Modeling

Automation of the CHARMM General Force Field (CGenFF) I: Bond Perception and Atom Typing

(2012) K. Vanommeslaeghe et al.   Journal of Chemical Information and Modeling

Adjunctive TNF Inhibition with Standard Treatment Enhances Bacterial Clearance in a Murine Model of Necrotic TB Granulomas

(2012) Ciaran Skerry et al.   PLoS One

Mycobacterium tuberculosis WhiB1 represses transcription of the essential chaperonin GroEL2

(2012) Melanie R. Stapleton et al.   TUBERCULOSIS

Filamin A is a phosphorylation target of membrane but not cytosolic adenylyl cyclase activity

(2011) Sarah L. Sayner et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Reversible Acetylation and Inactivation ofMycobacterium tuberculosisAcetyl-CoA Synthetase Is Dependent on cAMP

(2011) Hua Xu et al.   BIOCHEMISTRY

Pathway Profiling inMycobacterium tuberculosis

(2011) Suzanne T. Thomas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphodiesterase-4 Inhibition Alters Gene Expression and Improves Isoniazid – Mediated Clearance of Mycobacterium tuberculosis in Rabbit Lungs

(2011) Selvakumar Subbian et al.   PLoS Pathogens

Cyclic AMP signalling in mycobacteria: redirecting the conversation with a common currency

(2010) Guangchun Bai et al.   CELLULAR MICROBIOLOGY

Caseation of human tuberculosis granulomas correlates with elevated host lipid metabolism

(2010) Mi-Jeong Kim et al.   EMBO Molecular Medicine

Statistical potentials for fold assessment

(2010) Francisco Melo et al.   PROTEIN SCIENCE

Tuberculosis: What We Don't Know Can, and Does, Hurt Us

(2010) D. G. Russell et al.   SCIENCE

Cholesterol Metabolism Increases the Metabolic Pool of Propionate inMycobacterium tuberculosis

(2009) Xinxin Yang et al.   BIOCHEMISTRY

Role of Pseudomonas aeruginosa type III effectors in disease

(2009) Joanne Engel et al.   CURRENT OPINION IN MICROBIOLOGY

Mycobacterium tuberculosiscAMP Receptor Protein (Rv3676) Differs from the Escherichia coli Paradigm in Its cAMP Binding and DNA Binding Properties and Transcription Activation Properties

(2009) Melanie Stapleton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CHARMM: The biomolecular simulation program

(2009) B. R. Brooks et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

3-Ketosteroid 9α-hydroxylase is an essential factor in the pathogenesis ofMycobacterium tuberculosis

(2009) Yanmin Hu et al.   MOLECULAR MICROBIOLOGY

Cyclic AMP intoxication of macrophages by a Mycobacterium tuberculosis adenylate cyclase

(2009) Nisheeth Agarwal et al.   NATURE

Suppression of LPS-Induced TNF-  Production in Macrophages by cAMP Is Mediated by PKA-AKAP95-p105

(2009) E. A. Wall et al.   Science Signaling

Cyclic AMP

(2008) Carlos H. Serezani et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

cAMP levels withinMycobacterium tuberculosisandMycobacterium bovisBCG increase upon infection of macrophages

(2008) Guangchun Bai et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Tuberculous Granulomas Are Hypoxic in Guinea Pigs, Rabbits, and Nonhuman Primates

(2008) L. E. Via et al.   INFECTION AND IMMUNITY

Functional Characterization of a Vitamin B12-Dependent Methylmalonyl Pathway in Mycobacterium tuberculosis: Implications for Propionate Metabolism during Growth on Fatty Acids

(2008) S. Savvi et al.   JOURNAL OF BACTERIOLOGY

Stimulation of Mammalian G-protein-responsive Adenylyl Cyclases by Carbon Dioxide

(2008) Philip D. Townsend et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rv1675c (cmr) regulates intramacrophage and cyclic AMP-induced gene expression inMycobacterium tuberculosis-complex mycobacteria

(2008) Michaela A. Gazdik et al.   MOLECULAR MICROBIOLOGY

Mycobacterial persistence requires the utilization of host cholesterol

(2008) A. K. Pandey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA