Potential Contributions of the Tobacco Nicotine-Derived Nitrosamine Ketone (NNK) in the Pathogenesis of Steatohepatitis in a Chronic Plus Binge Rat Model of Alcoholic Liver Disease

Chronic plus binge ethanol feeding synergistically induces neutrophil infiltration and liver injury in mice: A critical role for E-selectin

(2013) Adeline Bertola et al.   HEPATOLOGY

Multifaceted roles of GSK-3 and Wnt/β-catenin in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention

(2013) J A McCubrey et al.   LEUKEMIA

Mouse model of chronic and binge ethanol feeding (the NIAAA model)

(2013) Adeline Bertola et al.   Nature Protocols

Insulin Resistance, Ceramide Accumulation and Endoplasmic Reticulum Stress in Experimental Chronic Alcohol-Induced Steatohepatitis

(2012) Teresa Ramirez et al.   ALCOHOL AND ALCOHOLISM

4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone Induces Retinoic Acid Receptor β Hypermethylation through DNA Methyltransferase 1 Accumulation in Esophageal Squamous Epithelial Cells

(2012) Jing Wang et al.   Asian Pacific Journal of Cancer Prevention

Risk factors for hepatocellular carcinoma in patients with chronic liver disease: a case–control study

(2012) Nghi B. Ha et al.   CANCER CAUSES & CONTROL

An LC–MS/MS method for concurrent determination of nicotine metabolites and the role of CYP2A6 in nicotine metabolite-mediated oxidative stress in SVGA astrocytes

(2012) Anusha Ande et al.   DRUG AND ALCOHOL DEPENDENCE

Roles of alcohol and tobacco exposure in the development of hepatocellular carcinoma

(2012) Vishnudutt Purohit et al.   LIFE SCIENCES

Deficiency of CCAAT/enhancer binding protein family DNA binding prevents malignant conversion of adenoma to carcinoma in NNK-induced lung carcinogenesis in the mouse

(2012) Shioko Kimura et al.   Molecular Cancer

Insulin Resistance, Ceramide Accumulation, and Endoplasmic Reticulum Stress in Human Chronic Alcohol-Related Liver Disease

(2012) Lisa Longato et al.   Oxidative Medicine and Cellular Longevity

Achaete-Scute Complex Homolog-1 Promotes DNA Repair in the Lung Carcinogenesis through Matrix Metalloproteinase-7 and O(6)-Methylguanine-DNA Methyltransferase

(2012) Xiao-Yang Wang et al.   PLoS One

Lipidic last breath of life in patients with alcoholic liver disease

(2012) Joanna Raszeja-Wyszomirska et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Limited Therapeutic Effect of N-Acetylcysteine on Hepatic Insulin Resistance in an Experimental Model of Alcohol-Induced Steatohepatitis

(2011) Mashiko Setshedi et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Synergistic Effect of Alcohol Consumption and Body Mass on Serum Concentrations of Cytokeratin-18

(2011) Arturo Gonzalez-Quintela et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Molecular Mechanisms of Alcoholic Liver Disease: Innate Immunity and Cytokines

(2011) Andrew M. Miller et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Hybrid Malondialdehyde and Acetaldehyde Protein Adducts Form in the Lungs of Mice Exposed to Alcohol and Cigarette Smoke

(2011) Michael L. McCaskill et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Emerging Role of Redox Dysregulation in Alcoholic and Nonalcoholic Fatty Liver Disease

(2011) Ariel E. Feldstein et al.   ANTIOXIDANTS & REDOX SIGNALING

Metabolites of a Tobacco-Specific Lung Carcinogen in Children Exposed to Secondhand or Thirdhand Tobacco Smoke in Their Homes

(2011) J. L. Thomas et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

The Role of Endoplasmic Reticulum Stress in Emphysema Results from Cigarette Smoke Exposure

(2011) Guixiang Gan et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Insulin signaling to hepatic lipid metabolism in health and disease

(2011) Karla F. Leavens et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Non-alcoholic fatty liver disease

(2011) Briohny W. Smith et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Alcohol Abuse, Endoplasmic Reticulum Stress and Pancreatitis

(2011) Stephen J. Pandol et al.   DIGESTIVE DISEASES

Comparison of single high-dose streptozotocin with partial pancreatectomy combined with low-dose streptozotocin for diabetes induction in rhesus monkeys

(2011) Xi Jin et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

The emerging role of autophagy in alcoholic liver disease

(2011) Wen-Xing Ding et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Acetaldehyde and gastric cancer

(2011) Mikko SALASPURO   Journal of Digestive Diseases

Pathogenesis of alcohol-induced liver disease: Classical concepts and recent advances

(2011) Devanshi Seth et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Serum Cytokeratin 18 and Cytokine Elevations Suggest A High Prevalence of Occupational Liver Disease in Highly Exposed Elastomer/Polymer Workers

(2011) Matt Cave et al.   JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE

Post-translational modifications of mitochondrial aldehyde dehydrogenase and biomedical implications

(2011) Byoung-Joon Song et al.   Journal of Proteomics

Metabolic factors in the development of hepatic steatosis and altered mitochondrial gene expression in vivo

(2011) Shaoyun Wang et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Epidemiology and potential mechanisms of tobacco smoking and heavy alcohol consumption in pancreatic cancer

(2011) Eric J. Duell   MOLECULAR CARCINOGENESIS

Serum Markers of Hepatocyte Death and Apoptosis Are Non Invasive Biomarkers of Severe Fibrosis in Patients with Alcoholic Liver Disease

(2011) Vanessa Jeannette Lavallard et al.   PLoS One

Metabolic effects of CYP2A6 and CYP2A13 on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced gene mutation—A mammalian cell-based mutagenesis approach

(2011) Huai-chih Chiang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Histopathological diagnosis of non-alcoholic and alcoholic fatty liver disease

(2011) Andrea Tannapfel et al.   VIRCHOWS ARCHIV

The role of ethanol metabolism in development of alcoholic steatohepatitis in the rat

(2010) Martin J. Ronis et al.   ALCOHOL

Alcoholic Liver Disease-Related Mortality in the United States: 1980–2003

(2010) Helga Paula et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Formation of acetaldehyde-derived DNA adducts due to alcohol exposure

(2010) Hsu-Sheng Yu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Diagnosis and management of alcoholic liver disease

(2010) Arthur J McCULLOUGH et al.   Journal of Digestive Diseases

Histopathological evaluation of fatty and alcoholic liver diseases

(2010) Lisa YERIAN   Journal of Digestive Diseases

Pathogenesis of alcoholic liver disease: interactions between parenchymal and non-parenchymal cells

(2010) Jessica I COHEN et al.   Journal of Digestive Diseases

Hepatocellular ballooning in NASH

(2010) Stephen Caldwell et al.   JOURNAL OF HEPATOLOGY

Endoplasmic reticulum stress in liver disease

(2010) Harmeet Malhi et al.   JOURNAL OF HEPATOLOGY

A meta-analysis of alcohol drinking and oral and pharyngeal cancers. Part 1: Overall results and dose-risk relation

(2010) Irene Tramacere et al.   ORAL ONCOLOGY

Early limited nitrosamine exposures exacerbate high fat diet-mediated type 2 diabetes and neurodegeneration

(2010) Ming Tong et al.   BMC Endocrine Disorders

Mitochondrial DNA Adducts in the Lung and Liver of F344 Rats Chronically Treated with 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone and (S)-4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol

(2009) Irina Stepanov et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Analysis of Pyridyloxobutyl and Pyridylhydroxybutyl DNA Adducts in Extrahepatic Tissues of F344 Rats Treated Chronically with 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone and Enantiomers of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol

(2009) Siyi Zhang et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Comparative Levels of O6-Methylguanine, Pyridyloxobutyl-, and Pyridylhydroxybutyl-DNA Adducts in Lung and Liver of Rats Treated Chronically with the Tobacco-Specific Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone

(2009) P. Upadhyaya et al.   DRUG METABOLISM AND DISPOSITION

Differential induction of ethanol-metabolizing CYP2E1 and nicotine-metabolizing CYP2B1/2 in rat liver by chronic nicotine treatment and voluntary ethanol intake

(2009) Jiang Yue et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Alcoholic liver disease

(2009) Robert S. O'Shea et al.   HEPATOLOGY

PPARδ agonist attenuates alcohol-induced hepatic insulin resistance and improves liver injury and repair

(2009) Maoyin Pang et al.   JOURNAL OF HEPATOLOGY

Nitrosamine exposure exacerbates high fat diet-mediated type 2 diabetes mellitus, non-alcoholic steatohepatitis, and neurodegeneration with cognitive impairment

(2009) Suzanne M de la Monte et al.   Molecular Neurodegeneration

The Liver-Brain Axis of Alcohol-Mediated Neurodegeneration: Role of Toxic Lipids

(2009) Suzanne De la Monte et al.   International Journal of Environmental Research and Public Health

Molecular Mechanisms of Alcoholic Fatty Liver

(2008) Vishnudutt Purohit et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Quantitation of Pyridylhydroxybutyl-DNA Adducts in Liver and Lung of F-344 Rats Treated with 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone and Enantiomers of Its Metabolite 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol

(2008) Pramod Upadhyaya et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Interference in clinical chemistry assays by the hemoglobin-based oxygen carrier, Hemospan®

(2008) Scott J. Cameron et al.   CLINICAL BIOCHEMISTRY

Cytokine and Chemokine Expression Associated with Steatohepatitis and Hepatocyte Proliferation in Rats Fed Ethanol via Total Enteral Nutrition

(2008) Martin J. J. Ronis et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Insulin resistance in experimental alcohol-induced liver disease

(2008) Suzanne M de la Monte et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Interplay between oxidative stress and immunity in the progression of alcohol-mediated liver injury

(2008) Matteo Vidali et al.   TRENDS IN MOLECULAR MEDICINE